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IL-4 and IL-13 in Cardiovascular Disease: From Immune Modulation to Therapeutic Possibilities – A Narrative Review
Published 2025-08-01“…Ahmet Turhan Kılıç,1 Rıdvan Bora,2 Burak Toprak1 1Department of Cardiovascular Surgery, Mersin City Education and Research Hospital, Mersin, Turkey; 2Department of Cardiology, Tarsus State Hospital, Mersin, TurkeyCorrespondence: Burak Toprak, Department of Cardiovascular Surgery, Mersin City Education and Research Hospital, Kuzeykent District, 31131 Street No: 1, Floor: 6, Flat No: 11, Yenişehir, Mersin, 33120, Turkey, Email brk.tprk@gmail.comBackground: Interleukin-4 (IL-4) and Interleukin-13 (IL-13) are central regulators of the Th2 immune response and play pivotal roles in vascular inflammation, endothelial dysfunction, and cardiovascular remodeling. …”
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Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis
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Parents’ State and Trait Anxiety Levels During Bloodletting Attempts in the Pediatric Emergency Department
Published 2025-08-01“…Introduction: Parental stress and anxiety during pediatric bloodletting in the pediatric emergency department (PED) are influenced by a complex interplay of factors, including the child’s medical condition, unfamiliarity with procedures, healthcare-provider interactions, and parental knowledge gaps. …”
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Research on the evolution mechanism of shale mechanical properties under variable bedding angles
Published 2025-03-01“…This leads to incorrect prediction of fracturing parameters, which results in inefficient fracturing reconstruction of shale reservoir. …”
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A New Sustainable Approach to Enhancing the Subtractive Process in the Additive–Subtractive Hybrid Manufacturing of AISI H13 Dry Machining
Published 2025-06-01“…The results of our research show a 65% reduction in force, a 50% reduction in tool wear, and a reduction in microstructural changes during machining while maintaining dry machining.…”
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Biopharmaceutical Trials of a Dosage Form, which Contain Methionine and Turmeric Extract (<i>Curcuma longa</i> L.)
Published 2021-05-01“…The presence of biologically active substances in the extract from the roots of turmeric extract (Curcuma longa L.) makes it reasonable and makes it possible to predict their effectiveness in pathological conditions caused by oxidative stress and immune disorders arising against its background. …”
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Domain-specific osmoadaptation revealed by metatranscriptomic analysis in hypersaline environments
Published 2025-07-01“…Further, metatranscriptomics coupled with the analysis of isoelectric point (pI) distributions revealed a remarkable repression of high-pI predicted proteins under high-salt concentration, particularly in Bacteria, suggesting a selective downregulation of basic proteins in response to osmotic stress and highlighting a potential adaptive mechanism. …”
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Formulation-Dependent Extrudability of Highly Filled Alginate System for Vaginal Drug Delivery
Published 2025-07-01“…The correlations between composition and material properties offer a basis for building predictive models for fine-tuning their composition of highly filled hydrogel systems.…”
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Genome-wide identification of SWEET gene family and functional analysis of BcSWEET1-2 associated with flowering in flowering Chinese cabbage (Brassica campestris)
Published 2025-07-01“…However, all BcSWEET proteins are predicted to be localized in the cell membrane. Prediction of transmembrane regions showed that all members contained the MtN3/saliva domain. …”
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Influence of the Cutting Angle on the Resistance of Bulldozer Working Equipment Blade Burial When the Machine Is Moving
Published 2025-07-01“…Constructive features and kinematics of the working equipment are considered, including a promising parallelogram scheme, which provides automatic reduction of the cutting angle during deepening. Calculations of the resistance of the blade penetration into the ground, and experimental data confirming the cutting force reduction up to 7%, for each degree of angle reduction, are given. …”
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The impact of self-efficacy on substance use in nursing students: the mediating role of sense of coherence
Published 2025-07-01“…Strengthening SOC through targeted interventions may help mitigate risky behaviors and improve overall well-being. Educational programs focusing on resilience, stress management, and coherence-building strategies could be beneficial for nursing students to support their future professional roles. …”
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Resilience in the shadows of loss: a hermeneutic phenomenological study of neonatal intensive care nurses’ coping after infant loss in Saudi Arabia
Published 2025-07-01“…Methods An interpretive phenomenological design grounded in Heidegger’s hermeneutic tradition was employed, with Lazarus and Folkman’s stress and coping theory providing the theoretical framework for analysis. …”
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Estrés y su afrontamiento en directores y directoras de colegios y escuelas en el circuito 03 de la provincia de Heredia
Published 2004-09-01“…The purpose of this study was to analyze how school principals working in the third circuit of the province of Heredia experienced and faced stress. 17 educational managers (11 women and 6 men) participated in the survey. …”
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