Adjuvanted RNA Origami—A Tunable Peptide Assembly Platform for Constructing Cancer Nanovaccines by Theresa Yip, Xinyi Tu, Xiaodong Qi, Hao Yan, Yung Chang

“…Conclusions: Our findings have significant implications for peptide vaccine design regarding peptide dosages and structural stability of RNA-OG complexed with peptides, which could guide the development of more effective peptide vaccines for cancer immunotherapy.…”
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Critical care, critical gaps: assessment of burnout and behavioral profiles of ICU healthcare workers in China—a multicenter cross-sectional study by Chao Qing Zhang, Xing Li, Lei He, BinBin Xu, Yan Wu, Junjie He, Wei Wang, Zhong Qian Lu

“…Gender, marital status, and ICU type were non-significant.ConclusionBurnout in ICU HCWs persists as a structural-behavioral challenge post-pandemic. Interventions should prioritize institutional support, equitable mental health access, and inclusion of vulnerable groups. …”
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FORMATION OF NATIVE AMERICAN WRITTEN LITERARY TRADITION by Oksana G. Shostak

“…In the article we used such methods as: historical-literary and historical-cultural methods as well as elements of structural analysis. The research deals with the ways of actualizing one of the most powerful concepts of the modern world – that of ethnicity, which stands out as a constituent of the basic Native American identity concept originated in the late 20th – early 21st centuries. …”
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A novel hybrid fuzzy analytical hierarchy process–game theory model for prioritizing factors affecting the deterioration of water pipelines by Eslam Mohammed Abdelkader, Tarek Zayed, Nehal Elshaboury

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Comprehensive RNA-Seq Analysis of Human Osteoclast Function in Response to <i>Bothrops moojeni</i> Venom Fractions: Pathways of Bone Resorption and Cytoskeletal Disruption by Fernanda D’Amélio, Hugo Vigerelli, Rodrigo Pinheiro Araldi, Isabel de Fátima Correia Batista, Daniel Carvalho Pimenta, Irina Kerkis

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Effectiveness of dolutegravir-based vs boosted darunavir-based first-line 3-drug regimens in people with HIV with advanced disease: A trial emulation by Roberta Gagliardini, Andrea Giacomelli, Cristina Mussini, Stephen R. Cole, Jessie K. Edwards, Carmela Pinnetti, Alessandro Raimondi, Spinello Antinori, Silvia Nozza, Valentina Mazzotta, Giulia Carla Marchetti, Sergio Lo Caputo, Alessandro Tavelli, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri

