AXIAL FLOW IN A ROTATIONAL COAXIAL RHEOMETER SYSTEM 1. BINGHAM PLASTIC

“…A definition for an approximate viscosity has been presented and a comparison has been made between predicted approximate and true viscosity…”
Get full text

Modelling and Analysis on Biomechanical Dynamic Characteristics of Knee Flexion Movement under Squatting by Jianping Wang, Kun Tao, Huanyi Li, Chengtao Wang

“…The results showed that the established dynamic FE models of knee are capable of predicting kinematics and the contact stresses during flexion, and could be an efficient tool for the analysis of total knee replacement (TKR) and knee prosthesis design.…”
Get full text

Research advances in the molecular regulatory mechanisms of fruit coloration in fruit trees by MA Shurui, CHI Fumei, SONG Yang

“…The interaction of light and temperature in environmental regulation and the accumulation of anthocyanin content under drought and other stresses significantly enhance the plant's resistance to stress environments. …”
Get full text

Severe tenosynovitis with rapidly fluctuating power Doppler activity, a clue for the diagnosis of Blau syndrome: a case report by Serena Pastore, Carolina Carraro, Eleonora De Martino, Alessia Pin, Irene Bruno, Nunzia Zanotta, Erica Valencic, Erica Valencic, Alberto Tommasini, Alberto Tommasini, Andrea Taddio, Andrea Taddio

“…The diagnosis can be challenging as symptoms may not always align with the classic triad.Case descriptionAn 8-year-old girl presented with fluctuant swellings in the wrists and ankles, strength reduction and stiffness. Blood tests showed lymphopenia, elevated inflammation markers and positivity of anti-nuclear antibodies. …”
Get full text

Rheology of rock–ice avalanche in a periodic chute flow by Zhiping Sun, Zhibo Dong

“…Depth-resolved profiles of six key parameters—velocity, solid volume fraction, shear stress, normal stress, shear rate, and inertia number—were recorded during steady flow conditions. …”
Get full text

Assessment of geomechanical properties of Sakhalin shelf reservoirs based on modeling results by V. Yu. Kerimov, G. N. Potemkin, A. K. Shatyrov

“…This initiates the formation of a local stress field, launches changes in the degree of fracture openness, and determines the secondary porosity and permeability of rocks. 3D modeling allowed us to calculate predicted permeability for each stratigraphic horizon. …”
Get full text

Laser powder bed fusion of a novel high-strength Al–Mg–Er–Zr-Sc alloy: Process, microstructure, and performance by Zhengjiang Gao, Hui Li, Teng Ma, Huan Yang, Wei Wang, Wu Wei, Hui Huang, Shengping Wen, Zuoren Nie

“…Both of keyholes caused by excessive energy input and unfused defects caused by insufficient energy input will decrease alloy density and induce stress concentration, resulting in a reduction in elongation. …”
Get full text

Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase by Iva Bozic, Danijela Savic, Marija Jovanovic, Ivana Bjelobaba, Danijela Laketa, Nadezda Nedeljkovic, Mirjana Stojiljkovic, Sanja Pekovic, Irena Lavrnja

“…Our results imply that low-dose ribavirin may alleviate nitrosative stress during neuroinflammation.…”
Get full text

Restoration of 3-dimensional aortic hemodynamics after the Ross procedure for unicuspid aortic valve disease using 4-dimensional flow magnetic resonance imagingCentral MessagePersp... by Andrew Zbihley, BA, Anthony Maroun, MD, Justin J. Baraboo, BS, Ethan Johnson, PhD, Meilynn Shi, BA, Bradley D. Allen, MD, Michael Markl, PhD, S. Chris Malaisrie, MD, Christopher K. Mehta, MD

“…Systolic peak velocity (PV), wall shear stress, and viscous energy loss (EL) of each MRI were assessed and compared. …”
Get full text

Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis by Xize Wu, Yuxi Huang, Jiaqi Ren, Xue Pan, Qiuying Wu, Qicheng Cai, Ruiying Wang, Teng Feng, Shan Gao, Bo Wang, Meijia Cheng, Meijia Cheng, Yue Li, Lihong Gong

“…A nomogram for predicting AS risk was constructed incorporating the expression levels of these five validated Hub genes. …”
Get full text

Dicalcium Silicate Induced Proinflammatory Responses through TLR2-Mediated NF-κB and JNK Pathways in the Murine RAW 264.7 Macrophage Cell Line by Shixiang Lai, Liangjiao Chen, Wei Cao, Shiman Cui, Xingyang Li, Wenchao Zhong, Mingyu Ma, Qingbin Zhang

