Highly selective HPK1 inhibitor NDI-101150 mediates immune cell activation and robust antitumor responses, distinct from immune checkpoint blockade by Samantha Carreiro, Christine Loh, Neelu Kaila, Fu-Shan Kuo, Scott Boiko, David N Ciccone, Joshua J McElwee, Peter J Tummino

“…Genetic HPK1 kinase inactivation or knockout in mice leads to immune cell activation and tumor growth suppression, providing a strong rationale for targeting HPK1 kinase activity as an immuno-oncology therapy.Methods A structure-guided drug design approach was used to identify a highly potent and selective small molecule inhibitor of HPK1 kinase activity, NDI-101150. …”
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First rangewide density estimate of the endemic and isolated Luangwa giraffe in Zambia by Catherine Sun, Frederike Otten, Rigardt Hoffman, Courtney Marneweck, Howard Maimbo, Charles-Albert Petre, Dusty Joubert, Tom Riffel, Matthew S. Becker, Stephanie Fennessy, Julian Fennessy, Michael B. Brown

“…However, sparse monitoring since the early 1900s has limited inferences about population size, structure, and range. To address this, we conducted the most spatially extensive and systematic survey to date of Luangwa giraffe across its distribution, extending survey effort 120 km south of their officially recognized extent. …”
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Informational and analytical support of planning processes of marketing actions in high-speed trains by E. A. Makarova, K. V. Surzhin, S. S. Morozov, S. V. Muktepavel, I. N. Spesivtseva

“…The functionality created on the basis of ACS “Express” is a flexible system of reports that are formed at the user's request, allowing you to view information on the structure of passenger traffic with varying degrees of detail for compiling programs to stimulate demand and analyze its effectiveness.…”
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Clinical and epidemiological characteristic of chronic hepatitis C in the republic of Tyva by A. A. Saryglar, S. O. Dongak, A. D. Ibrohimova, K. E. Novak, E. V. Esaulenko

“…The clinical profile of typical patients with chronic hepatitis C was established; whose share in the total structure of the examined was 38.4%.  Conclusion: There is a tendency to reduce the incidence of chronic hepatitis C in the Republic of Tyva. …”
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Changes in subarctic Pacific phytoplankton communities over the last two decades by Marta Konik, Marta Konik, Marta Konik, Brian P. V. Hunt, M. Angelica Peña, Toru Hirawake, Christian Marchese, Christian Marchese, Christian Marchese, Perumthuruthil Suseelan Vishnu, Perumthuruthil Suseelan Vishnu, Astrid Bracher, Astrid Bracher, Hongyan Xi, Maycira Costa

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Identifying the Educational Dimensions of Virtual Reality Technology on Museum Activities and Services: A Systematic Review by Abolfazl Sadegpour, Hasan Bolkhari Ghehi

“…The PRISMA Statement guidelines were precisely followed to structure the systematic review process in a meticulous and effective way. …”
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Interrelations of physical state parameters and biological age of students in the process of physical education by Oleksandr Pryimakov, Marek Sawczuk, Stanislav Prysiazhniuk, Nataliya Mazurok, Oleksandr Petrachkov

“…It was found that the key indicators of students' physical state (PS) structure, which exerted the most significant influence on BMI, differ between young men and women. …”
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Understanding and accessing the continuum of human/animal support services: A scoping review by Lisa Townsend, Grace Phillips, Janet Hoy-Gerlach, Heather Cammisa

“…This scoping review used Arksey and O’Malley’s framework to (1) create an initial map of HA/SS organizations in the United States (number and location); (2) describe their funding structure, (3) document the types of services provided, and (4) provide recommendations for expanding HA/SS. …”
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Isolation and characterization of a bioactive compound from Sphingomonas sanguinis DM with cytotoxic and molecular docking analysis by Mohamed A. Awad, Hesham S. M. Soliman, Samir F. El-Mashtoly, Yara E. Mansour, Bahig El-Deeb, Sherif F. Hammad

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Targeted genotyping (90K-SPET) facilitates genome-wide association studies and the prediction of yield-related traits in faba bean (Vicia faba L.) by Antonio Lippolis, Salvador A. Gezan, Jorrit Zuidgeest, Valeria Cafaro, Bert-Jan van Dinter, Geert Elzes, Maria-João Paulo, Luisa M. Trindade

“…Results The CGN panel was an optimal panel for performing high-resolution GWAS, showing large phenotypic variation, high narrow-sense heritability for all traits, and minimal genetic relatedness among accessions. Population structure analysis revealed the presence of four genetic groups. …”
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Conceptualizing the Public Component of Green Finance by Horyn Volodymyr P., Sydor Iryna P., Bula Pavlo V., Mudryi Taras P.

