A roadmap for personalized medicine: the findings of the IC2PerMed project by Flavia Beccia, Francesco Andrea Causio, Marzia Di Marcantonio, Ilda Hoxhaj, Chiara Cadeddu, Melissa Campagno, Lena Schleicher, Carmen Fotino, Maike Tauchert, Marta Lomazzi, Lili Wang, Wenya Wang, Huiyao Huang, Walter Ricciardi, Stefania Boccia, Stefania Boccia

“…The roadmap promotes best practice exchange and addresses potential barriers to PM adoption. It outlines structural actions including enhancing health literacy, fostering intersectoral and international collaboration, ongoing review of emerging technologies, and facilitating innovation market entry through needs assessment and Health Technology Assessment. …”
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Mechanisms of immune regulation and transplantation immunity in corneal transplants by V. V. Neroev, N. V. Balatskaya, E. V. Chentsova, Kh. M. Shamkhalova

“…Unlike other kinds of transplants, corneal grafting is often performed without tissue typing and systemic immunosuppression.High frequency of transparent corneal engraftment (up to 90% of cases) in the absence of risk factors is due to special immunoprivileged area in the anterior eye segment (functionally, a structural aggregation of the cornea and anterior chamber, AC) accomplished by local and systemic immunoregulatory mechanisms, i.e., phenomenon of immune deviation associated with anterior chamber of the eye (ACAID), components of the internal liquid medium, a watery moisture with immunosuppressive properties, e.g., IL-1ra, TSP-1,TGF-β2, regulatory complement proteins, α-MSH (alpha-melanocyte stimulating hormone), VIP (vasoactive intestinal peptide), indolamine 2,3-dioxygenase (IDO), calcitonin-gene-bound peptide (CGRP), somatostatin, etc.In addition to ACAID and liquid AC components, a contribution to the maintenance of immune privilege which is extremely important for a successful outcome of keratoplasty, is provided by other mechanisms, in particular, immunologically active membrane-associated molecules of corneal endothelium, i.e., PDL-1 (Programmed death ligand 1), and sVEGFR-1, sVEGFR-2, sVEGFR-3 involved in maintaining avascularity of the corneal tissue. …”
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The effect of rTMS intervention with different targets on neural remodeling in stroke patients: a randomized controlled trial by Li Zhao, Li Chen, Qiu Wang, Xinyi Li, Sha Li, Chunxiao Wan

“…Functional connectivity analysis revealed significantly increased resting-state functional connectivity (rsFC) in the contralateral dentate nucleus and ventromedial premotor area of the affected side in the SMA group relative to the M1 group (p = 0.0319), with this enhancement showing a strong positive correlation with balance function improvement (r = 0.637, p = 0.001). Structural MRI analysis indicated that while the M1 group exhibited a significant increase in gray matter volume (GMV) in the medial segment of the postcentral gyrus (p = 0.02), the SMA group showed significant GMV increases in the posterior cerebellum and chorionic lobule (p = 0.0428) that demonstrated a moderate positive correlation with improved balance function (r = 0.436, p = 0.038). …”
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Maternal and gestational factors associated with congenital anomalies among live births: a nationwide population-based study in Brazil from 2012 to 2020 by Qeren Hapuk Rodrigues Ferreira Fernandes, Enny S. Paixão, Maria da Conceição Nascimento Costa, Maria Glória Teixeira, Mauricio Lima Barreto, Angelina Xavier Acosta

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EDUCATIONAL TOURISM AS A BASIS FOR THE GROWTH OF ECONOMIC ACTIVITY OF THE LABOR MARKET by Olesia Iastremska

“…Theoretical and practical analysis of the work of specialists in the field of educational tourism and the functioning of the labor market has proved the need to use such research methods: monographic, analysis and synthesis, structural-logical method, systematic approach, theoretical generalization. …”
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Cross-species single-cell transcriptomic atlas of retinal photoreceptors reveals molecular signatures underlying color vision adaptation by Zhibin Li, Chengkai Yan, Yubao Lu, Yaqing Shu, Shilin Wu, Xi Cheng, Yuge Wang, Shishi Shen, Hui Yang, Gang Cao, Jianping Ji, Liangming Zhang, Jian Sun, Dongchang Xiao, Shasha Li, Wei Qiu

“…Summary: The retina exhibits conserved structural and functional features across species, yet the evolutionary mechanisms underlying color vision remain unclear. …”
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Glueballonia as Hopfions by Yuki Amari, Muneto Nitta, Chihiro Sasaki, Kenta Shigaki, Satoshi Yano, Shigehiro Yasui

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Improving the efficiency of the medicine provision system for patients with malignant neoplasms by Yu. A. Agafonova, D. V. Fedyaev, A. V. Snegovoy, V. V. Omelyanovskiy

