Embryo reintroduction to enhance genetic diversity in a Marsh deer population: first attempt, outcomes, challenges, and future perspectives by David Javier Galindo, David Javier Galindo, Pedro Henrique de Faria Peres, Eveline dos Santos Zanetti, Márcio Leite de Oliveira, Márcio Leite de Oliveira, Luciana Diniz Rola, José Maurício Barbanti Duarte

“…Traditional population restoration methods, such as individual translocation and ecological corridors, present challenges, including high costs, adaptation difficulties, pathogen introduction, and outbreeding risks. …”
Get full text

Influence of cognitive and emotional factors on motor dual-task performance in nursing home residents. The mediating and moderating roles of cognition, concerns about falling, well... by Thomas Jürgen Klotzbier, Julian Rudisch, Nadja Schott, Oliver Vogel, Thomas Cordes, Claudia Voelcker-Rehage, Bettina Wollesen

“…Background: This study aimed (1) to compare walking performance under single (ST) and dual-task (DT) conditions with varying cognitive tasks and degrees of difficulty, (2) to investigate the association of concerns about falling, depressive symptomatology, and psychological and physical well-being with ST and DT walking performance as well as cognitive and motor DT costs (cDTC; mDTC); and (3) to examine whether depressive symptomatology and well-being mediate or moderate the association between concerns about falling and DT performance in a large sample of German nursing home residents. …”
Get full text

Machine learning and molecular docking prediction of potential inhibitors against dengue virus by George Hanson, Joseph Adams, Daveson I. B. Kepgang, Luke S. Zondagh, Lewis Tem Bueh, Andy Asante, Soham A. Shirolkar, Maureen Kisaakye, Hem Bondarwad, Olaitan I. Awe

“…While the WHO-approved vaccine, Dengvaxia, and antiviral treatments like Balapiravir and Celgosivir are available, challenges such as drug resistance, reduced efficacy, and high treatment costs persist. This study aims to identify novel potential inhibitors of the Dengue virus (DENV) using an integrative drug discovery approach encompassing machine learning and molecular docking techniques.MethodUtilizing a dataset of 21,250 bioactive compounds from PubChem (AID: 651640), alongside a total of 1,444 descriptors generated using PaDEL, we trained various models such as Support Vector Machine, Random Forest, k-nearest neighbors, Logistic Regression, and Gaussian Naïve Bayes. …”
Get full text

Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 ran... by Gerry Rayman, Thomas Yates, Ramzi A Ajjan, Patrick Moore, Pratik Choudhary, Thozhukat Sathyapalan, Parth Narendran, Ahmed Iqbal, Rachel Ann Elliott, Sankalpa Neupane, Mark Evans, Hood Thabit, Lalantha Leelarathna, Emma G Wilmot, Katharine Barnard-Kelly, Iain Cranston, Thinzar Min, Yee S Cheah, Shafie Kamaruddin, Alistair Lumb

“…An economic evaluation for costs and patient outcomes will be undertaken.Ethics and dissemination The study was approved by the Health Research Authority, Health and Care Research Wales and the West Midlands-Edgbaston Research Ethics Committee (reference: 23/WM/0092). …”
Get full text

Multi-objective optimization of soil water-nitrogen management practice and seeding rate for sustainable soybean production on the Loess Plateau of China by Zhenqi Liao, Xiaohui Ding, Hongxin Zhang, Hui Zhang, Zhijun Li, Fucang Zhang, Junliang Fan

“…Compared with the local management strategy (NMN60D16), RWN30D32 significantly (p < 0.05) increased the canopy photosynthetic capacity, biological yield, grain yield, seed protein yield, seed oil yield, net income, ratio of output over input costs, crop water productivity, partial factor productivity of nitrogen and radiation use efficiency by 22.8 %, 66.7 %, 35.9 %, 20.1 %, 23.9 %, 69.8 %, 28.4 %, 29.0 %, 171.8 % and 18.5 %, while it decreased the hundred-grain weight, number of pods, seed protein content, seed oil content, energy use efficiency and carbon productivity by 5.4 %, 34.2 %, 11.6 %, 8.8 %, 20.5 % and 69.0 %, respectively. …”
Get full text

Exploring parental preferences for childhood obesity prevention program in China: a discrete choice experiment by Xinyang Ma, Taoran Liu, Jing Yu, Yangyang Gao, Chun Kai LEUNG, Shaolin Liang, Babatunde O. Akinwunmi, Xinchang Liu, Jian Huang, Casper J. P. Zhang, Wai-kit Ming

“…Results This study, involving 631 participants, demonstrates that in prioritizing attributes of childhood obesity prevention programs, parents place the greatest importance on additional costs (32.36%). This is followed by daily sleep duration (18.42%) and dietary choices (16.49%). …”
Get full text

Research on the effect of selective adsorption of CO2 by C@Fe3O4 for H2 purification by Longlong Lei, Hang Yuan, Hongguang Zhu, Jie Ma, Fanghui Pan, Fulu Lu