“…The generalization of scientific viewpoints from domestic and foreign economic science regarding the essence and structure of green finance has enabled the distinction of both public and private components within it. …”
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Development of intelligent monitoring system for tension overhead line construction based on multi-parameter sensing by Liu-Huo Wang, Qi Xiao, Feng Wang, Xiao-Bin Li, Hua-Shen Guan, Bao-Jun Liu

“…., and then it builds up the overall structure of the system’s monitoring points. Aiming at the characteristics of field construction of tension wire, a real-time data collection and processing model is designed, and LoRa communication technology and 4G communication technology are selected to interconnect the self constructed local area network and 4G wide area network, so as to complete the on-site interaction and long distance transmission of data. …”
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Demographic and socioeconomic factors affecting relative poverty level of older adults in Türkiye by Hüseyin Doğan, Kenan Özmen, Ceyhun Serçemeli, Ömer Alkan

“…Policies addressing older adults should incorporate flexible solutions based on household structure, prioritize health issues, and enhance community support. …”
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Determinants of physical activity level in pediatric oncological patients treated with cardiotoxic therapy – a study protocol by Julia Haponiuk-Skwarlińska, Jakub S. Gąsior, Katarzyna Albrecht, Paweł Łaguna, Bożena Werner

“…Abstract Background Childhood cancer and its therapy, especially that involving potentially cardiotoxic cancer treatment, can structurally affect muscle strength and heart function, and therefore may result in lowered physical activity (PA). …”
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Radiation-hygienic monitoring and assessment of the doses of the public residing on the radioactively contaminated territories of the Tula region by A. E. Lomovtsev, T. E. Sheveleva, A. S. Karpukhin, A. I. Volodicheva

“…Additionally, it included the assessment of the dynamics of concentration of 137Cs and 90Sr in food products, maximal values of mean annual effective doses of the public and contribution of the collective dose from medical exposure into the structure of the annual collective dose of the public. …”
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The repressor PrtR1 and the global H-NS-like regulators MvaT and MvaV enable the fine-tuning of R-tailocin expression in Pseudomonas protegens by Clara Margot Heiman, Hammam Antar, Florian Fournes, Christoph Keel, Jordan Vacheron

“…By combining reverse genetics, transcriptional reporters and chromatin immunoprecipitation sequencing (ChIP-seq), we show that the R-tailocin locus-specific LexA-like regulator PrtR1 represses R-tailocin gene expression by binding directly to the promoter region of the cluster, while the histone-like nucleoid structuring (H-NS) proteins MvaT and MvaV act as master regulators that indirectly regulate R-tailocin cluster expression. …”
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Coronavirus Anxiety Inventory’s (CAI) Turkish Adaptation: Testing its Validity and Reliability by Esra Asıcı, Halil İbrahim Sarı, Abdi Güngör

“…The results of the confirmatory factor analysis showed that the single-factor structure of the CAI with nine items had adequate fit indices, that is, it showed good features in terms of measuring coronavirus-related anxiety. …”
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Fault current limiting dynamic voltage restorer for power quality improvement in distribution system (case study: air force feeder) by Yechale Amogne, Efrata Admas, Wondifraw Asmare Alemu

“…In this paper, dual-function fault current limiter dynamic voltage restorer (FCL-DVR) topology is proposed. The proposed structure can perform both compensate supply voltage fluctuations and limit fault current. …”
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The stomatologic status of the population of the Far Eastern region

“…The authors carried out a comparative analysis of the frequency and structure of the dental diseases in different age groups of local and migrant adult population of the Far East. …”
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The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. by Xiaowen Jiang, Kun Zhao, Yi Sun, Xinyue Song, Chao Yi, Tianlong Xiong, Sen Wang, Yi Yu, Xiduo Chen, Run Liu, Xin Yan, Christopher L Antos

“…Using the zebrafish pectoral fin bud as a model for early vertebrate fin/limb development, we found that K+ channels also scale this anatomical structure, and we determined how one K+-leak channel, Kcnk5b, integrates into its developmental program. …”
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