Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer by Florian Uhlitz, Philip Bischoff, Stefan Peidli, Anja Sieber, Alexandra Trinks, Mareen Lüthen, Benedikt Obermayer, Eric Blanc, Yana Ruchiy, Thomas Sell, Soulafa Mamlouk, Roberto Arsie, Tzu‐Ting Wei, Kathleen Klotz‐Noack, Roland F Schwarz, Birgit Sawitzki, Carsten Kamphues, Dieter Beule, Markus Landthaler, Christine Sers, David Horst, Nils Blüthgen, Markus Morkel

“…Experimental targeting of EGFR‐BRAF‐MEK in cancer organoids affected signaling and gene expression contingent on predictive KRAS/BRAF mutations and induced cell plasticity overriding default developmental trajectories. …”
Get full text

Single nuclei RNA-sequencing unveils alveolar macrophages as drivers of endothelial damage in obese HFpEF-related pulmonary hypertension by Era Gorica, Jacopo Spezzini, Iliana Papadopoulou, Marialucia Telesca, Valeria Masciovecchio, Shafeeq A. Moahmmed, Alessandro Mengozzi, Hung-Wei Cheng, Natalia Atzemian, Ludovica Di Venanzio, Alessia Mongelli, Omer Dzemali, Vincenzo Calderone, Francesco Paneni, Christian M. Matter, Burkhard Ludewig, Frank Ruschitzka, Sarah Costantino

“…In vitro experiments were performed to study the mechanisms underlying metabolic stress-induced macrophage dysfunction using palmitic acid (PA), co-culture experiments were used to investigate the crosstalk between macrophages and endothelial cells. …”
Get full text

Détermination de l'influence du trajet de déformation sur la courbe limite de formage by Nguyen Nhat Thang

“… The aim of this study is to predict the strain path influence on the forming limit diagram, from the limit stress curve. …”
Get full text

Calidad de sueño, salud mental y actividad física en estudiantes universitarios de la Amazonía peruana (Sleep quality, mental health and physical activity in university students fr... by Jimmy Nelson Paricahua-Peralta, Edwin Gustavo Estrada-Araoz, Ronald Socrates Poma-Mollocondo, Libertad Velasquez-Giersch, Alhi Jordan Herrera-Osorio, George Jhon Cruz-Visa, Manuel Felipe Guevara-Duarez, Osbel Mora-Estrada, Elizabeth Orfelia Cruz-Laricano

“…In the context of higher education, sleep quality, mental health, and physical activity are key variables for understanding the overall well-being of students. …”
Get full text

Nutritional status, psychological status and quality of life of adolescents in selected childcare institutions in the Galle district of Sri Lanka by LTK De Zilva, Eric De Zoysa

“…Psychological status and QoL were assessed via validated Sinhala versions of the Depression Anxiety and Stress Scale (DASS 21) and Peds QLTM Generic 4.0 core scale, respectively. …”
Get full text

Hygro-mechanical model for concrete pavement with long-term drying analysis by Jakub Veselý, Vít Šmilauer

“…The validation covers autogenous and drying strain on the slab. The models predict drying-induced tensile stress up to 3.3 MPa, inducing additional loading on the slab, uncaptured by current design methods. …”
Get full text

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures by Nicholas A Graham, Aspram Minasyan, Anastasia Lomova, Ashley Cass, Nikolas G Balanis, Michael Friedman, Shawna Chan, Sophie Zhao, Adrian Delgado, James Go, Lillie Beck, Christian Hurtz, Carina Ng, Rong Qiao, Johanna ten Hoeve, Nicolaos Palaskas, Hong Wu, Markus Müschen, Asha S Multani, Elisa Port, Steven M Larson, Nikolaus Schultz, Daniel Braas, Heather R Christofk, Ingo K Mellinghoff, Thomas G Graeber

“…Using a pan‐cancer analysis of CNA data from patient tumors and experimental systems, here we show that principal component analysis‐defined CNA signatures are predictive of glycolytic phenotypes, including 18F‐fluorodeoxy‐glucose (FDG) avidity of patient tumors, and increased proliferation. …”
Get full text

Muscle Spatial Transcriptomic Reveals Heterogeneous Profiles in Juvenile Dermatomyositis and Persistence of Abnormal Signature After Remission by Margot Tragin, Séverine A. Degrelle, Baptiste Periou, Brigitte Bader-Meunier, Christine Barnerias, Christine Bodemer, Isabelle Desguerre, Mathieu Paul Rodero, François Jérôme Authier, Cyril Gitiaux

“…This work paves the way for a better understanding of the pathophysiology in affected muscle and the identification of biomarkers that predict relapse.…”
Get full text

Cuproptosis: a novel therapeutic mechanism in lung cancer by Cheng Luo, Xinhui Wu, Shipeng Zhang, Junwen Tan, Yuzhi Huo, Xinyue Zhang, Bo Ning, Yuanhang Ye, Fei Wang

“…These elements are vital for evaluating clinical interventions for lung cancer patients, predicting risks, and recognizing drug resistance. Moreover, we identified that pharmaceuticals facilitating copper ion transport (elesclomol and disulfiram), copper-chelating agents (DPEN, ATTM, and TETA), and nanoparticles engineered to transport copper are capable of effectively adjusting copper ion concentrations in lung cancer cells, subsequently inducing cuproptosis as a prospective treatment strategy for lung cancer. …”
Get full text

