Epidemiology of the main risk factors and total cardiovascular risk among Vologda citizens aged 35-64-years by A. I. Popugaev, A. M. Kalinina, S. A. Shalnova, A. D. Deev, A. V. Kontsevaya, V. S. Nechaev, R. A. Kasimov, N. V. Ryzhkova

“…Among 35-64-year-old Vologda citizens, there is an unmet demand for medical preventative help and targeted RF correction, including 94 000 preventative consultations and risk reduction programs.…”
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Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…Based on these converging mechanisms, we highlight potential therapeutic strategies, including the co-targeting of LDHA and oncogenic miRNAs (e.g., nanoparticle-mediated delivery of anti-miR-21), as well as liquid biopsy-based monitoring of circulating H3K18la and miRNA signatures to predict emerging resistance. By integrating metabolic, epigenetic, and immunologic perspectives, we position lactylation-miRNA crosstalk as a central regulatory axis in cancer therapy resistance and offer a conceptual framework to inform the development of future mechanism-driven interventions.…”
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Gut microbiota remodeling exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis in prenatal VPA-exposed C57BL/6 mice offspring by Zhaoming Liu, Zhaoming Liu, Caixia Wu, Caixia Wu, Zhaojian Sun, Zuoxian Lin, Yirong Sun, Nouman Amjad, Muhammad Majid, Rajesh Basnet, Zhiyuan Li, Zhiyuan Li, Zhiyuan Li

“…Gut microbiota profiles were analyzed via 16S rRNA sequencing, with functional pathway predictions using PICRUSt2 and KEGG databases.ResultsVPA-exposed mice exhibited ASD-like behaviors, including social deficits, repetitive stereotypic actions, and impaired spatial memory. …”
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A clinical case of diagnosis of autoimmune hepatitis at the stage of liver cirrhosis by O. A. Svitlytska, O. V. Riabokon, A. O. Svitlytskyі, N. H. Horbatkova, E. V. Kotliarevska

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Assessment of the adaptogenic properties of herbal tea based on pine needles and microstrobiles by S. D. Zhamsaranova, V. G. Shiretorova, S. A. Erdyneeva, A. A. Tykheev, S. N. Lebedeva

“…The scientific community shows an increasing interest to plant antioxidants as a means of alimentary restoration of functional reserves of the body after physical and emotional stresses. The aim of the work was to assess the adaptogenic activity of herbal tea developed on the basis of by-products of pine growing on the territory of Buryatia. …”
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Epilobieae genomes and the evolution of Myrtales by Dan Wang, Wenkai Li, Bing Yang, Yujia Shen, Jun He, Derek W. Dunn, Kang Huang, Baoguo Li

“…The WGD retained genes are enriched in Environmental information processing pathways, potentially enhancing resistance to biotic and abiotic stresses. These genes also show a preference for multiple exons, which may promote alternative splicing and functional diversification. …”
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DOES THE LOW LEVEL OF DEHYDROEPIANDROSTERONE SULFATE (DHEA-S) INDEPENDENTLY INFLUENCE RISK OF DEATH AT AGE 55 YEARS AND OLDER? by S. A. Shalnova, A. D. Deev, V. A. Metelskaya, A. V. Kapustina, A. E. Imaeva, Yu. A. Balanova, G. A. Muromtseva, M. A. Shkolnikova, V. M. Shkolnikov

“…The results analyzed, of the prospective cohort study “Stress, ageing and health”, that included 1876 persons at age 55 years and older. …”
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Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy by Noor Rizvi, Eliseos J. Mucaki, Emily L. Salmini, Monica Zhang, Sabina Trebinjac, Ezra Hahn, Lawrence Paszat, Sharon Nofech-Mozes, Michael T. Hallett, Eileen Rakovitch, Vanessa Dumeaux

“…Abstract Background Managing Ductal Carcinoma in Situ (DCIS) remains challenging due to the lack of reliable biomarkers to predict radiotherapy (RT) response, leading to both overtreatment of indolent disease and undertreatment of aggressive cases. …”
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Beyond the pandemic: the relationship between macroeconomic conditions and healthcare worker shortages in the United States by Kyla F. Woodward, Janette Dill, LaTonya Trotter, Bianca K. Frogner

“…Conclusions The easing of pandemic-era stresses on healthcare has not resolved healthcare workforce shortages. …”
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An investigation into sleep, perceived experiences, and exercise performance in elite male cyclists during the Tour de France by Josh Fitton, Bastien Lechat, Amy C. Reynolds, Barbara Toson, Jack Manners, Phuc Nguyen, Kelly A. Loffler, Thomas J. Altree, Peter Catcheside, Danny J. Eckert

