Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma by Andrea Anichini, Francesca P. Caruso, Vincenzo Lagano, Teresa M. R. Noviello, Rossella Tufano, Gabriella Nicolini, Alessandra Molla, Ilaria Bersani, Francesco Sgambelluri, Alessia Covre, Maria F. Lofiego, Sandra Coral, Anna Maria Di Giacomo, Elena Simonetti, Barbara Valeri, Mara Cossa, Filippo Ugolini, Sara Simi, Daniela Massi, Massimo Milione, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Michele Maio, Michele Ceccarelli, Roberta Mortarini, On behalf of the EPigenetic Immune-oncology Consortium Airc (EPICA) investigators

“…Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. …”
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The application of blockchain with a comparative approach and its impact on risk, flexibility and internal control evaluation by mohammadsadegh aminipoor, HamidReza GholamniaRoshan, azadeh kiapour, Iman Dadashi

“…Blockchain is essentially a public ledger, where groups of transactions or events are recorded and stored in a chain-like data structure; this approach creates a fast yet secure way to transfer funds. …”
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How do individuals with mental health disorder and spinal cord injury gain access to participate in voluntary sport groups in Switzerland? by Florence Epiney, Siegfried Nagel, Christopher Klenk

“…The coaches’ point of view was included to have a complementary perspective compared to the athletes to produce comprehensive insights. A semi-structured interview guideline was developed, discussed with experts and tested in a pilot interview (Braun & Clarke, 2022; Smith & Sparkes, 2020). …”
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exoALMA. XVII. Characterizing the Gas Dynamics around Dust Asymmetries by Lisa Wölfer, Marcelo Barraza-Alfaro, Richard Teague, Pietro Curone, Myriam Benisty, Misato Fukagawa, Jaehan Bae, Gianni Cataldi, Ian Czekala, Stefano Facchini, Daniele Fasano, Mario Flock, Maria Galloway-Sprietsma, Himanshi Garg, Cassandra Hall, Jane Huang, John D. Ilee, Andrés F. Izquierdo, Kazuhiro Kanagawa, Geoffroy Lesur, Cristiano Longarini, Ryan A. Loomis, Francois Menard, Anika Nath, Ryuta Orihara, Christophe Pinte, Daniel J. Price, Giovanni Rosotti, Jochen Stadler, Gaylor Wafflard-Fernandez, Andrew J. Winter, Hsi-Wei Yen, Tomohiro C. Yoshida, Brianna Zawadzki

“…While dust observations have revealed crescent structures in several disks, observations of their kinematic signatures are still lacking. …”
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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…At the heart of ART success is preimplantation genetic testing (PGT), which enables the detection of chromosomal anomalies, single-gene disorders, and structural rearrangements, enhancing embryo selection and mitigating genetic risk. …”
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Dynamics of turnover of sugar-lowering drugs in the retail segment of the pharmaceutical market from 2020 to 2024 by D. V. Kurkin, E. V. Makarova, V. I. Zvereva, A. R. Makarova, D. A. Bakulin, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, I. S. Krysanov, K. N. Koryanova, D. A. Galkina, N. A. Osadchenko, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva

“…Despite maintaining the leading position of metformin, the consumption structure is shifting towards more expensive schemes. …”
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Phase formation, microstructural and superconducting properties of YBCO added Ca-compounds extraction eggshells by Siew Hong Yap, Mohd Mustafa Awang Kechik, Syahrul Humaidi, Khairul Khaizi Mohd Shariff, Hussien Baqiah, Soo Kien Chen, Kean Pah Lim, Mohd Hafiz Mohd Zaid, Yazid Yaakob, Mohd Khalis Abdul Karim, Zainal Abidin Talib, Zhi Wei Loh, Aliah Nursyahirah Kamarudin, Abdul Halim Shaari, Muralidhar Miryala

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The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders by Daniel Alcolea, Jordi Clarimón, María Carmona‐Iragui, Ignacio Illán‐Gala, Estrella Morenas‐Rodríguez, Isabel Barroeta, Roser Ribosa‐Nogué, Isabel Sala, M. Belén Sánchez‐Saudinós, Laura Videla, Andrea Subirana, Bessy Benejam, Sílvia Valldeneu, Susana Fernández, Teresa Estellés, Miren Altuna, Miguel Santos‐Santos, Lídia García‐Losada, Alexandre Bejanin, Jordi Pegueroles, Víctor Montal, Eduard Vilaplana, Olivia Belbin, Oriol Dols‐Icardo, Sònia Sirisi, Marta Querol‐Vilaseca, Laura Cervera‐Carles, Laia Muñoz, Raúl Núñez, Soraya Torres, M. Valle Camacho, Ignasi Carrió, Sandra Giménez, Constance Delaby, Ricard Rojas‐Garcia, Janina Turon‐Sans, Javier Pagonabarraga, Amanda Jiménez, Rafael Blesa, Juan Fortea, Alberto Lleó

