Magnetically sensitive nanocomposites for targeted antitumor therapy with application of gemcitabine by N. M. Korniichuk, S. P. Turanska, A. L. Petranovska, M. V. Abramov, P. P. Gorbyk, N. Yu. Luk'yanova, N. V. Kusyak, V. F. Chekhun

“…The consequences of oxidative stress are induction of apoptosis, enhancement of lipid peroxidation processes, as well as structural and functional rearrangement of biological membranes. …”
Get full text

Cambios en las propiedades del suelo, posteriores a un incendio en el Parque Nacional Natural de Los Nevados, Colombia Soil changes after a fire event in a páramo ecosystem: Los Ne... by Juan Carlos Camargo-García, Miguel Ángel Dossman, José Alexander Rodríguez, Ligia María Arias, Jesús Hernando Galvis-Quintero

“…Consequently, physical properties of soils such as bulk density and structural stability were also deteriorated. Three years after the implementation of restoration activities, there are not evidences of the improvement of soils conditions; in fact, some properties tend to be more deteriorated. …”
Get full text

Community-engaged curriculum development using racial justice and biomedical lenses to address COVID-19 vaccine hesitancy in black individuals with rheumatologic conditions by Eseosa Olive Osaghae, Greta Sirek, Tonya Roberson, Mia Chandler, Ariel Childs, Monica Crespo-Bosque, Gina Curry, Amar Dhand, Mary Dollear, Alice Eggleston, Nnenna Ezeh, Dieufort Fleurissaint, Denice Garrett, Gail Granville, Muriel Jean-Jacques, Elena Losina, Elena Losina, Holly Milaeger, Lutfiyya Muhammad, Mary Ann Nelson, Chisa Nosamiefan, Bisola Ojikutu, Bisola Ojikutu, Bisola Ojikutu, Neil Pillai, Mary Beth Son, Marie Jacques Toussaint, Ana Valle, Jessica N. Williams, Michael York, Karen Mancera-Cuevas, Candace H. Feldman, Candace H. Feldman, Rosalind Ramsey-Goldman

Get full text

Evaluation of the efficacy and safety of a combination of chondroitin sulfate and glucosamine sulfate for knee and hip osteoarthritis in real clinical practice by A. E. Karateev, Yu. V. Barysheva, Ya. V. Belokon, T. Yu. Bolshakova, Yu. Yu. Grabovetskaya, E. A. Dolzhenkova, L. N. Eliseeva, O. B. Ershova, E. V. Zonova, I. Yu. Chernova, A. O. Isakanova, M. N. Kirpikova, V. T. Komarov, E. V. Kryukova, A. I. Kulikov, D. I. Lakhin, L. A. Levasheva, L. V. Masneva, L. V. Menshikova, Yu. V. Mishina, S. V. Norina, Yu. N. Pashkovsky, A. V. Petrov, A. G. Rusanov, A. V. Sarapulova, K. A. Svodtseva, O. V. Semagina, A. N. Sudakova, S. N. Tkachenko, M. M. Toporkov, S. K. Tutelyan, G. R. Fadienko, O. S. Filonenko, O. P. Fomina, A. S. Chernov

“…A combination of chondroitin and glucosamine is widely used in clinical practice as both a symptomatic and structure-modifying agent for the treatment of osteoarthritis (OA). …”
Get full text

Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

“…In this paper, we report a discovery of seven cluster candidates with massive quiescent galaxies at z  ∼ 2 in the 3.5 deg ^2 area of the XMM Large Scale Structure field, roughly doubling the known cluster sample at this frontier redshift if confirmed. …”
Get full text

Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice by Tiago H. Zaninelli, Victor Fattori, Olivia K. Heintz, Kristeena R. Wright, Philip R. Bennallack, Danielle Sim, Hussain Bukhari, Kathryn L. Terry, Allison F. Vitonis, Stacey A. Missmer, Avacir C. Andrello, Raymond M. Anchan, Stephen K. Godin, Dara Bree, Waldiceu A. Verri Jr., Michael S. Rogers

Get full text

Unravelling the advances of CRISPR-Cas9 as a precise antimicrobial therapy: A systematic review by Hannay Crystynah Almeida de Souza, Pedro Panzenhagen, Anamaria Mota Pereira dos Santos, Ana Beatriz Portes, Juliana Fidelis, Carlos Adam Conte-Junior

Get full text

Dynamics and Trends in the Incidence of Rabies in the Russian Federation and some Adjacent Regions of Eurasia in 2013–2021 by O. N. Zaykova, M. A. Losich, E. V. Rusakova, O. A. Verkhovsky, A. A. Shabeykin, T. V. Grebennikova

“…As a result, the proportion of dogs and cats in the morbidity structure has significantly increased, which, given their proximity to humans, ensures the maintenance of a high level of epidemiological risk. …”
Get full text

Ultrasound Phenotype-Based Approach to Treatment Choice in Osteoarthritis by Rositsa Karalilova, Velichka Popova, Konstantin Batalov, Dimitar Kolev, Lyatif Kodzhaahmed, Dimitrina Petrova-Stoyankova, Nikola Tepeliev, Tsvetelina Kostova, Lili Mekenyan, Zguro Batalov

