Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…Based on these converging mechanisms, we highlight potential therapeutic strategies, including the co-targeting of LDHA and oncogenic miRNAs (e.g., nanoparticle-mediated delivery of anti-miR-21), as well as liquid biopsy-based monitoring of circulating H3K18la and miRNA signatures to predict emerging resistance. By integrating metabolic, epigenetic, and immunologic perspectives, we position lactylation-miRNA crosstalk as a central regulatory axis in cancer therapy resistance and offer a conceptual framework to inform the development of future mechanism-driven interventions.…”
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DOES THE LOW LEVEL OF DEHYDROEPIANDROSTERONE SULFATE (DHEA-S) INDEPENDENTLY INFLUENCE RISK OF DEATH AT AGE 55 YEARS AND OLDER? by S. A. Shalnova, A. D. Deev, V. A. Metelskaya, A. V. Kapustina, A. E. Imaeva, Yu. A. Balanova, G. A. Muromtseva, M. A. Shkolnikova, V. M. Shkolnikov

“…The results analyzed, of the prospective cohort study “Stress, ageing and health”, that included 1876 persons at age 55 years and older. …”
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Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy by Noor Rizvi, Eliseos J. Mucaki, Emily L. Salmini, Monica Zhang, Sabina Trebinjac, Ezra Hahn, Lawrence Paszat, Sharon Nofech-Mozes, Michael T. Hallett, Eileen Rakovitch, Vanessa Dumeaux

“…Abstract Background Managing Ductal Carcinoma in Situ (DCIS) remains challenging due to the lack of reliable biomarkers to predict radiotherapy (RT) response, leading to both overtreatment of indolent disease and undertreatment of aggressive cases. …”
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Beyond the pandemic: the relationship between macroeconomic conditions and healthcare worker shortages in the United States by Kyla F. Woodward, Janette Dill, LaTonya Trotter, Bianca K. Frogner

“…Conclusions The easing of pandemic-era stresses on healthcare has not resolved healthcare workforce shortages. …”
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Laser powder bed fusion of a novel high-strength Al–Mg–Er–Zr-Sc alloy: Process, microstructure, and performance by Zhengjiang Gao, Hui Li, Teng Ma, Huan Yang, Wei Wang, Wu Wei, Hui Huang, Shengping Wen, Zuoren Nie

“…Both of keyholes caused by excessive energy input and unfused defects caused by insufficient energy input will decrease alloy density and induce stress concentration, resulting in a reduction in elongation. …”
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Dicalcium Silicate Induced Proinflammatory Responses through TLR2-Mediated NF-κB and JNK Pathways in the Murine RAW 264.7 Macrophage Cell Line by Shixiang Lai, Liangjiao Chen, Wei Cao, Shiman Cui, Xingyang Li, Wenchao Zhong, Mingyu Ma, Qingbin Zhang

“…The detection results showed that C2S and TCP particles had no obvious toxicity in RAW 264.7 cells and did not cause obvious apoptosis, although they both caused an oxidative stress response by producing ROS when the concentrations were at 100 μg/mL. …”
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Exploring biochemical responses and cellular adaptations of Chlorella sorokiniana to polyethylene microplastic exposure by Jyoti Rawat, Pooja Bhatnagar, Abhilasha Mishra, Manisha Nanda, Prateek Gururani, Afzal Hussain, Mikhail S. Vlaskin, Sanjay Kumar, Monu Verma, Hyunook Kim, Vinod Kumar

“…Under the MP stress, reactive oxygen species (ROS) and phenolic levels were reduced, whereas flavonoid content increased. …”
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An investigation into sleep, perceived experiences, and exercise performance in elite male cyclists during the Tour de France by Josh Fitton, Bastien Lechat, Amy C. Reynolds, Barbara Toson, Jack Manners, Phuc Nguyen, Kelly A. Loffler, Thomas J. Altree, Peter Catcheside, Danny J. Eckert

“…Relative performance output (Performance Index; 0–1000) negatively predicted sleep duration (r [95% CI]; −0.32 [−0.46, −0.17]) and sleep quality (−0.34 [−0.47, −0.19]) during the race. …”
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<i>Colletotrichum capsici</i>-Induced Disease Development in Postharvest Pepper Associated with Cell Wall Metabolism and Phenylpropanoid Metabolism by Yunfen Liu, Qian Song, Feilong Yin, Yuanli Liang, Mubo Song, Meiying He, Liang Shuai

