Deep learning and genomic best linear unbiased prediction integration: An approach to identify potential nonlinear genetic relationships between traits by F. Shokor, P. Croiseau, H. Gangloff, R. Saintilan, T. Tribout, T. Mary-Huard, B.C.D. Cuyabano

“…Deep learning (DL) offers a promising alternative for capturing nonlinear genetic relationships due to its ability to identify complex patterns without prior assumptions about the data structure. We proposed a novel hybrid model that that combines both DL and GBLUP (DLGBLUP), which uses the output of the traditional GBLUP, and enhances its predicted genetic values (PGV) by accounting for nonlinear genetic relationships between traits using DL. …”
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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors by Mia Madel Alfajaro, Emma L. Keeler, Ning Li, Nicholas J. Catanzaro, I-Ting Teng, Zhe Zhao, Michael W. Grunst, Boyd Yount, Alexandra Schäfer, Danyi Wang, Arthur S. Kim, Aleksandra Synowiec, Mario A. Peña-Hernández, Samantha Zepeda, Ridwan Arinola, Ramandeep Kaur, Bridget L. Menasche, Jin Wei, Gabriel A. Russell, John Huck, Jaewon Song, Aaron Ring, Akiko Iwasaki, Rohit K. Jangra, Sanghyun Lee, David R. Martinez, Walther Mothes, Pradeep D. Uchil, John G. Doench, Alicen B. Spaulding, Ralph S. Baric, Leonid Serebryannyy, Yaroslav Tsybovsky, Tongqing Zhou, Daniel C. Douek, Craig B. Wilen

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Synthesis, physical-chemical and biological properties of 1,8-disubstituted compounds of theobromine. III. 8-Amino-p-chlorobenzyltheobromines by D. G. Ivanchenko, M. I. Romanenko, A. M. Kamyshny, N. M. Polishchuk

“…There have been developed available laboratory-based methods for the synthesis of 8-aminosubstituted 1-p-chlorobenzyltheobromine, the structure of which has been proved by data obtained from elemental analysis and NMR- spectroscopy. …”
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Adherence to Medical Treatment in Elderly Patients with Coronary Artery Disease in the Settings of Primary Outpatient Care by S. K. Zyryanov, S. B. Fitilev, A. V. Vozzhaev, I. I. Shkrebneva, N. N. Shindryaeva, D. A. Klyuev, L. N. Stepanyan, A. M. Lutsenko, A. T. Tsai, A. A. Danilova

“…Medical history and structure of pharmacotherapy do not influence level of adherence in this population. …”
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High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization by Beatriz Fernández Rubio, Fernando Docobo Pérez, Laura Herrera Hidalgo, Luis Eduardo López-Cortés, Rafael Luque Márquez, José Manuel Lomas Cabezas, Luis Fernando López-Cortés, Marta Mejías Trueba, Ana Belén Guisado Gil, Alicia Gutiérrez Valencia, Arístides de Alarcón González, María Victoria Gil Navarro

“…Ceftriaxone free concentration was measured at three time-points: before the administration (C_min) and two and four hours after ceftriaxone administration (C₂ and C₄). Both structural and covariate population pharmacokinetic models were built. …”
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The Attitude of Pregnant Women and Health Workers for Influenza Vaccination by N. I. Briko, T. S. Saltykova, A. N. Gerasimov, A. A. Pozdnyakov, E. B. Brusina, L. P. Zueva, A. V. Lyubimova, A. A. Golubkova, T. G. Suranova, T. V. Tolokonnikova, V. B. Turkutyukov, V. I. Shumilov, V. A. Kalinkina, O. V. Kovalishena, L. D. Belotserkovtsova

“…Influenza and ARVI - the main nosological form in structure of all infectious diseases. Influenza is especially dangerous to pregnant women. …”
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Territorially Stratified Modeling for Sustainable Management of Free-Roaming Cat Populations in Spain: A National Approach to Urban and Rural Environmental Planning by Octavio P. Luzardo, Ruth Manzanares-Fernández, José Ramón Becerra-Carollo, María del Mar Travieso-Aja

“…These data were stratified by municipal population size and applied to national census figures to generate a model-ready demographic structure. We then implemented a stochastic simulation using Vortex software to project long-term population dynamics over a 25-year horizon. …”
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Modeling the Meaning of Individual Words Using Cultural Cartography and Keystroke Dynamics by Tatiana A. Litvinova, Olga V. Dekhnich

“…The material of the study is a newly developed dataset containing associative reactions to the keywords of Russian culture, anonymized data about the informants, as well as the reaction time while producing associations measured using a program that records keystrokes. The proposed research methodology includes both the existing approaches (automatic extraction of relations from texts based on data from language models and methods of vector semantics, i.e., “cultural cartography using word embeddings”) and a new list of features developed by the authors to describe individual differences in the meaning of a word based on the data from neurobiology about the meaning structure of word. …”
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ChemicalUniverseMachine. I. Uncovering the Cosmic Evolution of Metals in the Galaxy–Interstellar Medium–Circumgalactic Medium Ecosystem by Moka Nishigaki, Peter Behroozi, Masami Ouchi, Hong Guo, Rachel S. Somerville, Anna R. Gallazzi, Kimihiko Nakajima, Kuria Watanabe