“…Although various technological pathways have been proposed in this research field, issues such as low separation efficiency, high energy consumption, and high costs are prevalent to varying degrees across these different methods. …”
Get full text

Decentralized biobanking platform for organoid research networks by Marielle Gross, Marielle Gross, Ananya Dewan, Mario Macis, Mario Macis, Eve Budd, M. Eifler, Olayinka Odeniran, Jeff Kahn, Jeff Kahn, Jeff Kahn, Robert Clell Miller, Robert Clell Miller, William Sanchez

“…Implementing de-bi with ERC-1155 showed potential to minimize gas costs of on-chain activity vs ERC-721, though complementary layer-2 solutions will be essential for economic viability.ConclusionDecentralized biobanking has the potential to enhance efficiency, increase translational impact and drive research discovery through implementation of NFT digital twins for organoid research networks. …”
Get full text

Challenges and Lessons Learned from a Field Trial on the Understanding of the Porcine Respiratory Disease Complex by Elisa Crisci, Andrew R. Kick, Lizette M. Cortes, John J. Byrne, Amanda F. Amaral, Kim Love, Hao Tong, Jianqiang Zhang, Phillip C. Gauger, Jeremy S. Pittman, Tobias Käser

“…PRDC causes severe lung pathology, leading to reduced performance, increased mortality rates, and higher production costs in the global pig industry. Our goal was to conduct a comprehensive study correlating both the anti-PRRSV immune response and 21 secondary infectious agents with PRDC severity. …”
Get full text

Overcoming practical challenges to pilot Sierra Leone’s first school-based distribution of piperonyl butoxide-synergist ITNs: findings from a 2023 assessment in Kono district by Keith Esch, Fredrick Yamba, Kevin Opondo, Musa Sillah-Kanu, David Schnabel, Prince Owusu, Raymond Sudoi, Malia Skjefte, Wani Lahai, Mohamed G. Sheku, Mariama Kabba Jibatteh, Augustine Ngegbe, Jenny Carlson, Temitayo Labor, Djenam Jacob, Charlene Youseff, Elisabeth Tyler, Prince Nallo, Dennis Marke, Stephen Poyer

“…Gaps should be addressed for SBD scale-up. Research on costing, sustained levels of ITN use and access, and the effect of SBD ITNs on malaria parasitaemia may be considered by the NMCP.…”
Get full text

A patient self-report disability identifier within health service electronic medical records: evaluation of patient, carer and clinician acceptability by Joanne Rowe, Alexandra Devine, Nicole Merrick, Marie Huska, Kristen Morris, Kath Feely, Ahuva Segal, Louise Mogg, Jenni Medland, Rebecca Jamwal, Alison Smith, Maricar Gleich, Jeremiah Munakabayo, Christine Imms

“…Data analysis explored perspectives and experiences across eight constructs: general acceptability, affective attitude, burden, ethicality, intervention coherence, opportunity costs, self-efficacy, and perceived effectiveness. …”
Get full text

Diagnostic utility of single-locus DNA methylation mark in Sotos syndrome developed by nanopore sequencing-based episignature by Takeshi Mizuguchi, Nobuhiko Okamoto, Taiki Hara, Naoto Nishimura, Masamune Sakamoto, Li Fu, Yuri Uchiyama, Naomi Tsuchida, Kohei Hamanaka, Eriko Koshimizu, Atsushi Fujita, Kazuharu Misawa, Kazuhiko Nakabayashi, Satoko Miyatake, Naomichi Matsumoto

“…These signatures have generally been tested using methylation arrays, requiring additional experimental and evaluation costs. As an alternative, long-read sequencing can simultaneously and accurately evaluate genetic and epigenetic changes. …”
Get full text

From “open ocean” to “exposed aquaculture”: why and how we are changing the standard terminology describing “offshore aquaculture” by Tyler Sclodnick, Michael Chambers, Barry Antonio Costa-Pierce, Barry Antonio Costa-Pierce, Tobias Dewhurst, Nils Goseberg, Nils Goseberg, Kevin Gerald Heasman, Wolf Isbert, Gesche Krause, Daniel Wieczorek, Till Markus, Bela H. Buck, Bela H. Buck

“…The indices do not provide a definitive answer as to the potential financial success of a site as this requires other inputs relating to infrastructure costs, annual production, distance from port, sales strategy, etc. …”
Get full text

Targeted next-generation sequencing: a promising approach for Mycobacterium tuberculosis detection and drug resistance when applied in paucibacillary clinical samples by Wenting Jin, Meixia Wang, Yang Wang, Beidi Zhu, Qingqing Wang, Chunmei Zhou, Pei Li, Chaohui Hu, Jun Liu, Jue Pan, Jiachang Chen, Bijie Hu

