Highly selective HPK1 inhibitor NDI-101150 mediates immune cell activation and robust antitumor responses, distinct from immune checkpoint blockade by Samantha Carreiro, Christine Loh, Neelu Kaila, Fu-Shan Kuo, Scott Boiko, David N Ciccone, Joshua J McElwee, Peter J Tummino

“…Genetic HPK1 kinase inactivation or knockout in mice leads to immune cell activation and tumor growth suppression, providing a strong rationale for targeting HPK1 kinase activity as an immuno-oncology therapy.Methods A structure-guided drug design approach was used to identify a highly potent and selective small molecule inhibitor of HPK1 kinase activity, NDI-101150. …”
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Epidemiological Aspects of Monitoring the Sensitivity of <i>Staphylococcus aureus</i> Strains by N. Kh. Otamuratova, G. K. Abdukhalilova, D. R. Akhmedova, Yu. A. Tursunova

“…Conclusion. In the general structure of microorganisms of the hospital, Staphylococcus aureus strains prevailed (50%). …”
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Epigenetic Modifiers to Treat Retinal Degenerative Diseases by Evgenya Y. Popova, Lisa Schneper, Aswathy Sebastian, Istvan Albert, Joyce Tombran-Tink, Colin J. Barnstable

“…To extend our findings, we tested the hypothesis that this effect was due to altered chromatin structure by using a range of inhibitors of chromatin condensation to prevent photoreceptor degeneration in the rd10 mouse model. …”
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Dysphagia in pediatric intensive care unit patients (review) by I. A. Lisitsa, Yu. S. Aleksandrovich, A. N. Zavyalova, O. V. Lisovskii, S. A. Razumov

“…The review analyzes the causes, features of diagnosis and treatment of dysphagia in pediatric patients with PIСS. 5 groups of causes in the structure of PIСS that can lead to the development of dysphagia were considered: infectious-trophic, vegetative-metabolic, neuromuscular, emotional-cognitivecomplications and decreased quality of life compared to the premorbid level. …”
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First rangewide density estimate of the endemic and isolated Luangwa giraffe in Zambia by Catherine Sun, Frederike Otten, Rigardt Hoffman, Courtney Marneweck, Howard Maimbo, Charles-Albert Petre, Dusty Joubert, Tom Riffel, Matthew S. Becker, Stephanie Fennessy, Julian Fennessy, Michael B. Brown

“…However, sparse monitoring since the early 1900s has limited inferences about population size, structure, and range. To address this, we conducted the most spatially extensive and systematic survey to date of Luangwa giraffe across its distribution, extending survey effort 120 km south of their officially recognized extent. …”
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Identification and Analysis of the Plasma Membrane H⁺-ATPase Gene Family in Cotton and Its Roles in Response to Salt Stress by Cong Cheng, Fengyuan Zhang, Li Li, Zhiyong Ni

“…Chromosomal localization and collinearity analyses elucidated the distribution characteristics of this gene family within the cotton genomes. Gene structure and phylogenetic analyses demonstrated the conservation of this family across cotton species, whereas the examination of <i>cis</i>-acting elements in gene promoters highlighted their involvement in environmental stress and hormone response categories. …”
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Informational and analytical support of planning processes of marketing actions in high-speed trains by E. A. Makarova, K. V. Surzhin, S. S. Morozov, S. V. Muktepavel, I. N. Spesivtseva

“…The functionality created on the basis of ACS “Express” is a flexible system of reports that are formed at the user's request, allowing you to view information on the structure of passenger traffic with varying degrees of detail for compiling programs to stimulate demand and analyze its effectiveness.…”
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Clinical and epidemiological characteristic of chronic hepatitis C in the republic of Tyva by A. A. Saryglar, S. O. Dongak, A. D. Ibrohimova, K. E. Novak, E. V. Esaulenko

“…The clinical profile of typical patients with chronic hepatitis C was established; whose share in the total structure of the examined was 38.4%.  Conclusion: There is a tendency to reduce the incidence of chronic hepatitis C in the Republic of Tyva. …”
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Grassland bird nest ecology and survival in upland habitat buffers near wooded edges by Ross R. Conover, L. Wes Burger Jr., Eric T. Linder

“…Nest survival was influenced by among‐ and within‐season temporal effects and local vegetation structure, but not by buffer width. Nest success varied substantially between years and within seasons for dickcissel (12.9% and 19.1% early in the seasons of 2003 and 2004, respectively), but not for red‐winged blackbird (15.1%). …”
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EPIDEMIOLOGICAL ASPECTS THE INCIDENCE OF CANCER OF THE KIDNEY AND BLADDER IN PRIMORSKY KRAI by G. N. Alexeyeva, P. F. Kiku, V. G. Moreva, L. I. Gurina, M. V. Volkov, S. V. Yudin

“…The incidence of bladder cancer in men tended to rise from the continental bioclimatic zone to the coast in all ecological zones mainly due to differences in the structure of the bioclimate between the coast and continental areas of Primorsky Krai. …”
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DEVELOPMENT OF METHODS OF SIMULATION OF THE INTERACTION OF BIOLOGICALLY ACTIVE SUBSTANCES WITH THE ACTIVE CENTER OF ANGIOTENSIN-CONVERTING ENZYME by A. A. Glushko, A. S. Chiriapkin, V. S. Chiriapkin, A. M. Murtuzalieva, Yu. A. Polkovnikova

