Simulation of Wellbore Stability during Underbalanced Drilling Operation by Reda Abdel Azim

“…Therefore, this paper presents an approach to simulate the wellbore stability by incorporating finite element modelling and thermoporoelastic environment to predict the instability conditions. Analytical solutions for stress distribution for isotropic and anisotropic rocks are presented to validate the presented model. …”
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Student Nurses Perception on the Socio-Economic, Environmental and Psychological Factors and how they Affect Academic Achievement in School of Nursing, Usmanu Danfodiyo University... by Umar, A., Muhammad, U.T., Magori, Z.Z. and Suleiman, F.

“…The significant factors that influence academic achievement as identified by the respondents were parental income, parent educational level, school basic amenities, school structure, and stress. …”
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Research on Failure Mechanism and Parameter Sensitivity of Zonal Disintegration in Deep Tunnel by Xutao Zhang, Qiang Gao, Shicai Cui, Changrui Duan

“…The theoretical solutions of radial displacement and radial stresses and tangential stresses of deep surrounding rock mass were calculated. …”
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An Exploratory Study Into the Effects of Regular Cold‐Water Sea Swimming on Daily Indices of Mental Health by Jill Forsten, Mark A. Wetherell

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Aurones as new modulators of hypoxia inducible factor-1 (HIF-1) to prevent cardiac cell death by Léa Di Maria, Brayan Roulier, Morane Beaumet, Romain Haudecoeur, Ahcène Boumendjel, Elise Belaïdi, Basile Pérès

“…Interestingly, only the three 7-hydroxyaurones enhanced cell viability under CoCl₂-induced stress, showing efficiencies comparable to curcumin (120–140 % improvement at 100 μM). …”
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Antibacterial Evaluation of Tricyclic Antidepressants Against <i>S. aureus</i> and the Possible Pathways of the Mechanism of Action by Vitória Pessoa de Farias Cabral, Daniel Sampaio Rodrigues, Lívia Gurgel do Amaral Valente Sá, Lara Elloyse Almeida Moreira, Cecília Rocha da Silva, João Batista de Andrade Neto, Érica Rayanne Mota da Costa, Thais Lima Ferreira, Leilson Carvalho de Oliveira, Beatriz Oliveira de Souza, Dávylla Rênnia Saldanha Pinheiro, Bruno Coêlho Cavalcanti, Islay Lima Magalhães, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior

“…The mechanism of TCAs, isolated and combined with OXA, was associated with a reduction in cell viability, resulting from their action on the bacterial genetic material and generation of oxidative stress. …”
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Overexpression of the STOX1B isoform of STOX1 triggers preeclampsia-like symptoms through HNF4α-dependent alterations of coagulation cascades in mice by Hélène Collinot, Louise Strubé, Ikram Benouda, Johan Castille, Sandrine Floriot, Nathalie Daniel-Carlier, Bruno Passet, Franck Lager, Isabelle Lagoutte, Gilles Renault, Benjamin Saintpierre, Maryline Favier, Djihane Djeridane, Céline Méhats, Francisco Miralles, Jean-Luc Vilotte, Daniel Vaiman

“…The two isoforms have opposite function on major genes involved in trophoblast syncytialization and oxidative stress management. Placenta-fetal overexpression of STOX1A induces preeclampsia in mice. …”
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THE FEATURES OF THE FACE SKIN CONSTRUCTION THAT INFLUENCE ON THE FORMATION OF CICATRICAL TISSUES DURING SUGICAL INTERVENTIONS by K.P. Lokes, D.S. Avetikov, S.O. Stavitsky, O.O. Rozkolupa, N.S. Lutsenko

“…The largest structures of the extracellular matrix are elastin fibers, which are mainly localized in tissues subject to high mechanical stress, such as skin, lungs, or arteries. These structures represent a very complex organization whose core consists of elastin surrounded by a mantle of microfibrils. …”
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The Cardiac Dysfunction Caused by Metabolic Alterations in Alzheimer's Disease by Jiayuan Murphy, Tran Ngoc Van Le, Julia Fedorova, Yi Yang, Meredith Krause-Hauch, Kayla Davitt, Linda Ines Zoungrana, Mohammad Kasim Fatmi, Edward J. Lesnefsky, Edward J. Lesnefsky, Ji Li, Di Ren

“…To reveal the mechanism by which AD leads to cardiac systolic dysfunction, the immunoblotting analysis showed increased activation of AMP-activated protein kinase (AMPK) in 5XFAD left ventricular and brain tissue, indicating altered energy metabolism. Mito Stress Assays examining mitochondrial function revealed decreased basal and maximal oxygen consumption rate, as well as defective pyruvate dehydrogenase activity in the 5XFAD heart and brain. …”
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Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation by Chiara Sassoli, Federica Pierucci, Alessia Tani, Alessia Frati, Flaminia Chellini, Francesca Matteini, Ambra Vestri, Giulia Anderloni, Daniele Nosi, Sandra Zecchi-Orlandini, Elisabetta Meacci

