Loss of cadherin 17 downregulates LGR5 expression, stem cell properties and drug resistance in metastatic colorectal cancer cells by Ruben A. Bartolomé, Laura Pintado-Berninches, Javier Robles, Tania Calvo-López, Issam Boukich, Pablo Otero-Núñez, Jose Manuel Gonzalez-Sancho, J. Ignacio Casal

“…Loss of CDH17 resulted in a marked down-regulation of the intestinal cancer stem cell (CSC) marker LGR5, leading to the inhibition of Wnt/β-catenin signaling, suppression of pluripotency genes such as MYC, and a subsequent reduction in stemness properties. Treatment with CDH17/integrin blocking antibodies produced similar effects, decreasing both, LGR5 expression and Wnt signaling. …”
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Prognostic factors for stent restenosis in patients with coronary artery disease undergoing percutaneous coronary intervention by M. А. Meshkova, I. A. Starodubtseva, A. A. Pashkova

“…Elevated baseline Lp(a) values combined with VEGF and TGF-β levels in blood plasma indicates a high risk of stent restenosis, which may be new biomarkers for predicting the progression of coronary artery disease. …”
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Lupus nephritis serum induces changes in gene expression in human glomerular endothelial cells, which is modulated by L-sepiapterin: implications for redox-mediated endothelial dys... by Jim C Oates, Dayvia A Russell, Margaret Markiewicz, Justin P Van Beusecum, Sandra M Sanchez, Jeremy L Barth

“…More importantly, L-Sep modulates gene expression in a fashion consistent with reduction of oxidative stress and increased NO production. …”
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Inhibition of LINC00707/miR‐223‐3p/FKBP5 axis has a protective effect on diabetic kidney disease by Hongzhen Ye, Yiting Chen, Hong Xia, Lingbo Lv, Lijun Gao

“…Upon downregulating LINC00707, we observed an increase in cellular proliferative activity, alongside elevated levels of Podocin, Nephrin, and CD2AP. Concurrently, the reduction of LINC00707 was associated with decreased levels of MDA, as well as proinflammatory cytokines. …”
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Orexin A ameliorates HBV X protein-induced cytotoxicity and inflammatory response in human hepatocytes by Li Wang, Tao He, Baishun Wan, Xiaoqian Wang, Ling Zhang

“…When orexin A is added to the cells, it mitigates HBx-induced oxidative stress indicator 4-hydroxynonenal (4-HNE) and reactive oxygen species (ROS) as well the NADPH subunit NADPH oxidase 4 (NOX-4). …”
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Association Between Human Embryo Culture Conditions, Cryopreservation, and the Potential Risk of Birth Defects in Children Conceived Through Assisted Reproduction Technology by Romualdo Sciorio, Luca Tramontano, Giuseppe Gullo, Steven Fleming

“…Assisted reproduction technology (ART) has advanced significantly over the past four decades, leading to improved pregnancy outcomes and a reduction in complications, particularly those associated with multiple pregnancies. …”
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Phenolic profile and protective role of Calendula officinalis against molybdenum-induced toxiciy in Allium cepa by Fatih Kutluer

“…Molybdenum caused a multifaceted toxicity in Allium cepa; a decline in physiological development, a decline in germination percentage to 73%, accompanied by a significant reduction in root length and weight gain values in comparison to the control values. …”
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Melatonin attenuates thiocyanate-induced vasoconstriction in aortic rings by Alexander M. Prusa, Christian A. Plass

“…In rings which were preincubated with melatonin at a concentration of 360 pM, a 56.5% reduction of effect size could be achieved (4.09 ± 1.22 mN versus 9.41 ± 1.74 mN, P < 0.0001). …”
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Germinación y Desarrollo de Plántulas de Tres Híbridos de Maíz bajo Soluciones Osmóticas. V. Polietilenglicol by Jesús Rafael Méndez Natera, Faida Taimi Ybarra Pérez, José Fernando Merazo Pinto

“…The results indicated that polyethylene glycol 400 didn't differentiate resistance and/or tolerance to drought (water stress) among the three corn cultivars evaluated   …”
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Productivity and adaptability parameters of triticale for green feed in the steppe part of the Rostov region by A. V. Krokhmal’, E. A. Gordinskaya, N. I. Barulina

