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Functional annotation of the Hippo pathway somatic mutations in human cancers
Published 2024-11-01Get full text
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3663
Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without
Published 2025-12-01Get full text
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3664
Parental Phasing Study Identified Lineage-Specific Variants Associated with Gene Expression and Epigenetic Modifications in European–Chinese Hybrid Pigs
Published 2025-05-01“…In this study, we established three crossbred pig families derived from distant genetic lineages and systematically identified variants from different lineages, including single nucleotide polymorphisms (SNPs) and structural variations (SVs). At the phase level, we quantitatively analyzed gene expression, four histone modifications (H3K4me3, H3K27ac, H3K4me1, and H3K27me3), and the binding strength of transcription factor (CTCF) in backfat (BF) and longissimus dorsi (LD) muscle. …”
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Clinical and Epidemiological Characteristics of Hepatocellular Carcinoma in the Republic of Saha (Yakutia)
Published 2020-07-01“…The Republic of Sakha (Yakutia) is a hyperendemic region of the Russian Federation in terms of the incidence of hepatocellular carcinoma with a predominance of the male population in its structure. The rate of decrease in the incidence of liver cancer in the country will depend on the effectiveness of the regional program for the elimination of viral hepatitis and the decrease in the incidence of cirrhosis of the liver of non-infectious etiology.…”
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3666
Spatial variation in time to diagnosis of visceral leishmaniasis in Bihar, India
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3667
Antimicrobial resistance in a protracted war setting: a review of the literature from Palestine
Published 2025-06-01“…Notably, most studies attributed AMR to local practices, often overlooking broader structural and socio-political drivers. This review underscores the need to contextualize AMR within the environment, particularly under conditions of sustained warfare.IMPORTANCEThis study goes beyond merely reviewing and summarizing data on AMR in the occupied Palestinian territories (oPt), a region enduring chronic war-like conditions. …”
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Why do older adults hesitate to get the flu vaccine? A cross-sectional study on vaccine hesitancy in the post-COVID-19 era
Published 2025-07-01“…Multinomial logistic regression models were used to identify predictors of vaccine hesitancy, adjusting for sociodemographic variables, self-reported health status and self-report vaccination experiences. Structural equation modeling (SEM) was employed to examine the underlying factors contributing to vaccine hesitancy and quantify their interrelationships.ResultsA high proportion (85.2%) of participants exhibited influenza vaccine hesitancy, with 16.2% being complete refusers. …”
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Distribution of variants of the <i>TNFA</i> gene regulatory sites among Russian women of Caucasian origin with leiomyoma
Published 2025-06-01“…The aim of our research was to analyze the distribution of TNF-238, TNF- 308 and TNF-863 structural variants at the regulatory region of the TNFA gene in a representative group of Caucasian patients with UF compared with a matched group of healthy women followed by assessment of personalized prognostic significance of suggested differences. 180 patients diagnosed with uterine fibroids and 98 practically healthy women were examined. …”
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The impact of lifestyle sports on the sleep quality of depressed high school students in Jiangsu Province, China: based on cross-sectional study
Published 2025-03-01“…The mediation model of depression between lifestyle sports and sleep quality was constructed via the Model4 model and other models in the SPSS macro program Process4.0. From the 32,974 valid questionnaires, 14,943 depressed high school students (SDS ≥ 53) were screened out, and structural equation modeling of the relationships between the six dimensions of lifestyle sports and the sleep quality of depressed high school students has been established via AMOS 28.0. …”
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A rural practice affinity model: recognizing the role of emergency medicine competency
Published 2025-06-01“…A partial correlation matrix between the variables of interest (general self-efficacy, emergency medicine competency, rural practice self-efficacy, and rural practice intentions) - controlling for the effects of relationships, financial aspects, personal aspects, and social desirability - was created and subjected to a structural equation model. Results: Our initial rural practice affinity model resulted in a poor fit of the model to the data. …”
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Strengthening health system's capacity for pre-exposure prophylaxis for adolescent girls and young women and adolescent boys and young men in South Africa (SHeS'Cap-PrEP): Protocol...
Published 2022-01-01“…In South Africa, various approaches of delivering PrEP have been adopted at different service delivery points (facility-based only, school-based only, community-based only and hybrid school-facility and community-facility models) to overcome challenges associated with individual, structural, and health systems related barriers that may hinder access to and uptake of PrEP among these populations. …”
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A Study Protocol for a Comprehensive Evaluation of Two Artificial Intelligence‐Based Tools in Title and Abstract Screening for the Development of Evidence‐Based Cancer Guidelines...
Published 2025-08-01“…Completing a CPG through the Program in Evidence‐Based Care (PEBC), a globally acknowledged guideline program supported by Ontario Health (Cancer Care Ontario), typically takes about 2 years. …”
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Digital transformation of nephrology POCUS education—Integrating a multiagent, artificial intelligence, and human collaboration-enhanced curriculum with expert feedback
Published 2025-03-01“…AI models contributed significantly to the curriculum's foundational structure, while human experts provided critical clinical insights. …”
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<sup>119</sup>Sn Element-Specific Phonon Density of States of BaSnO<sub>3</sub>
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THE SUMMER TEMPERATURES FORECAST BY THE METHOD OF SINGULAR-SPECTRAL ANALYSIS IN THE SOUTH OF RUSSIA IN 2019-2023
Published 2022-07-01“…Using of the first twenty main components (MC20) made it possible to study and restore the internal structure of the entire time series as accurately as possible for a subsequent forecast for 5 years. …”
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Identifying predictors and assessing causal effect on hypertension risk among adults using Double Machine Learning models: Insights from Bangladesh Demographic and Health Survey.
Published 2025-07-01“…We used logistic regression, Random forest model, Double Machine Learning (DML), and Shapley Additive exPlanations (SHAP) based on a pre-defined causal structure.<h4>Results</h4>The dataset included 11,815 individuals, and the prevalence of hypertension was 38.40%. …”
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A review of circular RNAs in colorectal cancer: insights into biomarker discovery and therapeutic targeting
Published 2025-07-01“…Circular RNAs (circRNAs), a subclass of endogenous ncRNAs characterized by their covalently enclosed loop structure, demonstrate greater stability than linear RNAs, making them potential candidates for clinical applications. …”
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