Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain by Ang Zhang, Shenyu Wang, Yao Sun, Yikun Zhang, Long Zhao, Yang Yang, Yijian Zhang, Lei Xu, Yangyang Lei, Jie Du, Hu Chen, Lian Duan, Mingyi He, Lintao Shi, Lei Liu, Quanjun Wang, Liangding Hu, Bin Zhang

“…Our attempt to devise a novel CAR structure capable of recognizing both tumor antigens and PDL1 encountered challenges since direct targeting of PDL1 resulted in systemic adverse effects. …”
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Effect of Mediterranean diet or mindfulness‐based stress reduction during pregnancy on placental volume and perfusion: A subanalysis of the IMPACT BCN randomized clinical trial by Ayako Nakaki, Eugenio Denaro, Maddalena Crimella, Roberta Castellani, Kilian Vellvé, Nora Izquierdo, Annachiara Basso, Cristina Paules, Rosa Casas, Leticia Benitez, Irene Casas, Marta Larroya, Mariona Genero, Sara Castro‐Barquero, Alex Gomez‐Gomez, Óscar J. Pozo, Eduard Vieta, Ramon Estruch, Alfons Nadal, Eduard Gratacós, Francesca Crovetto, Fàtima Crispi, Lina Youssef

“…Results on placental intravoxel incoherent motion perfusion fraction and diffusion coefficient were similar among the study groups. Conclusions Structured interventions during pregnancy based on Mediterranean diet or Stress reduction are associated with a lower proportion of small placentas, which is consistent with the previously observed beneficial effects of these interventions on fetal growth.…”
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Balancing ethics and conservation: Assessing short‐term behavioral impacts of biopsy sampling in a recovering whale population by Leena Riekkola, Simon Childerhouse, Rochelle Constantine, Ros Cole, Robert Harcourt, Dorothea Heimeier, Dave Lundquist, Catherine Meyer, Mike Ogle, Debbie Steel, Esther Stuck, Aimee van derReis, Emma L. Carroll

“…Abstract Long‐term monitoring programs based on individual identification have provided a sound basis for monitoring the status of endangered and recovering species. …”
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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…In this study, a series of bis(7)-harmine derivatives were designed and synthesized as multifunctional drugs for the treatment of AD.MethodsThe derivatives were synthesized by chemical methods and their structure was confirmed by nuclear magnetic resonance (NMR). …”
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Hierarchizing multi-scale environmental effects on agricultural pest population dynamics: a case study on the annual onset of Bactrocera dorsalis population growth in Senegalese or... by Caumette, Cécile, Diatta, Paterne, Piry, Sylvain, Chapuis, Marie-Pierre, Faye, Emile, Sigrist, Fabio, Martin, Olivier, Papaïx, Julien, Brévault, Thierry, Berthier, Karine

“…We gathered abundance data from a three-year monitoring conducted in 69 mango orchards as well as environmental data (i.e. orchard management, landscape structure and weather variability) across a range of spatial scales. …”
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Fecal microbiota transplantation alleviates cognitive impairment by improving gut microbiome composition and barrier function in male rats of traumatic brain injury following gas e... by Xinwen Dong, Yaguang Su, Zheng Luo, Cuiying Li, Jie Gao, Xiaofeng Han, Sanqiao Yao, Weidong Wu, Linqiang Tian, Yichun Bai, Guizhi Wang, Wenjie Ren

“…FMT improved intestinal structure and up-regulated expression of tight junction proteins Claudin-1, Occludin, and ZO-1, potentially contributing to its protective effects on both brain and gut.ConclusionTransplantation of gut microbiota from healthy rats significantly enhanced cognitive function in male rats with traumatic brain injury caused by a gas explosion, through the modulation of gut microbiome composition and the improvement of both gut and brain barrier integrity via the gut-brain axis. …”
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KONDISI GEOLOGI LOKAL KOTA BENGKULU BERDASARKAN GROUND SHEAR STRAIN (GSS) by Nanang Sugianto, M. Farid, Suhendra Suhendra

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Intervening on Calorie Intake or Eating Timing in Older Adults: Lessons Learned in the Healthy Aging and Late-Life Outcomes Randomized Controlled Pilot Trial by Fanning J, Rejeski WJ, Nicklas BJ, Kritchevsky SB, Miller ME, Houston DK, Walkup MP, Kennedy K, Stowe CL, Ford S, Yow D

“…Open-ended feedback underscored the value of the group-based structure of the program and remote delivery to reduce travel burden, the need for reduced burden associated with food logging, and the need to identify methods for enhancing perceived value of TRE among older adults.Conclusion: An intervention designed to promote CR, primarily delivered remotely and supported by self-monitoring technology, is both feasible and acceptable to many older adults.Keywords: aging, technology, behavior, obesity, pilot…”
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Selenium nanoparticle loaded on PVA/chitosan biofilm synthesized from orange peels: antimicrobial and antioxidant properties for plum preservation by Hamza T. O. Abdelaziz, Eldin M. Seif Mohamed, Samir K. A. Younis, Nada Ahmed, Mary N. Michaeel, Samah H. Abu-Hussien, Ashraf Bakry, Naglaa M. Ebeed, Mohamed A. Nasser, Mohamed K. Abou El-Nasr, Mahmoud A. A. Ali, Bahaa Hemdan, Mahmoud Salah, Salwa M. El-Sayed

