Tumor tissue-of-origin classification using miRNA-mRNA-lncRNA interaction networks and machine learning methods by Ankita Lawarde, Ankita Lawarde, Masuma Khatun, Prakash Lingasamy, Prakash Lingasamy, Andres Salumets, Andres Salumets, Andres Salumets, Vijayachitra Modhukur, Vijayachitra Modhukur

“…Using transcriptomic profiles from 14 cancer types in The Cancer Genome Atlas (TCGA), we constructed co-expression networks and applied multiple feature selection techniques including recursive feature elimination (RFE), random forest (RF), Boruta, and linear discriminant analysis (LDA) to identify a minimal yet informative subset of miRNA features. Ensemble ML algorithms were trained and validated with stratified five-fold cross-validation for robust performance assessment across class distributions.ResultsOur models achieved an overall 99% classification accuracy, distinguishing 14 cancer types with high robustness and generalizability. …”
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Label semantics and image features aware remote sensing sample retrieval from multi-source datasets for AI-enabled remote sensing monitoring by XingTao Ren, XingTao Ren, Yan Ma, YiXin Zhou, YiXin Zhou

“…Future work may focus on further optimizing the retrieval algorithms and expanding the range of supported data platforms to enhance the robustness and scalability of the system.…”
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