A roadmap for personalized medicine: the findings of the IC2PerMed project by Flavia Beccia, Francesco Andrea Causio, Marzia Di Marcantonio, Ilda Hoxhaj, Chiara Cadeddu, Melissa Campagno, Lena Schleicher, Carmen Fotino, Maike Tauchert, Marta Lomazzi, Lili Wang, Wenya Wang, Huiyao Huang, Walter Ricciardi, Stefania Boccia, Stefania Boccia

“…The roadmap promotes best practice exchange and addresses potential barriers to PM adoption. It outlines structural actions including enhancing health literacy, fostering intersectoral and international collaboration, ongoing review of emerging technologies, and facilitating innovation market entry through needs assessment and Health Technology Assessment. …”
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Algorithm for analyzing randomness in point patterns by Tony Sampaio, Jorge Rocha, Cláudia M. Viana, Silvana Camboin, Fábio Marcelo Breunig, Edenilson Nascimento, Elaine de Cacia de Lima Frick

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Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination by Jaigeeth Deveryshetty, Ayush Mistry, Sushil Pangeni, Mohamed Ghoneim, Monica Tokmina-Lukaszewska, Steven K. Gore, Jie Liu, Vikas Kaushik, Simrithaa Karunakaran, Angela Taddei, Wolf-Dietrich Heyer, Taekjip Ha, Brian Bothner, Edwin Antony

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Theoretical investigation on PD-L1-In-1 for cancer immunotherapy via density functional theory by Bijay Sijapati Magar, Kiran Pudasainee, Prakash Pandey, Mahesh Kumar Neupane, Rupak Raj Lamichhane, Basanta Gurung, Khagendra Tripathi, Binod Adhikari

“…Abstract This study presents a comprehensive theoretical analysis of PD-L1-In-1 (C21H23N5O2) using the B3LYP functional with the 6-311G(d) basis set, focusing on its structural, electronic, and spectroscopic properties. …”
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How technological innovation and organizational culture influence circular economy adoption over time in Saudi Arabian manufacturing by Naima Sadaoui, Houcine Benlaria, Naeimah Fahad Almawishir, Balsam Saeed Abdelrhman, Sumaya Awad Khader Ahmed, Lotfi Zabat, Badreldin Mohamed Ahmed Abdulrahman, Rania Alaa Eldin Ahmed Khedr

“…Our study focuses on 222 people in executive and sustainability officer positions in different parts of the Kingdom of Saudi Arabia (KSA), who are actively involved in adopting new technologies and promoting the circular economy. We used Structural Equation Modeling (SEM) to examine how new technologies, organizational culture, supply chain integration, employee attitudes, and time affect the adoption of the circular economy. …”
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Barriers and Opportunities for Entrepreneurship Development in Ukraine: Towards a Sustainable and Resilient Economic Future by Svitlana Kropelnytska, Sergiy Yekimov, Oleh Aleksandrovych

“…The findings suggest that entrepreneurship can become a key driver of Ukraine’s long-term resilience and reconstruction if targeted policies are implemented to dismantle structural barriers, scale inclusive financing mechanisms, and promote entrepreneurial education and innovation. …”
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Predictors of Long-Term Outcomes after Surgical Myocardial Revascularization by V. S. Kaveshnikov, M. A. Kuzmichkina, V. N. Serebryakova

“…Data of Russian and foreign literature show that the long-term prognosis after CABG is largely determined by preoperative factors, in particular – age, set of cardiovascular risk factors (RF) and comorbidity, specifically – severity of coronary and systemic atherosclerosis, incident cardiovascular complications, structural and functional state of the heart. In the aggregate these factors reflect the cumulative effect and further potential of actual cardiovascular RFs, affect longterm risk of adverse events, and determine the therapeutic targets of secondary prevention. …”
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Artificial intelligence, job seeker, and career trajectory: How AI-based learning experiences affect commitment of fresh graduates to be an accountant? by Agung Maulana, Rakotoarisoa Maminirina Fenitra, Slamet Sutrisno, Kurniawan

“…This study grounds in Self-determination Theory (SDT) and Social Cognitive Career Theory (SCCT) to answer the questions and utilizes a multiple mediation model with partial least squares structural equation modeling (PLS-SEM) to analyze survey data gathered from 698 fresh graduates in accounting and finance program across the country (Indonesia). …”
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Relationship Between Physical Fitness Attributes and Dynamic Knee Valgus in Adolescent Basketball Athletes by Aleksandar Stojiljkovic, Eleni Karagianni, Varsamo Antoniou, Garyfallia Pepera

“…While neuromuscular control and structural alignment contribute to DKV, recent evidence indicates that lower limb muscle power (LLMP) and cardiorespiratory fitness (CRF) may significantly influence DKV. …”
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The effect of different intensities Resistance Training on expression mir-204 and transcription factors of osteogenic, Runx2 and biomechanical properties on bone in Old male Wistar... by ZAHRA HEMATI FARSANI, Ebrahim Banitalebi, Mohamad Faramarzi, Amin Bigham-Sadegh

