Targeting MARCO in combination with anti-CTLA-4 leads to enhanced melanoma regression and immune cell infiltration via macrophage reprogramming by Hidenori Takahashi, Rana Falahat, Patricio Perez-Villarroel, James J Mulé

“…Macrophage Receptor with Collagenous Structure (MARCO) is one of a family of class-A scavenger receptors expressed by Mφ in the TME and is one of the most upregulated transcripts in dendritic cells (DC) following their ex vivo uptake of dead tumor cells. …”
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Flipping the curriculum for resident didactics: In-Training and certifying examination scores in an internal medicine residency. by Luke McCoy, Ronald Markert, Elysha Thoms, Olivia Noall, Kathryn Burtson

“…The curriculum followed a 13-block annual structure aligned with ABIM content areas. We compared IM-ITE and IM-CE scores of residents who completed the full flipped curriculum to those trained under the prior LB model.…”
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The role of Universal Grammar and crosslinguistic influence in the interpretation of recursive set-subset adjectives in adult Romanian L1-English L2 bilinguals by Adina Camelia Bleotu, Adina Camelia Bleotu, Deborah Foucault, Tom Roeper, Usha Lakshmanan

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Functional annotation of the Hippo pathway somatic mutations in human cancers by Han Han, Zhen Huang, Congsheng Xu, Gayoung Seo, Jeongmin An, Bing Yang, Yuhan Liu, Tian Lan, Jiachen Yan, Shanshan Ren, Yue Xu, Di Xiao, Jonathan K. Yan, Claire Ahn, Dmitry A. Fishman, Zhipeng Meng, Kun-Liang Guan, Ruxi Qi, Ray Luo, Wenqi Wang

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Optimization study of dynamic emergency feeder bus paths with the sudden interruption of urban railway traffic by Dejie Xu, Huilin Geng, Changwu Hui, Liang Gong, Hang Yuan, Qian Liu

“…A Back Propagation (BP) neural network estimates the emergency demand at each affected station, using historical and structural factors. These estimates are integrated into the hybrid optimization process, improving routing efficiency. …”
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Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without by Felix Eckstein, Wolfgang Wirth, Ali Guermazi, Frank Roemer, Michael Nevitt, Christoph Ladel, Leena Sharma, David J. Hunter, C. Kent Kwoh

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Clinical and Epidemiological Characteristics of Hepatocellular Carcinoma in the Republic of Saha (Yakutia) by S. S. Sleptsova, S. I. Malov, E. D. Savilov, S. I. Semenov, V. K. Semenova, L. A. Stepanenko, O. B. Ogarkov, I. V. Malov

“…The Republic of Sakha (Yakutia) is a hyperendemic region of the Russian Federation in terms of the incidence of hepatocellular carcinoma with a predominance of the male population in its structure. The rate of decrease in the incidence of liver cancer in the country will depend on the effectiveness of the regional program for the elimination of viral hepatitis and the decrease in the incidence of cirrhosis of the liver of non-infectious etiology.…”
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Spatial variation in time to diagnosis of visceral leishmaniasis in Bihar, India by Emily S. Nightingale, Joy Bindroo, Pushkar Dubey, Khushbu Priyamvada, Aritra Das, Caryn Bern, Sridhar Srikantiah, Ashok Kumar, Mary M. Cameron, Tim C. D. Lucas, Sadhana Sharma, Graham F. Medley, Oliver J. Brady

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Community-level mental health screening and referral using task-sharing with student volunteers in Kerala, India: a scalable model for low and middle income countries by Saju Madavanakadu Devassy, Lorane Scaria, Shyba Babu, Rajeev S.P., Lijo K.J., Amal Tom Jose, Kiran Thampi, Robin E. Gearing

“…The increasing incidence of common mental disorders in India exacerbates the treatment gap. Structural fragmentation prevents effective screening and treatment, despite several policies and programs. …”
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Parental Phasing Study Identified Lineage-Specific Variants Associated with Gene Expression and Epigenetic Modifications in European–Chinese Hybrid Pigs by Chenyu Li, Mei Ge, Keren Long, Ziyin Han, Jing Li, Mingzhou Li, Zhiyan Zhang

“…In this study, we established three crossbred pig families derived from distant genetic lineages and systematically identified variants from different lineages, including single nucleotide polymorphisms (SNPs) and structural variations (SVs). At the phase level, we quantitatively analyzed gene expression, four histone modifications (H3K4me3, H3K27ac, H3K4me1, and H3K27me3), and the binding strength of transcription factor (CTCF) in backfat (BF) and longissimus dorsi (LD) muscle. …”
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CanvasHero: The role of artificial intelligence in cultivating resilience among children and youth using the 6-part story method in mass war trauma by Yuval Haber, Inbar Levkovich, Iftach Tzafrir, Karny Gigi, Dror Yinon, Dorit Hadar Shoval, Zohar Elyoseph

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Antimicrobial resistance in a protracted war setting: a review of the literature from Palestine by Ramya Kumar, Osama Tanous, David Mills, Bram Wispelwey, Yara Asi, Weeam Hammoudeh, Omar Dewachi

“…Notably, most studies attributed AMR to local practices, often overlooking broader structural and socio-political drivers. This review underscores the need to contextualize AMR within the environment, particularly under conditions of sustained warfare.IMPORTANCEThis study goes beyond merely reviewing and summarizing data on AMR in the occupied Palestinian territories (oPt), a region enduring chronic war-like conditions. …”
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Why do older adults hesitate to get the flu vaccine? A cross-sectional study on vaccine hesitancy in the post-COVID-19 era by Xinyue Wang, Sanmei Wen, Jiaqian Wu, Ziyi Cui, Hong Shen, Shiyao Hu, Shujun Zeng, Yan Tang

