The Yin and Yang of hsa-miR-1244 expression levels during activation of the UPR control cell fate by Paulina Czechowicz, Magdalena Gebert, Sylwia Bartoszewska, Leszek Kalinowski, James F. Collawn, Rafal Bartoszewski

“…These analyses demonstrated that the outcome of this reduction during ER stress supported both IRE1 signaling and elevated BIP expression. …”
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Optimization Design Method of Pipe-Insulating Joints Based on Surrogate Model and Genetic Algorithm by Chen Guo, Zheng Yang, Jianbo Dong, Yanchao Yue, Linjun Tian, Ping Ma

“…In these examples, the maximum stress under the design dimensions given by the optimization algorithm has a maximum error of 8.98% and an average error of 4.63% compared to the preset maximum stress target, while the stress predicted by the surrogate model has a maximum error of 9.65% and an average error of 5.33% compared to the actual stress. …”
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Long-term efficacy and safety of artificial urinary sphincter AMS 800^ТМ implantations by E. I. Veliev, A. A. Tomilov, E. N. Golubtsova

“…Introduction. Stress urinary incontinence in men in most cases occurs after radical prostatectomy or surgery of benign prostate hyperplasia. …”
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System biology-based assessment of the molecular mechanism of epigallocatechin gallate in Parkinson’s disease: via network pharmacology, in-silico evaluation & in-vitro studies by Hannah Lalengzuali Fanai, Jagdish Chand, Sheikh F. Ahmad, Sabry M. Attia, Talha Bin Emran

“…EGCG targets were identified using Swiss target prediction, revealing 31 targets modulated by EGCG. …”
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USING OF NORMOBARIC HYPOXIC ENVIRONMENTS IN THE CORRECTION OF NONPATHOLOGICAL NEUROTIC MANIFESTATIONS OF HAZARDOUS OCCUPATIONS by D. V. Shatov, A. O. Ivanov, V. S. Groshiun, A. V. Baranov, N. V. Kochubeynik, S. G. Afendikov, S. M. Groshilin

“…It is shown that an effective means of correction of nonpathological stress-induced neurotic manifestations of hazardous occupations is normobaric hypoxic therapy conducted by creating artificial gas-air environments in the hypoxic complex. …”
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Strength of monolithic ceramic crowns supported by incisors by N. R. Usubova

“…Monolithic restorations are becoming increasingly popular due to the reduction of technical complications. The upper incisors are the most affected teeth due to their location and protrusion.Aim. …”
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Multi-Material Topology Optimization Taking into Account the Position of Material Interfaces in 3D by Robert Renz, Niklas Frank, Albert Albers

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Impact of Various Carbon Sources on the Growth Efficiency, Antioxidant Efficacy, and Immunity of Clariid Catfish Clarias gariepinus (Burchell 1822) by Omoniyi Michal Popoola, Tunde Olowolafe, Ayomide Miracle Oyelade, Blessing Aderonke Oguntokun

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Analysis of nonlinear responses of asphalt pavements under overloading and tropical climate temperature conditions by Abhinav Kumar, Ankit Gupta, Kumar Anupam, W.A.A.S. Premarathna

“…A 25 % overloading resulted in a reduction of subgrade rutting life by 62.33 %, whereas an increase in mix temperature by 10° C at intermediate temperature reduced asphalt fatigue life by 29.34 % and subgrade rutting life by 42.03 %.…”
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Esculetin Attenuates Doxorubicin-Induced Kidney Damage By Reducing Heat Shock Proteins Expression Levels by Hamid Ceylan, Melike Karaman, Hilal Tosun, Habibe Karadaş, Neslihan Öztürk, Medine Sibel Karağaç, Duygu Kizir, Esra Nur Yeşilkent, Yeliz Demir

“…Additionally, the combination of DOX and esculetin demonstrates a reduction in the increase caused by DOX alone. The study suggests that esculetin could serve as a potential protective agent for shielding kidney tissue from oxidative damage and apoptosis.…”
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Assessment of neurotoxicity of rotenone and the possible protective effect of alpha lipoic acid in adult male albino rats by Miriam Ramzy Riad, Abdelghany Hassan Abdelghany, Nahla Mohamed Salah

