Suggested Topics within your search.
Suggested Topics within your search.
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2021
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2022
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2023
Highly selective HPK1 inhibitor NDI-101150 mediates immune cell activation and robust antitumor responses, distinct from immune checkpoint blockade
Published 2025-07-01“…Genetic HPK1 kinase inactivation or knockout in mice leads to immune cell activation and tumor growth suppression, providing a strong rationale for targeting HPK1 kinase activity as an immuno-oncology therapy.Methods A structure-guided drug design approach was used to identify a highly potent and selective small molecule inhibitor of HPK1 kinase activity, NDI-101150. …”
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2024
First rangewide density estimate of the endemic and isolated Luangwa giraffe in Zambia
Published 2025-05-01“…However, sparse monitoring since the early 1900s has limited inferences about population size, structure, and range. To address this, we conducted the most spatially extensive and systematic survey to date of Luangwa giraffe across its distribution, extending survey effort 120 km south of their officially recognized extent. …”
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2025
Clinical and epidemiological characteristic of chronic hepatitis C in the republic of Tyva
Published 2023-04-01“…The clinical profile of typical patients with chronic hepatitis C was established; whose share in the total structure of the examined was 38.4%. Conclusion: There is a tendency to reduce the incidence of chronic hepatitis C in the Republic of Tyva. …”
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2026
Conceptualizing the Public Component of Green Finance
Published 2025-03-01“…The generalization of scientific viewpoints from domestic and foreign economic science regarding the essence and structure of green finance has enabled the distinction of both public and private components within it. …”
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2027
Development of intelligent monitoring system for tension overhead line construction based on multi-parameter sensing
Published 2025-07-01“…., and then it builds up the overall structure of the system’s monitoring points. Aiming at the characteristics of field construction of tension wire, a real-time data collection and processing model is designed, and LoRa communication technology and 4G communication technology are selected to interconnect the self constructed local area network and 4G wide area network, so as to complete the on-site interaction and long distance transmission of data. …”
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2028
Radiation-hygienic monitoring and assessment of the doses of the public residing on the radioactively contaminated territories of the Tula region
Published 2019-09-01“…Additionally, it included the assessment of the dynamics of concentration of 137Cs and 90Sr in food products, maximal values of mean annual effective doses of the public and contribution of the collective dose from medical exposure into the structure of the annual collective dose of the public. …”
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2029
Coronavirus Anxiety Inventory’s (CAI) Turkish Adaptation: Testing its Validity and Reliability
Published 2021-08-01“…The results of the confirmatory factor analysis showed that the single-factor structure of the CAI with nine items had adequate fit indices, that is, it showed good features in terms of measuring coronavirus-related anxiety. …”
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2030
Fault current limiting dynamic voltage restorer for power quality improvement in distribution system (case study: air force feeder)
Published 2025-07-01“…In this paper, dual-function fault current limiter dynamic voltage restorer (FCL-DVR) topology is proposed. The proposed structure can perform both compensate supply voltage fluctuations and limit fault current. …”
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2031
The stomatologic status of the population of the Far Eastern region
Published 2020-04-01“…The authors carried out a comparative analysis of the frequency and structure of the dental diseases in different age groups of local and migrant adult population of the Far East. …”
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2032
The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b.
Published 2024-03-01“…Using the zebrafish pectoral fin bud as a model for early vertebrate fin/limb development, we found that K+ channels also scale this anatomical structure, and we determined how one K+-leak channel, Kcnk5b, integrates into its developmental program. …”
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2033
Mind maps for eliciting and assessing plant awareness: A preliminary study on pre‐service teachers
Published 2025-07-01“…A qualitative procedure was developed to analyze them, encompassing three perspectives: information structure, artistic performance (e.g., graphic richness), and scientific performance (plant knowledge, per content categories). …”
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2034
Impact of the atmosphere state on interaction of aircraft vortex and condensation trails
Published 2022-05-01“…It should also be noted that the contrail, while interacting with the vortex wake, can reveal its structure and visualize the processes of propagation and attenuation of the vortex wake. …”
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2035
QUALITY OF NATIONAL ECONOMIC GROWTH: FACTORS AND DETERMINANTS
Published 2015-09-01“…The subject / topic: TThe theme of this article is very relevant in the light of changes in the global geo-economic structure and changing the role and place ofRussiain world economic and geopolitical relations. …”
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2036
Development of social vocalizations in mice.
Published 2011-03-01“…Vocal bouts from older animals, p13 and adult, had significantly more sequential structure than those from younger mice. Overall, these results demonstrate substantial changes in social vocalizations with age. …”
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2037
The role of chromosomal rearrangements, polyploidy, and genome size variation in the diversity and ecological distribution of Asparagus L. species: a landscape cytogenetics meta-an...
Published 2024-11-01“…We used spatial principal component analysis (sPCA) to analyze the contribution of spatial variables to the cytogenetic structure of the studied Asparagus species. We used Bioclim and Maxent species distribution models (SDMs) to predict and identify areas suitable for selected Asparagus species in response to climate change by 2050. …”
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2038
The effect of genotype of the plant-host on the morpho-cultural properties of Septoria leaf blotch agents
Published 2018-05-01“…To study intravarietal variability of pathogen according to morpho-cultural traits there was carried out an analysis of isolates in three main criteria: appearance and structure of the colonies, speed of colonies growth in the nutrient surrounding, intensity of fungi sporulation. …”
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2039
Improving mental health services for young refugees: The role of organisational readiness in residential care facilities
Published 2025-04-01“…The participants provided information about the facility structure and characteristics, evaluation of the care provided for mental health within and outside the facility, and preparedness for UYRs’ mental health problems. …”
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2040
FORMING LIFE COMPETENCIES AND ENSURING THE ACQUISITION OF SUSTAINABLE DEVELOPMENT GOALS IN THE PROCESS OF INTEGRATED LEARNING IN SECONDARY AND HIGHER EDUCATION (WITH THE EXAMPLE OF...
Published 2019-06-01“…The concept of Life competence, its structure, which consists of knowledge, attitudes and life skills, is explored; several framework documents that underlie the development of a competence-based approach to learning were studied, among those documents: the Recommendation of the European Parliament and the Council of the EU on “Key Competences for Lifelong Learning”, 2006; Resolution of the UN General Assembly “Transforming our World: The 2030 Agenda for Sustainable Development for the period up to 2030”, 2015; the Report “Global Assessment of Educational Programs for Life Skills Training”, UNICEF, 2012; Guideline “The Cambridge Framework for Life Competencies”, Cambridge, 2018, 2019; “Competence for Life”, Atlas Corps, 2018, methodological materials of the IJPOOH project “Educational policy and peer-to-peer education in New Ukrainian school, and “Competent training, favorable for health, safety, successful socialization and self-realization of personality”, 2018. …”
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