An spike-accum® bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity by Jean Pierre Bikorimana, Nathanael A. Caveney, Nehme EL-Hachem, Gabrielle A. Mandl, John A. Capobianco, Daniela Stanga, Jamilah Abusarah, Mark A. Hancock, Roudy Farah, Marina P. Gonçalves, Darryl Falzarano, Mingmin Liao, Glenn Hamonic, Qiang Liu, Simon Beaudoin, Sebastien Talbot, Moutih Rafei

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Deep learning and genomic best linear unbiased prediction integration: An approach to identify potential nonlinear genetic relationships between traits by F. Shokor, P. Croiseau, H. Gangloff, R. Saintilan, T. Tribout, T. Mary-Huard, B.C.D. Cuyabano

“…Deep learning (DL) offers a promising alternative for capturing nonlinear genetic relationships due to its ability to identify complex patterns without prior assumptions about the data structure. We proposed a novel hybrid model that that combines both DL and GBLUP (DLGBLUP), which uses the output of the traditional GBLUP, and enhances its predicted genetic values (PGV) by accounting for nonlinear genetic relationships between traits using DL. …”
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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors by Mia Madel Alfajaro, Emma L. Keeler, Ning Li, Nicholas J. Catanzaro, I-Ting Teng, Zhe Zhao, Michael W. Grunst, Boyd Yount, Alexandra Schäfer, Danyi Wang, Arthur S. Kim, Aleksandra Synowiec, Mario A. Peña-Hernández, Samantha Zepeda, Ridwan Arinola, Ramandeep Kaur, Bridget L. Menasche, Jin Wei, Gabriel A. Russell, John Huck, Jaewon Song, Aaron Ring, Akiko Iwasaki, Rohit K. Jangra, Sanghyun Lee, David R. Martinez, Walther Mothes, Pradeep D. Uchil, John G. Doench, Alicen B. Spaulding, Ralph S. Baric, Leonid Serebryannyy, Yaroslav Tsybovsky, Tongqing Zhou, Daniel C. Douek, Craig B. Wilen

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Adherence to Medical Treatment in Elderly Patients with Coronary Artery Disease in the Settings of Primary Outpatient Care by S. K. Zyryanov, S. B. Fitilev, A. V. Vozzhaev, I. I. Shkrebneva, N. N. Shindryaeva, D. A. Klyuev, L. N. Stepanyan, A. M. Lutsenko, A. T. Tsai, A. A. Danilova

“…Medical history and structure of pharmacotherapy do not influence level of adherence in this population. …”
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The Attitude of Pregnant Women and Health Workers for Influenza Vaccination by N. I. Briko, T. S. Saltykova, A. N. Gerasimov, A. A. Pozdnyakov, E. B. Brusina, L. P. Zueva, A. V. Lyubimova, A. A. Golubkova, T. G. Suranova, T. V. Tolokonnikova, V. B. Turkutyukov, V. I. Shumilov, V. A. Kalinkina, O. V. Kovalishena, L. D. Belotserkovtsova

“…Influenza and ARVI - the main nosological form in structure of all infectious diseases. Influenza is especially dangerous to pregnant women. …”
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ChemicalUniverseMachine. I. Uncovering the Cosmic Evolution of Metals in the Galaxy–Interstellar Medium–Circumgalactic Medium Ecosystem by Moka Nishigaki, Peter Behroozi, Masami Ouchi, Hong Guo, Rachel S. Somerville, Anna R. Gallazzi, Kimihiko Nakajima, Kuria Watanabe

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High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization by Beatriz Fernández Rubio, Fernando Docobo Pérez, Laura Herrera Hidalgo, Luis Eduardo López-Cortés, Rafael Luque Márquez, José Manuel Lomas Cabezas, Luis Fernando López-Cortés, Marta Mejías Trueba, Ana Belén Guisado Gil, Alicia Gutiérrez Valencia, Arístides de Alarcón González, María Victoria Gil Navarro

“…Ceftriaxone free concentration was measured at three time-points: before the administration (C_min) and two and four hours after ceftriaxone administration (C₂ and C₄). Both structural and covariate population pharmacokinetic models were built. …”
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Measuring Faculty Excellence: Introducing a Model by Anoush Dehnadi Moghadam

“…There are various criteria for this evaluation, which generally focus more on research performance, while the main objective of hiring faculty members has been the development of education. The common structure of academic scoring,  rewarding  research  More than teaching (4). …”
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Fifty years of geophysical researches of glaciers in Institute of Geography, the Russian Academy of Sciences, 1966–2016 by V. M. Kotlyakov, Yu. Ya. Macheret

“…Elbrus; (6) detailed data on the ice thicknesses and the subglacial relief had been obtained for 40 glaciers in framework of different national and international programs and projects; the data can be used to solve a wide range of practical and theoretical problems, including numerical modeling. …”
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Magnetically sensitive nanocomposites for targeted antitumor therapy with application of gemcitabine by N. M. Korniichuk, S. P. Turanska, A. L. Petranovska, M. V. Abramov, P. P. Gorbyk, N. Yu. Luk'yanova, N. V. Kusyak, V. F. Chekhun

