Overcoming beta-lactam resistance in Pseudomonas aeruginosa by targeting metallo-beta-lactamase VIM-1: a one-microsecond molecular dynamics simulation study by Mohammed Salleh M. Ardawi, Samar A. Badreddine, Muhammad Yasir, Muhammad Yasir, Aiah M. Khateb, Aiah M. Khateb, Safaa A. Turkistani, Ahmed Afandi, Samah O. Noor, Adhari Alselmi, Adhari Alselmi, Vivek Dhar Dwivedi, Vivek Dhar Dwivedi, Esam I. Azhar, Esam I. Azhar

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Applications of Multiplex Immunohistochemistry in Evaluating Spatiotemporal Heterogeneity of T Cells by Mercedes Machuca-Ostos, Tim de Martines, Kanako Yoshimura, Junichi Mitsuda, Sumiyo Saburi, Alisa Kimura, Hiroki Morimoto, Koichi Yoshizawa, Nana Sakurai, Nanako Murakami, Kayo Kitamoto, Makoto Yasuda, Yoichiro Sugiyama, Hiroshi Ogi, Saya Shibata, Aya Miyagawa-Hayashino, Eiichi Konishi, Kyoko Itoh, Takahiro Tsujikawa, Shigeru Hirano

“…However, challenges remain in understanding the spatial and temporal profiles of T cells with differential phenotypes due to difficulties in single-cell analysis with preserved tissue structures. Here, we provide an optimized 12-marker multiplex immunohistochemical (IHC) panel and single-cell-based quantitative assessment to identify the spatial distributions of T cell phenotypes in formalin-fixed paraffin-embedded sections. …”
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Perceptions regarding rabies prevention and control in two different community settings in Vietnam using a Q-sorting approach by Doan Hoang Phu, Trang Phuong Thao, Mai Duong Tieu, Dung Nguyen Thi Thuy, Trang Nguyen Thi Phuong, Pawin Padungtod, Dinh Bao Truong

“…Although awareness of rabies is high, structural limitations – particularly inadequate access to veterinary services – hinder effective control. …”
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Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy by Zhibo Hu, Yu Zhou, Cailing Gao, Junfen Liu, Congqing Pan, Jun Guo

“…Results In vitro, AS-IV led to a significant reduction in blood urea nitrogen (BUN), urine albumen-to-creatinine ratio (UACR), serum creatinine (CREA), and hyperglycemia in db/db mice and lessen the pathological alterations in the kidney. Moreover, pyrin structural domain of the NLR family pyrin domain containing 3 (NLRP3), cleaved-caspase-1, gasdermin D (GSDMD), IL-18, and IL-1β were down-expressed and podocyte markers podocin and nphs1 were up-regulated following AS-IV intervention. …”
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Correlation between headache, cervical pain, and bruxism: retrospective study on TMD patients by Raúl E. Frugone-Zambra, Gianfranco Battaglia-Ardito, Andrea Berzaghi, A Joaquín Poblete-Gutiérrez, Carmen Luz Gonzalez-Poblete, Antonio Jiménez-Silva, Cristóbal Frugone-Zaror, Verónica Bittner-Schmidt, Sergio Bortolini

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Graded Finiteness of Persian Complement Clauses Based on Landau's Minimalist view and Givon's Functionalist Approach by Foroozandeh Zardashti, Bahram Modarresi, Mohammad Mehdi Esmaaili

“…Additionally, other scholars, such as Meshkatodini (2000), Moeinzadeh & Mosafa Jahromi (2009), and Alikhouei & Modaresi (2018), have provided implicit evidence supporting the non-finiteness of Persian complement clauses.Cross-linguistic evidence suggests that the varied structures of complement clauses and the diverse theoretical approaches to their analysis have led to contradictory opinions among linguists. …”
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Assessment of Early Fuchs Endothelial Corneal Dystrophy and CTG Trinucleotide Expansion Positivity Using Scheimpflug Imaging by Stanley S.J. Poh, MBBS, Kai Yuan Tey, MBBS, Gary S.L. Peh, PhD, Dawn J.H. Neo, MSc, Hla Myint Htoon, PhD, Evan K.L. Lee, Yu Qiang Soh, MBBS, V Vinod Mootha, MD, Jodhbir S. Mehta, PhD

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Implementing innovative technology promoting self-awareness of brain health and self-determination in obtaining a timely dementia diagnosis: protocol for a multimethods, concurrent... by Sharon L Naismith, Helen Macpherson, Bernice Redley, Alison M Hutchinson, Lidia Engel, Liliana Orellana, Loren Mowszowski, Tanita Botha, Tracey K Bucknall, Rajesh Vasa, Kon Mouzakis, Eva Yuen, Tanya Petrovich, Terence W H Chong, Kelly Burns, Stephanie Daly, Justine Lomas, Jessica Rivera Villicana, Andrew Vouliotis

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Comparison of climate-phenology-hydrology associations at two long-term studied forest watersheds in subtropical mountainous Taiwan by Chung-Te Chang, Jun-Yi Lee, Jyh-Min Chiang, Hsueh-Ching Wang, Cho-ying Huang, Jr-Chuan Huang, Chiu-Hsien Wang, Chun-Wei Tseng

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c.7156C > T p.(Gln2386*) variant causes loss-of-function of the USP9X gene in a female-restricted X-linked syndromic intellectual disability: a case report by Talyta Alves da Silva Campos, Alex Honda Bernardes, Irene Plaza Pinto, Hiane Aparecida da Silva Teixeira, Juliana Ferreira da Silva, Victor Cortázio do Prado Santos, Raffael Zatarin, Aparecido Divino da Cruz

