Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer by Etienne Rouleau, Ana Oaknin, Christophe Klein, Alexandra Leary, Sebastien Gouy, Patricia Pautier, Catherine Genestie, Amandine Maulard, Judith Michels, Marco de Bruyn, Emeline Colomba-Blameble, Annechien Plat, Juan Francisco Grau Bejar, Elisa Yaniz Galende, Qinghe Zeng, Audrey Le Formal, Elodie Edmond, Maëva Moreau

“…However not all responses and predictors of primary resistance are lacking.Methods We compared the immune tumor microenvironment of MMRd EC ICI-responders (Rs) and ICI non-responders (NRs), using spatial multiplexed immune profiling and unsupervised hierarchical clustering analysis.Results Overall, NRs exhibited drastically lower CD8+, absent terminally differentiated T cells, lack of mature tertiary lymphoid structures and dendritic cells, as well as loss of human leukocyte antigen class I. …”
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A Deep Learning-Based Probabilistic Approach for Non-Destructive Testing of Aircraft Components Using Laser Ultrasonic Data by Adriano Liso, Cosimo Patruno, Angelo Cardellicchio, Pierfrancesco Ardino, Nicola Gallo, Giuseppe del Prete, Valerio Dentico, Veronica Vespini, Sara Coppola, Pietro Ferraro, Vito Reno

“…Composite structures are commonly used in complex applications such as automotive and aerospace due to their high strength-to-weight ratio. …”
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Exploring the space of self-reproducing ribozymes using generative models by Camille N. Lambert, Vaitea Opuu, Francesco Calvanese, Polina Pavlinova, Francesco Zamponi, Eric J. Hayden, Martin Weigt, Matteo Smerlak, Philippe Nghe

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PPARγ promotes urothelial remodeling during urinary tract obstruction by Mohammad El-Harakeh, Felipe Rodriguez-Tirado, Andrew J. Hardman, Alexa Miehls, Oumoulkhairy Camara, Kelly M. Grounds, Glenis Tocaj, Macie Kercsmar, Birong Li, Xin Wang, Brian Becknell, Ashley R. Jackson

“…Prior studies show that congenital and acquired UTO initiate a conserved, protective program of renal urothelium remodeling that culminates in expansion of uroplakin (UPK)+ cells to promote renal structural integrity. …”
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Analysis of fracture characteristics and biodegradation resistance of natural fibers geotextiles from Typha domingensis, Eleocharis sp., and Syagrus coronata, under waterproofing R... by Luiz Diego Vidal Santos, Francisco Sandro Rodrigues Holanda, Jackson José Menezes Barbosa Filho, Willyan Farias Oliveira, Emersson Guedes da Silva, Eliana Midori Sussuchi, Sandro Griza, Cristiano Teles de Menezes

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Fostering Critical Thinking through Socio-Scientific Issue-Based Problem-Based Learning in Stoichiometry Instruction by Aida Hajijah, Mariam Nasution, Nur Azizah Putri Hasibuan, Lelya Hilda, Najah Yousef Baroud

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In silico and in vivo Study of the Anti-Inflammatory Activity of Azomethine Derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide and 2-substituted 5,6,7,8-tetra... by Chiriapkin, A.S., Kodonidi, I.P., Abisalova, I.L., Diakova, I.N.

“…In silico prediction of anti-inflammatory activity was performed using the AutoDock 4.0 program. The virtual structures of the test compounds were constructed in HyperChem 8.0.4. …”
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Efficacy of neoadjuvant chemotherapy with docetaxel and cisplatin in patients with squamous cell carcinoma of the oral cavity at high risk of progression by S. I. Kutukova, Yu. V. Ivaskova, N. P. Beliak, G. A. Raskin, A. A. Varankina, A. I. Yaremenko, A. Ya. Razumova, A. O. Cheremnykh, M. F. Manna, R. V. Orlova

“…At the 1st stage of our study, we retrospectively analyzed the data of 98 patients and determine that the NACT for patients with oral cavity squamous cell carcinoma, with 3 or more factors of an unfavorable prognosis (peripheral blood parameters indicating the presence of systemic inflammation, reduced level of infiltration of tumor structures by CD8‑tumor infiltrating lymphocytes and low expression of programmed death-ligand 1 (PD-L1) on tumor and immune cells) significantly reduces the risk of death and disease progression: hazard ratio 0.33; 95 % confidence interval 0.13–0.86; p = 0.0231. …”
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Entrustable Professional Activities (EPAs) for Medical Student Leadership Curriculum Across Campuses by Joann Farrell Quinn, Kira K Zwygart, Amy B Smith, Deborah DeWaay, Michael Dowdy, Robin Schroeder