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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…At the heart of ART success is preimplantation genetic testing (PGT), which enables the detection of chromosomal anomalies, single-gene disorders, and structural rearrangements, enhancing embryo selection and mitigating genetic risk. …”
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Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (ST... by Florence Schleich, MD, PhD, Désirée Larenas-Linnemann, MD, FAAAAI, Dist.Intl.FACAAI, Alan Altraja, MD, PhD, Luis Pérez de Llano, MD, PhD, Konstantinos Kostikas, MD, PhD, FERS, Mohsen Sadatsafavi, MD, PhD, Arnaud Bourdin, MD, PhD, Roy Alton Pleasants, PharmD, Mark Hew, MBBS, PhD, FRACP, Wenjia Chen, PhD, Libardo Jiménez-Maldonado, MD, Simon Couillard, MD, MSc, Charlotte Suppli Ulrik, MD, DMSc, Adeeb A. Bulkhi, MD, MS, Ming-Ju Tsai, MD, PhD, George C. Christoff, MD, MPH, PhD, Nikolaos G. Papadopoulos, MD, PhD, FRCP, Paul E. Pfeffer, MRCP(UK), PhD, Dermot Ryan, MD, FRCGP, Celine Bergeron, MD, FRCPC, MSc, Mona S. Al-Ahmad, MD, FRCPC, Delbert R. Dorscheid, MD, PhD, Eileen Wang, MD, MPH, John D. Blakey, PhD, Belinda Cochrane, MBBS (Hons), MD, Matthew J. Peters, MD, PhD, Todor A. Popov, MD, PhD, Carlos A. Torres-Duque, MD, Susanne Hansen, PhD, Francesca Puggioni, MD, Kirsty Fletton, MBChB, Laila Salameh, PhD, Peter G. Middleton, MBBS, BSc(Med), PhD, FRACP, FERS, Paulo Márcio Pitrez, MD, PhD, Chin Kook Rhee, MD, PhD, Eve Denton, MBBS(Hons), MPH, PhD, FRACP, Kenneth R. Chapman, MSc, MD, FRCPC, FACP, FERS, Lauri Lehtimäki, MD, PhD, Ruth B. Murray, PhD, Chau-Chyun Sheu, MD, PhD, David J. Jackson, FRCP, PhD, Riyad Al-Lehebi, MD, FRCPC, Mariko Siyue Koh, MBBS, MRCP (UK), FCCP, Bassam Mahboub, MD, Ledit R.F. Ardusso, MD, Athena Gogali, MD, PhD, Giorgio Walter Canonica, MD, Piotr Kuna, MD, PhD, Martin Sivori, MD, PhD, Renaud Louis, MD, PhD, Shelley Abercromby, BSc(Hons), Giuseppe Guida, MD, PhD, Bernt Bøgvald Aarli, MD, PhD, Aaron Beastall, MSc, Victoria Carter, BSc, Ghislaine Scelo, PhD, John Townend, PhD, Borja G. Cosio, MD, PhD, Pujan H. Patel, MD, Celine Yun Yi Goh, MBBS, Zsuzsanna Csoma, MD, PhD, John W. Upham, MBBS, PhD, FRACP, João A. Fonseca, MD, PhD, Peter G. Gibson, MBBS, FRACP, Christine Jenkins, AM, MD, FRACP, Guy G. Brusselle, MD, PhD, Anne Chèvremont, Andréanne Côté, MD, MSc, FRCPC, Carlos Andrés Celis-Preciado, MD, MSc, Ivan Solarte, MD, MHPE, Celeste M. Porsbjerg, MD, PhD, Asger Sverrild, MD, PhD, Paula Kauppi, MD, PhD, Stelios Loukides, MD, FERS, Michael P. Makris, MD, PhD, Andriana I. Papaioannou, MD, PhD, Enrico Heffler, MD, PhD, Jeffrey Shi Kai Chan, MBChB, MPH, FESC, Hyonsoo Joo, MD, PhD, Liam G. Heaney, MD, Wei-Han Cheng, PhD, Njira Lugogo, MD, Michael E. Wechsler, MD, MMSc, Cláudia Chaves Loureiro, MD, PhD, Bellanid Rodríguez-Cáceres, BSc, Tatsuya Nagano, MD, PhD, Zhixiao Wang, PhD, Hao-Chien Wang, MD, PhD, Jorge Máspero, MD, Fernando Saldarini, MD, Ana María Stok, MD, Anahi Yañez, MD, Philip G. Bardin, PhD, Sinthia Z. Bosnic-Anticevich, PhD, Vidya Navaratnam, BMBS, MSc, PhD, Mohit Bhutani, MD, FRCPC, FCCP, M. Diane Lougheed, MSc, MD, FRCP(C), Lyle Melenka, MD, FRCP, B.MSc, Petros Bakakos, MD, Konstantinos P. Exarchos, MD, PhD, Aggelos A. Ladias, MD, Dóra Lúdvíksdóttir, MD, PhD, Takashi Iwanaga, MD, PhD, Elvia Angelica Contreras Contreras, MD, Sverre Lehmann, MD, PhD, José Alberto Ferreira, MD, Rebecca Gall, MD, Pin-Kuei Fu, MD, PhD, Diahn-Warng Perng, MD, PhD, Flavia Hoyte, MD, Rohit Katial, MD, Unnur S. Björnsdóttir, MD, Camille Taillé, MD, PhD, Christian Taube, MD, Breda Cushen, MD, PhD, Lakmini Bulathsinhala, MPH, Leif Bjermer, MD, PhD, David B. Price, FRCGP

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Implementation and Costs of an Agroforestry System in a Degraded Area of the Brazilian Semi-Arid Region by Israel Pereira de Quadro, Antônio Gilvan da Cruz de Souza, Danilo Batista Nogueira, Isac Gabriel Abrahão Bomfim, Aelton Biasi Giroldo

“…Specifically, we analyzed the system’s establishment process, estimated its costs, assessed structural development over time, and compared species performance and carbon accumulation across different biodiversity arrangements. …”
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Predicting HIV self-testing intentions among Chinese college students: a dual-model analysis integrating health belief constructs and machine learning prioritization by Yan Jiang, Jing Li, Jing Li, Jingfen Lu, Liping He, Lin Hu, Jiazhen He, Xianli Huang, Yuchao Li

“…Random forest modeling prioritized these psychological constructs (mean decrease Gini &gt;2.5), identifying male students and arts majors as critical subpopulations requiring targeted intervention.DiscussionOur dual-method analysis establishes that campus HIV control necessitates: 1) Gender-specific prevention programs addressing male students’ elevated risk exposure; 2) HBM-informed education strengthening self-efficacy and environmental cues; 3) Structural interventions reducing testing barriers through discreet service delivery. …”
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Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against <i>Naegleria fowleri</i> by Ahmed H. E. Hassan, Hương Giang Lê, Tuấn Cường Võ, Minji Kim, Joo Hwan No, Mohamed H. Aboutaleb, Jaehoon Sim, Byoung-Kuk Na, Yong Sup Lee