“…Notably, active S1PR1/MMP-2 signalling is required for F-actin structure assembly (lamellipodia, microspikes, and stress fibers) and, in turn, cell proliferation. Moreover, in experimental conditions resembling the damaged/regenerating tissue microenvironment (hypoxia), S1P/S1PR1 system is also required for HIF-1α expression and vinculin reduction. …”
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Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10 by Fengdong Zhang, Yongchang Han, Fan Li, Boya Guo, Jian Chen, Wenchuan Zhou, Pan Xiao, Hui Ma, Yongyan Jin, Jia Feng, Yuna Min

“…Our previous study demonstrated that egg exosome-derived miRNAs may play a key role in modulating embryonic oxidation-reduction process, whereas the exact function and mechanism were still poorly understood. …”
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Dietary non-enzymatic antioxidant capacity and risk of breast cancer: the Swedish National March Cohort by Daniela Mariosa, Marta Ponzano, Alessandra Grotta, Ylva Trolle Lagerros, Essi Hantikainen, Hans-Olov Adami, Mauro Serafini, Rino Bellocco, Weimin Ye

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Decoding metabolic trade-offs in Halomonas elongata: Chemostat-based flux remodeling for industrial ectoine biosynthesis by Junxiong Yu, Hao Liu, Yudi Wang, Runlin Ju, Yue Zhang, Ali Moshin, Yingping Zhuang, Meijin Guo, Zejian Wang

“…These findings establish H. elongata as a paradigm of dynamic flux rewiring, where carbon economy is strategically reallocated between stress-protective solute biosynthesis and energy homeostasis. …”
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Is frequent handling with reinforcement effective in improving management practices for feedlot heifers? by Vitor R. Pacor, Messy H. A. Pantoja, Douglas H. S. Almeida, Isabela M. D. Batista, Milena S. Consorti, Cihan Çamakçı, Cristiane G. Titto

“… Aim of study: This study aimed to evaluate the effect of frequent handling of feedlot female cattle to decrease animal handling time and stress indicators. Area of study: Brazil, São Paulo State. …”
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus by Qiaolin Wang, Yutong Wu, Lianlian Ouyang, Xiaoli Min, Meiling Zheng, Lingyu Gao, Xiaoyun Chen, Zhi Hu, Shuang Yang, Wenjuan Jiang, Sujie Jia, Qianjin Lu, Ming Zhao

“…Results We observed a significant reduction in CD8αα + IELs, accompanied by a marked increase in CD8αβ + IELs in Lpr mice. …”
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Unveiling the Cardioprotective Potential of Hydroxytyrosol: Insights from an Acute Myocardial Infarction Model by Alejandra Bermúdez-Oria, Eugenia Godoy, Virginia Pérez, Camila Musci Ferrari, Martin Donato, Juan Fernández-Bolaños, Tamara Zaobornyj, Verónica D’Annunzio

“…These findings highlight the efficacy of HT in reducing oxidative stress and preserving mitochondrial function, critical factors in cardiac disease. …”
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Fabrication and performance of a novel polymer composite waterproof adhesive layer with enhanced hydrophobicity for concrete bridge decks by Bonan Ma, Fei Wang, Jiaqi Li, Chaodong Yang, Wentao Jia, Kaisheng Luo, Enhui Yang, Yanjun Qiu

“…Even after prolonged water immersion, the reduction in bonding strength was minimal (less than 5 %). …”
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The time to perform spinal or general anaesthesia in COVID-19 positive parturients requiring emergency caesarean delivery: a prospective crossover simulation study by Marcelo Epsztein Kanczuk, Nicholas J Lightfoot, Alison Pighills, Antony Ji, Casey Steele, Daniel Bartlett

“…Background: Spinal anaesthesia is the commonest performed technique for caesarean deliveries except in the emergency setting where general anaesthesia is preferred due to its rapid onset and predictability. There are several modifications to performing general anaesthesia for COVID-19 patients in Australia. …”
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A new similitude law for testing scaled RC structures by Jamin Park, Seong-Cheol Lee, Yunbyeong Chae, Jae-Yeol Cho

“…The simulation results clearly show that the new similitude law can predict the prototype’s response better than other similitude laws proposed in previous studies.…”
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Effects of effort-reward imbalance on emergency nurses’ health: a mediating and moderating role of emotional exhaustion and work-family conflict by Yuanyuan Tan, Jing Zhou, Jing Zhou, Jing Zhou, Hao Zhang, Hao Zhang, Hao Zhang, Lin Lan, Lin Lan, Lin Lan, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Xiaomin Yu, Xiaomin Yu, Xiaomin Yu, Luying Zhong, Luying Zhong, Luying Zhong, Ling Zhu, Ling Zhu, Ling Zhu, Yongli Gao, Yongli Gao, Yongli Gao

“…The mediation effect is tested by the bias correction Bootstrap sample size was set to 5,000.ResultConsidering emotional exhaustion as a mediating variable, the direct predictive influence of ERI on somatic symptoms and sleep disorders continues to be statistically significant (β = 0.271, 0.137, p &lt; 0.01). …”
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