Revitalising terraced landscapes: Co-production of ecosystem services for sustainable futures by Christos Zoumides, Adriana Bruggeman, Hakan Djuma

“…We examine the use of advanced biophysical assessments, mapping tools, and stakeholder-driven approaches to enhance field assessment, monitoring capabilities and tackle management challenges under changing socio-economic conditions. We stress the urgent need for education and capacity-building initiatives to counteract indigenous knowledge loss and sustain traditional practices. …”
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Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats by Peng Li, Geng-Rong Chen, Fu Wang, Ping Xu, Li-Ying Liu, Ya-Ling Yin, Shuang-Xi Wang

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Myopia Progression Risk: Seasonal and Lifestyle Variations in Axial Length Growth in Czech Children by Stepan Rusnak, Vaclav Salcman, Lenka Hecova, Zdenek Kasl

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Emotional Exhaustion in University Teachers: Contributing Aspects and Mediating Mechanisms by Alejandra Trillo, David Ortega-Jiménez, Karina Ocampo-Vásquez, Marina R. Ramírez, Tatiana Mansanillas, Francisco D. Bretones

“…Nowadays, employees in the higher education sector are faced with an increasingly demanding environment, which can lead to high levels of stress and emotional exhaustion. …”
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Caregiving for people with dementia in a rural context in South Africa by Thavanesi Gurayah

“…Services that would alleviate caregiver burden are education, caregiver training, a financial grant and respite care. …”
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Psychiatric aspects of spondyloarthritis by T. A. Lisitsyna, D. Yu. Veltishchev, E. L. Nasonov, A. M. Lila

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M.U.P.S (Medically Unexplained Physical Symptoms): Is the Accurate Diagnosis Necessary for the Rehab-Team? by Avi Ohry, Atzmon Tsur

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Laser powder bed fusion of a novel high-strength Al–Mg–Er–Zr-Sc alloy: Process, microstructure, and performance by Zhengjiang Gao, Hui Li, Teng Ma, Huan Yang, Wei Wang, Wu Wei, Hui Huang, Shengping Wen, Zuoren Nie

“…Both of keyholes caused by excessive energy input and unfused defects caused by insufficient energy input will decrease alloy density and induce stress concentration, resulting in a reduction in elongation. …”
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Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase by Iva Bozic, Danijela Savic, Marija Jovanovic, Ivana Bjelobaba, Danijela Laketa, Nadezda Nedeljkovic, Mirjana Stojiljkovic, Sanja Pekovic, Irena Lavrnja

“…Our results imply that low-dose ribavirin may alleviate nitrosative stress during neuroinflammation.…”
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Restoration of 3-dimensional aortic hemodynamics after the Ross procedure for unicuspid aortic valve disease using 4-dimensional flow magnetic resonance imagingCentral MessagePersp... by Andrew Zbihley, BA, Anthony Maroun, MD, Justin J. Baraboo, BS, Ethan Johnson, PhD, Meilynn Shi, BA, Bradley D. Allen, MD, Michael Markl, PhD, S. Chris Malaisrie, MD, Christopher K. Mehta, MD

“…Systolic peak velocity (PV), wall shear stress, and viscous energy loss (EL) of each MRI were assessed and compared. …”
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Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis by Xize Wu, Yuxi Huang, Jiaqi Ren, Xue Pan, Qiuying Wu, Qicheng Cai, Ruiying Wang, Teng Feng, Shan Gao, Bo Wang, Meijia Cheng, Meijia Cheng, Yue Li, Lihong Gong

“…A nomogram for predicting AS risk was constructed incorporating the expression levels of these five validated Hub genes. …”
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Dicalcium Silicate Induced Proinflammatory Responses through TLR2-Mediated NF-κB and JNK Pathways in the Murine RAW 264.7 Macrophage Cell Line by Shixiang Lai, Liangjiao Chen, Wei Cao, Shiman Cui, Xingyang Li, Wenchao Zhong, Mingyu Ma, Qingbin Zhang