“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state by Wanyang Sun, Rong Wang, Shuhua Ouyang, Wanli Liang, Junwei Duan, Wenyong Gong, Lianting Hu, Xiujuan Chen, Yifang Li, Hiroshi Kurihara, Xinsheng Yao, Hao Gao, Rongrong He

Get full text

Viable Approach of Tuning Oxide Semiconductor Thin Films in Solution‐Processed Heterojunction Thin Films Transistors for Both Higher Performances and Stability by Jun‐Su Eun, Jinuk Lee, Jeong‐Hyeon Na, Jun‐Hyeong Park, Won Park, Junhao Feng, Kyung‐Ho Seo, Jaewon Jang, In Man Kang, Do‐Kyung Kim, Jin‐Hyuk Bae

“…However, trap‐limited conduction becomes dominant in the bilayer with an excessively thick top layer, thereby leading to a significant reduction in mobility and positive bias stability. …”
Get full text

Composite single-cell protein as a sustainable fishmeal substitute: Enhancing growth and health in largemouth bass (Micropterus salmoides) by Jian Chen, Jianqiang Huang, Ling Pan, Fuping Song, Yonghua Hu, Shuang Zhang, Yan Wang

“…Functional predictions indicated enhanced pathways in “Cell motility” and “Immune system,” with enrichment of the NOD-like receptor signaling pathway. …”
Get full text

Brazilian Morus nigra Attenuated Hyperglycemia, Dyslipidemia, and Prooxidant Status in Alloxan-Induced Diabetic Rats by Ivanildo I. da S. Júnior, Humberto de Moura Barbosa, Débora C. R. Carvalho, Ruideglan de Alencar Barros, Flávia Peixoto Albuquerque, Dionísio Henrique Amaral da Silva, Grasielly R. Souza, Nathália A. C. Souza, Larissa A. Rolim, Flaviane M. M. Silva, Glória I. B. P. Duarte, Jackson R. G. da S. Almeida, Flávio Monteiro de Oliveira Júnior, Dayane A. Gomes, Eduardo C. Lira

“…Acute EEMn treatment reduced hyperglycemia, improved oral glucose tolerance, and minimized dyslipidemia and oxidative stress leading to a reduction in atherogenic index in alloxan-induced diabetic rats.…”
Get full text

Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults by Xinliang Zheng, Wenxin Zhou, Zhuoying Jiang, Chan Ding, Minqian Feng, Yongxin Li, Fitri Kurniasari, Shuanghua Xie, Huadong Xu

“…Environmental metal exposure has been associated with oxidative stress and aging, but its effect on α-Klotho levels remains unclear. …”
Get full text

Effect of legacy and emerging pollutants on genome-wide methylation patterns in black hake (Merluccius polli) natural populations by Carmen Blanco-Fernandez, María Bobes-Villa, Ainhoa López, Daniel Menéndez, Kathryn R. Elmer, Eva Garcia-Vazquez, Gonzalo Machado-Schiaffino

“…Elevated Pb was significantly associated with a reduction in hake condition factor. Differentially methylated loci were associated with diverse pathways associated to responses for all pollutants (e.g. immune response, gene expression regulation), pointing to signs of stress within the population. …”
Get full text

Study on Macroscopic and Microscopic Mechanical Behavior of Magnetorheological Elastomers by Representative Volume Element Approach by Shulei Sun, Xiongqi Peng, Zaoyang Guo

“…Then by introducing the Maxwell stress tensor, a two-dimensional plane stress RVE for the MRE is developed in COMSOL Multiphysics to study its response under a magnetic field. …”
Get full text

The impact of ride hailing on parking (and vice versa) by Alejandro Henao, Wesley E. Marshall

“…This includes building a classification tree-based model to predict the replaced driving trips as a function of car ownership, destination land type, parking stress, and demographics. …”
Get full text

Influence of the Steel Fiber Content on the Flexural Fatigue Behavior of Recycled Aggregate Concrete by Yan Tan, Chenxu Zhou, Jinzhi Zhou

“…Two-parameter Weibull distribution is fitted to the test data to generate fatigue models at different survival probabilities, and fatigue life can be accurately predicted using the developed model. Therefore, it is feasible to replace the natural concrete with the recycled aggregate concrete with appropriate steel fiber content in some aspects, which is of great significance to green development.…”
Get full text

SUITABLE METHODOLOGY FOR THE DESIGN OF CIRCULAR REINFORCED CONCRETE SILOS by Hawra Mohamed Ali M. Taher

“…This research also reveals the discrepancy between theoretical predictions and numerical simulations, meaning that there is a requirement for further improvement in the design of silos. …”
Get full text

Effects and mechanisms of warming on the relationship between soil organic matter degradation and methylmercury production in Hg-contaminated soil by Siqi Zhang, Sihua Zhu, Shanyi Tian, Jianxu Wang, Yongguang Yin, Jitao Lv, Yongmin Wang, Tao Jiang, Zhenwu Tang, Dingyong Wang

“…Future research should incorporate contaminated soils into global carbon models to improve SOM turnover predictions in terrestrial systems.…”
Get full text