CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa by Yu Zhang, Tingting Zhang, Xue Xiao, Yejun Wang, Adam Kawalek, Jinzhao Ou, Anmin Ren, Wenhao Sun, Vincent de Bakker, Yujie Liu, Yuelong Li, Liang Yang, Liang Ye, Ning Jia, Jan-Willem Veening, Xue Liu

“…We classify the essential genes by response time and growth reduction, pinpointing the most vulnerable therapeutic targets in this species. …”
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Hesperidin-β-Cyclodextrin inclusion complexes: A novel approach for preventing and treating acute lung injury caused by seawater drowning by Jingjing Hou, Mengdi Zhang, Zheyi Han, Wanmei Wang, Haiying Qiu, Jingwei Yuan, Fang An, Yan Wu

“…The administration of Hep-β-CD via the pulmonary route has been found to be highly effective in preventing seawater drowning-induced ALI in mice, achieved through modulation of key inflammatory mediators and a reduction in oxidative stress. The study demonstrated that Hep-β-CD administration significantly decreased the levels of pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-6 (IL-6), which are known to contribute to the pathogenesis of ALI. …”
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Estimation of Longitudinal and Transverse Elastic Moduli of Native Brazilian Woods by Static Bending Tests by Fabricio da Silva Aguiar, Guilherme dos Santos Silva, Herisson Ferreira dos Santos, Elvys Dias Reis, Francisco Antonio Rocco Lahr, André Luis Christoforo

“…The results showed that, for L/h ratios below 18, the apparent modulus of elasticity was significantly affected by shear effects, exhibiting reductions of up to 18.47%. The E/G ratio ranged from 14.84 to 21.15, corresponding to a reduction of up to 7% and an increase of up to 32%, respectively, about the value proposed by ABNT NBR 7190-1 (2022). …”
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Development and engineering application validation of alkali-activated full-component shield tunnel spoil regenerated solid-waste grouting material by Zhiran Yang, Yu Zhou, Li Wang, Shizhuo Zou, Jinfei Chai, Yufei Fang, Shichao Jiang, Hui Ma

“…Rheological analyses revealed reduced yield stress and enhanced shear-thinning behavior. Hydration heat demonstrated bimodal exothermic characteristics, confirming effective aluminosilicate activation and polymerization. …”
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Phase-Resolved Functional Lung MRI Evaluation of Dynamic Hyperinflation Induced by Metronome-Paced Tachypnea in Patients with Chronic Obstructive Pulmonary Disease by R. A. Müller, F. Klimeš, A. Voskrebenzev, L. Behrendt, T. F. Kaireit, M. Wernz, M. Zubke, A. L. Kern, M. R. Prince, W. Shen, C. B. Cooper, R. G. Barr, J. M. Hohlfeld, J. Vogel-Claussen

“…MPT in combination with phase-resolved functional lung (PREFUL) MRI can be used to assess stress-driven ventilation dynamics globally and regionally. …”
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Combining mindfulness intervention and open-label placebo treatment for chronic pain: a protocol for a feasibility study by Chung Jung Mun, Estrella Contreras, Yushu Xiao, Ryan Eckert, Alexandra Harting, Sathvika Damera, Iosef Perez, Hemant K. Pandey, Aram S. Mardian, Frank LoVecchio, Luana Colloca, Kelly E. Dunn, Michael Todd, Roger B. Fillingim, Mary C. Davis

“…Abstract Background Mindfulness-based interventions, such as mindfulness-based stress reduction (MBSR), are efficacious mind–body treatments for chronic pain, though their modest effect sizes suggest room for improvement. …”
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Ectomycorrhizal fungal community succession and fragmentation across forest edges nearly three decades postharvest by Olivia M. Rianhard, J. Marty Kranabetter, Latina V. Penkova, Daniel M. Durall, Melanie D. Jones

“…The negative effect of edges on EMF reproduction and some taxa abundance in the forest adjacent to openings is relevant when designing green‐tree retention forestry systems, suggesting medium to large patches of trees may reduce fragmentation stress and better sustain an array of late‐seral fungi.…”
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Novel and Highly Potent Therapeutic Agent, Trametes Robiniophila Murr (Huaier), Mitigates Pulmonary Vascular Remodeling in Rodents by Huangshu Ye, Yue Zhang, Li Hu, Yuxin Feng, Tianfan Zhu, Qi Meng, Xiaoxuan Sun, Miaojia Zhang, Zhengsheng Mao, Feng Chen, Yanfang Yu, Qiang Wang, Jie Wang

“…Methods Huaier treatment effectively mitigated hypoxia‐ and monocrotaline‐induced PH in rodent models, as evidenced by reductions in pulmonary artery pressure, right ventricular hypertrophy, and vascular remodeling. …”
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Research of problems and prospects of development of public control in the information and communication space by D. A. Okolyshev

“…Based on the research conducted, a model of public control has been developed and tested in relation to the results of monitoring the provision of quality education. The study has established the strategic importance and advantage of using intelligent semantic analysis systems for the implementation of public control. …”
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Axiological Systems Theory: a general model of society by Francisco Parra-Luna

“…This can also be seen in institutions: Education stresses knowledge; Economy the material side of living; the Armed Forces, security and order; etc. …”
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Neuroprotective properties of GABA and its derivatives in diabetic encephalopathy in old animals by I. N. Tyurenkov, D. A. Bakulin, A. V. Smirnov, M. R. Ekova, A. I. Bisinbekova, G. L. Snigur, Yu. I. Velikorodnaya, E. I. Morkovin, D. V. Verkholyak, O. S. Vasilyeva