“…By this period stem reduction of the varieties ‘Tornado’, ‘Styuard’, ‘Ariozo’ and ‘Bemol 20’ was 13–16 %, that of the varieties ‘Argo’ and ‘Agraf’ 26 % and 4 % respectively. …”
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Impact of set configurations on hemodynamics, cardiac autonomic, and metabolic responses by Carlos Brendo Ferreira Reis, Victor Hugo Gasparini-Neto, Lucas Rangel Affonso de Miranda, Leticia Nascimento Santos Neves, Eliseo Iglesias-Soler, Nuno Manuel Frade de Sousa, Luciana Carletti, Richard Diego Leite

“… Introduction: Isometric exercise (IE) can be used as a non-pharmacologic treatment for blood pressure (BP) reduction. However, the effect of IE set configuration with impulse-to-rest ratio equated on hemodynamic, autonomic, and metabolic responses need to be clarified. …”
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Comportement social du porc domestique et son importance pour le bien-être animal en élevage by Caroline CLOUARD-MÉSANGE

“…Pourtant, leur prévalence est bien plus élevée que celle des comportements agonistiques, et ils seraient impliqués dans de nombreux processus biologiques, comme la reconnaissance et la communication sociale, l’affinité ou la réduction du stress. En favorisant des états mentaux positifs, ces comportements pourraient être d’une importance capitale pour le maintien du bien-être des porcs en élevage, et il est nécessaire de mieux comprendre leurs fonctions et déterminants. …”
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Research on optimization method for excavation sequence of deep chamber groups by ZANG Jincheng, LI Donghao, ZHANG Lu, SUN Lingfeng, HUANG Yubing

“…The weighted total score of Scheme 3 was 11， and the cumulative deformation increment of all chambers was 178 mm， representing a 30.26% reduction in excavation interference compared to the least optimal scheme. …”
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Impact of synthetic and herbal dyes on photosynthesis and ROS scavenging enzyme activities in Spirodela polyrhiza by Vineet Soni, Upma Bhatt, Pooja Tailor, Reto J. Strasser

“…At 2.5 g/L SC, a 94.18% reduction in trapped energy flux (TR₀/CSm) and a 96.1% decline in electron transport rate (ET₀/CSm) were observed, along with a significant decrease in chlorophyll content. …”
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Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1. by Andoria Tjondrokoesoemo, Ki Ho Park, Christopher Ferrante, Shinji Komazaki, Sebastian Lesniak, Marco Brotto, Jae-Kyun Ko, Jingsong Zhou, Noah Weisleder, Jianjie Ma

“…The mean frequency of osmotic stress induced Ca²⁺ sparks was reduced in shRNA-Bin1, indicating compromised DHPR activation. …”
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Trimetazidine MB treatment in patients with chronic heart failure by T. E. Morozova, E. I. Ivanova

“…After 16 weeks of the treatment, clinical improvement and CHF FC reduction were observed in 28 % and 26 % of the patients from Groups I and II, respectively. …”
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Effect of cultivation feed diet using local food processing by-products on the growth and flavor factor in the Malabar grouper Epinephelus malabaricus by Makoto Takahashi, Shingo Udagawa, Chihiro Yamauchi, Yoshimi Imura, Taekyoung Seong, Akihiro Takemura

“…However, liver histology revealed no signs of metabolic stress, and IGF-1 gene expression levels were higher in the FW-D group, indicating active growth signaling. …”
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Occupational violence against nursing staff in the surgical wards of Murzuq locality hospitals, Libya (2024) by Eltagi Elsadeg Sulliman Rahama, Mohammed Elmadani, Malak Mokhtar Mohammed, Zainab Ali Osman Eqrer

“…The variables included demographic data (gender, experience) and information on violence types, sources, impacts, and reduction strategies. The data were analysed via SPSS v27, with descriptive statistics applied. …”
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Therapeutic aspects of hormone replacement therapy in postmenopausal women with metabolic syndrome: cardiologist’s opinion by T. V. Adasheva, V. S. Zadionchenko, O. N. Poryvkina, O. Yu. Demicheva, T. M. Terekhova, M. A. Mironova

“…The therapy was associated with MC improvement and BP reduction. The medication demonstrated cardioprotective and antioxidant activity.…”
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Drosophila melanogaster inhabiting northern regions of European Russia are infected with Wolbachia which adversely affects their life span by N. V. Roshina, A. V. Symonenko, A. V. Krementsova, Е. A. Tsybul’ko, V. E. Alatortsev, E. G. Pasyukova, D. V. Mukha

“…The infection rate varied from year to year showing a tendency to reduc­tion, its overall level being within the range previously observed in other habitats. …”
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