The Cardiac Dysfunction Caused by Metabolic Alterations in Alzheimer's Disease by Jiayuan Murphy, Tran Ngoc Van Le, Julia Fedorova, Yi Yang, Meredith Krause-Hauch, Kayla Davitt, Linda Ines Zoungrana, Mohammad Kasim Fatmi, Edward J. Lesnefsky, Edward J. Lesnefsky, Ji Li, Di Ren

“…To reveal the mechanism by which AD leads to cardiac systolic dysfunction, the immunoblotting analysis showed increased activation of AMP-activated protein kinase (AMPK) in 5XFAD left ventricular and brain tissue, indicating altered energy metabolism. Mito Stress Assays examining mitochondrial function revealed decreased basal and maximal oxygen consumption rate, as well as defective pyruvate dehydrogenase activity in the 5XFAD heart and brain. …”
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Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10 by Fengdong Zhang, Yongchang Han, Fan Li, Boya Guo, Jian Chen, Wenchuan Zhou, Pan Xiao, Hui Ma, Yongyan Jin, Jia Feng, Yuna Min

“…Our previous study demonstrated that egg exosome-derived miRNAs may play a key role in modulating embryonic oxidation-reduction process, whereas the exact function and mechanism were still poorly understood. …”
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Dietary non-enzymatic antioxidant capacity and risk of breast cancer: the Swedish National March Cohort by Daniela Mariosa, Marta Ponzano, Alessandra Grotta, Ylva Trolle Lagerros, Essi Hantikainen, Hans-Olov Adami, Mauro Serafini, Rino Bellocco, Weimin Ye

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Decoding metabolic trade-offs in Halomonas elongata: Chemostat-based flux remodeling for industrial ectoine biosynthesis by Junxiong Yu, Hao Liu, Yudi Wang, Runlin Ju, Yue Zhang, Ali Moshin, Yingping Zhuang, Meijin Guo, Zejian Wang

“…These findings establish H. elongata as a paradigm of dynamic flux rewiring, where carbon economy is strategically reallocated between stress-protective solute biosynthesis and energy homeostasis. …”
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Is frequent handling with reinforcement effective in improving management practices for feedlot heifers? by Vitor R. Pacor, Messy H. A. Pantoja, Douglas H. S. Almeida, Isabela M. D. Batista, Milena S. Consorti, Cihan Çamakçı, Cristiane G. Titto

“… Aim of study: This study aimed to evaluate the effect of frequent handling of feedlot female cattle to decrease animal handling time and stress indicators. Area of study: Brazil, São Paulo State. …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Results We observed a significant reduction in CD8αα + IELs, accompanied by a marked increase in CD8αβ + IELs in Lpr mice. …”
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Unveiling the Cardioprotective Potential of Hydroxytyrosol: Insights from an Acute Myocardial Infarction Model by Alejandra Bermúdez-Oria, Eugenia Godoy, Virginia Pérez, Camila Musci Ferrari, Martin Donato, Juan Fernández-Bolaños, Tamara Zaobornyj, Verónica D’Annunzio

“…These findings highlight the efficacy of HT in reducing oxidative stress and preserving mitochondrial function, critical factors in cardiac disease. …”
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Fabrication and performance of a novel polymer composite waterproof adhesive layer with enhanced hydrophobicity for concrete bridge decks by Bonan Ma, Fei Wang, Jiaqi Li, Chaodong Yang, Wentao Jia, Kaisheng Luo, Enhui Yang, Yanjun Qiu

“…Even after prolonged water immersion, the reduction in bonding strength was minimal (less than 5 %). …”
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The time to perform spinal or general anaesthesia in COVID-19 positive parturients requiring emergency caesarean delivery: a prospective crossover simulation study by Marcelo Epsztein Kanczuk, Nicholas J Lightfoot, Alison Pighills, Antony Ji, Casey Steele, Daniel Bartlett

“…Background: Spinal anaesthesia is the commonest performed technique for caesarean deliveries except in the emergency setting where general anaesthesia is preferred due to its rapid onset and predictability. There are several modifications to performing general anaesthesia for COVID-19 patients in Australia. …”
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In Silico Assessment of the Influence of Talus Osteochondral Lesion Size and Location on Ankle Joint Stability using Tilted Talar Dome Plane Orientations by Lercan Aslan MD, Omer Subasi PhD, Bedri Karaismailoglu MD, FEBOT, Cihad C. Gedik, Batuhan Yuruk, Soheil Ashkani-Esfahani MD, Ilker Eren

“…It is revealed that the stress parameters are highly misleading and do not predict ankle stability. …”
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Unveiling the Impact of Climatic Factors on the Distribution Patterns of <i>Caragana</i> spp. in China’s Three Northern Regions by Weiwei Zhao, Yujia Liu, Yanxia Li, Chunjing Zou, Hideyuki Shimizu