“…Relative performance output (Performance Index; 0–1000) negatively predicted sleep duration (r [95% CI]; −0.32 [−0.46, −0.17]) and sleep quality (−0.34 [−0.47, −0.19]) during the race. …”
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Time-dose response and mechanistic specificity of berberine in renal fibrosis from a multi-model integration perspective: a systematic review and meta-analysis on animal models by Ruyi Nie, Ziting Yuan, Yizhe Wu, Minqi Pan, Jiandong Lu, Jiandong Lu, Guoliang Xiong, Guoliang Xiong

“…The Meta-analysis revealed that BBR significantly lowered serum creatinine, blood urea nitrogen, α-SMA, and TGF-β1 levels, alongside reductions in renal fibrosis area and oxidative stress markers. …”
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State of the antioxidant system in mitochondria of skin cells during experimental B16/F10 melanoma growth with chronic neurogenic pain by E. M. Frantsiyants, I. V. Neskubina, E. I. Surikova, L. K. Trepitaki, L. A. Nemashkalova, I. V. Kaplieva, N. S. Lesovaya

“…The growth of В16/F10 melanoma together with chronic neurogenic pain restructures the antioxidant system of skin mitochondria towards generation of reductive stress under the influence of chronic pain, which can affect the growth and development of experimental melanoma.…”
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Fenofibrate treatment during withdrawal reverses symptoms of ethanol-induced depression in male rats by Marcelo León, Camila Vásquez-Ulloa, Lucas Marambio-Ruiz, Diliana Pérez-Reytor, Eduardo Karahanian, Eduardo Karahanian

“…However, ethanol-induced reductions in sucrose intake after withdrawal—reflecting anhedonia—were not reversed by fenofibrate. …”
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Land Cover Transformations and Thermal Responses in Representative North African Oases from 2000 to 2023 by Tallal Abdel Karim Bouzir, Djihed Berkouk, Safieddine Ounis, Sami Melik, Noradila Rusli, Mohammed M. Gomaa

“…The results reveal substantial reductions in bare soil (e.g., 48.10% in Siwa) and notable urban expansion (e.g., 136.01% in Siwa and 48.46% in Ghadames). …”
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Spatial association and trade-off/synergy relationships between ecosystem health and human well-being: a case study of the Manas River Basin by Ruiming Xiao, Xiaobin Dong, Xuechao Wang, Xiaomin Xiao, Yichen Yan, Rui Liu, Yuxin Qi

“…High EH–high HWB clusters were predominantly in midstream oases, whereas high EH–low HWB clusters were located in southern forests. (4) Trade-offs and synergies varied along the landscape gradient: ecological stress traded off with all HWB types, while ecological function showed stable synergies with EnvWB and increasing synergies with EcoWB and ECWB. …”
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MoveMentor—examining the effectiveness of a machine learning and app-based digital assistant to increase physical activity in adults: protocol for a randomised controlled trial by Corneel Vandelanotte, Stewart Trost, Danya Hodgetts, Tasadduq Imam, MD Mamunur Rashid, Quyen G. To, Carol Maher

“…Secondary outcomes include app engagement and retention, quality of life, depression, anxiety, stress, sitting time, sleep, workplace productivity, absenteeism, presenteeism and habit strength. …”
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Critical success factors for implementing robotic process automation in the hotel industry by Yuemeng Ge, Ke Xia, Muhammad Asif, Asli Ersoy, Muhammad Farrukh Shahzad

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Prevalence and correlates of nonsuicidal self-injury among youths in Singapore: findings from the National Youth Mental Health Study by Sherilyn Chang, Janhavi Ajit Vaingankar, Bernard Tan, Yeow Wee Brian Tan, Ellaisha Samari, S. Archana, Yi Chian Chua, Yi Ping Lee, Charmaine Tang, Swapna Verma, Mythily Subramaniam

“…The Deliberate Self-Harm Inventory and Depression Anxiety Stress Scales Short Form were used to assess NSSI behaviours and mental health symptoms. …”
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Wonder and Curiosity in Early Childhood: Pedagogical Inspirations from Catherine L'Ecuyer's 'The Wonder Approach' by Krystyna Heland-Kurzak

“…The paper concludes by stressing the need for an internalized learning approach, urging educators and caregivers to embrace the mystery and protect the sense of wonder in children, resisting societal pressures for accelerated development. …”
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The effect of rs776746 polymorphism in the <i>CYP3A5</i> gene on heart rate when using bisoprolol in patients with acute coronary syndrome by V. A. Shumkov, K. A. Zagorodnikova, S. A. Boldueva, A. A. Murzina

“…Of the parameters listed, only the CYP3A5 genotype significantly predicted the dose of bisoprolol (F=8.5; p&lt;0.005; R2=0.096).Conclusion. …”
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