“…We analyzed the regulatory legal documents regulating drug care and drug provision in the Russian Federation, data from depersonalized (anonymized) registers of the structure of hospitalizations in a day hospital for 2021. …”
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Sustainable building: Achieving thermal comfort in hot and humid climate using building performance simulation by Niniek Pratiwi, Abdi Gunawan Djafar, Rahmayanti Rahmayanti, Nur Mutmainnah, Arlan Kaharu

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An Image Grid Can Be Worth a Video: Zero-Shot Video Question Answering Using a VLM by Wonkyun Kim, Changin Choi, Wonseok Lee, Wonjong Rhee

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THE INFLUENCE OF THE LEVEL OF SOCIAL INTELLIGENCE DEVELOPMENT ON THE CHOICE OF RESPONSE STRATEGY IN CONFLICT SITUATIONS by Olena V. Karapetrova

“…The concept of social intelligence, its structure and functions, modern approaches to the problem of social intelligence development in young people are considered. …”
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“Standard Assessment Framework”: A Proposal to Fill a Gap in the “Paris Declaration” by Hellmut W. Eggers, Daniel Svoboda

“…It therefore presents simultaneously, however, a general grid that should structure findings in a much more detailed way, to be consigned to a SAF Data-Base that can be built up on the basis of experiences made in the past and on those accumulating further under current evaluation work. …”
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Socio-Demographic Factors Contributing to Teenage Pregnancy in Bidibidi Refugee Settlement Zone Four Yumbe District. by Momone, Evaline

“…The socio-demographic factors contributing to teenage pregnancy include age, socioeconomic status, education, family structure, cultural and religious influences, access to healthcare, peer influence, geographical location, and media impact. …”
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Enhanced ammonia decomposition using a Pd-Ag membrane reactor for high-purity hydrogen production by Erasmo Salvatore Napolitano, Cristina Italiano, Adele Brunetti, Minju Thomas, Antonio Vita, Giuseppe Barbieri

“…The catalyst was synthesized using solution combustion techniques, and its structure–activity relationship was thoroughly investigated through a range of advanced characterization methods, including N2 physisorption, X-ray diffraction (XRD), hydrogen temperature-programmed reduction (H2-TPR), and transmission electron microscopy (TEM).The performance of the membrane reactor was evaluated by varying the feed pressure and flow rate, using either single ammonia or a simulated outlet stream from a conventional reactor with ammonia conversions ranging from 20 % to 50 %. …”
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High‐Resolution and Surface‐Sensitive Tip‐Enhanced Raman Spectroscopy Characterization of Strained‐Silicon Devices through Cleanroom‐Compatible Plasmonic Probes by Chiara Mancini, Anacleto Proietti, Giancarlo La Penna, Luca Buccini, Daniele Passeri, Narciso Gambacorti, Marco Rossi

“…TERS enables not only the detection of strain in the crystal structure but also its magnitude at different levels of depth, despite the penetration depth of the laser employed. …”
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Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Here, we investigate the prevalence of cryptic coral groups and assess evidence for their permeability to gene flow (hybridisation) via a structured literature review of genomic studies. Using reproducible criteria to detect distinct genetic groups that are sympatric, we find that 68% of nominal species represented in population genomic studies show evidence for comprising partially reproductively isolated groups and that these distinct groups are often linked by gene flow. …”
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Comprehensive approach to the choice of therapy in patients with osteoarthritis at the first visit to the doctor. Expert consensus (literature review and resolution) by A. M. Lila, O. N. Tkacheva, N. N. Yakhno, A. V. Naumov, L. I. Alekseeva, Yu. V. Kotovskaya, M. V. Putilina, M. L. Kukushkin, A. Yu. Kochish, E. A. Taskina, G. R. Abuzarova

“…Pain relief is a priority in the formation of individual therapeutic programs for patients with OA, starting from their first request for medical assistance. …”
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Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue by Sara AL-Ghadban, Walter Cromer, Marisol Allen, Christopher Ussery, Michael Badowski, David Harris, Karen L. Herbst

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Infections in patients with acute luekemia treated with different regimens by T. N. Aleksandrova, V. N. Yadrikhinskaya, I. I. Mulina

“…Aim of the study: to analyze the frequency and structure of infectious complications in patients with acute leukemia, who received different chemotherapy regimens. …”
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Species and index diversity of macrofungi from two different locations in East Kalimantan by MUHAMMAD FAUZI ARIF, HILDIANA APRILIANI DHIU DEMO, FERDINA YULIANI, NUBLI HAZMI, IMAM ROSADI, ERVINDA YULIATIN, SUGIANUR SUGIANUR, HERY ABRIYANTO

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