Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs by Lei Liu, Guoqiang Yi, Yilong Yao, Yuwen Liu, Jiang Li, Yalan Yang, Mei Liu, Lingzhao Fang, Delin Mo, Longchao Zhang, Yonggang Liu, Yongchao Niu, Liyuan Wang, Xiaolu Qu, Zhangyuan Pan, Lei Wang, Muya Chen, Xinhao Fan, Yun Chen, Yongsheng Zhang, Xingzheng Li, Zhen Wang, Yijie Tang, Hetian Huang, Pengxiang Yuan, Yuying Liao, Xinjian Li, Zongjun Yin, Di Liu, Dongjie Zhang, Quanyong Zhou, Wangjun Wu, Jicai Jiang, Yahui Gao, George E. Liu, Lixian Wang, Yaosheng Chen, Kui Li, Martien A. M. Groenen, Zhonglin Tang

“…Using nine genomes—seven of which were newly generated, high‐quality de novo assembled genomes—and 1081 resequencing genomes, we built a pan‐genome and identified 134.24 Mb nonredundant nonreference sequences, 1099 novel protein‐coding genes, 187,927 structural variations (SVs) and 30,143,962 single‐nucleotide polymorphisms (SNPs). …”
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Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity by Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)

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The application of blockchain with a comparative approach and its impact on risk, flexibility and internal control evaluation by mohammadsadegh aminipoor, HamidReza GholamniaRoshan, azadeh kiapour, Iman Dadashi

“…Blockchain is essentially a public ledger, where groups of transactions or events are recorded and stored in a chain-like data structure; this approach creates a fast yet secure way to transfer funds. …”
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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…At the heart of ART success is preimplantation genetic testing (PGT), which enables the detection of chromosomal anomalies, single-gene disorders, and structural rearrangements, enhancing embryo selection and mitigating genetic risk. …”
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Dynamics of turnover of sugar-lowering drugs in the retail segment of the pharmaceutical market from 2020 to 2024 by D. V. Kurkin, E. V. Makarova, V. I. Zvereva, A. R. Makarova, D. A. Bakulin, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, I. S. Krysanov, K. N. Koryanova, D. A. Galkina, N. A. Osadchenko, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…Despite maintaining the leading position of metformin, the consumption structure is shifting towards more expensive schemes. …”
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The proposed model of the body of knowledge of digital transformation for the Central Bank of the Islamic Republic of Iran by Samira Tahmasebi Ashtiani, Mohammad Hasanzadeh, Atefeh Sharif, Mostafa Amini

“…Purpose: A body of knowledge is a formal description of a field that includes a complete set of theories, methods, concepts in a structured way, and technologies. If we consider knowledge alone as the factor of individual superiority, the flow of knowledge is the factor of group superiority. …”
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Relationship between prenatal anxiety, depression, pregnancy stress and their social determinants by Weicui Meng, Sufeila Shalayiding, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…Given that psychological problems during pregnancy may lead to short-term and long-term adverse outcomes for both mothers and infants, clarifying their network structure and core social determinants holds important public health significance for formulating regional intervention strategies. …”
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Phase formation, microstructural and superconducting properties of YBCO added Ca-compounds extraction eggshells by Siew Hong Yap, Mohd Mustafa Awang Kechik, Syahrul Humaidi, Khairul Khaizi Mohd Shariff, Hussien Baqiah, Soo Kien Chen, Kean Pah Lim, Mohd Hafiz Mohd Zaid, Yazid Yaakob, Mohd Khalis Abdul Karim, Zainal Abidin Talib, Zhi Wei Loh, Aliah Nursyahirah Kamarudin, Abdul Halim Shaari, Muralidhar Miryala

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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…Microscopic analysis at 21 dai revealed that the resistant cultivar (JP) root structure remained largely unaffected, while the roots of the susceptible cultivar (83-1) exhibited significant tissue distortion and gall formation, underscoring the effectiveness of the resistance mechanisms. …”
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The Characteristic of Measles Epidemic Process in Kyrgyz Republic by M. S. Niiazalieva, O. V. Tsvirkun, V. S. Toygombaeva, I. Sh. Aldjambaeva, G. S. Ishenapysova, R. A. Frolov, G. S. Dadanova

“…This hypothesis confirmed by the high percentage of unvaccinated children of this age in the structure of the sickindividuals. All this casts doubt on the official data on the coverage of children of this age with preventive vaccinations (95.7%) and indicates the accumulation of contingents susceptible to measles. …”
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Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing by Xiaozhen Zhou, Pengchao Ma, Yihao Liu, Zhaojian Wang, Shida Chen, Zekun Cheng, Songlu Tseng, Hui Wu, Mengdi Zhang, Fengzhou Du, Nanze Yu, Xiao Long, Jiuzuo Huang, Xiumei Wang