“…SELECT’s dual-campus structure, spanning Tampa, FL, and Allentown, PA, presents a unique opportunity to implement and assess EPAs in a longitudinal fashion across four years of training on both campuses; the Tampa campus and regional campus in Allentown.   …”
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Factors Associated with Caregiver Burden in Families of Patients with Palliative and Chronic Illness: A Cross-Sectional Study by Haroen H, Juniarti N, Sari CWM, Prista Sari S, Arovah NI, Pardosi JF, Wibowo DA

“…At the same time, feelings of not being optimal enough in providing care were the statement most frequently acknowledged by caregivers.Conclusion: Psychosocial and structural factors influence caregiver burden. These findings highlight the need for integrated interventions, including psychosocial support, financial security, and caregiver education, to mitigate burden in this population.Keywords: caregiver burden, chronic illness, family caregiver, palliative care…”
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Substantiation of the necessity to develop a competency model of training specialist in pharmacy on the basis of intellectual educational system by V. O. Demchenko, O. A. Ryzhov, N. A. Ivankova

“…The study was conducted using the methods of semantic evaluation of legal and scientific documents, comparison, systemic and structural logical analysis. Results and discussion. …”
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Characterization of Biocalcium Microparticles from Saltwater Crocodile (<i>Crocodylus porosus</i>) Bone and Their Potential for Enhancing Fish Bologna Quality by Theeraphol Senphan, Natthapong Mungmueang, Supatra Karnjanapratum, Sutee Wangtueai, Akkasit Jongjareonrak, Suthasinee Yarnpakdee

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A Systematic Review of Maternal and Child Health Policies in Addressing Stunting: Trends and Challenges by Pratiwi Ramlan, Phill Sukri, Muh. Tang Abdullah, Muhammad Akmal Ibrahim, Jamaluddin Ahmad, Khaeriyad Adri

“…Data analysis from various studies emphasized the importance of evidence-based strategies that combine medical interventions with structural, social and economic transformation. Conclusion: In conclusion, this review emphasizes the importance of collaboration between various sectors, including health, education, and agriculture, in addressing stunting. …”
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Development of a Holistic Nursing Model Based on Transcultural Nursing to Improve the Quality of Life of Patients with Type-2 Diabetes Mellitus by Ni Wayan Suniyadewi, Yuni Sufyanti Arief, Ninuk Dian Kurniawati, I Dewa Ayu Rismayanti, Ni Wayan Trisnadewi, Iswatun Iswatun

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Machine Learning-Based Prediction of First Trimester Down Syndrome Risk in East Asian Populations by Chen YT, Chen GJ, Lin YS

“…Yen-Tin Chen,1,2 Gina Jinna Chen,3 Yu-Shiang Lin1 1In-Service Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 2Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei, Taiwan; 3Department of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, People’s Republic of ChinaCorrespondence: Yu-Shiang Lin, In-Service Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, No. 250, Wuxing St., Xinyi Dist., Taipei City, 110, Taiwan, Email eriklin@tmu.edu.twPurpose: Down syndrome is the most common chromosomal abnormality in newborns, often leading to developmental delays and congenital structural anomalies. …”
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Combined analysis of 16S rRNA gene sequencing data reveals core vaginal bacteria across livestock species by Lucille C. Jonas, Lucille C. Jonas, Curtis R. Youngs, Stephan Schmitz-Esser, Stephan Schmitz-Esser

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Impact measuring the of technological innovation driven by co-creation of value on the performance of multinationals in emerging markets by Geraldo Cardoso de Oliveira Neto, Oseias do Prado Soares, Benny Kremer Costa, Rodrigo Neri Bueno da Silva, Priscila Rezende da Costa, Roberto Bernardes, Flávio Luiz Rodrigues, André Silva de Carvalho, Dirceu da Silva

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LVRT Measurement Model and Transient Parameter Identification of Wind Turbine Based on Chaotic Particle Swarm by Dan LI, Shiyao QIN, Shaolin LI, Jing HE

“…Firstly, based on the DFIG model and control structure of the Power System Integrated Stability Program (PSASP), a low voltage ride through (LVRT) control mathematical model is established to analyze the fault transient process, and the LVRT transient control core parameters are clarified. …”
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Enhancing antioxidant activity of corn bract and silk juices through biotransformation of polyphenols by Lactobacillus paracasei TJ199 fermentation by Xiaohui Tang, Huanyong Lv, Hailong Wang, Huixin Yang, Baogang Zhang, Ling Cong, Xinyi Li, Menghan Ma, Yunhe Xu, Lili Zhang

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Building the 8-star doctor: a modified Delphi study to define, teach, and assess health professions education for undergraduate medical students by Sara Jamil Khan, Rahila Yasmeen, Shazia Imran

“…Abstract Background As global trends in medical education shift toward integrated curricula, there remains a lack of consensus on the core components of Health Professions Education (HPE) to be embedded within undergraduate medical programs. This study aims to identify and structure key HPE topics relevant to the MBBS curriculum, with the goal of enhancing students’ foundational competencies in teaching, leadership, and professionalism. …”
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