“…These effects may be due to higher levels of the Klotho proteins, Nrf2 and BDNF, as well as lower levels of NF-κB, which may underlie the suppression of the oxidative stress, the reduction of MDA and inflammation (TNF-α).Conclusion. …”
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Experimental study on the sensitive neighboring area range of red sandstone under rheological disturbance effect by Bo WANG, Yongzheng REN, Zhiyin TIAN, Shiji MA, Xiangyu GAO, Hongxu SUN, Jun WANG, Wanpeng HUANG

“…This study, under different confining pressure conditions, subdivides the axial stress levels of red sandstone rheology, selecting stages of cumulative residual deformation development under rock rheological disturbance effects (attenuation stage, near constant speed stage, and acceleration stage). …”
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Biological effects of cinnamaldehyde in animal cancer models: a systematic review and meta-analysis by Dan Luo, Xu Luo, Jinghui Xie, Keying Ye, Xiangjin Wang, Xiyue Hu, Chenhao Liu, Yi Liu

“…Pooled results indicated that CA administration was associated with reductions tumor volume and tumor weight in animal models. …”
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Exploring the molecular mechanism of OsROS1a in regulating resistance to bacterial leaf streak through transcriptome and DNA methylation profiling in rice (Oryza sativa L.) by Xiaofang Xie, Xuansong Yang, Libin Lu, Tong Li, Mingyue Qin, Huazhong Guan, Yan Zheng, Tao Lan, Weiren Wu

“…The DEGs in cluster 1 were enriched in the biological process related to defense response, response to stress, oxidation-reduction, etc. Integration of the methylome and transcriptome data revealed 112 overlapping differentially methylated and expressed genes (DMEGs). …”
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Effects of vitamin E administration on serum lipid profile in diabetic patients: a grade-assessed systematic review and dose–response meta-analysis of RCTs by Mehdi Karimi, Mohammad Amin Karimi, Farzad Fayedeh, Fatemeh Ziyafati Kafi, Kimia Kazemi, Sharareh Jahangiri, Omid Asbaghi

“…Studies have shown that Vitamin E, as a potent antioxidant, may improve serum lipid profile by reducing oxidative stress and inflammation. However, findings on its effects on diabetic patients remain inconsistent. …”
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Effect of levodopa and clioquinol on antioxidant capacity in Parkinson’s disease rhesus monkeys by LI Like, SHI Liangqin, LIU Heng, LUO Qihui, HUANG Chao, LIU Wentao, CHEN Xiaolin, CHEN Zhengli

“…In addition, vocalization reduction was the first symptom, but it was indistinct; furthermore, we found that the monkeys became increasingly bradykinetic, and finally presented with tremors, which were stronger and earlier at the arms than at the legs. …”
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Yttrium oxide nanoparticles induce selective cytotoxicity, genomic instability and ROS mitochondrial P53 mediated apoptosis in human pancreatic cancer cells by Hanan R. H. Mohamed, George M. Hakeem, Yasmin Abdel Latif, Shahd H. Elnawasani, Maria Nagy, Basma A. Mohamed, Rawan Essam, Gehan Safwat

“…This study aimed to explore the impact of Y2O3-NPs on cell proliferation, DNA integrity, and oxidative stress in pancreatic cancer (PANC-1) and human skin fibroblast (HSF) cells. …”
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PHONETIC REHABILITATION FOR REMOVABLE DENTAL PROSTHETICS by M. Nidzelsky, V. Chikor, N. Tsvetkova

“…According to the results of these methods, high personal anxiety is the main factor that causes the development of psycho-emotional stress during orthopedic treatment. There is also a speech adaptation, which is the result of the interaction of the active organs of the articulation apparatus with dentures. …”
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Antibacterial Evaluation of Tricyclic Antidepressants Against <i>S. aureus</i> and the Possible Pathways of the Mechanism of Action by Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lívia Gurgel do Amaral Valente Sá, Lara Elloyse Almeida Moreira, Cecília Rocha da Silva, João Batista de Andrade Neto, Érica Rayanne Mota da Costa, Thais Lima Ferreira, Leilson Carvalho de Oliveira, Beatriz Oliveira de Souza, Dávylla Rênnia Saldanha Pinheiro, Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior

“…The mechanism of TCAs, isolated and combined with OXA, was associated with a reduction in cell viability, resulting from their action on the bacterial genetic material and generation of oxidative stress. …”
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Overexpression of the STOX1B isoform of STOX1 triggers preeclampsia-like symptoms through HNF4α-dependent alterations of coagulation cascades in mice by Hélène Collinot, Louise Strubé, Ikram Benouda, Johan Castille, Sandrine Floriot, Nathalie Daniel-Carlier, Bruno Passet, Franck Lager, Isabelle Lagoutte, Gilles Renault, Benjamin Saintpierre, Maryline Favier, Djihane Djeridane, Céline Méhats, Francisco Miralles, Jean-Luc Vilotte, Daniel Vaiman

“…The two isoforms have opposite function on major genes involved in trophoblast syncytialization and oxidative stress management. Placenta-fetal overexpression of STOX1A induces preeclampsia in mice. …”
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