A Proposed Diagnostic and Treatment Algorithm for the Management of Lumbar Discogenic Pain by Lorio MP, Beall DP, Myers TJ, Naidu RK, McRoberts WP, Davis TT, Gage EG, Calodney AK, Verrills P, De Palma MJ, Amirdelfan K, Block JE

“…., Walnut Creek, CA, USA; 12Private Practice, San Francisco, CA, USACorrespondence: Jon E Block, Private Practice, 2210 Jackson Street, Ste. 401, San Francisco, CA, 94115, USA, Tel +1 415-775-7947, Email jb@drjonblock.comBackground: There is renewed interest in the intervertebral disc as a target for treatments aimed at ameliorating lumbar discogenic pain by restoring and preserving the natural structure and function of this component of the vertebral motion segment.Methods: Using a modified Delphi methodology involving a panel of 11 experts, we developed a simple, understandable clinical algorithm to serve as a foundation for objective decision making regarding the diagnosis and treatment of lumbar discogenic pain throughout the entire continuum of care. …”
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High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization by Beatriz Fernández Rubio, Fernando Docobo Pérez, Laura Herrera Hidalgo, Luis Eduardo López-Cortés, Rafael Luque Márquez, José Manuel Lomas Cabezas, Luis Fernando López-Cortés, Marta Mejías Trueba, Ana Belén Guisado Gil, Alicia Gutiérrez Valencia, Arístides de Alarcón González, María Victoria Gil Navarro

“…Ceftriaxone free concentration was measured at three time-points: before the administration (C_min) and two and four hours after ceftriaxone administration (C₂ and C₄). Both structural and covariate population pharmacokinetic models were built. …”
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Replanting the Birthing Trees: A Call to Transform Intergenerational Trauma into Cycles of Healing and Nurturing by Catherine Chamberlain, Jacynta Krakouer, Paul Gray, Madeleine Lyon, Shakira Onwuka, Ee Pin Chang, Lesley Nelson, Valda Duffield, Janine Mohamed, Shaydeen Stocker, Yalmay Yunupingu, Sally Maymuru, Bronwyn Rossingh, Fiona Stanley, Danielle Cameron, Marilyn Metta, Tess M. Bright, Renna Gayde, Bridgette Kelly, Tatiana Corrales, Roz Walker, Tamara Lacroix, Helen Milroy, Alison Weatherstone, Kimberley A. Jones, Kristen Smith, Marcia Langton

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Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial by Dean A. Fennell, Kayleigh Hill, Min Zhang, Charlotte Poile, Sean Ewings, Essa Y. Baitei, Joanna Dzialo, Nada Nusrat, Jan Rogel, Daniel Faulkner, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Kim Mallard, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Liz Darlison, Peter Wells-Jordan, Cathy Richards, James Harber, Aleksandra Bzura, Jake Spicer, Catrin Pritchard, Tamihiro Kamata, Jens C. Hahne, Maymun Jama, Edward J. Hollox, Jason F. Lester, Jin-Li Luo, Zisen Zhou, Hongji Yang, Huiyu Zhou, Astero Klampatsa, Gareth O. Griffiths

“…Non-synonymous and neoantigen mutation burden were no different between groups, however R-mesotheliomas were infiltrated with activated CD8+ T- and CD19+ B-lymphocytes, organised into tertiary lymphoid structures. B-cell infiltration correlated with pro-inflammatory chemokines including IL24 and CCL19. …”
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Cross-species comparison of rodent and human decision-making in the Iowa Gambling Task in select neurological and psychiatric disorders: translational approach to examine age- and... by Varsha Singh, Manjari Tripathi, Sarat P. Chandra, Rohit Verma, Sushil Kumar Jha, Harvinder Singh Chhabra, Mrinmoy Chakravarty, Mrinmoy Chakravarty, Shambhovi Mitra, Indupriya B, Ankit Jha, Sakshi Sharma, Jyotsna Pandey, Divyanshi Pandey, Insha Shamshad, Ekta Ahlawat, Titli Saha, Chloé César, Suman Jain

