Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Identification of yield-related QTLs and their applications using DH population in maize by Yifei Wang, Dongxu Yao, Junfeng Song, Xiaochun Zhang, Yanbin Zhu, Zhichun Luo, Jinsheng Lai, Weibin Song, Tianxia Yang

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Study on the influence of fracture geometry characteristics on the shear behaviors of fractured rock mass by Chaolei Wu, Lishuai Jiang, Yang Li, Kefang Tao, Mingtao Gao, Xin Yang, Jiaming Liu

“…The results show that: (1) The failure of sand-powder 3D-printed fractured rock-like specimens exhibits brittle characteristics. The shear stress–shear displacement relationship can be divided into five stages: compaction, elasticity, unstable development, peak, and post-peak. …”
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Orexin A ameliorates HBV X protein-induced cytotoxicity and inflammatory response in human hepatocytes by Li Wang, Tao He, Baishun Wan, Xiaoqian Wang, Ling Zhang

“…When orexin A is added to the cells, it mitigates HBx-induced oxidative stress indicator 4-hydroxynonenal (4-HNE) and reactive oxygen species (ROS) as well the NADPH subunit NADPH oxidase 4 (NOX-4). …”
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Phenolic profile and protective role of Calendula officinalis against molybdenum-induced toxiciy in Allium cepa by Fatih Kutluer

“…These findings suggest the potential therapeutic applications of C. officinalis in mitigating metal-induced oxidative stress. Future investigations are required to further characterize and identify natural extracts with antioxidant properties, with a focus on their mechanistic pathways.…”
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Melatonin attenuates thiocyanate-induced vasoconstriction in aortic rings by Alexander M. Prusa, Christian A. Plass

“…Melatonin, a non-toxic indolamine with various physiologic functions, is believed to protect against inflammatory processes and oxidative stress. It has been demonstrated that melatonin serves as free radical scavenger and represents a potent antioxidant. …”
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Germinación y Desarrollo de Plántulas de Tres Híbridos de Maíz bajo Soluciones Osmóticas. V. Polietilenglicol by Jesús Rafael Méndez Natera, Faida Taimi Ybarra Pérez, José Fernando Merazo Pinto

“…The results indicated that polyethylene glycol 400 didn't differentiate resistance and/or tolerance to drought (water stress) among the three corn cultivars evaluated   …”
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CORN HAIR EXTRACT AS CORROSION INHIBITOR FOR ST37 STEEL IN 3% HCL MEDIA by Sefrilita Risqi Adikaning Rani, Rahmaniah Rahmaniah, Hernawati Hernawati, Nurhidayah Nurhidayah, Fira Yurdanianti

“…The results also indicated that the test of morphological characteristics of ST37 steel shows four types of corrosion formed such as stress, uniform, pitting, and pitting corrosions. …”
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In-situ joining of SiCf/SiC composites to single-crystal CMSX-6 superalloy via active unidirectional casting technology by Yingxin Wang, Fu Wang, Qiang Yang, Dichen Li, Yunsong Zhao, Jiantao Wu

“…This desirable performance is ascribed to the combined effects of the pinning mechanism, which arises from the infiltration of molten CMSX-6 into SiCf/SiC composite, and the reduction of residual thermal stress afforded by the graded interface formed during joining.…”
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Impact of synthetic and herbal dyes on photosynthesis and ROS scavenging enzyme activities in Spirodela polyrhiza by Vineet Soni, Upma Bhatt, Pooja Tailor, Reto J. Strasser

“…At 2.5 g/L SC, a 94.18% reduction in trapped energy flux (TR₀/CSm) and a 96.1% decline in electron transport rate (ET₀/CSm) were observed, along with a significant decrease in chlorophyll content. …”
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Trimetazidine MB treatment in patients with chronic heart failure by T. E. Morozova, E. I. Ivanova

“…After 16 weeks of the treatment, clinical improvement and CHF FC reduction were observed in 28 % and 26 % of the patients from Groups I and II, respectively. …”
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Effect of cultivation feed diet using local food processing by-products on the growth and flavor factor in the Malabar grouper Epinephelus malabaricus by Makoto Takahashi, Shingo Udagawa, Chihiro Yamauchi, Yoshimi Imura, Taekyoung Seong, Akihiro Takemura