“…Purpose:  Bones are largely influenced by nutrition, activity levels and lifestyle, and structural adaptations in the form and size of the bone occur by the forces of weight bearing and forces applied by the muscles. …”
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How Physicians Learn to Say "I'm Sorry": Power, Culture, and Apology in Medical Education by Stephanie Quon, Sarah Low, Sarah Zhou, Katherine Zheng

“…Empathy training facilitated sincere apologies, yet few programs assessed long-term behaviors or addressed structural barriers.Conclusion: Teaching apology in medicine requires more than communication skills, it demands longitudinal, systems-based efforts that foster humility, transparency, and institutional accountability.…”
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Determinants of physical activity level in pediatric oncological patients treated with cardiotoxic therapy – a study protocol by Julia Haponiuk-Skwarlińska, Jakub S. Gąsior, Katarzyna Albrecht, Paweł Łaguna, Bożena Werner

“…Abstract Background Childhood cancer and its therapy, especially that involving potentially cardiotoxic cancer treatment, can structurally affect muscle strength and heart function, and therefore may result in lowered physical activity (PA). …”
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Addressing nutritional inequities in vulnerable Colombian communities: an analysis from socioeconomic, cultural, and healthcare challenges by Omaira Valencia, Jenny Alexandra Hernández Montoya, María Carolina López, Juliana Damelines

“…Abstract Background Malnutrition remains a significant public health challenge in low-middle-income countries, particularly in rural and ethnic communities where structural inequalities exacerbate health disparities. …”
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The repressor PrtR1 and the global H-NS-like regulators MvaT and MvaV enable the fine-tuning of R-tailocin expression in Pseudomonas protegens by Clara Margot Heiman, Hammam Antar, Florian Fournes, Christoph Keel, Jordan Vacheron

“…By combining reverse genetics, transcriptional reporters and chromatin immunoprecipitation sequencing (ChIP-seq), we show that the R-tailocin locus-specific LexA-like regulator PrtR1 represses R-tailocin gene expression by binding directly to the promoter region of the cluster, while the histone-like nucleoid structuring (H-NS) proteins MvaT and MvaV act as master regulators that indirectly regulate R-tailocin cluster expression. …”
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Decommissioning and post-irradiation examination of the LHC beam dumps by N. Solieri, A. Lund, A.-P. Bernardes, L. R. Buonocore, A. Cherif, S. De Man, M. Di Castro, S. Di Giovannantonio, G. Dumont, S. El-Idrissi, E. Farina, D. Grenier, E. Grenier-Boley, M. Himmerlich, A. Infantino, A. Lechner, R. Mouret, D. Pazem, A. T. Perez-Fontenla, E. Romagnoli, S. Sgobba, C. Tromel, C. Veiga Almagro, M. Calviani

“…Endoscopic inspections of these beam dumps and experimental high-intensity proton-beam irradiation of material samples raised concerns about the structural integrity of the carbon-based materials in their cores. …”
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KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing by Dishiwen Liu, Huiyu Chen, Yuntao Fu, Yajun Yao, Shanqing He, Youcheng Wang, Zhen Cao, Xuewen Wang, Mei Yang, Qingyan Zhao

“…Inhibiting the KCa3.1/AKT/Rab27a signaling pathway reduces myocardial tissue structural remodeling in AF.…”
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An exploratory study of implementing a breakthrough series collaborative in early childhood education and care centers in the United States by Tamara Halle, Anne Douglass, Jennifer Cleveland, Tiffany Bamdad, Hallie Garrison, Kerensa Nagle, Kathryn Tout, Jennifer Agosti, Stephanie Doyle, Diana Gal-Szabo

“…As for improvements in short-term outcomes, teachers’ sense of efficacy increased over time, and participants reported structural changes to organizational functions (such as staff meetings and protected staff time) that removed barriers and allowed educators the time and space to take initiative for quality improvement activities. …”
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Unemployment as a new phenomenon of the transition economy of Russia in 1990–2000: causes, problems, solutions (on the example of the Southern Urals) by O. V. Salikhova, N. V. Baryshnikova

“…To achieve this goal, the following methods were used: statistical, system-structural, descriptive, comparative-historical. The sources include materials from federal and regional archives, statistical data from the Orenburg, Chelyabinsk regions and the Republic of Bashkortostan. …”
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Impact of women’s economic empowerment on technology entrepreneurship intentions via mediation of self-efficacy by Sura Al-Ayed, Sultan Alateeg

“…The analysis, conducted using structural equation modeling, revealed several important findings. …”
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Stochastic and Percolating Models of Blocking Computer Networks Dynamics during Distribution of Epidemics of Evolutionary Computer Viruses by S. A. Lesko, A. S. Alyoshkin, V. V. Filatov

“…On one hand, this model is based on the use of percolation theory methods, which makes it possible to determine such structural-information characteristics of networks as the dependence of the percolation threshold on the average number of connections per one node (network density). …”
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