Emerging phenotype: Maturity-onset diabetes of the young type 5 (MODY-5) – mechanisms, clinical spectrum, and unmet needs by Fahrul Nurkolis, Rony Abdi Syahputra, Andika Priamas Nugrahanto, Nurpudji Astuti Taslim, Arifa Mustika, Raymond Rubianto Tjandrawinata, Dante Saksono Harbuwono, Sidartawan Soegondo

“…Molecular disruptions prominently include alterations in NF-κB signaling pathways, increased oxidative stress, mitochondrial dysfunction, and heightened profibrotic TGF-β activity, leading to early and severe multisystem complications. …”
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Effect of multi-walled carbon nanotube exposure on the expression pattern of genes involved in silymarin synthesis pathway in Silybum Marianum L. by Forough Asakereh, Alireza Etminan, Reza Azizinezhad, Mansour Ghorbanpour, Alireza Pour-Aboughadareh

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Profilin Pfy1 is critical for cell wall integrity and virulence in Candida albicans by Xun Sun, Yueqing Wang, Xiaomin Yang, Xi Xiang, Lili Zou, Xiaowen Liu, Gang Luo, Qi Han

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Peritraumatic distress and its association with resilience among a sample of war-exposed Palestinian population: a cross-sectional study by Suheir S. Sabbah, Hamzeh Yacoub, Rita Yacoub, Zaid Yacoub, Khalil Sabbah, Yousef B. Ghannam

“…Higher PTD was significantly associated with higher resilience (B = 0.3, β = 0.301, p < 0.001), a finding that may reflect adaptive coping processes in highly stressful environments. Additional predictors of resilience included age, educational level, employment status, and health condition. …”
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The relationship of within-individual and between-individual variation in mental health with bodyweight: An exploratory longitudinal study. by Julia Mueller, Amy L Ahern, Rebecca A Jones, Stephen J Sharp, Alan Davies, Arabella Zuckerman, Benjamin I Perry, Golam M Khandaker, Emanuella De Lucia Rolfe, Nick J Wareham, Kirsten L Rennie

“…It is, therefore, unclear how small fluctuations in mental wellbeing within individuals predict bodyweight over short time periods, e.g. within the next month. …”
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Fatigue Analysis of Random Vibration for Converter Cabinet by DING Jie, TANG Yutu

“…The fatigue life is predicted in frequency domain according to the results of frequency response analysis on the finite element of the converter’s cabinet and the ASD(Acceleration Spectral Density) spectrum from the standard GB/T 21563-2008 Railway applications- Rolling stock equipment- Shock and vibration tests. …”
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The needs and unmet needs for people living with dementia, caregivers and care workers in dementia health care systems: a systematic review by Michele Sorrentino, Michele Sorrentino, Michelangelo Mercogliano, Claudio Fiorilla, Irene Stilo, Federica Esposito, Marcello Moccia, Marcello Moccia, Luigi Lavorgna, Giuseppina Affinito, Elena Salvatore, Maria Pia Sormani, Anna Odone, Anna Odone, Azeem Majeed, Fabiana Rubba, Maria Triassi, Maria Triassi, Raffaele Palladino, Raffaele Palladino, Raffaele Palladino

“…Psychosocial and emotional support are essential for managing stress and ensuring quality of life. Caregivers demand education about dementia care, progression, and self-care, while healthcare workers need training, and interdisciplinary teams. …”
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TXNIP promotes viral replication by disrupting MAVS-mediated antiviral signaling and serves as a therapeutic target for antiviral therapy by Ruilin Chen, Wenyu Wu, Jiajia Han, Qiyun Lei, Jiawan Chen, Dan Guo, Chan Wang, Xiaodong Tang, Min Zou, Shuwen Liu, Xingang Yao

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Hemodynamic assessment of rupture risk during growth stages in middle cerebral artery aneurysms treated with coiling by Rifaqat Ali, Hana Ihsan Hassan, Aman Sharma, Aashim Dhawan, P. Sharma, Waam Mohammed Taher, Mariem Alwan, Ali Fawzi Al-Hussainy, Mahmood Jasem Jawad, Hiba Mushtaq

“…In contrast, coiling consistently suppressed these metrics across all volumes: peak WSS fell below 100 Pa, average WSS remained under 5 Pa, and OSI was reduced to below 0.03. AWSS and OSI reductions indicated dampened flow oscillations and reduced biomechanical stress. …”
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Acute Coronary Syndrome in Patients With 2 Type Diabetes Mellitus (Review of Literature; Description of the Clinical Case) by Bilous Z., Abrahamovych О., Mazur N., Ryabokon S., Ilenkiv N., Bevza N.