“…However, liver histology revealed no signs of metabolic stress, and IGF-1 gene expression levels were higher in the FW-D group, indicating active growth signaling. …”
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Therapeutic aspects of hormone replacement therapy in postmenopausal women with metabolic syndrome: cardiologist’s opinion by T. V. Adasheva, V. S. Zadionchenko, O. N. Poryvkina, O. Yu. Demicheva, T. M. Terekhova, M. A. Mironova

“…The therapy was associated with MC improvement and BP reduction. The medication demonstrated cardioprotective and antioxidant activity.…”
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A Novel Bacteriophage Targeting <i>mcr-9 Enterobacter kobei</i> with Potential Application in Fresh Leafy Greens by Alberto Pintor-Cora, Andrea Carpintero, Ángel Alegría, Apostolos Giannis, Teresa-María Lopez-Díaz, Jesús A. Santos, Jose M. Rodríguez-Calleja

“…In vitro assays using BioTrac (SY-LAB) impedance technology confirmed the sustained lytic activity of FENT2 under food-related stress conditions, including pH levels from 5 to 7 and NaCl concentrations up to 2%. …”
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Drosophila melanogaster inhabiting northern regions of European Russia are infected with Wolbachia which adversely affects their life span by N. V. Roshina, A. V. Symonenko, A. V. Krementsova, Е. A. Tsybul’ko, V. E. Alatortsev, E. G. Pasyukova, D. V. Mukha

“…The infection rate varied from year to year showing a tendency to reduc­tion, its overall level being within the range previously observed in other habitats. …”
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Climate change adaptation, greenhouse gas mitigation and economic profitability of conservation agriculture: Some examples from cereal systems of Indo-Gangetic Plains by Tek B Sapkota, M L Jat, Jeetendra P Aryal, R K Jat, Arun Khatri-Chhetri

“…This paper examines conservation agriculture (CA) from the perspective of: (i) increased yield and farm income, (ii) adaptation to heat and water stresses, and (iii) reduction in greenhouse gas (GHGs) emissions. …”
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Cadmium-induced impairment in growth, photosynthetic apparatus and redox regulation in green amaranth (Amaranthus viridis L.) plant attenuated by salicylic acid and methyl jasmonat... by Md Tanveer Hussain, Md Sabibul Haque, Md Fazle Rabbi, Hafsa Tasnim, Md Asiful Haque, Arnab Saha, Akm Golam Sarwar, Md Nesar Uddin, Md Alamgir Hossain

“…An extensive activity of antioxidants and considerable reduction in Cd uptake and translocation from medium-root-shoot was apparent due to the supplementation of SA and MeJA. …”
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Numerical Simulation of Surrounding Rock Vibration and Damage Characteristics Induced by Blasting Construction in Bifurcated Small-Spacing Tunnels by Mingshe Sun, Yantao Wang, Guangwei Dai, Kezhi Song, Xuyang Xie, Kejia Yu

“…When the bench method is employed, an increase in the bench length leads to a reduction in the damage to the intermediate rock wall. …”
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Can detox nutrition be an adjunct in the treatment and rehabilitation of patients infected with the COVID-19 virus? by T. L. Pilat, A. V. Istomin, E. A. Gordeeva, R. A. Khanferyan

“…Nutritional support for a month with detoxification jelly contributed to a significant reduction in symptoms of intoxication: weakness and fatigue, temperature fluctuations, fears, anxiety, suspiciousness, etc. disappeared. …”
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Exposure to placental microplastic and placental and umbilical cord blood telomere length by Shuo Zhang, Huiyue Chen, Long Li, Zhipeng Li, Dan Wang

“…Quantile g-computation indicated significant cumulative effects of microplastics on TL, with PBS contributing the most to TL reduction. BKMR analysis highlighted non-linear exposure-response relationships, with lower quantiles showing positive associations and higher quantiles indicating detrimental effects on TL, potentially due to oxidative stress or inflammation. …”
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