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Community-engaged curriculum development using racial justice and biomedical lenses to address COVID-19 vaccine hesitancy in black individuals with rheumatologic conditions by Eseosa Olive Osaghae, Greta Sirek, Tonya Roberson, Mia Chandler, Ariel Childs, Monica Crespo-Bosque, Gina Curry, Amar Dhand, Mary Dollear, Alice Eggleston, Nnenna Ezeh, Dieufort Fleurissaint, Denice Garrett, Gail Granville, Muriel Jean-Jacques, Elena Losina, Elena Losina, Holly Milaeger, Lutfiyya Muhammad, Mary Ann Nelson, Chisa Nosamiefan, Bisola Ojikutu, Bisola Ojikutu, Bisola Ojikutu, Neil Pillai, Mary Beth Son, Marie Jacques Toussaint, Ana Valle, Jessica N. Williams, Michael York, Karen Mancera-Cuevas, Candace H. Feldman, Candace H. Feldman, Rosalind Ramsey-Goldman

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POTENSI PEMBENTUKAN LAPISAN SUPER DAN ULTRA KERAS SENYAWA KOMPOSIT NITRIDA MENGGUNAKAN KAIDAH ELEKTRODEPOSISI by Esmar Budi

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Measuring Faculty Excellence: Introducing a Model by Anoush Dehnadi Moghadam

“…There are various criteria for this evaluation, which generally focus more on research performance, while the main objective of hiring faculty members has been the development of education. The common structure of academic scoring,  rewarding  research  More than teaching (4). …”
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Fifty years of geophysical researches of glaciers in Institute of Geography, the Russian Academy of Sciences, 1966–2016 by V. M. Kotlyakov, Yu. Ya. Macheret

“…Basic results of these studies are the following: (1) the new data on the ice thicknesses, ice volumes, subglacial relief, internal structure, and thermal state of the glaciers were obtained; (2) the two‑layered (polythermal) glaciers consisting of the upper layer of cold ice and the lower layer of temperate water‑filled ice had been revealed in Svalbard for the first time; spatial distribution of cold, polythermal and temperate glaciers had been determined; (3) the evidences were obtained that measured changes in thickness of the upper cold ice layer in polythermal glaciers can be used to estimate the long‑period variations of regional climates and serve as regional paleothermometers; (4) methods for estimating the water content in temperate and polythermal glaciers from the RES data were developed; and its space‑time variations in temperate ices of the Svaldbald glaciers were estimated since even small water content inside of them can noticeably change their dynamic behavior; (5) methods for estimating the ice volume within glaciers in large regions of mountain and polar glaciations had been created; the ice storages were estimated in Svalbard, Franz Josef Land, Dzhungrsky Alatau, the Great Caucasus, and Mt. …”
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EMS Potentials in MENA region by Haytham Qosa, Mohamed Rashad Abdelaziz

“…Results The input from the four national societies revealed variation in governance, structure, and scope of services of EMS among them. …”
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EVERYDAY PRACTICES IN THE NEW MEDIA DISCOURSE (BY THE EXAMPLE OF COOKING SHOWS) / ПОВСЕДНЕВНЫЕ ПРАКТИКИ В ДИСКУРСЕ НОВЫХ МЕДИА (НА ПРИМЕРЕ КУЛИНАРНЫХ ШОУ)... by SIYUKHOVA AMINET M. / СИЮХОВА А.М.

“…The article addresses the everyday practices as the content of screen media programs. The main object of analysis is television programs devoted to food and cooking as the most popular ones in a series of programs about everyday practices. …”
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Evaluation of the efficacy and safety of a combination of chondroitin sulfate and glucosamine sulfate for knee and hip osteoarthritis in real clinical practice by A. E. Karateev, Yu. V. Barysheva, Ya. V. Belokon, T. Yu. Bolshakova, Yu. Yu. Grabovetskaya, E. A. Dolzhenkova, L. N. Eliseeva, O. B. Ershova, E. V. Zonova, I. Yu. Chernova, A. O. Isakanova, M. N. Kirpikova, V. T. Komarov, E. V. Kryukova, A. I. Kulikov, D. I. Lakhin, L. A. Levasheva, L. V. Masneva, L. V. Menshikova, Yu. V. Mishina, S. V. Norina, Yu. N. Pashkovsky, A. V. Petrov, A. G. Rusanov, A. V. Sarapulova, K. A. Svodtseva, O. V. Semagina, A. N. Sudakova, S. N. Tkachenko, M. M. Toporkov, S. K. Tutelyan, G. R. Fadienko, O. S. Filonenko, O. P. Fomina, A. S. Chernov

