Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…At the heart of ART success is preimplantation genetic testing (PGT), which enables the detection of chromosomal anomalies, single-gene disorders, and structural rearrangements, enhancing embryo selection and mitigating genetic risk. …”
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Dynamics of turnover of sugar-lowering drugs in the retail segment of the pharmaceutical market from 2020 to 2024 by D. V. Kurkin, E. V. Makarova, V. I. Zvereva, A. R. Makarova, D. A. Bakulin, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, I. S. Krysanov, K. N. Koryanova, D. A. Galkina, N. A. Osadchenko, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…Despite maintaining the leading position of metformin, the consumption structure is shifting towards more expensive schemes. …”
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Relationship between prenatal anxiety, depression, pregnancy stress and their social determinants by Weicui Meng, Sufeila Shalayiding, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…Given that psychological problems during pregnancy may lead to short-term and long-term adverse outcomes for both mothers and infants, clarifying their network structure and core social determinants holds important public health significance for formulating regional intervention strategies. …”
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Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing by Xiaozhen Zhou, Pengchao Ma, Yihao Liu, Zhaojian Wang, Shida Chen, Zekun Cheng, Songlu Tseng, Hui Wu, Mengdi Zhang, Fengzhou Du, Nanze Yu, Xiao Long, Jiuzuo Huang, Xiumei Wang

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Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency by A. Jerrod Anzalone, Sharon Patrick, Amber Abel, Brad Price, Elizabeth Reisher, Kent Ripplinger, Mary Emmett, Ronald Horswell, San Chu, William B. Hillegass, Francisco S. Sy, Brian Melancon, H. Timothy Bunnell, Lucio Miele, Mary Helen Mays, Joseph Keawe‘aimoku Kaholokula, Elizabeth S. Chen, Karen M. Crowley, Indra Neil Sarkar, Susan L. Santangelo, Clifford J. Rosen, Jeremy Harper, David Bard, William Beasley, Sally L. Hodder

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The Characteristic of Measles Epidemic Process in Kyrgyz Republic by M. S. Niiazalieva, O. V. Tsvirkun, V. S. Toygombaeva, I. Sh. Aldjambaeva, G. S. Ishenapysova, R. A. Frolov, G. S. Dadanova

“…This hypothesis confirmed by the high percentage of unvaccinated children of this age in the structure of the sickindividuals. All this casts doubt on the official data on the coverage of children of this age with preventive vaccinations (95.7%) and indicates the accumulation of contingents susceptible to measles. …”
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Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight by Congrong Wang, Brigitte Reimann, Tim S Nawrot, Dries S Martens, John Wright, Rosemary McEachan, Johanna Lepeule, Wenlun Yuan, Leda Chatzi, Marina Vafeiadi, Regina Grazuleviciene, Sandra Andrusaityte, Oliver Robinson, Jordi Sunyer, Hector Keun, Chung-Ho E. Lau, Alexandros P. Siskos, Muireann Coen, Eva Borràs, Eduard Sabidó, Juan R. González, Marta Vives-Usano, Xavier Estivill, Angel Carracedo, Carlos Ruiz-Arenas, Inés Quintela, Maribel Casas, Mark Nieuwenhuijsen, Ibon Tamayo, Kristine B Gutzkow, Cathrine Thomsen, Amrit K. Sakhi, Mariona Bustamante, Lea Maitre, Martine Vrijheid, Michelle Plusquin, Rossella Alfano

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The quantitative study of marked individuals in ecology, evolution and conservation biology: a foreword to the EURING 2003 Conference by J. C. Senar, A. A. Dhondt, M. J. Conroy

“…The Proceedings follow the same general structure as the Conference. We organised the EURING meeting in 10 technical sessions, covering what we considered as fastest growing areas in the field. …”
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Sustainable forest management: success and challenges in Ethiopia by Rusha Begna Wakweya

“…However, more effective governance structures are needed to balance the goals of forest conservation and community development2. …”
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Home Occupant Archetypes by Marco Antonio ORTIZ SANCHEZ

“…Parallelly, in-depth and semi-structured interviews were conducted, which are techniques used to gather qualitative behavioural data from the home occupants. …”
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Clinical syndromes linked to biallelic germline variants in MCM8 and MCM9 by Noah C. Helderman, Ting Yang, Claire Palles, Diantha Terlouw, Hailiang Mei, Ruben H.P. Vorderman, Davy Cats, Marcos Díaz-Gay, Marjolijn C.J. Jongmans, Ashwin Ramdien, Irma van de Beek, Thomas F. Eleveld, Andrew Green, Frederik J. Hes, Marry M. van den Heuvel-Eibrink, Annelore Van Der Kelen, Sabine Kliesch, Roland P. Kuiper, Inge M.M. Lakeman, Lisa E.E.L.O. Lashley, Leendert H.J. Looijenga, Manon S. Oud, Johanna Steingröver, Yardena Tenenbaum-Rakover, Carli M. Tops, Frank Tüttelmann, Richarda M. de Voer, Dineke Westra, Margot J. Wyrwoll, Mariano Golubicki, Marina Antelo, Laia Bonjoch, Mariona Terradas, Laura Valle, Ludmil B. Alexandrov, Hans Morreau, Tom van Wezel, Sergi Castellví-Bel, Yael Goldberg, Maartje Nielsen

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Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis by Kornelius Schulze, Tim Daniel Rose, Lorenz Adlung, Manuela Peschka, Francesca Pagani, Joao Gorgulho, Thorben W. Fründt, Ismail Labgaa, Philipp K. Haber, Carolin Zimpel, Darko Castven, Arndt Weinmann, Teresa Garzia-Lezana, Moritz Waldmann, Thomas Renné, Hannah Voß, Manuela Moritz, Dorian Orlikowski, Hartmut Schlüter, Jan Baumbach, Myron Schwartz, Ansgar W. Lohse, Samuel Huber, Bruno Sangro, Rocio I.R. Macias, Laura Izquierdo-Sanchez, Jesus M. Banales, Henning Wege, Jens U. Marquardt, Augusto Villanueva, Josch Konstantin Pauling, Johann von Felden

