Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…Based on these converging mechanisms, we highlight potential therapeutic strategies, including the co-targeting of LDHA and oncogenic miRNAs (e.g., nanoparticle-mediated delivery of anti-miR-21), as well as liquid biopsy-based monitoring of circulating H3K18la and miRNA signatures to predict emerging resistance. By integrating metabolic, epigenetic, and immunologic perspectives, we position lactylation-miRNA crosstalk as a central regulatory axis in cancer therapy resistance and offer a conceptual framework to inform the development of future mechanism-driven interventions.…”
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Gut microbiota remodeling exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis in prenatal VPA-exposed C57BL/6 mice offspring by Zhaoming Liu, Zhaoming Liu, Caixia Wu, Caixia Wu, Zhaojian Sun, Zuoxian Lin, Yirong Sun, Nouman Amjad, Muhammad Majid, Rajesh Basnet, Zhiyuan Li, Zhiyuan Li, Zhiyuan Li

“…Gut microbiota profiles were analyzed via 16S rRNA sequencing, with functional pathway predictions using PICRUSt2 and KEGG databases.ResultsVPA-exposed mice exhibited ASD-like behaviors, including social deficits, repetitive stereotypic actions, and impaired spatial memory. …”
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A clinical case of diagnosis of autoimmune hepatitis at the stage of liver cirrhosis by O. A. Svitlytska, O. V. Riabokon, A. O. Svitlytskyі, N. H. Horbatkova, E. V. Kotliarevska

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DOES THE LOW LEVEL OF DEHYDROEPIANDROSTERONE SULFATE (DHEA-S) INDEPENDENTLY INFLUENCE RISK OF DEATH AT AGE 55 YEARS AND OLDER? by S. A. Shalnova, A. D. Deev, V. A. Metelskaya, A. V. Kapustina, A. E. Imaeva, Yu. A. Balanova, G. A. Muromtseva, M. A. Shkolnikova, V. M. Shkolnikov

“…The results analyzed, of the prospective cohort study “Stress, ageing and health”, that included 1876 persons at age 55 years and older. …”
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Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy by Noor Rizvi, Eliseos J. Mucaki, Emily L. Salmini, Monica Zhang, Sabina Trebinjac, Ezra Hahn, Lawrence Paszat, Sharon Nofech-Mozes, Michael T. Hallett, Eileen Rakovitch, Vanessa Dumeaux

“…Abstract Background Managing Ductal Carcinoma in Situ (DCIS) remains challenging due to the lack of reliable biomarkers to predict radiotherapy (RT) response, leading to both overtreatment of indolent disease and undertreatment of aggressive cases. …”
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Laser powder bed fusion of a novel high-strength Al–Mg–Er–Zr-Sc alloy: Process, microstructure, and performance by Zhengjiang Gao, Hui Li, Teng Ma, Huan Yang, Wei Wang, Wu Wei, Hui Huang, Shengping Wen, Zuoren Nie

“…Both of keyholes caused by excessive energy input and unfused defects caused by insufficient energy input will decrease alloy density and induce stress concentration, resulting in a reduction in elongation. …”
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Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase by Iva Bozic, Danijela Savic, Marija Jovanovic, Ivana Bjelobaba, Danijela Laketa, Nadezda Nedeljkovic, Mirjana Stojiljkovic, Sanja Pekovic, Irena Lavrnja

“…Our results imply that low-dose ribavirin may alleviate nitrosative stress during neuroinflammation.…”
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Beyond the pandemic: the relationship between macroeconomic conditions and healthcare worker shortages in the United States by Kyla F. Woodward, Janette Dill, LaTonya Trotter, Bianca K. Frogner

“…Conclusions The easing of pandemic-era stresses on healthcare has not resolved healthcare workforce shortages. …”
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Dicalcium Silicate Induced Proinflammatory Responses through TLR2-Mediated NF-κB and JNK Pathways in the Murine RAW 264.7 Macrophage Cell Line by Shixiang Lai, Liangjiao Chen, Wei Cao, Shiman Cui, Xingyang Li, Wenchao Zhong, Mingyu Ma, Qingbin Zhang

“…The detection results showed that C2S and TCP particles had no obvious toxicity in RAW 264.7 cells and did not cause obvious apoptosis, although they both caused an oxidative stress response by producing ROS when the concentrations were at 100 μg/mL. …”
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Exploring biochemical responses and cellular adaptations of Chlorella sorokiniana to polyethylene microplastic exposure by Jyoti Rawat, Pooja Bhatnagar, Abhilasha Mishra, Manisha Nanda, Prateek Gururani, Afzal Hussain, Mikhail S. Vlaskin, Sanjay Kumar, Monu Verma, Hyunook Kim, Vinod Kumar