“…When we added siRNA-TLR2-1, a significant reduction was observed. These findings support the theory that C2S particles induce proinflammatory responses through the TLR2-mediated NF-κB and JNK pathways in the murine RAW 264.7 macrophage cell line.…”
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Exploring biochemical responses and cellular adaptations of Chlorella sorokiniana to polyethylene microplastic exposure by Jyoti Rawat, Pooja Bhatnagar, Abhilasha Mishra, Manisha Nanda, Prateek Gururani, Afzal Hussain, Mikhail S. Vlaskin, Sanjay Kumar, Monu Verma, Hyunook Kim, Vinod Kumar

“…Under the MP stress, reactive oxygen species (ROS) and phenolic levels were reduced, whereas flavonoid content increased. …”
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SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction by Ying Yang, Longlong Zheng, Jiaxing He, Tao Wu, Haicheng Yang, Bo Zhang, Shuai Zhou, Yueyue Lu, Xianli He, Jibin Li, Nan Wang

“…In the present investigation, we observed a significant reduction in SLC44A2 expression in colorectal cancer (CRC), and low SLC44A2 expression was closely associated with poorer survival of CRC patients. …”
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THE ROLE OF GENETICALLY DETERMINED BODY RESISTANCE OF WARM-BLOODED ANIMALS TO HYPOXIA IN THE REALIZATION OF EFFECTOR FUNCTIONS OF NEUTROPHILS IN THE MODEL OF ADJUVANT-INDUCED RHEUM... by Elena Georgievna Pukhaeva, Alibek Kirilovich Badtiev, Fatima Elbrusovna Salamova, Stanislav Georgievich Dzgoev, Alina Muratbekovna Kupeeva

“…Given that human and animal populations are genetically heterogeneous in terms of the body's resistance to oxygen deficiency, the modern approach to predicting and treating diseases associated with impaired immune regulation requires taking into account the role of hypoxia in the implementation of pathogenetic mechanisms of inflammation. …”
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Effect of extreme pH levels on early larval stages of the Pacific abalone (Haliotis discus hannai Ino, 1953) by Dian Yuni Pratiwi, Irfan Zidni, Mi-Jin Choi, Young Dae Oh, Tae Min Kim, Han Kyu Lim

“…However, at 30 hpf, a significant reduction in the oxygen consumption rate was observed only at pHs 9 and 10 (p < 0.05). …”
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<i>Colletotrichum capsici</i>-Induced Disease Development in Postharvest Pepper Associated with Cell Wall Metabolism and Phenylpropanoid Metabolism by Yunfen Liu, Qian Song, Feilong Yin, Yuanli Liang, Mubo Song, Meiying He, Liang Shuai

“…These insights highlight the need for early intervention strategies to mitigate postharvest losses by targeting pathogen-induced stress responses and cell wall integrity preservation.…”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Gut microbiome and metabolome interactions in Crohn’s disease: mechanistic insights into exclusive enteral nutrition-induced remission by Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Quan Zhou, Quan Zhou, Mengli Xue, Mengli Xue, Mengli Xue, Mengli Xue, Xing Yu, Xing Yu, Xing Yu, Xing Yu, Xue’e Chen, Xue’e Chen, Xue’e Chen, Xue’e Chen, Jintong Chen, Jintong Chen, Jintong Chen, Jintong Chen, Chengdang Wang, Chengdang Wang, Chengdang Wang, Chengdang Wang

“…Importantly, EEN therapy was associated with a reduction in oxidative stress and an improvement in gut barrier function.ConclusionThis study comprehensively integrates microbiome and metabolome analyses, providing new insights into the mechanism of action of EEN therapy in CD. …”
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Implications of thermal stratification and radiative heat flux in blood-based ternary and dihybrid nanomaterial flow through a stretchable cylinder by Muzher Saleem, Ghada A. Khouqeer, Fazal Haq, Naglaa AbdelAll, Arshad Hussain, Mohammed Sallah

“…A reduction of 4 % in the skin friction coefficient of THNF compared to HNF is noticed. …”
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