“…These insights highlight the need for early intervention strategies to mitigate postharvest losses by targeting pathogen-induced stress responses and cell wall integrity preservation.…”
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Time-dose response and mechanistic specificity of berberine in renal fibrosis from a multi-model integration perspective: a systematic review and meta-analysis on animal models by Ruyi Nie, Ziting Yuan, Yizhe Wu, Minqi Pan, Jiandong Lu, Jiandong Lu, Guoliang Xiong, Guoliang Xiong

“…The Meta-analysis revealed that BBR significantly lowered serum creatinine, blood urea nitrogen, α-SMA, and TGF-β1 levels, alongside reductions in renal fibrosis area and oxidative stress markers. …”
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Implications of thermal stratification and radiative heat flux in blood-based ternary and dihybrid nanomaterial flow through a stretchable cylinder by Muzher Saleem, Ghada A. Khouqeer, Fazal Haq, Naglaa AbdelAll, Arshad Hussain, Mohammed Sallah

“…A reduction of 4 % in the skin friction coefficient of THNF compared to HNF is noticed. …”
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Impacts of diffusion and chemical reaction on heat transfer in Casson nanofluids flow over a flat plate with accretion by J. Jayaprakash, Vediyappan Govindan

“…Conversely, more chemical reactions reduce the heat transfer rate. Concentration reduction can inhibit convective heat and mass transfer, which can reduce the efficiency of systems. …”
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A randomized cross-over study of the acute effects of running 5 km on glucose, insulin, metabolic rate, cortisol and Troponin T. by Boris Keselman, Marta Vergara, Sofia Nyberg, Fredrik H Nystrom

“…Since also Troponin T was detected in plasma in a majority of the participants, our data suggest that it is possible to induce considerable metabolic stress by running merely 5 km, when striving for maximal speed.…”
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Psychodrama: implementation, study design and effectiveness: a systematic review by Jesús Maya, Miriam Pérez-Berbel, Laura Giraldo-Arroyave, Irene Hurtado

“…In relation to the effectiveness of psychodrama, positive and significant results were found, for example, in the reduction of post-traumatic stress levels, the empowerment of women in vulnerable situations, improvement in the quality of life and symptoms of patients with schizophrenia, or improvement in antisocial behavior in adolescents. …”
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Seeds of success: seed biology and germination response of Gazania weed in Australia by Muhammad Adnan, Babar Shahzad, Marisa Collins, Ali Ahsan Bajwa

“…Populations did not differ in their germination response to moisture stress. Seeds did not germinate beyond -1.2 MPa water potential, while 50% germination inhibition occurred at -0.67 MPa. …”
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DNA Damage Response Regulation Alleviates Neuroinflammation in a Mouse Model of α-Synucleinopathy by Sazzad Khan, Himanshi Singh, Jianfeng Xiao, Mohammad Moshahid Khan

“…Overall, these results suggest that targeting the DDR via ATM inhibition reduces genotoxic stress, suppresses neuroinflammation, and improves behavioral outcomes in a mouse model of α-synucleinopathy. …”
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Implementing nature walking groups in mental health services as a transdiagnostic approach to promote recovery: a study ​protocol for a non-randomised trial by Nicole Snowdon, Zubair Ahmed Ratan, Katarzyna Olcon, Peter Destry, Julaine Allan

“…On each walk, facilitators will draw participant attention to one of the natural features and guide participants through stress reduction and mindfulness activities, lasting 3 to 10 min in duration. …”
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Role of lipopolysaccharide in genesis of microvascular complications in type 1 diabetes mellitus by V. A. Beloglazov, I. A. Yatskov, D. I. Ulyanova

“…According to current literature, the main pathogenetic links in the development of microvascular complications in DM1 concern, e.g., direct glucosemediated endothelial damage, oxidative stress, as well as microvascular fibrotic processes. …”
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TECHNOLOGICAL PECULIARITIES OF THERMAL BARRIER COATINGS BASED ON ZIRCONIUM DIOXIDE by V. V. Okovity, O. G. Devoino, V. A. Okovity, V. M. Astashinsky

“…As a result, the metal-ceramic Al2O3 layer is formed at a metal-ceramic interface and it changes a stress state of the coating that causes a reduction of protective properties. …”
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Targeting ESKAPE pathogens with ZnS and Au@ZnS Core–Shell nanoconjugates for improved biofilm control by Shaikh Imran Ibrahim, Ajith Manayil Parambil, Neha Jha, Anuj Kumar Tomar, Paulraj Rajamani, Xiao Jian, Eepsita Priyadarshini, Shao Chuxiao

“…Further investigations, including cell permeability assay, reactive oxygen species analysis, and comet analysis, demonstrated that the Au@ZnS NC induced oxidative stress, destabilizing cell structure, macromolecule destruction, and DNA strand breakage. …”
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