“…The obtained technique can be used for studying the interaction of substances, similar in structure to lisinopril with the active center of the enzyme (ACE).…”
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MITOCHONDRIAL DYSFUNCTION AS POSSIBLE CAUSE OF IMPAIRED FOLLICULAR DEVELOPMENT by A. A. Pozdnyakova, M. A. Volodina, S. J. Rshtuni, L. A. Marchenko, M. Yu. Vysokikh

“…On the other hand mitochondria play central role in intracellular signal transmission and maintain functional state and cellular structure of tissues, organs and systems of an organism controlling cell proliferation, differentiation and apoptosis. …”
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Genome-wide identification and expression profiling of the bZIP gene family in Chrysanthemum indicum and the functional analysis of CibZIP29 under cadmium stress by Shengyan Chen, Yin Zhang, Kaiyuan Zhang, Shuguang Liu, Yujia Yang, Xingnong Xu

“…Phylogenetic analysis grouped them into 12 subgroups, supported by conserved motifs, gene, and protein structure analyses. Tandem and segmental duplications were found to be key drivers of CibZIP gene family expansion, with Ka/Ks analysis indicating purifying selection of duplicated genes. …”
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The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of Stem Cells by Jianghong Xiang, Yihan Lai, Zuping He

“…By maintaining the chromatin loop structure, the cohesin complex is involved in DNA repair and gene transcription, which in turn controls the pluripotency, self-renewal, and differentiation of stem cells. …”
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Cross-species single-cell transcriptomic atlas of retinal photoreceptors reveals molecular signatures underlying color vision adaptation by Zhibin Li, Chengkai Yan, Yubao Lu, Yaqing Shu, Shilin Wu, Xi Cheng, Yuge Wang, Shishi Shen, Hui Yang, Gang Cao, Jianping Ji, Liangming Zhang, Jian Sun, Dongchang Xiao, Shasha Li, Wei Qiu

“…Summary: The retina exhibits conserved structural and functional features across species, yet the evolutionary mechanisms underlying color vision remain unclear. …”
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The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7 by Maya K. Gelbard, Miranda Grace, Annika von Schoeler-Ames, Ida Gnanou, Karl Munger

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Organic and Synthetic Substitutes in Tracheal Reconstruction: A Scoping Review (2015–2025) by Ana Caroline dos Santos, Guilherme Machado Holzlsauer, João Paulo Ruiz Lucio de Lima Parra, Raí André Querino Candelária, Thamires Santos da Silva, Rodrigo da Silva Nunes Barreto, Maria Angelica Miglino

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Post-conflict nutritional status of school-age children in North Wollo zone, Northeast Ethiopia: a multi-center cross-sectional study by Zelalem Dejazmach, Birtukan Gizachew Ayal, Woldeteklehaymanot Kassahun, Getinet Kumie, Muluemebet Kassa, Berihun Mulu Yayeh, Seada Seid Ahmed, Abebe Worku Gela, Habtu Debash, Selamawit Ayalew, Asmamaw Ameshe, Abebaw Alamrew, Mulu Shiferaw Asfaw, Sefineh Fenta feleke, Melese Abate Reta

“…Socio-demographic data was collected through a structured questionnaire, and anthropometric measurements were transformed into indices using the World Health Organization’s Anthro-software. …”
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Continuity of care in lumbar disc herniation: a systematic review and meta-analysis providing a deeper look into postoperative efficacy by Ying Lin, Ying Lin, Qiaoling Chen, Qiaoling Chen, RouMei Wang, Bing Zhang, Bing Zhang, Rui Huang, Yiguang Bai, Yiguang Bai

“…Continuity of care ensures seamless, coordinated, and high-quality management across healthcare transitions to optimize outcomes and reduce readmission risk. Insufficient structured postoperative care programs after diskharge may hinder recovery, lower quality of life, and increase complication risks.ObjectivesThis study aims to explore the significance of continuity of care in enhancing the recovery outcomes of patients with lumbar disk herniation post-surgery through a meta-analysis.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted an extensive search across several databases, including MEDLINE (PubMed), EMBASE, Web of Science, Google Scholar, CINAHL, EBSCO, Cochrane Library and Scopus, without restrictions on language or publication date. …”
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The contribution of personalized video feedback to robotic partial nephrectomy training in realistic 3D tumor kidney models: design, production and implementation by Ahmet Furkan Sarıkaya, Kayhan Tarım, Ersin Köseoğlu, Arif Özkan, İbrahim Can Aykanat, Baris Esen, Umut Can Karaarslan, Mustafa Müdüroğlu, Şevval Kanlı, Murat Can Kiremit, Yakup Kordan, Mevlana Derya Balbay, Tarık Esen, Serdar Aydın, Serdar Aydın, Abdullah Erdem Canda, Abdullah Erdem Canda

“…This suggests that structured preparatory training with objective performance targets can enhance learning outcomes in surgical simulation. …”
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