“…<b>Introduction/Objectives:</b> Osteoarthritis (OA) is a chronic systemic disease that affects the entire array of joint structures. It is one of the most common chronic, socially significant diseases, associated with a decline in the quality of life of patients and constantly increasing the cost of treatment. …”
Get full text

Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
Get full text

Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs by Lei Liu, Guoqiang Yi, Yilong Yao, Yuwen Liu, Jiang Li, Yalan Yang, Mei Liu, Lingzhao Fang, Delin Mo, Longchao Zhang, Yonggang Liu, Yongchao Niu, Liyuan Wang, Xiaolu Qu, Zhangyuan Pan, Lei Wang, Muya Chen, Xinhao Fan, Yun Chen, Yongsheng Zhang, Xingzheng Li, Zhen Wang, Yijie Tang, Hetian Huang, Pengxiang Yuan, Yuying Liao, Xinjian Li, Zongjun Yin, Di Liu, Dongjie Zhang, Quanyong Zhou, Wangjun Wu, Jicai Jiang, Yahui Gao, George E. Liu, Lixian Wang, Yaosheng Chen, Kui Li, Martien A. M. Groenen, Zhonglin Tang

“…Using nine genomes—seven of which were newly generated, high‐quality de novo assembled genomes—and 1081 resequencing genomes, we built a pan‐genome and identified 134.24 Mb nonredundant nonreference sequences, 1099 novel protein‐coding genes, 187,927 structural variations (SVs) and 30,143,962 single‐nucleotide polymorphisms (SNPs). …”
Get full text

Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity by Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)

Get full text

The application of blockchain with a comparative approach and its impact on risk, flexibility and internal control evaluation by mohammadsadegh aminipoor, HamidReza GholamniaRoshan, azadeh kiapour, Iman Dadashi

“…Blockchain is essentially a public ledger, where groups of transactions or events are recorded and stored in a chain-like data structure; this approach creates a fast yet secure way to transfer funds. …”
Get full text

How do individuals with mental health disorder and spinal cord injury gain access to participate in voluntary sport groups in Switzerland? by Florence Epiney, Siegfried Nagel, Christopher Klenk

“…The coaches’ point of view was included to have a complementary perspective compared to the athletes to produce comprehensive insights. A semi-structured interview guideline was developed, discussed with experts and tested in a pilot interview (Braun & Clarke, 2022; Smith & Sparkes, 2020). …”
Get full text

A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…At the heart of ART success is preimplantation genetic testing (PGT), which enables the detection of chromosomal anomalies, single-gene disorders, and structural rearrangements, enhancing embryo selection and mitigating genetic risk. …”
Get full text

MSA-3D: Dissecting Galaxies at z ∼ 1 with High Spatial and Spectral Resolution by Ivana Barišić, Tucker Jones, Kris Mortensen, Themiya Nanayakkara, Yuguang Chen, Ryan Sanders, James S. Bullock, Kevin Bundy, Claude-André Faucher-Giguère, Karl Glazebrook, Alaina Henry, Mengting Ju, Matthew Malkan, Takahiro Morishita, Danail Obreschkow, Namrata Roy, Juan M. Espejo Salcedo, Alice E. Shapley, Tommaso Treu, Xin Wang, Kyle B. Westfall

“…Here we describe the multiplexed slit-stepping method, which is >15 times more efficient than the NIRSpec IFS mode for our program. As an example of the data quality, we present a case study of an individual galaxy at z = 1.104 (stellar mass M _* = 10 ^10.3 M _⊙ , star formation rate, SFR = 3 M _⊙ yr ^−1 ) with prominent face-on spiral structure. …”
Get full text

Dynamics of turnover of sugar-lowering drugs in the retail segment of the pharmaceutical market from 2020 to 2024 by D. V. Kurkin, E. V. Makarova, V. I. Zvereva, A. R. Makarova, D. A. Bakulin, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, I. S. Krysanov, K. N. Koryanova, D. A. Galkina, N. A. Osadchenko, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…Despite maintaining the leading position of metformin, the consumption structure is shifting towards more expensive schemes. …”
Get full text

Propuesta metodológica para la enseñanza de la biomedicina orientada a las herramientas de detección y diagnóstico molecular para estudiantes de Medicina by Gabriela Naranjo, Carolina Tituaña-Puente, Camila Maldonado, Daniela Alejandra Velasco-Uquillas, Grecia Victoria Vivas-Colmenares, José Rubén Ramírez-Iglesias

“…Methods: The proposed structure is based on the requirements of basic science subjects that students must complete to understand molecular diagnostics. …”
Get full text

Relationship between prenatal anxiety, depression, pregnancy stress and their social determinants by Weicui Meng, Sufeila Shalayiding, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…Given that psychological problems during pregnancy may lead to short-term and long-term adverse outcomes for both mothers and infants, clarifying their network structure and core social determinants holds important public health significance for formulating regional intervention strategies. …”
Get full text

Evaluating snow depth retrievals from Sentinel-1 volume scattering over NASA SnowEx sites by Z. Hoppinen, Z. Hoppinen, R. T. Palomaki, G. Brencher, D. Dunmire, D. Dunmire, E. Gagliano, A. Marziliano, J. Tarricone, J. Tarricone, H.-P. Marshall

Get full text