“…Methods Participants of the SPIN cohort provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological and neuropsychological evaluations, and undergo a structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video‐polysomnogram, 18F‐fluorodeoxyglucose PET, amyloid PET, Tau PET). …”
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Relationship between prenatal anxiety, depression, pregnancy stress and their social determinants by Weicui Meng, Sufeila Shalayiding, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…Given that psychological problems during pregnancy may lead to short-term and long-term adverse outcomes for both mothers and infants, clarifying their network structure and core social determinants holds important public health significance for formulating regional intervention strategies. …”
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Evaluating snow depth retrievals from Sentinel-1 volume scattering over NASA SnowEx sites by Z. Hoppinen, Z. Hoppinen, R. T. Palomaki, G. Brencher, D. Dunmire, D. Dunmire, E. Gagliano, A. Marziliano, J. Tarricone, J. Tarricone, H.-P. Marshall

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Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing by Xiaozhen Zhou, Pengchao Ma, Yihao Liu, Zhaojian Wang, Shida Chen, Zekun Cheng, Songlu Tseng, Hui Wu, Mengdi Zhang, Fengzhou Du, Nanze Yu, Xiao Long, Jiuzuo Huang, Xiumei Wang

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Building a collaborative ecosystem across the IDeA-CTR networks in response to a public health emergency by A. Jerrod Anzalone, Sharon Patrick, Amber Abel, Brad Price, Elizabeth Reisher, Kent Ripplinger, Mary Emmett, Ronald Horswell, San Chu, William B. Hillegass, Francisco S. Sy, Brian Melancon, H. Timothy Bunnell, Lucio Miele, Mary Helen Mays, Joseph Keawe‘aimoku Kaholokula, Elizabeth S. Chen, Karen M. Crowley, Indra Neil Sarkar, Susan L. Santangelo, Clifford J. Rosen, Jeremy Harper, David Bard, William Beasley, Sally L. Hodder

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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…Microscopic analysis at 21 dai revealed that the resistant cultivar (JP) root structure remained largely unaffected, while the roots of the susceptible cultivar (83-1) exhibited significant tissue distortion and gall formation, underscoring the effectiveness of the resistance mechanisms. …”
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The Characteristic of Measles Epidemic Process in Kyrgyz Republic by M. S. Niiazalieva, O. V. Tsvirkun, V. S. Toygombaeva, I. Sh. Aldjambaeva, G. S. Ishenapysova, R. A. Frolov, G. S. Dadanova

“…This hypothesis confirmed by the high percentage of unvaccinated children of this age in the structure of the sickindividuals. All this casts doubt on the official data on the coverage of children of this age with preventive vaccinations (95.7%) and indicates the accumulation of contingents susceptible to measles. …”
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Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight by Congrong Wang, Brigitte Reimann, Tim S Nawrot, Dries S Martens, John Wright, Rosemary McEachan, Johanna Lepeule, Wenlun Yuan, Leda Chatzi, Marina Vafeiadi, Regina Grazuleviciene, Sandra Andrusaityte, Oliver Robinson, Jordi Sunyer, Hector Keun, Chung-Ho E. Lau, Alexandros P. Siskos, Muireann Coen, Eva Borràs, Eduard Sabidó, Juan R. González, Marta Vives-Usano, Xavier Estivill, Angel Carracedo, Carlos Ruiz-Arenas, Inés Quintela, Maribel Casas, Mark Nieuwenhuijsen, Ibon Tamayo, Kristine B Gutzkow, Cathrine Thomsen, Amrit K. Sakhi, Mariona Bustamante, Lea Maitre, Martine Vrijheid, Michelle Plusquin, Rossella Alfano

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Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context by Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sullivan, Yi Lu

“…We estimated familial aggregation/coaggregation using generalised estimating equations, heritability and genetic correlations using structural equation modelling. We also analysed ∼30,000 genotyped MDD cases from the UK Biobank and a Swedish cohort to explore which polygenic risk score (PRS) may predispose individuals to psychotic MDD. …”
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The quantitative study of marked individuals in ecology, evolution and conservation biology: a foreword to the EURING 2003 Conference by J. C. Senar, A. A. Dhondt, M. J. Conroy

“…The Proceedings follow the same general structure as the Conference. We organised the EURING meeting in 10 technical sessions, covering what we considered as fastest growing areas in the field. …”
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Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…Evidence indicates that such deliberate targeting aims to destabilize Gaza’s social structure and hinder long-term development. The findings highlight the urgent need for international accountability to halt these acts, safeguard education as a fundamental right and rebuild Gaza’s education system to ensure resilience and continuity amid conflict. …”
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Genetic Diversity and Relationship Analysis of Different Local and International Cultivars and some Strawberry Clones (Fragaria× ananassa Duch) by Masume Abedi, Mehdi Hadadinejad, Kamran Ghasemi, Ghafar Kiani

“…Therefore, shoot density may decrease as the plant grows, resulting in a more open structure with fewer leaves. Finally, considering the genetic distance among the cultivars, it appears that crossing these genotypes could yield greater heterosis, which can be leveraged to produce new cultivars and enhance orchard yields. …”
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The Magnetic Field in Quiescent Star-forming Filament G16.96+0.27 by Qi-Lao Gu, Tie Liu, Zhi-Qiang Shen, Sihan Jiao, Julien Montillaud, Mika Juvela, Xing Lu, Chang Won Lee, Junhao Liu, Pak Shing Li, Xunchuan Liu, Doug Johnstone, Woojin Kwon, Kee-Tae Kim, Ken’ichi Tatematsu, Patricio Sanhueza, Isabelle Ristorcelli, Patrick Koch, Qizhou Zhang, Kate Pattle, Naomi Hirano, Dana Alina, James Di Francesco

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