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POTENSI PEMBENTUKAN LAPISAN SUPER DAN ULTRA KERAS SENYAWA KOMPOSIT NITRIDA MENGGUNAKAN KAIDAH ELEKTRODEPOSISI by Esmar Budi

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Measuring Faculty Excellence: Introducing a Model by Anoush Dehnadi Moghadam

“…There are various criteria for this evaluation, which generally focus more on research performance, while the main objective of hiring faculty members has been the development of education. The common structure of academic scoring,  rewarding  research  More than teaching (4). …”
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Fifty years of geophysical researches of glaciers in Institute of Geography, the Russian Academy of Sciences, 1966–2016 by V. M. Kotlyakov, Yu. Ya. Macheret

“…Elbrus; (6) detailed data on the ice thicknesses and the subglacial relief had been obtained for 40 glaciers in framework of different national and international programs and projects; the data can be used to solve a wide range of practical and theoretical problems, including numerical modeling. …”
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EMS Potentials in MENA region by Haytham Qosa, Mohamed Rashad Abdelaziz

“…Results The input from the four national societies revealed variation in governance, structure, and scope of services of EMS among them. …”
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Magnetically sensitive nanocomposites for targeted antitumor therapy with application of gemcitabine by N. M. Korniichuk, S. P. Turanska, A. L. Petranovska, M. V. Abramov, P. P. Gorbyk, N. Yu. Luk'yanova, N. V. Kusyak, V. F. Chekhun

“…The consequences of oxidative stress are induction of apoptosis, enhancement of lipid peroxidation processes, as well as structural and functional rearrangement of biological membranes. …”
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Cambios en las propiedades del suelo, posteriores a un incendio en el Parque Nacional Natural de Los Nevados, Colombia Soil changes after a fire event in a páramo ecosystem: Los Ne... by Juan Carlos Camargo-García, Miguel Ángel Dossman, José Alexander Rodríguez, Ligia María Arias, Jesús Hernando Galvis-Quintero

“…Consequently, physical properties of soils such as bulk density and structural stability were also deteriorated. Three years after the implementation of restoration activities, there are not evidences of the improvement of soils conditions; in fact, some properties tend to be more deteriorated. …”
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Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice by Tiago H. Zaninelli, Victor Fattori, Olivia K. Heintz, Kristeena R. Wright, Philip R. Bennallack, Danielle Sim, Hussain Bukhari, Kathryn L. Terry, Allison F. Vitonis, Stacey A. Missmer, Avacir C. Andrello, Raymond M. Anchan, Stephen K. Godin, Dara Bree, Waldiceu A. Verri Jr., Michael S. Rogers

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Evaluation of the efficacy and safety of a combination of chondroitin sulfate and glucosamine sulfate for knee and hip osteoarthritis in real clinical practice by A. E. Karateev, Yu. V. Barysheva, Ya. V. Belokon, T. Yu. Bolshakova, Yu. Yu. Grabovetskaya, E. A. Dolzhenkova, L. N. Eliseeva, O. B. Ershova, E. V. Zonova, I. Yu. Chernova, A. O. Isakanova, M. N. Kirpikova, V. T. Komarov, E. V. Kryukova, A. I. Kulikov, D. I. Lakhin, L. A. Levasheva, L. V. Masneva, L. V. Menshikova, Yu. V. Mishina, S. V. Norina, Yu. N. Pashkovsky, A. V. Petrov, A. G. Rusanov, A. V. Sarapulova, K. A. Svodtseva, O. V. Semagina, A. N. Sudakova, S. N. Tkachenko, M. M. Toporkov, S. K. Tutelyan, G. R. Fadienko, O. S. Filonenko, O. P. Fomina, A. S. Chernov

“…A combination of chondroitin and glucosamine is widely used in clinical practice as both a symptomatic and structure-modifying agent for the treatment of osteoarthritis (OA). …”
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Ultrasound Phenotype-Based Approach to Treatment Choice in Osteoarthritis by Rositsa Karalilova, Velichka Popova, Konstantin Batalov, Dimitar Kolev, Lyatif Kodzhaahmed, Dimitrina Petrova-Stoyankova, Nikola Tepeliev, Tsvetelina Kostova, Lili Mekenyan, Zguro Batalov

“…<b>Introduction/Objectives:</b> Osteoarthritis (OA) is a chronic systemic disease that affects the entire array of joint structures. It is one of the most common chronic, socially significant diseases, associated with a decline in the quality of life of patients and constantly increasing the cost of treatment. …”
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Unravelling the advances of CRISPR-Cas9 as a precise antimicrobial therapy: A systematic review by Hannay Crystynah Almeida de Souza, Pedro Panzenhagen, Anamaria Mota Pereira dos Santos, Ana Beatriz Portes, Juliana Fidelis, Carlos Adam Conte-Junior

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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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