“…A combination of chondroitin and glucosamine is widely used in clinical practice as both a symptomatic and structure-modifying agent for the treatment of osteoarthritis (OA). …”
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Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice by Tiago H. Zaninelli, Victor Fattori, Olivia K. Heintz, Kristeena R. Wright, Philip R. Bennallack, Danielle Sim, Hussain Bukhari, Kathryn L. Terry, Allison F. Vitonis, Stacey A. Missmer, Avacir C. Andrello, Raymond M. Anchan, Stephen K. Godin, Dara Bree, Waldiceu A. Verri Jr., Michael S. Rogers

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Magnetically sensitive nanocomposites for targeted antitumor therapy with application of gemcitabine by N. M. Korniichuk, S. P. Turanska, A. L. Petranovska, M. V. Abramov, P. P. Gorbyk, N. Yu. Luk'yanova, N. V. Kusyak, V. F. Chekhun

“…The consequences of oxidative stress are induction of apoptosis, enhancement of lipid peroxidation processes, as well as structural and functional rearrangement of biological membranes. …”
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Cambios en las propiedades del suelo, posteriores a un incendio en el Parque Nacional Natural de Los Nevados, Colombia Soil changes after a fire event in a páramo ecosystem: Los Ne... by Juan Carlos Camargo-García, Miguel Ángel Dossman, José Alexander Rodríguez, Ligia María Arias, Jesús Hernando Galvis-Quintero

“…Consequently, physical properties of soils such as bulk density and structural stability were also deteriorated. Three years after the implementation of restoration activities, there are not evidences of the improvement of soils conditions; in fact, some properties tend to be more deteriorated. …”
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Unravelling the advances of CRISPR-Cas9 as a precise antimicrobial therapy: A systematic review by Hannay Crystynah Almeida de Souza, Pedro Panzenhagen, Anamaria Mota Pereira dos Santos, Ana Beatriz Portes, Juliana Fidelis, Carlos Adam Conte-Junior

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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…At the heart of ART success is preimplantation genetic testing (PGT), which enables the detection of chromosomal anomalies, single-gene disorders, and structural rearrangements, enhancing embryo selection and mitigating genetic risk. …”
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Dynamics of turnover of sugar-lowering drugs in the retail segment of the pharmaceutical market from 2020 to 2024 by D. V. Kurkin, E. V. Makarova, V. I. Zvereva, A. R. Makarova, D. A. Bakulin, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, I. S. Krysanov, K. N. Koryanova, D. A. Galkina, N. A. Osadchenko, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…Despite maintaining the leading position of metformin, the consumption structure is shifting towards more expensive schemes. …”
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The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders by Daniel Alcolea, Jordi Clarimón, María Carmona‐Iragui, Ignacio Illán‐Gala, Estrella Morenas‐Rodríguez, Isabel Barroeta, Roser Ribosa‐Nogué, Isabel Sala, M. Belén Sánchez‐Saudinós, Laura Videla, Andrea Subirana, Bessy Benejam, Sílvia Valldeneu, Susana Fernández, Teresa Estellés, Miren Altuna, Miguel Santos‐Santos, Lídia García‐Losada, Alexandre Bejanin, Jordi Pegueroles, Víctor Montal, Eduard Vilaplana, Olivia Belbin, Oriol Dols‐Icardo, Sònia Sirisi, Marta Querol‐Vilaseca, Laura Cervera‐Carles, Laia Muñoz, Raúl Núñez, Soraya Torres, M. Valle Camacho, Ignasi Carrió, Sandra Giménez, Constance Delaby, Ricard Rojas‐Garcia, Janina Turon‐Sans, Javier Pagonabarraga, Amanda Jiménez, Rafael Blesa, Juan Fortea, Alberto Lleó

“…Methods Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neuropsychological evaluations, and undergo a structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video‐polysomnogram, 18F‐fluorodeoxyglucose PET, amyloid PET, Tau PET). …”
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