“…The effect of each individual pathogenic marker on the clinical course and complications of these patients remains undetermined; therefore, the study of the clinical course of ACS with comorbid type 2 diabetes mellitus and the prediction of complications are important for improving the prognosis in these patients. …”
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Identification of genetic locus with resistance to take-all in the wheat-Psathyrostachys huashanica Keng introgression line H148 by Sheng-sheng BAI, Han-bing ZHANG, Jing HAN, Jian-hui WU, Jia-chuang LI, Xing-xia GENG, Bo-ya LÜ, Song-feng XIE, De-jun HAN, Ji-xin ZHAO, Qun-hui YANG, Jun WU, Xin-hong CHEN

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Simulation of Wellbore Stability during Underbalanced Drilling Operation by Reda Abdel Azim

“…Therefore, this paper presents an approach to simulate the wellbore stability by incorporating finite element modelling and thermoporoelastic environment to predict the instability conditions. Analytical solutions for stress distribution for isotropic and anisotropic rocks are presented to validate the presented model. …”
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Student Nurses Perception on the Socio-Economic, Environmental and Psychological Factors and how they Affect Academic Achievement in School of Nursing, Usmanu Danfodiyo University... by Umar, A., Muhammad, U.T., Magori, Z.Z. and Suleiman, F.

“…The significant factors that influence academic achievement as identified by the respondents were parental income, parent educational level, school basic amenities, school structure, and stress. …”
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Aurones as new modulators of hypoxia inducible factor-1 (HIF-1) to prevent cardiac cell death by Léa Di Maria, Brayan Roulier, Morane Beaumet, Romain Haudecoeur, Ahcène Boumendjel, Elise Belaïdi, Basile Pérès

“…Interestingly, only the three 7-hydroxyaurones enhanced cell viability under CoCl₂-induced stress, showing efficiencies comparable to curcumin (120–140 % improvement at 100 μM). …”
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Antibacterial Evaluation of Tricyclic Antidepressants Against <i>S. aureus</i> and the Possible Pathways of the Mechanism of Action by Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lívia Gurgel do Amaral Valente Sá, Lara Elloyse Almeida Moreira, Cecília Rocha da Silva, João Batista de Andrade Neto, Érica Rayanne Mota da Costa, Thais Lima Ferreira, Leilson Carvalho de Oliveira, Beatriz Oliveira de Souza, Dávylla Rênnia Saldanha Pinheiro, Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior

“…The mechanism of TCAs, isolated and combined with OXA, was associated with a reduction in cell viability, resulting from their action on the bacterial genetic material and generation of oxidative stress. …”
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Overexpression of the STOX1B isoform of STOX1 triggers preeclampsia-like symptoms through HNF4α-dependent alterations of coagulation cascades in mice by Hélène Collinot, Louise Strubé, Ikram Benouda, Johan Castille, Sandrine Floriot, Nathalie Daniel-Carlier, Bruno Passet, Franck Lager, Isabelle Lagoutte, Gilles Renault, Benjamin Saintpierre, Maryline Favier, Djihane Djeridane, Céline Méhats, Francisco Miralles, Jean-Luc Vilotte, Daniel Vaiman

“…The two isoforms have opposite function on major genes involved in trophoblast syncytialization and oxidative stress management. Placenta-fetal overexpression of STOX1A induces preeclampsia in mice. …”
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Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10 by Fengdong Zhang, Yongchang Han, Fan Li, Boya Guo, Jian Chen, Wenchuan Zhou, Pan Xiao, Hui Ma, Yongyan Jin, Jia Feng, Yuna Min

“…Our previous study demonstrated that egg exosome-derived miRNAs may play a key role in modulating embryonic oxidation-reduction process, whereas the exact function and mechanism were still poorly understood. …”
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Dietary non-enzymatic antioxidant capacity and risk of breast cancer: the Swedish National March Cohort by Daniela Mariosa, Marta Ponzano, Alessandra Grotta, Ylva Trolle Lagerros, Essi Hantikainen, Hans-Olov Adami, Mauro Serafini, Rino Bellocco, Weimin Ye

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Decoding metabolic trade-offs in Halomonas elongata: Chemostat-based flux remodeling for industrial ectoine biosynthesis by Junxiong Yu, Hao Liu, Yudi Wang, Runlin Ju, Yue Zhang, Ali Moshin, Yingping Zhuang, Meijin Guo, Zejian Wang

“…These findings establish H. elongata as a paradigm of dynamic flux rewiring, where carbon economy is strategically reallocated between stress-protective solute biosynthesis and energy homeostasis. …”
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Is frequent handling with reinforcement effective in improving management practices for feedlot heifers? by Vitor R. Pacor, Messy H. A. Pantoja, Douglas H. S. Almeida, Isabela M. D. Batista, Milena S. Consorti, Cihan Çamakçı, Cristiane G. Titto

“… Aim of study: This study aimed to evaluate the effect of frequent handling of feedlot female cattle to decrease animal handling time and stress indicators. Area of study: Brazil, São Paulo State. …”
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