“…Using the Biomod2 ensemble model, current and future climate scenario-based suitable habitats for <i>Caragana</i> spp. were predicted. This study innovatively combined quantitative analyses with Kira’s thermal indexes (warmth index, coldness index) and Wenduo Xu’s humidity index (HI) to elucidate species-specific relationships between distribution patterns and hydrothermal climatic constraints. …”
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Alkaloidal Extracts from Avicennia africana P. Beauv. (Avicenniaceae) Leaf: An Antiplasmodial, Antioxidant, and Erythrocyte Viable by Mustapha A. Ahmed, Elvis O. Ameyaw, Francis A. Armah, Patrick M. Fynn, Isaac Asiamah, George Ghartey-Kwansah, Felix K. Zoiku, Ebenezer Ofori-Attah, Christian K. Adokoh

“…Dexrazoxane was found to be the main compound predicted, with an 86% peak area in the quaternary alkaloidal extract. …”
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MiR-455-5p Mitigates Interleukin-1 β-induced Chondrocyte Damage Linked to Osteoarthritis by Targeting TNFAIP8 by Tao Zhang, Wei Wang, Jinlei Sun, Long Luo, Yuan Li, Zhixiong Xu, Wensheng Xu

“…TargetScan was used to predict the binding sites between miR-455-5p and tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8), which were then confirmed by dual-luciferase reporter assays. …”
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Estimating the genetic parameters of resilience toward known and unknown disturbances in sheep using wool fibre diameter and body weight variability by Erin G. Smith, Samuel F. Walkom, Dominic L. Waters, Sam A. Clark

“…However, it is unclear whether resilience indicators derived from different longitudinal data series can predict resilience to known or unknown disturbances in sheep. …”
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The phenomenon of Type A and B personality prevalence and their correlation to the anti-health behavior of Polish physicians by Józefa Dąbek, Sławomir Wojczyk, Julia Bijoch, Oskar Sierka

“…Physicians with Type A personality achieved higher score values on all subscales of the My Eating Habits Questionnaire than physicians with intermediate and Type B personalities.ConclusionThe occurrence of Type A personality was associated with, among others, worse eating habits, more frequent sleep deprivation, and exposure to stress and low physical activity. There is a need to conduct educational activities at an early school stage regarding the benefits of following healthy lifestyle recommendations, and consequently limiting the development of diseases and their complications.…”
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A new similitude law for testing scaled RC structures by Jamin Park, Seong-Cheol Lee, Yunbyeong Chae, Jae-Yeol Cho

“…The simulation results clearly show that the new similitude law can predict the prototype’s response better than other similitude laws proposed in previous studies.…”
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Effects of effort-reward imbalance on emergency nurses’ health: a mediating and moderating role of emotional exhaustion and work-family conflict by Yuanyuan Tan, Jing Zhou, Jing Zhou, Jing Zhou, Hao Zhang, Hao Zhang, Hao Zhang, Lin Lan, Lin Lan, Lin Lan, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Xiaomin Yu, Xiaomin Yu, Xiaomin Yu, Luying Zhong, Luying Zhong, Luying Zhong, Ling Zhu, Ling Zhu, Ling Zhu, Yongli Gao, Yongli Gao, Yongli Gao

“…The mediation effect is tested by the bias correction Bootstrap sample size was set to 5,000.ResultConsidering emotional exhaustion as a mediating variable, the direct predictive influence of ERI on somatic symptoms and sleep disorders continues to be statistically significant (β = 0.271, 0.137, p &lt; 0.01). …”
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Caged-hypocrellin mediated photodynamic therapy induces chromatin remodeling and disrupts mitochondrial energy metabolism in multidrug-resistant Candida auris by Xinyao Liu, Yiran Tao, Linwan Zhang, Yuzhou Liu, Dongmei Shi, Jiao Wang, Peng Xue, Bin Xu, Wenjie Fang, Yuping Ran

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Radiological characteristics of lumbar vertebrae in patients with low back pain and change of motor control of the muscles of the lumbopelvic region by V.A. Kolesnichenko, H.H. Holka, I.V. Hresko, O.H. Fadieiev, A.O. Oliinyk, B.P. Vvedensky, D.B. Vvedensky

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Bacteriome Diversity of Soil Islands Associated With Bromeliads From Ironstone Outcrops in the Brazilian Pantanal by Fernanda M. R. Godoy, Gecele M. Paggi, Aline P. Lorenz, Jeferson V. Ramos, Daniel G. Franco, Fernando M. L. Calarge, Nayara F. L. Garcia, Marcus V. S. Urquiza, Jolimar A. Schiavo, Nalvo F. Almeida, Marivaine S. Brasil

“…Knowledge about the diversity and distribution of microorganisms in natural environments is essential for understanding the dominant microbial groups and predicting their ecological functions. This study is aimed at describing the bacteriome diversity in soils associated with bromeliads in the Brazilian Pantanal region, utilizing genomic approaches. …”
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