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Techno-Functional, Rheological, and Physico-Chemical Properties of Gelatin Capsule By-Product for Future Functional Food Ingredients by Sasina Sanprasert, Pudthaya Kumnerdsiri, Anusorn Seubsai, Piyangkun Lueangjaroenkit, Jaksuma Pongsetkul, Sylvia Indriani, Tanyamon Petcharat, Samart Sai-ut, Kanrawee Hunsakul, Utthapon Issara, Subhash V. Pawde, Saroat Rawdkuen, Thomas Karbowiak, Young Hoon Jung, Passakorn Kingwascharapong

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Assessing the efficacy of 3D window double screens (3D-WDS) in reducing malaria transmission in northeastern Tanzania: Study protocol for a two-arm cluster-randomised controlled tr... by William N. Kisinza, Subam Kathet, Victor Mwingira, Maija Meri, Frank S. Magogo, Veneranda M. Bwana, Hanna Granroth-Wilding, Pendael Machafuko, Patrick Tungu, Mikko Aalto, Tomi Hakala, Markku Honkala, Seppo Meri, Ayman Khattab

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Genomic insights into genetic diversity and seed coat color change in common bean composite populations by Eva Plestenjak, Eva Plestenjak, Mohamed Neji, Lovro Sinkovič, Vladimir Meglič, Barbara Pipan

“…The results suggest that variation in seed coat color is controlled by both regulatory and structural genetic changes, providing valuable information for breeding programs.ConclusionThis study provides a detailed analysis of the genetic architecture of seed coat color variation in common bean. …”
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Evaluating the long-term impact of a distance learning course on attitudes, skills, practices, and knowledge in gender-affirming healthcare among healthcare professionals in Italy by Matteo Marconi, Ughetta Maria Favazzi, Pietro Carbone, Debora Guerrera, Angela Ruocco, Martina Manoli, Martina Manoli, Cristiana Barbati, Francesca Molinaro, Federica Maria Regini, Andrea Vittozzi, Alfonso Mazzaccara, Marina Pierdominici

“…The findings underscore the need for structural support and integrated reinforcement to embed gender-affirming care into routine practice.…”
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Assessing the context within academic health institutions toward improving equity-based, community and patient-engaged research by Prajakta Adsul, Shannon Sanchez-Youngman, Elizabeth Dickson, Belkis Jacquez, Alena Kuhlemeier, Michael Muhammad, Katherine J. Briant, Bridgette Hempstead, Jason A. Mendoza, Lisa G. Rosas, Anisha Patel, Patricia Rodriguez Espinosa, Tabia Akintobi, Paige Castro-Reyes, Lori Carter-Edwards, Nina Wallerstein

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Cognitive gains and cortical thickness changes after 12 weeks of resistance training in older adults with low and high risk of mild cognitive impairment: Findings from a randomized... by Simona Kušleikienė, Gal Ziv, Wouter A.J. Vints, Erika Krasinskė, Milda Šarkinaite, Orgesa Qipo, Ivan Bautmans, Uwe Himmelreich, Nerijus Masiulis, Vida J. Česnaitienė, Oron Levin

“…Background: In this randomized controlled trial, we assessed the neuroprotective effect of a 12-week resistance training (RT) program on executive control and cortical thickness of the prefrontal, temporal, parietal, and central cortex, regions prone to structural decline in individuals with mild cognitive impairment (MCI). …”
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Pediatric to adult healthcare transitioning for adolescents living with HIV in Nigeria: A national survey. by Okikiolu A Badejo, William N A Menson, Nadia A Sam-Agudu, Jennifer Pharr, Salome Erekaha, Tamara Bruno, Gift Nwanne, Olabanjo Ogunsola, Jude Ilozumba, Olusegun Busari, Echezona E Ezeanolue

“…Comprehensive HIV treatment facilities with ≥1 year of HIV service provision and ≥20 ALHIVs enrolled were selected. A structured questionnaire assessed availability of treatment, care and transition services for ALHIV. …”
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For-profit growth and academic decline: a retrospective nationwide assessment of Brazilian medical schools by Bruno B. Andrade, Bruno B. Andrade, Klauss Villalva-Serra, Klauss Villalva-Serra, Rodrigo C. Menezes, Rodrigo C. Menezes, Luiz F. Quintanilha, Katia de Miranda Avena, Katia de Miranda Avena

“…These patterns suggest a structural misalignment between the commercial logic of expansion and the core educational mission of medical training. …”
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Composition and Diversity Variation of Avifauna, along Different Vegetative Habitat Types in a Human-Modified Area, University of Kelaniya, Sri Lanka by B. K. A. Bellanthudawa, N. M. S. K. Nawalage, S. Subanky, P. A. B. G. Panagoda, H. W. G. A. S. Weerasinghe, L. K. D. N. Tharaka, H. M. A. K. Handapangoda, H. K. A. D. Silva, D. M. S. N. Dissanayake, M. S. J. Abeywickrama

“…Comparatively, medical center area habitat contributes to the highest species diversity with many flowering and fruiting trees while providing sufficient food resources and high floral structural complexity. Recorded avifaunal community composition ensures considerable conservation value to university premises of Kelaniya. …”
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Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken by Wen Li, Yuxing Luo, Shoujia Zhu, Mengyuan Wang, Xuli Zhao, Zhonghua Ning

“…Such insights may advance future strategies to improve egg quality and productivity in poultry breeding programs.…”
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