In silico studies to understand the interactions of flavonoid inhibitor with nsp12-RNA dependent RNA polymerase of SARS-CoV-2 and its homologs by Shamiya Anwar Kizhakkiniyakath, Tejaswini Choudhury, Madhan Vishal Rajan, Sagar Rathee, Basant Meena, Gururao Hariprasad

“…Complexes with the top inhibitor molecule were modelled using Discovery Studio and Desmond suite of programs. Results: SARS-CoV-2 RdRp has a minimum of 80 % sequence similarity with its homologs, with the secondary structural elements, catalytic residues and metal binding residues being conserved. …”
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The state of cancer care in Russia: breast cancer. Epidemiology and survival of patients. The impact of the SARS-CoV-2-beta-coronavirus epidemic (clinical and population study) by V. M. Merabishvili, V. F. Semiglazov, A. V. Komiakhov, T. Yu. Semiglazova, P. V. Krivorotko, А. M. Belyaev

“…The localization and histological structure of the incidence of breast cancer in women remains unchanged. …”
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Application of the criteria-based assessment system to the tasks of developing the functional literacy of students in teaching chemistry by Kulumbetova Onlassyn, Unerbayeva Zulfiya, Zhussupova Leilya, Zhussupbekova Nursulu, Uzakova Assem

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DEVELOPMENT OF ELECTRONIC TEXTBOOKS IN HELPNDOC SYSTEM by Alexander Yu. Stremnev

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4,4A-Dihydroxanthones as Promising Compounds for Creation of New Antimicrobials by V. V. Frolova, S. V. Gurina, N. M. Chernov, I. P. Yakovlev

“…In order to predict the biological activity of the new derivatives of 4,4a-dihydroxanthone, the PASS (Prediction ofActivity Spectra for Substances) computer program was used. It allows predicting the biological activity spectrum of chemical compounds based on the analysis of structure-activity interrelation. …”
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Explainable artificial intelligence for targeted protein degradation predictions by Francis J. Prael III, Jutta Blank, William C. Forrester, Lingling Shen, Raquel Rodríguez-Pérez

“…Explainable ML or, more generally, explainable artificial intelligence (XAI) aims at “opening the black box” by estimating how model inputs – e.g., chemical structures – contribute to model predictions. Although a variety of model interpretation methods have been proposed, XAI for medicinal chemistry is still an active field of research and XAI strategies are dominated by proofs of concept rather than by practical applications in drug discovery programs. …”
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Formation of intellectual capital in the context of an innovatively oriented educational organization based on the principles of quality management by K. A. Kouzmina

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Drifting long-lived. To the 50th anniversary of the opening of the “North Pole -22” station by V. V. Lukin

Subjects: “…fine thermohaline water structure…”
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Development levels for time planning model ofroad constru ction at design stages by T. V. Bobrova, E. A. Pokalyukhina

“…The necessity of an individual approach to the decomposition of road structure elements taking into account the complex of natural and man-made factors is substantiated. …”
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Priority development areas as a tool for enterprises support in Russian monotowns by S. G. Beleva, V. V. Veterinarov, G. S. Kozlyakov, O. V. Suchkova

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CONCERNING AGRICULTURAL EDUCATION PROGRESS IN RUSSIA by Elena N. Akhapkina, Larisa A. Krokhmal

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FEATURES OF WRITTEN LANGUAGE COMMUNICATION BY MEANS OF THE UKRAINIAN LANGUAGE (on the example of official-business, epistolary and conversational-functional styles) by Catherine S. Bondarchuk, Olha A. Chumachenko

“…Achieving this goal involves a number of tasks: 1) to outline the features of construction, placement of details, language tools of business letters; 2) to study the structure and linguistic richness of Lesya Ukrainka’s letters; 3) identify typical and different linguistic and stylistic means of business and private letters; 4) analyze the features of messages transmitted using instant messaging programs Viber and Telegram; 5) to investigate the influence of gender on the features of language means of various forms of written communication. …”
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Russia: property and state. The history of post-Soviet law enforcement (Part I) by Alexander V. Butakov

“…The relevance of the article is stipulated by the gap in the study of property and the state as a consistent system.The purpose of the article is to confirm or disprove the hypothesis that each way of organizing property such as private, mixed (corporate) and general (collective) potentially stimulates the existence of a certain state structure.The methodology. The author uses normative structuralism. …”
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THE PROBLEM OF REINDUSTRIALIZATION OF THE WORLD ECONOMY by A. N. Zakharov

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Caracterización molecular de introducciones colombianas de zapallo Cucurbita moschata Molecular characterization of colombian introductions of squash Cucurbita moschata by Javier A. Restrepo S, Franco A Vallejo C

“…The Fst values indicated that exist genetic structure between most of the introductions. The most of the genetic variation between the introductions corresponded to variations between them inside each department.…”
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Malignant neoplasms of the vulva: epidemiology and survival of patients in Russia (clinical-population study) by V. M. Merabishvili, I. V. Berlev, A. F. Urmancheeva, E. V. Bakhidze, E. A. Ulrikh

“…To study the prevalence of vulvar cancer based on the newly created population cancer registries database of the NWFRR, to consider the detailed structure of this tumor localization taking into account the fourth digit of the International Classification of Diseases-10, the histological structure of tumors, and the calculation of one-year and five-year patient survival.Materials and methods. …”
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Critical care services in Bagmati province of Nepal: A cross sectional survey [version 3; peer review: 3 approved, 1 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Data were collected through structured questionnaires administered via face-to-face and telephone interviews. …”
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On reliability, safety, and readability of programming languages on the example of Ada language by A. V. Leont’ev

“…These suggestions are mainly related to the reliability and safety of simple, typical structures and statements in programming: typification, compile-time elaborations of variables, status of variables, high-level statements, etc. …”
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Transport Infrastructure as a Basis for NATO Mobility in Europe: Key Directions and Formats for Development by T. Kh. Meloyan

“…Particular attention is paid to the projects of the Three Seas Initiative (Via Carpatia, Via Baltica, Rail-2-Sea), initiatives within the Trans-European Transport Network (TEN-T) and the Permanent Structured Cooperation (PESCO) programs. Based on the provisions of securitization theory, the author demonstrates mechanisms through which civilian projects acquire military significance, forming dual-use infrastructure. …”
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