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Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency by A. Jerrod Anzalone, Sharon Patrick, Amber Abel, Brad Price, Elizabeth Reisher, Kent Ripplinger, Mary Emmett, Ronald Horswell, San Chu, William B. Hillegass, Francisco S. Sy, Brian Melancon, H. Timothy Bunnell, Lucio Miele, Mary Helen Mays, Joseph Keawe‘aimoku Kaholokula, Elizabeth S. Chen, Karen M. Crowley, Indra Neil Sarkar, Susan L. Santangelo, Clifford J. Rosen, Jeremy Harper, David Bard, William Beasley, Sally L. Hodder

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The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders by Daniel Alcolea, Jordi Clarimón, María Carmona‐Iragui, Ignacio Illán‐Gala, Estrella Morenas‐Rodríguez, Isabel Barroeta, Roser Ribosa‐Nogué, Isabel Sala, M. Belén Sánchez‐Saudinós, Laura Videla, Andrea Subirana, Bessy Benejam, Sílvia Valldeneu, Susana Fernández, Teresa Estellés, Miren Altuna, Miguel Santos‐Santos, Lídia García‐Losada, Alexandre Bejanin, Jordi Pegueroles, Víctor Montal, Eduard Vilaplana, Olivia Belbin, Oriol Dols‐Icardo, Sònia Sirisi, Marta Querol‐Vilaseca, Laura Cervera‐Carles, Laia Muñoz, Raúl Núñez, Soraya Torres, M. Valle Camacho, Ignasi Carrió, Sandra Giménez, Constance Delaby, Ricard Rojas‐Garcia, Janina Turon‐Sans, Javier Pagonabarraga, Amanda Jiménez, Rafael Blesa, Juan Fortea, Alberto Lleó

“…Methods Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neuropsychological evaluations, and undergo a structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video‐polysomnogram, 18F‐fluorodeoxyglucose PET, amyloid PET, Tau PET). …”
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Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context by Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sullivan, Yi Lu

“…We estimated familial aggregation/coaggregation using generalised estimating equations, heritability and genetic correlations using structural equation modelling. We also analysed ∼30,000 genotyped MDD cases from the UK Biobank and a Swedish cohort to explore which polygenic risk score (PRS) may predispose individuals to psychotic MDD. …”
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The quantitative study of marked individuals in ecology, evolution and conservation biology: a foreword to the EURING 2003 Conference by J. C. Senar, A. A. Dhondt, M. J. Conroy

“…The Proceedings follow the same general structure as the Conference. We organised the EURING meeting in 10 technical sessions, covering what we considered as fastest growing areas in the field. …”
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Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…Evidence indicates that such deliberate targeting aims to destabilize Gaza’s social structure and hinder long-term development. The findings highlight the urgent need for international accountability to halt these acts, safeguard education as a fundamental right and rebuild Gaza’s education system to ensure resilience and continuity amid conflict. …”
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Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight by Congrong Wang, Brigitte Reimann, Tim S Nawrot, Dries S Martens, John Wright, Rosemary McEachan, Johanna Lepeule, Wenlun Yuan, Leda Chatzi, Marina Vafeiadi, Regina Grazuleviciene, Sandra Andrusaityte, Oliver Robinson, Jordi Sunyer, Hector Keun, Chung-Ho E. Lau, Alexandros P. Siskos, Muireann Coen, Eva Borràs, Eduard Sabidó, Juan R. González, Marta Vives-Usano, Xavier Estivill, Angel Carracedo, Carlos Ruiz-Arenas, Inés Quintela, Maribel Casas, Mark Nieuwenhuijsen, Ibon Tamayo, Kristine B Gutzkow, Cathrine Thomsen, Amrit K. Sakhi, Mariona Bustamante, Lea Maitre, Martine Vrijheid, Michelle Plusquin, Rossella Alfano

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Evaluation and Comparison of Resource sustainability of Two Forest Reserves in Hamadan Province by Mohsen Akbari, Alireza Ildoromi, Farhad Ghasemi Aghbash, Iman Pajohan

“…Biodiversity, with the lowest score in both reserves including legal measures and organizational structure, economic and social functions, forest production functions, forest resources, conservation functions with the lowest score have the greatest impact on the instability of two forest reserves respectively. …”
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Sustainable forest management: success and challenges in Ethiopia by Rusha Begna Wakweya

“…However, more effective governance structures are needed to balance the goals of forest conservation and community development2. …”
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