“…The consequences of oxidative stress are induction of apoptosis, enhancement of lipid peroxidation processes, as well as structural and functional rearrangement of biological membranes. …”
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Cambios en las propiedades del suelo, posteriores a un incendio en el Parque Nacional Natural de Los Nevados, Colombia Soil changes after a fire event in a páramo ecosystem: Los Ne... by Juan Carlos Camargo-García, Miguel Ángel Dossman, José Alexander Rodríguez, Ligia María Arias, Jesús Hernando Galvis-Quintero

“…Consequently, physical properties of soils such as bulk density and structural stability were also deteriorated. Three years after the implementation of restoration activities, there are not evidences of the improvement of soils conditions; in fact, some properties tend to be more deteriorated. …”
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Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice by Tiago H. Zaninelli, Victor Fattori, Olivia K. Heintz, Kristeena R. Wright, Philip R. Bennallack, Danielle Sim, Hussain Bukhari, Kathryn L. Terry, Allison F. Vitonis, Stacey A. Missmer, Avacir C. Andrello, Raymond M. Anchan, Stephen K. Godin, Dara Bree, Waldiceu A. Verri Jr., Michael S. Rogers

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Evaluation of the efficacy and safety of a combination of chondroitin sulfate and glucosamine sulfate for knee and hip osteoarthritis in real clinical practice by A. E. Karateev, Yu. V. Barysheva, Ya. V. Belokon, T. Yu. Bolshakova, Yu. Yu. Grabovetskaya, E. A. Dolzhenkova, L. N. Eliseeva, O. B. Ershova, E. V. Zonova, I. Yu. Chernova, A. O. Isakanova, M. N. Kirpikova, V. T. Komarov, E. V. Kryukova, A. I. Kulikov, D. I. Lakhin, L. A. Levasheva, L. V. Masneva, L. V. Menshikova, Yu. V. Mishina, S. V. Norina, Yu. N. Pashkovsky, A. V. Petrov, A. G. Rusanov, A. V. Sarapulova, K. A. Svodtseva, O. V. Semagina, A. N. Sudakova, S. N. Tkachenko, M. M. Toporkov, S. K. Tutelyan, G. R. Fadienko, O. S. Filonenko, O. P. Fomina, A. S. Chernov

“…A combination of chondroitin and glucosamine is widely used in clinical practice as both a symptomatic and structure-modifying agent for the treatment of osteoarthritis (OA). …”
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Unravelling the advances of CRISPR-Cas9 as a precise antimicrobial therapy: A systematic review by Hannay Crystynah Almeida de Souza, Pedro Panzenhagen, Anamaria Mota Pereira dos Santos, Ana Beatriz Portes, Juliana Fidelis, Carlos Adam Conte-Junior

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Ultrasound Phenotype-Based Approach to Treatment Choice in Osteoarthritis by Rositsa Karalilova, Velichka Popova, Konstantin Batalov, Dimitar Kolev, Lyatif Kodzhaahmed, Dimitrina Petrova-Stoyankova, Nikola Tepeliev, Tsvetelina Kostova, Lili Mekenyan, Zguro Batalov

“…<b>Introduction/Objectives:</b> Osteoarthritis (OA) is a chronic systemic disease that affects the entire array of joint structures. It is one of the most common chronic, socially significant diseases, associated with a decline in the quality of life of patients and constantly increasing the cost of treatment. …”
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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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Dynamics of turnover of sugar-lowering drugs in the retail segment of the pharmaceutical market from 2020 to 2024 by D. V. Kurkin, E. V. Makarova, V. I. Zvereva, A. R. Makarova, D. A. Bakulin, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, I. S. Krysanov, K. N. Koryanova, D. A. Galkina, N. A. Osadchenko, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…Despite maintaining the leading position of metformin, the consumption structure is shifting towards more expensive schemes. …”
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Relationship between prenatal anxiety, depression, pregnancy stress and their social determinants by Weicui Meng, Sufeila Shalayiding, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…Given that psychological problems during pregnancy may lead to short-term and long-term adverse outcomes for both mothers and infants, clarifying their network structure and core social determinants holds important public health significance for formulating regional intervention strategies. …”
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The Characteristic of Measles Epidemic Process in Kyrgyz Republic by M. S. Niiazalieva, O. V. Tsvirkun, V. S. Toygombaeva, I. Sh. Aldjambaeva, G. S. Ishenapysova, R. A. Frolov, G. S. Dadanova

“…This hypothesis confirmed by the high percentage of unvaccinated children of this age in the structure of the sickindividuals. All this casts doubt on the official data on the coverage of children of this age with preventive vaccinations (95.7%) and indicates the accumulation of contingents susceptible to measles. …”
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Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency by A. Jerrod Anzalone, Sharon Patrick, Amber Abel, Brad Price, Elizabeth Reisher, Kent Ripplinger, Mary Emmett, Ronald Horswell, San Chu, William B. Hillegass, Francisco S. Sy, Brian Melancon, H. Timothy Bunnell, Lucio Miele, Mary Helen Mays, Joseph Keawe‘aimoku Kaholokula, Elizabeth S. Chen, Karen M. Crowley, Indra Neil Sarkar, Susan L. Santangelo, Clifford J. Rosen, Jeremy Harper, David Bard, William Beasley, Sally L. Hodder

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