“…Macroscopic and stereomicroscopic findings showed a significant reduction in the dark color of neuromelanin pigment in SN. …”
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The Transcription Factor SsSR Mediates Ergosterol Biosynthesis and Virulence in <i>Sclerotinia sclerotiorum</i> by Huihui Zhao, Xiaofan Liu, Jintao Jiang, Jiatao Xie, Yanping Fu, Yang Lin, Tao Chen, Bo Li, Xiao Yu, Xueqiong Xiao, Xueliang Lyu, Weidong Chen, Daohong Jiang, Jiasen Cheng

“…The deletion of <i>SsSR</i> or <i>SsCYP51</i> does not affect the growth or acid production of <i>S. sclerotiorum</i>, but it leads to a reduction in ergosterol, significantly diminishing virulence and impairing the stress tolerance of the hyphae. …”
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Interactive effects of hydrodynamics and microplastics on bioaccumulation, histopathological alterations, biomarker responses, and gene expression in grass carp brain by Majid Rasta, Mian Adnan Kakakhel, Mojtaba S. Taleshi, Niloofar S. Lashkaryan, Jia Manke, Liming Liu, Shan-e-hyder Soomro, Xiaotao Shi

“…Furthermore, this group demonstrated significantly increased superoxide dismutase (SOD) and lipid peroxidation (LPO) activities, along with significant reduction in acetylcholinesterase (AChE) activity (p < 0.05), providing clear evidence of oxidative stress and neurotoxicity. …”
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Hyperbaric Oxygen Therapy in Patients with COVID-19 by S. S. Petrikov, A. K. Evseev, O. A. Levina, A. K. Shabanov, V. V. Kulabukhov, N. Yu. Kutrovskaya, N. V. Borovkova, Е. V. Klychnikova, I. V. Goroncharovskaya, E. V. Tazina, K. А. Popugaev, D. A. Kosolapov, D. S. Slobodeniuk

“…In all examined patients with new coronavirus infection caused by SARS-CoV-2, positive changes such as dyspnea reduction and improvement of general well-being were registered after hyperbaric oxygen therapy sessions. …”
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Association of early acetaminophen administration with mortality in surgical intensive care patients: a retrospective cohort study by Jiajing Li, Yihao Li, Min Zhong, Hanli Chen, Ziyang Wang, Jianwei Wu, Yongyong Shi

“…BackgroundAcetaminophen, a widely used analgesic, has drawn attention for its potential to reduce oxidative stress through inhibiting lipid peroxidation and scavenging free radicals. …”
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Integrated responses of gas exchange and hydraulic traits of wheat leaves to different combination of VPD and soil moisture by Lijuan Wang, Yanqun Zhang, Hao Li, Xinlong Hu, Pancen Feng, Yan Mo, Baozhong Zhang, Di Xu, Shihong Gong

“…However, reductions in net photosynthetic rate (An, 27 %) and stomatal conductance (gs, 65 %) under combined stresses were comparable to those observed under l-SM of the LVPD, where Aₙ declined by 34 % and gₛ by 54 %. …”
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A mathematical theory of elasticity for photoelastic experimental hybrid method by Bruno R. Mose, Dong-Kil Shin, Jeong Hwan Nam, B. O. Alunda

“…PEHM has been shown as an important and powerful tool used by experimental stress analysts to predict the stress state in complex engineering structures. …”
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Understanding Acceleration-Based Load Metrics: From Concepts to Implementation by João Freitas, Alexandre Moreira, João Carvalho, Filipe Conceição, Luisa Estriga

“…In time-series comparisons, Jerk Modulus and cAccel’Rate were predictably found to be nearly identical, while Body Load was the most distinct. …”
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Stronger tree size-mortality association with increasing droughts and basal areas: A meta-analysis by Bradley Nixon, William Hammond, Chris Zou, Lu Zhai

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Genome-wide identification, characterization and evolutionary analysis of the pyrroline-5-carboxylate synthetase (P5CS), succinic semialdehyde dehydrogenase (SSADH), and dehydrin (... by Amaal Maghraby, Mohamed Alzalaty

“…Conclusions Our results provide comprehensive insights into the P5CS, SSADH, and DHN genes, including their protein structures and predicted interaction features. These findings offer valuable targets for tomato breeding programs aimed at developing stress-tolerant varieties under changing climate conditions.…”
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