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Study on Innovative Practices to Promote Girls’ Retention and Transition to Secondary and Higher Learning Institutions in Sub-Saharan Africa. by Ayiga, Natal, Adyanga, Francis Akena, Akello, Jacqueline

“…The primary data was collected by using 7 tools containing both quantitative and qualitative data. The structured questionnaire, in-depth interviews, and Focus Group Discussions (FGDs) were used to collect the data. …”
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改性秸秆灰负载Pt催化甘油氧化性能研究Glycerol oxidation catalyzed by modified straw ash supported Pt by 王聪莹1， 于静2， 崔佳欣1 WANG Congying1，YU Jing2，CUI Jiaxin1

“…In order to achieve high value utilization of biomass, Pt-based catalysts of Pt/ash-b, Pt/ash-a, Pt/ash-ba and Pt/ash-CeO2 were prepared by pre-treating straw ash using alkali modification, acid modification, combined acid and alkali modification, and introduction of CeO2, respectively. The composition, structure, loading amount of Pt, size of Pt particle, surface acidity and alkalinity, and Pt reduction activity of the catalysts were determined by X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), inductively coupled plasma-atomic emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), CO2 programmed temperature-raising desorption (CO2-TPD) and NH3 programmed temperature-raising desorption (NH3-TPD), and hydrogen-programmed temperature-raising reduction (H2-TPR), respectively. …”
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Insights from a Pseudo-Polygyny Cohort unmasking high sperm concentration and low forward motility as potential risk factors for recurrent failure of sperm donation IVF (RFDI), a s... by Tiancheng Zhang, Fan Dong, Xu Zhang, Ping Ping, Jin Qiu, Zhen Lu, Huachun Zou, Qian Xiao, Jianhui Li, Gaoyue Zhang, Huijuan Shi, Xiangfeng Chen

“…We investigated potential risk factors for UMI leveraging data from a sperm bank with a “one male to multiple females” structure to reduce confounding arising from female factors. …”
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Advancing ocean monitoring and knowledge for societal benefit: the urgency to expand Argo to OneArgo by 2030 by Virginie Thierry, Hervé Claustre, Orens Pasqueron de Fommervault, Nathalie Zilberman, Kenneth S. Johnson, Brian A. King, Susan E. Wijffels, Udaya T. V. S. Bhaskar, Magdalena Alonso Balmaseda, Mathieu Belbeoch, Marine Bollard, Jacqueline Boutin, Phillip Boyd, Romain Cancouët, Fei Chai, Stefano Ciavatta, Rich Crane, Sophie Cravatte, Sophie Cravatte, Giorgio Dall’Olmo, Damien Desbruyères, Paul J. Durack, Andrea J. Fassbender, Katja Fennel, Yosuke Fujii, Florent Gasparin, Alberto González-Santana, Claire Gourcuff, Alison Gray, Helene T. Hewitt, Steven R. Jayne, Gregory C. Johnson, Nicolas Kolodziejczyk, Arnaud Le Boyer, Pierre-Yves Le Traon, Pierre-Yves Le Traon, William Llovel, M. Susan Lozier, John M. Lyman, John M. Lyman, Elaine L. McDonagh, Elaine L. McDonagh, Adrian P. Martin, Benoit Meyssignac, Kristian S. Mogensen, Tamaryn Morris, Peter R. Oke, Walker O. Smith, Breck Owens, Noé Poffa, Joanna Post, Dean Roemmich, Ryan R. Rykaczewski, Shubha Sathyendranath, Megan Scanderbeg, Carolyn Scheurle, Oscar Schofield, Karina von Schuckmann, James Scourse, Janet Sprintall, Toshio Suga, Toshio Suga, Marina Tonani, Esmee van Wijk, Esmee van Wijk, Xiaogang Xing, Hao Zuo

“…Effective and sustainable monitoring of the physical, biogeochemical state and ecosystem structure of the ocean, to enable climate adaptation, carbon management and sustainable marine resource management is urgently needed. …”
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從前瞻因應理論觀點探討翻轉教學策略應用 於退休準備課程在不同需求程度上之 教學成效 Exploring the Application of Flipped Teaching Strategies in Retirement Preparation Courses: An Analysis of Educational Effectiveness From... by 胡夢鯨 Menq-Jing Hwu, 施宇澤 Yu-Ze Shih, 劉霽瑈 Ji-Rou Liu, 陳雅雯 Ya-Wen Chen

“…An initial needs survey grounded in active aging principles was conducted, gathering structured data to shape the curriculum. The 11-week experimental course applied flipped teaching strategies such as pre-class reading, classroom discussions, self-directed learning, and field-based activities. …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe by Deborah De Moortel, Michelle C Turner, Ella Arensman, Alex Binh Vinh Duc Nguyen, Víctor Gonzalez

“…title=Population_structure_and_ageing…”
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Online Job Portals: the Future of Labor Market Regulation in the Republic of Belarus by E. V. Vankevich, O. V. Zaitseva

“…The authors formulated the difficulties of forming a single portal of vacancies for labor market analysts: - different criteria for structuring information in the description of vacancies and resumes, the use of different classifiers; - lack of unification in the use of methodological and methodological approaches (understanding the labor market situation, division into types of economic activities, categories of vacancies and resumes); - weak structuring and arbitrariness in the description of the required skills; - closed information. …”
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