“…The tNGS assay used in this study costs USD 96 and has a 12 hour turnaround time. Nonetheless, tNGS has a great deal of promise for enhancing TB detection while also addressing DR strains.…”
Get full text

Modeling maize growth and nitrogen dynamics using CERES-Maize (DSSAT) under diverse nitrogen management options in a conservation agriculture-based maize-wheat system by Kamlesh Kumar, C. M. Parihar, H. S. Nayak, D. R. Sena, Samarth Godara, Rajkumar Dhakar, Kiranmoy Patra, Ayan Sarkar, Sneha Bharadwaj, Prakash Chand Ghasal, A. L.Meena, K. Srikanth Reddy, T. K. Das, S. L. Jat, D. K. Sharma, Y. S. Saharawat, Upendra Singh, M. L. Jat, M. K. Gathala

“…Abstract Agricultural field experiments are costly and time-consuming, and often struggling to capture spatial and temporal variability. …”
Get full text

Genomic Prediction of Kernel Water Content in a Hybrid Population for Mechanized Harvesting in Maize in Northern China by Ping Luo, Ruisi Yang, Lin Zhang, Jie Yang, Houwen Wang, Hongjun Yong, Runze Zhang, Wenzhe Li, Fei Wang, Mingshun Li, Jianfeng Weng, Degui Zhang, Zhiqiang Zhou, Jienan Han, Wenwei Gao, Xinlong Xu, Ke Yang, Xuecai Zhang, Junjie Fu, Xinhai Li, Zhuanfang Hao, Zhiyong Ni

“…Genomic prediction enables rapid selection of maize varieties with low kernel water content (KWC), facilitating the development of mechanized maize harvesting and reducing costs. This study evaluated and characterized the KWC and grain yield (GY) of hybrid maize in northern China and used genomic prediction to identify superior hybrid combinations with low kernel water content at maturity (MKWC) and high GY adapted to northern China. …”
Get full text

Malaria parasite burden and heterogeneity of risk factors among Central African Republic refugees: a cross-sectional study in the Gado-Badzere refugee camp in Eastern Cameroon by Zidedine Nematchoua Weyou, Felicite Djemna Djieyep, Rene Ning Teh, Michel Lontsi-Demano, Cheikh Cambel Dieng, Roland Bamou, Eugenia Lo, Helen Kuokuo Kimbi, Helen Kuokuo Kimbi, Irene Ule Ngole Sumbele

“…Demographic characteristics, malaria risk factors, treatment-seeking behaviors and costs to cure malaria were assessed using semi-structured questionnaires.ResultsOf the 1,304 participants, 525 (40.3%) were malaria parasite positive with moderate geometric mean parasite density (GMPD) of 1100 parasites/μl of blood. …”
Get full text

Surgeon Sex and Postoperative Resource Utilization: A Population-Based Cohort Study by Kiyan Heybati, BHSc, Raj Satkunasivam, MD, MS, Khatereh Aminoltejari, MD, MSc, FRCSC, Hannah S. Thomas, MBChB, MS, Arghavan Salles, MD, PhD, Natalie Coburn, MD, MPH, Frances C. Wright, MD, Med, FRCSC, Lesley Gotlib Conn, PhD, Amy N. Luckenbaugh, MD, Sanjana Ranganathan, MD, Carlos Riveros, MD, Jason Sutherland, PhD, Colin McCartney, MBChB, PhD, FRCA, FFARCSI, FRCPC, Kathleen Armstrong, MD, MSc, FRCSC, Barbara Bass, MD, Allan S. Detsky, MD, PhD, CM, Angela Jerath, MD, MSc, Christopher J. D. Wallis, MD, PhD

“…Prior studies have shown that patients of female physicians experience better outcomes and have lower healthcare costs compared with patients of male physicians. …”
Get full text

Rubber Crumb Infill in Synthetic Turf and Health Outcomes: A Review of the Literature on Polycyclic Aromatic Hydrocarbons and Metalloids by Shamshad Karatela, Igor Popovic, Zahra Sobhani, Shiv Basant Kumar, Thava Palanisami, Li-Zi Lin, Gunther Paul

“…Synthetic turf has become a popular alternative to natural grass due to low upkeep costs; however, its health impacts have not been clearly elucidated. …”
Get full text

Performance of community health workers and associated factors in responding to yellow fever and COVID-19 outbreaks: A case study of Masaka District, Uganda, 2022 by Nicholas Muhumuza, Eric Segujja, Abel Wilson Walekhwa, Angela Kisakye, Brenda Nakazibwe, Prossy Nakito, Charity Mutesi, Carolyne Nyamar, Sarah Paige, Suzanne Kiwanuka

“…Barriers included use of foot as means of transport (CPR=0.69; 95% CI: [0.58-0.84]), never refunded transport costs to attend supervision meeting (CPR=0.72; 95% CI: [0.64-0.81]) and shortage of PPE (CPR=0.78; 95% CI: [0.71-0.86]). …”
Get full text