“…Multinomial logistic regression models were used to identify predictors of vaccine hesitancy, adjusting for sociodemographic variables, self-reported health status and self-report vaccination experiences. Structural equation modeling (SEM) was employed to examine the underlying factors contributing to vaccine hesitancy and quantify their interrelationships.ResultsA high proportion (85.2%) of participants exhibited influenza vaccine hesitancy, with 16.2% being complete refusers. …”
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Distribution of variants of the <i>TNFA</i> gene regulatory sites among Russian women of Caucasian origin with leiomyoma by V. I. Konenkov, A. V. Shevchenko, V. F. Prokofiev, E. G. Koroleva

“…The aim of our research was to analyze the distribution of TNF-238, TNF- 308 and TNF-863 structural variants at the regulatory region of the TNFA gene in a representative group of Caucasian patients with UF compared with a matched group of healthy women followed by assessment of personalized prognostic significance of suggested differences. 180 patients diagnosed with uterine fibroids and 98 practically healthy women were examined. …”
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The impact of lifestyle sports on the sleep quality of depressed high school students in Jiangsu Province, China: based on cross-sectional study by Xianghe Chen, Yuxin Yang, Jianbo Hu, Shengjie Jin, Pengcheng Lu, Xinyu Zeng, Xiaoyan Yi, Rongbin Yin, Chenghao Zhong

“…The mediation model of depression between lifestyle sports and sleep quality was constructed via the Model4 model and other models in the SPSS macro program Process4.0. From the 32,974 valid questionnaires, 14,943 depressed high school students (SDS ≥ 53) were screened out, and structural equation modeling of the relationships between the six dimensions of lifestyle sports and the sleep quality of depressed high school students has been established via AMOS 28.0. …”
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A rural practice affinity model: recognizing the role of emergency medicine competency by Eliseo Orrantia, Theresa Kline, Lindsay Nutbrown, Erin Cameron, Margaret Cousins

“…A partial correlation matrix between the variables of interest (general self-efficacy, emergency medicine competency, rural practice self-efficacy, and rural practice intentions) - controlling for the effects of relationships, financial aspects, personal aspects, and social desirability - was created and subjected to a structural equation model. Results: Our initial rural practice affinity model resulted in a poor fit of the model to the data. …”
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Development of interest in training by creation emotional and comfortable educational environment by Olga M. Shentsova

“…Pedagogical approach to a solution consists of the following: to present in pedagogical process a possibility of interesting aspects of the educational activity; to excite and constantly maintain the students’ state of active interest by educational processes; to purposefully form and develop interest as the valuable property of the personality in training, promoting her informative activity.Interest in training – “is a form of manifestation of need of the personality for cognitive activity, owing to her emotional appeal and the vital importance, through active aspiration to knowledge acquisition, abilities, possession where in organic unity intellectual, emotional and strong-willed processes interact”.Also the personal and activity training is considered, including the personal focused and individual, informative and synergetic approaches, the levels of development of interest in training are marked out; tools for the emotional and comfortable educational environment, which influences efficiency of development of students’ interest in training at universities. The structural model of the educational environment has been developed, that includes spatial and subject, social, actionable, information and technological, substantial and spiritual components, which are considered by the authors in detail.When determining the educational environment we have used the method of the vector modeling, developed by V.Yasvin, which is based on the system of coordinates, consisting of an axis of FD “freedom-dependence” and an axis of AP “activity-passivity”. …”
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Strengthening health system's capacity for pre-exposure prophylaxis for adolescent girls and young women and adolescent boys and young men in South Africa (SHeS'Cap-PrEP): Protocol... by Edward Nicol, Trisha Ramraj, Mbuzeleni Hlongwa, Wisdom Basera, Ngcwalisa Jama, Carl Lombard, Tracy McClinton-Appollis, Darshini Govindasamy, Desiree Pass, Noluntu Funani, Sarah Aheron, Ariana Paredes-Vincent, Jennifer Drummond, Mireille Cheyip, Sibongile Dladla, Jason Bedford, Cathy Mathews

“…In South Africa, various approaches of delivering PrEP have been adopted at different service delivery points (facility-based only, school-based only, community-based only and hybrid school-facility and community-facility models) to overcome challenges associated with individual, structural, and health systems related barriers that may hinder access to and uptake of PrEP among these populations. …”
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A Study Protocol for a Comprehensive Evaluation of Two Artificial Intelligence‐Based Tools in Title and Abstract Screening for the Development of Evidence‐Based Cancer Guidelines... by Xiaomei Yao, Ashirbani Saha, Sharan Saravanan, Ashley Low, Jonathan Sussman

“…Completing a CPG through the Program in Evidence‐Based Care (PEBC), a globally acknowledged guideline program supported by Ontario Health (Cancer Care Ontario), typically takes about 2 years. …”
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Digital transformation of nephrology POCUS education—Integrating a multiagent, artificial intelligence, and human collaboration-enhanced curriculum with expert feedback by Mohammad S Sheikh, Kianoush B Kashani, James R Gregoire, Charat Thongprayoon, Jing Miao, Iasmina M Craici, Wisit Cheungpasitporn, Fawad M Qureshi

“…AI models contributed significantly to the curriculum's foundational structure, while human experts provided critical clinical insights. …”
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