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Genetic risk factors underlying white matter hyperintensities and cortical atrophy
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Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression
Published 2025-01-01“…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors
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Transcriptomic and proteomic studies of body size and carcass traits and the longest dorsal muscle in Tibetan sheep
Published 2025-05-01“…Result The body size traits, carcass traits, and muscle fiber structure of plateau-type Tibetan and Zhashijia sheep were compared. …”
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The FinnBrain multimodal neonatal template and atlas collection
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The beneficial effect of spiritual social support on depression and quality of life in chronic renal failure patients undergoing haemodialysis
Published 2025-01-01“…Methods: The current investigation utilised a quasi-experimental approach with a preand post-test control group structure. Ninety-two patients from Rumah Sakit Islam Surabaya were separated into two groups: intervention (n = 46) versus control (n = 46). …”
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Vaccine Hesitancy and Immunization Patterns in Central and Eastern Europe: Sociocultural, Economic, Political, and Digital Influences Across Seven Countries
Published 2025-06-01“…Differences were influenced by healthcare system structure, public trust, exposure to misinformation, and digital communication strategies.Conclusion: Addressing vaccine hesitancy requires targeted, context-sensitive communication and digital literacy programs. …”
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Construction and Preliminary Validation of the Children's Academic Readiness Test to Enter Primary School in Afghanistan Country
Published 2024-03-01“…The results also showed that the assessment test has appropriate validity (structural validity and factor analysis) and reliability (Cronbach's alpha). …”
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A review of mixed-integer linear formulations for framework-based energy system models
Published 2024-12-01“…Consequently, numerous reviews have compared the capabilities and application cases of established energy system optimization frameworks with respect to their model features or adaptability but widely neglect the frameworks’ underlying mathematical structure. This limits their added value for users who not only want to use models but also program them themselves.To address this issue, we follow a hybrid approach by not only reviewing 63 optimization-based frameworks for energy system modeling with a focus on their mathematical implementation but also conducting a meta-review of 68 existing literature reviews.Our work reveals that the basic concept of network-based energy flow optimization has remained the same since the earliest publications in the 1970s. …”
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Intestine‐Decipher Engineered Capsules Protect Against Sepsis‐induced Intestinal Injury via Broad‐spectrum Anti‐inflammation and Parthanatos Inhibition
Published 2025-03-01“…The intestine, owing to its distinct structure and physiological environment, plays a pivotal role in the pathophysiology of sepsis. …”
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Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice
Published 2025-07-01“…Additionally, protein structure extraction, protein-protein docking analysis, and data visualization were conducted.Results: Histomorphometry and flow cytometry showed that most seminiferous tubules in the therapy groups exhibited normal morphology and restored spermatogenesis, unlike the azoospermia group. …”
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease
Published 2024-10-01“…METHODS A multidisciplinary approach was used to identify ceperognastat (LY3372689) as a potent OGA inhibitor, including an extensive discovery effort with synthetic chemistry, structure‐based drug design, and in vivo OGA enzyme occupancy studies. …”
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Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular...
Published 2025-06-01“…Moreover, functional and structural cerebral mechanisms involved are still poorly documented. …”
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The Attitude of Pregnant Women and Health Workers for Influenza Vaccination
Published 2017-02-01“…Influenza and ARVI - the main nosological form in structure of all infectious diseases. Influenza is especially dangerous to pregnant women. …”
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Association Analysis of <i>SLC11A1</i> Polymorphisms with Somatic Cell Score in Chinese Holstein Cows
Published 2025-05-01“…The bioinformatic analysis showed that these mutations affected the secondary and tertiary structure of <i>SLC11A1</i> mRNA, suggesting that they may affect gene expression or protein translation and function. …”
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