“…Under the MP stress, reactive oxygen species (ROS) and phenolic levels were reduced, whereas flavonoid content increased. …”
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SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction by Ying Yang, Longlong Zheng, Jiaxing He, Tao Wu, Haicheng Yang, Bo Zhang, Shuai Zhou, Yueyue Lu, Xianli He, Jibin Li, Nan Wang

“…In the present investigation, we observed a significant reduction in SLC44A2 expression in colorectal cancer (CRC), and low SLC44A2 expression was closely associated with poorer survival of CRC patients. …”
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An investigation into sleep, perceived experiences, and exercise performance in elite male cyclists during the Tour de France by Josh Fitton, Bastien Lechat, Amy C. Reynolds, Barbara Toson, Jack Manners, Phuc Nguyen, Kelly A. Loffler, Thomas J. Altree, Peter Catcheside, Danny J. Eckert

“…Relative performance output (Performance Index; 0–1000) negatively predicted sleep duration (r [95% CI]; −0.32 [−0.46, −0.17]) and sleep quality (−0.34 [−0.47, −0.19]) during the race. …”
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Effect of extreme pH levels on early larval stages of the Pacific abalone (Haliotis discus hannai Ino, 1953) by Dian Yuni Pratiwi, Irfan Zidni, Mi-Jin Choi, Young Dae Oh, Tae Min Kim, Han Kyu Lim

“…However, at 30 hpf, a significant reduction in the oxygen consumption rate was observed only at pHs 9 and 10 (p < 0.05). …”
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<i>Colletotrichum capsici</i>-Induced Disease Development in Postharvest Pepper Associated with Cell Wall Metabolism and Phenylpropanoid Metabolism by Yunfen Liu, Qian Song, Feilong Yin, Yuanli Liang, Mubo Song, Meiying He, Liang Shuai

“…These insights highlight the need for early intervention strategies to mitigate postharvest losses by targeting pathogen-induced stress responses and cell wall integrity preservation.…”
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Time-dose response and mechanistic specificity of berberine in renal fibrosis from a multi-model integration perspective: a systematic review and meta-analysis on animal models by Ruyi Nie, Ziting Yuan, Yizhe Wu, Minqi Pan, Jiandong Lu, Jiandong Lu, Guoliang Xiong, Guoliang Xiong

“…The Meta-analysis revealed that BBR significantly lowered serum creatinine, blood urea nitrogen, α-SMA, and TGF-β1 levels, alongside reductions in renal fibrosis area and oxidative stress markers. …”
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Implications of thermal stratification and radiative heat flux in blood-based ternary and dihybrid nanomaterial flow through a stretchable cylinder by Muzher Saleem, Ghada A. Khouqeer, Fazal Haq, Naglaa AbdelAll, Arshad Hussain, Mohammed Sallah

“…A reduction of 4 % in the skin friction coefficient of THNF compared to HNF is noticed. …”
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Impacts of diffusion and chemical reaction on heat transfer in Casson nanofluids flow over a flat plate with accretion by J. Jayaprakash, Vediyappan Govindan

“…Conversely, more chemical reactions reduce the heat transfer rate. Concentration reduction can inhibit convective heat and mass transfer, which can reduce the efficiency of systems. …”
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A randomized cross-over study of the acute effects of running 5 km on glucose, insulin, metabolic rate, cortisol and Troponin T. by Boris Keselman, Marta Vergara, Sofia Nyberg, Fredrik H Nystrom

“…Since also Troponin T was detected in plasma in a majority of the participants, our data suggest that it is possible to induce considerable metabolic stress by running merely 5 km, when striving for maximal speed.…”
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Psychodrama: implementation, study design and effectiveness: a systematic review by Jesús Maya, Miriam Pérez-Berbel, Laura Giraldo-Arroyave, Irene Hurtado

“…In relation to the effectiveness of psychodrama, positive and significant results were found, for example, in the reduction of post-traumatic stress levels, the empowerment of women in vulnerable situations, improvement in the quality of life and symptoms of patients with schizophrenia, or improvement in antisocial behavior in adolescents. …”
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Factors influencing the performance of cardiopulmonary resuscitation by lay rescuers: A qualitative study based on the Theory of Planned Behavior. by Zhikang Zhong, Weiwei Li, Lin Zhou, Liang Liu

“…To improve intervention rates, it is crucial to target emotional barriers (virtual reality (VR)-based anxiety reduction) and address systemic constraints (AED availability and simplified Good Samaritan laws) while leveraging artificial intelligence tools to reinforce positive norms. …”
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