“…When we added siRNA-TLR2-1, a significant reduction was observed. These findings support the theory that C2S particles induce proinflammatory responses through the TLR2-mediated NF-κB and JNK pathways in the murine RAW 264.7 macrophage cell line.…”
Get full text

Exploring biochemical responses and cellular adaptations of Chlorella sorokiniana to polyethylene microplastic exposure by Jyoti Rawat, Pooja Bhatnagar, Abhilasha Mishra, Manisha Nanda, Prateek Gururani, Afzal Hussain, Mikhail S. Vlaskin, Sanjay Kumar, Monu Verma, Hyunook Kim, Vinod Kumar

“…Under the MP stress, reactive oxygen species (ROS) and phenolic levels were reduced, whereas flavonoid content increased. …”
Get full text

SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction by Ying Yang, Longlong Zheng, Jiaxing He, Tao Wu, Haicheng Yang, Bo Zhang, Shuai Zhou, Yueyue Lu, Xianli He, Jibin Li, Nan Wang

“…In the present investigation, we observed a significant reduction in SLC44A2 expression in colorectal cancer (CRC), and low SLC44A2 expression was closely associated with poorer survival of CRC patients. …”
Get full text

THE ROLE OF GENETICALLY DETERMINED BODY RESISTANCE OF WARM-BLOODED ANIMALS TO HYPOXIA IN THE REALIZATION OF EFFECTOR FUNCTIONS OF NEUTROPHILS IN THE MODEL OF ADJUVANT-INDUCED RHEUM... by Elena Georgievna Pukhaeva, Alibek Kirilovich Badtiev, Fatima Elbrusovna Salamova, Stanislav Georgievich Dzgoev, Alina Muratbekovna Kupeeva

“…Given that human and animal populations are genetically heterogeneous in terms of the body's resistance to oxygen deficiency, the modern approach to predicting and treating diseases associated with impaired immune regulation requires taking into account the role of hypoxia in the implementation of pathogenetic mechanisms of inflammation. …”
Get full text

Effect of extreme pH levels on early larval stages of the Pacific abalone (Haliotis discus hannai Ino, 1953) by Dian Yuni Pratiwi, Irfan Zidni, Mi-Jin Choi, Young Dae Oh, Tae Min Kim, Han Kyu Lim

“…However, at 30 hpf, a significant reduction in the oxygen consumption rate was observed only at pHs 9 and 10 (p < 0.05). …”
Get full text

<i>Colletotrichum capsici</i>-Induced Disease Development in Postharvest Pepper Associated with Cell Wall Metabolism and Phenylpropanoid Metabolism by Yunfen Liu, Qian Song, Feilong Yin, Yuanli Liang, Mubo Song, Meiying He, Liang Shuai

“…These insights highlight the need for early intervention strategies to mitigate postharvest losses by targeting pathogen-induced stress responses and cell wall integrity preservation.…”
Get full text

Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
Get full text

Gut microbiome and metabolome interactions in Crohn’s disease: mechanistic insights into exclusive enteral nutrition-induced remission by Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Quan Zhou, Quan Zhou, Mengli Xue, Mengli Xue, Mengli Xue, Mengli Xue, Xing Yu, Xing Yu, Xing Yu, Xing Yu, Xue’e Chen, Xue’e Chen, Xue’e Chen, Xue’e Chen, Jintong Chen, Jintong Chen, Jintong Chen, Jintong Chen, Chengdang Wang, Chengdang Wang, Chengdang Wang, Chengdang Wang

“…Importantly, EEN therapy was associated with a reduction in oxidative stress and an improvement in gut barrier function.ConclusionThis study comprehensively integrates microbiome and metabolome analyses, providing new insights into the mechanism of action of EEN therapy in CD. …”
Get full text

Implications of thermal stratification and radiative heat flux in blood-based ternary and dihybrid nanomaterial flow through a stretchable cylinder by Muzher Saleem, Ghada A. Khouqeer, Fazal Haq, Naglaa AbdelAll, Arshad Hussain, Mohammed Sallah

“…A reduction of 4 % in the skin friction coefficient of THNF compared to HNF is noticed. …”
Get full text

Impacts of diffusion and chemical reaction on heat transfer in Casson nanofluids flow over a flat plate with accretion by J. Jayaprakash, Vediyappan Govindan

“…Conversely, more chemical reactions reduce the heat transfer rate. Concentration reduction can inhibit convective heat and mass transfer, which can reduce the efficiency of systems. …”
Get full text