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THE ARTISTIC POTENTIAL OF CHORAL CONDUCTING IN CONTEMPORARY UKRAINE by Lyudmyla SHUMSKA, Yuliia PUCHKO-KOLESNYK, Lyudmyla KOSTENKO, Oleksandr VILA-BOTSMAN, Olha MARTYNOVSKA

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Mechanisms of immune regulation and transplantation immunity in corneal transplants by V. V. Neroev, N. V. Balatskaya, E. V. Chentsova, Kh. M. Shamkhalova

“…Unlike other kinds of transplants, corneal grafting is often performed without tissue typing and systemic immunosuppression.High frequency of transparent corneal engraftment (up to 90% of cases) in the absence of risk factors is due to special immunoprivileged area in the anterior eye segment (functionally, a structural aggregation of the cornea and anterior chamber, AC) accomplished by local and systemic immunoregulatory mechanisms, i.e., phenomenon of immune deviation associated with anterior chamber of the eye (ACAID), components of the internal liquid medium, a watery moisture with immunosuppressive properties, e.g., IL-1ra, TSP-1,TGF-β2, regulatory complement proteins, α-MSH (alpha-melanocyte stimulating hormone), VIP (vasoactive intestinal peptide), indolamine 2,3-dioxygenase (IDO), calcitonin-gene-bound peptide (CGRP), somatostatin, etc.In addition to ACAID and liquid AC components, a contribution to the maintenance of immune privilege which is extremely important for a successful outcome of keratoplasty, is provided by other mechanisms, in particular, immunologically active membrane-associated molecules of corneal endothelium, i.e., PDL-1 (Programmed death ligand 1), and sVEGFR-1, sVEGFR-2, sVEGFR-3 involved in maintaining avascularity of the corneal tissue. …”
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The effect of rTMS intervention with different targets on neural remodeling in stroke patients: a randomized controlled trial by Li Zhao, Li Chen, Qiu Wang, Xinyi Li, Sha Li, Chunxiao Wan

“…Functional connectivity analysis revealed significantly increased resting-state functional connectivity (rsFC) in the contralateral dentate nucleus and ventromedial premotor area of the affected side in the SMA group relative to the M1 group (p = 0.0319), with this enhancement showing a strong positive correlation with balance function improvement (r = 0.637, p = 0.001). Structural MRI analysis indicated that while the M1 group exhibited a significant increase in gray matter volume (GMV) in the medial segment of the postcentral gyrus (p = 0.02), the SMA group showed significant GMV increases in the posterior cerebellum and chorionic lobule (p = 0.0428) that demonstrated a moderate positive correlation with improved balance function (r = 0.436, p = 0.038). …”
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Application of marine bacterial alginate lyases in wastewater treatment, biofilm removal and green technology by M.U.K. Anjung, H. Nursyam, A.A. Prihanto, E. Chasanah

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Maternal and gestational factors associated with congenital anomalies among live births: a nationwide population-based study in Brazil from 2012 to 2020 by Qeren Hapuk Rodrigues Ferreira Fernandes, Enny S. Paixão, Maria da Conceição Nascimento Costa, Maria Glória Teixeira, Mauricio Lima Barreto, Angelina Xavier Acosta

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Special Features of a 24-hour Arterial Blood Pressure Profile in Healthy Children During the Period of Adaptation to Studying at Different School Types by I. N. Zakharova, T. M. Tvorogova, I. I. Pshenichnikova, M. A. Shkolnikova

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EDUCATIONAL TOURISM AS A BASIS FOR THE GROWTH OF ECONOMIC ACTIVITY OF THE LABOR MARKET by Olesia Iastremska

“…Theoretical and practical analysis of the work of specialists in the field of educational tourism and the functioning of the labor market has proved the need to use such research methods: monographic, analysis and synthesis, structural-logical method, systematic approach, theoretical generalization. …”
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Knowledge, Attitude, and Practice of Medical Staff Towards Metabolic Syndrome in Schizophrenia in Chinese Hospitals: A Cross-Sectional Study by Wang Y, Yu X, Chen H, Tang C, Zhang N

“…Approximately 64.9% of participants had experience treating patients with schizophrenia and metabolic syndrome, and this experience was significantly associated with higher practice scores. Structural equation model analysis revealed that knowledge influenced attitude (β = 0.10), attitude influenced practice (β = 0.82), and knowledge directly influenced practice (β = 0.50).Conclusion: Medical staff possess adequate knowledge, positive attitude, and proactive practice concerning metabolic syndrome in schizophrenia. …”
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The Bioethics-CSR Divide by Caio Caesar Dib

“…Furthermore, CSR and business and human rights are at the forefront of contemporary issues, such as the limits to sustainable development and appropriate governance structures, which may lead to the acceptance of values and accomplishment of goals cherished by bioethics. …”
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