Showing 9,321 - 9,340 results of 9,536 for search '(((structured OR structure) OR structures) OR structural) programming', query time: 0.20s Refine Results
  1. 9321
  2. 9322
  3. 9323

    Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

    Published 2025-01-01
    “…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
    Get full text
    Article
  4. 9324
  5. 9325

    Transcriptomic and proteomic studies of body size and carcass traits and the longest dorsal muscle in Tibetan sheep by Dehui Liu, Xue Li, Lei Wang, Quanbang Pei, Jincai Zhao, De Sun, Qianben Ren, Buying Han, Hanjing Jiang, Wenkui Zhang, Rong Li, Guoxiang Bao, Song Wang, Fei Tian, Sijia Liu, Kai Zhao, Dehong Tian

    Published 2025-05-01
    “…Result The body size traits, carcass traits, and muscle fiber structure of plateau-type Tibetan and Zhashijia sheep were compared. …”
    Get full text
    Article
  6. 9326
  7. 9327

    The beneficial effect of spiritual social support on depression and quality of life in chronic renal failure patients undergoing haemodialysis by Susanti, Bistara Difran Nobel, Arif Helmi Setiawan, Ikwan Mochamad, Umamah Faridah, Zahroh Chilyatiz, Sham Fatimah Binti, Nordin Roswati Binti, Cherry Mustamu Alva

    Published 2025-01-01
    “…Methods: The current investigation utilised a quasi-experimental approach with a preand post-test control group structure. Ninety-two patients from Rumah Sakit Islam Surabaya were separated into two groups: intervention (n = 46) versus control (n = 46). …”
    Get full text
    Article
  8. 9328

    Vaccine Hesitancy and Immunization Patterns in Central and Eastern Europe: Sociocultural, Economic, Political, and Digital Influences Across Seven Countries by Kurpas D, Stefanicka–Wojtas D, Soll–Morka A, Lomper K, Uchmanowicz B, Blahova B, Bredelytė A, Dumitra GG, Hudáčková V, Javorska K, Juhász Z, Manulik S, Mohos A, Skarbalius E, Tkachenko VI, Uchmanowicz I

    Published 2025-06-01
    “…Differences were influenced by healthcare system structure, public trust, exposure to misinformation, and digital communication strategies.Conclusion: Addressing vaccine hesitancy requires targeted, context-sensitive communication and digital literacy programs. …”
    Get full text
    Article
  9. 9329
  10. 9330

    Construction and Preliminary Validation of the Children's Academic Readiness Test to Enter Primary School in Afghanistan Country by Mohammad Naeem Rasooli, Ahmad Abedi, Mohammad Ashori

    Published 2024-03-01
    “…The results also showed that the assessment test has appropriate validity (structural validity and factor analysis) and reliability (Cronbach's alpha). …”
    Get full text
    Article
  11. 9331
  12. 9332

    A review of mixed-integer linear formulations for framework-based energy system models by Maximilian Hoffmann, Bruno U. Schyska, Julian Bartels, Tristan Pelser, Johannes Behrens, Manuel Wetzel, Hans Christian Gils, Chuen-Fung Tang, Marius Tillmanns, Jan Stock, André Xhonneux, Leander Kotzur, Aaron Praktiknjo, Thomas Vogt, Patrick Jochem, Jochen Linßen, Jann M. Weinand, Detlef Stolten

    Published 2024-12-01
    “…Consequently, numerous reviews have compared the capabilities and application cases of established energy system optimization frameworks with respect to their model features or adaptability but widely neglect the frameworks’ underlying mathematical structure. This limits their added value for users who not only want to use models but also program them themselves.To address this issue, we follow a hybrid approach by not only reviewing 63 optimization-based frameworks for energy system modeling with a focus on their mathematical implementation but also conducting a meta-review of 68 existing literature reviews.Our work reveals that the basic concept of network-based energy flow optimization has remained the same since the earliest publications in the 1970s. …”
    Get full text
    Article
  13. 9333
  14. 9334
  15. 9335

    Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

    Published 2025-07-01
    “…Additionally, protein structure extraction, protein-protein docking analysis, and data visualization were conducted.Results: Histomorphometry and flow cytometry showed that most seminiferous tubules in the therapy groups exhibit­ed normal morphology and restored spermatogenesis, unlike the azoospermia group. …”
    Get full text
    Article
  16. 9336

    Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

    Published 2024-10-01
    “…METHODS A multidisciplinary approach was used to identify ceperognastat (LY3372689) as a potent OGA inhibitor, including an extensive discovery effort with synthetic chemistry, structure‐based drug design, and in vivo OGA enzyme occupancy studies. …”
    Get full text
    Article
  17. 9337
  18. 9338
  19. 9339
  20. 9340

    Association Analysis of <i>SLC11A1</i> Polymorphisms with Somatic Cell Score in Chinese Holstein Cows by Kai Liu, Yufang Liu, Tuo Li, Qiuling Li, Jinyu Wang, Yongfu An, Yuze Yang, Kaiyang Li, Mingxing Chu

    Published 2025-05-01
    “…The bioinformatic analysis showed that these mutations affected the secondary and tertiary structure of <i>SLC11A1</i> mRNA, suggesting that they may affect gene expression or protein translation and function. …”
    Get full text
    Article