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Translingual neural stimulation induced changes in intra- and inter-network functional connectivity in mild-moderate traumatic brain injury patients by Daniel Y. Chu, Jiancheng Hou, Thomas Hosseini, Veena A. Nair, Nagesh Adluru, Yuri Danilov, Kurt A. Kaczmarek, Mary E. Meyerand, Mitchell Tyler, Mitchell Tyler, Vivek Prabhakaran

“…Recently, translingual neural stimulation (TLNS) has emerged as a potential therapy for mmTBI-related balance and gait deficits by inducing neuroplastic changes in the brain gray matter structure. However, it is still unclear how interactions within and between functional networks in brain are affected by TLNS. …”
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Pre-breeding in alfalfa germplasm develops highly differentiated populations, as revealed by genome-wide microhaplotype markers by Cesar A. Medina, Dongyan Zhao, Meng Lin, Manoj Sapkota, Alexander M. Sandercock, Craig T. Beil, Moira J. Sheehan, Brian M. Irish, Long-Xi Yu, Hari Poudel, Annie Claessens, Virginia Moore, Jamie Crawford, Julie Hansen, Donald Viands, Michael D. Peel, Neal Tilhou, Heathcliffe Riday, E. Charles Brummer, Zhanyou Xu

“…Principal component analysis and discriminant analysis of principal components revealed significant population structure among the alfalfa populations based on geographical origin, while the check cultivars formed a central cluster. …”
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Impact of dietary polyphenols from shredded, steam-exploded pine on growth performance, organ indices, meat quality, and cecal microbiota of broiler chickens by Chris Major Ncho, Vaishali Gupta, Akshat Goel, Chae-Mi Jeong, Ji-Young Jung, Si-Young Ha, Jeong-Uk Eom, Han-Sul Yang, Jae-Kyung Yang, Yang-Ho Choi

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Artificial neural network-based forecasting of air temperature reduction in a tube bank under electric field by Ekuong Tang, Attakorn Asanakham, Thoranis Deethayat, Tanongkiat Kiatsiriroat

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ATF7IP inhibits Sorafenib-induced ferroptosis in hepatocellular carcinoma cells by inhibiting CYB5R2 transcription and stabilizing PARK7 protein by Yijie Su, Sirui Huang, Yang Duan, Liang Zhang, Shengyun Feng, Yingge Lv, Bei Lan, Chenghao Xuan

“…Ferroptosis, an iron-dependent form of programmed cell death, arises from the accumulation of lipid peroxides at toxic levels. …”
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Accessing a New Population of Supermassive Black Holes with Extensions to the Event Horizon Telescope by Xinyue Alice Zhang, Angelo Ricarte, Dominic W. Pesce, Michael D. Johnson, Neil Nagar, Ramesh Narayan, Venkatessh Ramakrishnan, Sheperd Doeleman, Daniel C. M. Palumbo

“…We find that the linearly polarized structure evolves substantially with the Eddington ratio, with greater evolution at larger inclinations, complicating potential spin inferences for inclined sources. …”
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Development and Validation of the EBP‐Affinity Questionnaire: A Mixed‐Method Study by Lenny J. Tange, Maud Heinen, Raymond T.C.M. Koopmans, Dirk F. deKorne, Anke Persoon, Robert Lindeboom, Debby L. Gerritsen, Marleen H. Lovink

“…Phase 2: Principal component analysis revealed a two‐factor structure with good internal reliability (N = 428 questionnaires). …”
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A novel missense single-nucleotide polymorphism (c.149G>A) in the bovine leptin gene and its association with growth traits in Madura cattle by Kuswati Kuswati, Irida Novianti, Rizki Prafitri, Wike Andre Septian, Rafika Febriani Putri, Chairdin Dwi Nugraha, Ahmad Furqon

“…This SNP deviated from HWE (p < 0.05), indicating potential selection pressure or population structure effects. While no statistically significant associations were found between genotypes and growth traits (p > 0.05), the AA genotype showed the highest mean values across most body measurements. …”
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Multidisciplinary management of a norovirus outbreak in Tuscany, Italy by Clara Girardi, Lucia Kundisova, Francesca Marconi, Alessandra Guidi, Johanna Alexandra Iamarino, Veronica Gallinoro, Silvia Mele, Giovanni Nardone, Maurizio Grani, Giovanni Munaò, Luca Cianti, Paola Picciolli, Ylenia Zizzo, Loria Bianchi, Martina Sartoni

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Physicochemical and functional optimization of probiotic yogurt with encapsulated Lacticaseibacillus paracasei E1 enriched with green tea using Box–Behnken design by Muhaimin Rifa'i, Mochammad Fitri Atho'illah, Siti Nur Arifah, Aditya Ragil Suharto, Aghnia Nuri Fadhilla, Nur Alfi Maghfirotus Sa'adah, Esha Ardiansyah, Rahmi Izati, Belinda Nabiila Al Faizah, Dawama Nur Fadlilah, Septhyanti Aprilia Kavitarna, Shinta Oktya Wardhani, Wisnu Barlianto, Hideo Tsuboi, Yoga Dwi Jatmiko

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An spike-accum® bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity by Jean Pierre Bikorimana, Nathanael A. Caveney, Nehme EL-Hachem, Gabrielle A. Mandl, John A. Capobianco, Daniela Stanga, Jamilah Abusarah, Mark A. Hancock, Roudy Farah, Marina P. Gonçalves, Darryl Falzarano, Mingmin Liao, Glenn Hamonic, Qiang Liu, Simon Beaudoin, Sebastien Talbot, Moutih Rafei

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