Integrated bioinformatics and experimental validation identify lysosome and immune infiltration-related genes as therapeutic targets in late-onset major depressive disorder by Jian-Zhen Hu, Yao Gao, Xiao-Na Song, Dan Wang, Xin-Zhe Du, Xiao Wang, Xiao-Dong Hu, Sha Liu

“…The changes in the expression of selected genes were confirmedthrough a chronic unpredictable mild stress model. The ITCM database predicted small molecule drugs targeting lysosome-relatedgenes. …”
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The role of the Mediterranean Diet in preventing the development and complications of lifestyle diseases – a Review by Alicja Kapciak, Julia Górny, Rafał Kaczorowski, Aleksandra Pelczarska, Michał Janiszewski, Marcin Komorowski, Tomasz Forenc, Jaromir Hunia, Jonasz Jurek

“…Particular attention is given to its effects on weight loss, improvements in glycemic markers, reductions in low density lipoproteins (LDL) cholesterol levels, and blood pressure control. …”
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes by Tiffany K. Miles, Tiffany K. Miles, Angela K. Odle, Stephanie D. Byrum, Stephanie D. Byrum, Stephanie D. Byrum, Alex N. Lagasse, Anessa C. Haney, Victoria G. Ortega, Ashley K. Herdman, Melanie C. MacNicol, Melanie C. MacNicol, Angus M. MacNicol, Gwen V. Childs

“…Ingenuity Pathway Analysis indicated that the DEGs included targets of critical upstream regulators important for pituitary cell function and plasticity (CREB, Fox01, cAMP, STAT3, insulin, TRH, GnRH, and leptin signaling pathways), with most pathways predicted to be downregulated by the HFD. Unlike controls, HFD-fed mutant cell populations exhibited DEGs consistent with the downregulation of translational regulatory pathways. …”
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Experimental and Explicit FE Studies on Flexural Behavior of Superposed Slabs by Qi Ye, Ping Zhang, Ke Ye, Wei Wang, Zeshen Li, Yueqing Gao, Tianyu Xie, Chaofeng Liang

“…The FE simulations accurately predicted the flexural performance, with maximum deviations of 8.9% for the yield load and 6.5% for the ultimate load. …”
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Identification of Quality-Related Genomic Regions and Candidate Genes in Silage Maize by Combining GWAS and Meta-Analysis by Yantian Lu, Yongfu Ding, Can Xu, Shubin Chen, Chunlan Xia, Li Zhang, Zhiqing Sang, Zhanqin Zhang

“…Furthermore, enrichment analysis predicted 300 and 5669 candidate genes through GWAS and meta-analysis, respectively, highlighting pathways such as cellular metabolism, the biosynthesis of secondary metabolites, ribosome function, carbon metabolism, protein processing in the endoplasmic reticulum, and amino acid biosynthesis. …”
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Pupil responses to social stimuli are associated with adaptive behaviors across the first 24 months of life by Rebecca Grzadzinski, Raymond S. Carpenter, Josh Rutsohn, Alapika Jatkar, Kattia Mata, Ambika Bhatt, Maria M. Ortiz-Juza, Madison R. Dennehey, Donna Gilleskie, Jed T. Elison, Nicolas Pégard, Jose Rodriguez-Romaguera

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Impact of Co-Occurring Psychiatric Comorbidities and Substance Use Disorders on Outcomes in Adolescents and Young Adults with Opioid Use Disorder: A Retrospective Cohort Study by Ligang Liu, Erin R. McKnight, Andrea E. Bonny, Heqing Tao, Pujing Zhao, Milap C. Nahata

“…Depression (<i>p</i> = 0.04), post-traumatic stress disorder (<i>p</i> = 0.002), and alcohol use disorder (<i>p</i> = 0.04) were associated with prolonged retention, whereas cannabis use disorder predicted shorter retention (<i>p</i> = 0.02). …”
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Investigation of nepetolide as a novel lead compound: Antioxidant, antimicrobial, cytotoxic, anticancer, anti-inflammatory, analgesic activities and molecular docking evaluation by Tanzeel ur Rehman, Arif-ullah Khan, Azar Abbas, Javid Hussain, Farman Ullah Khan, Kimberly Stieglitz, Shamsher Ali

“…Enhanced hydrogen bonding was predicted with Autodock showing 6–8 hydrogen bonds per target. …”
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Dynamic analysis of the water, food, and energy nexus in minab county: An integrated approach to sustainable water resource management in hormozgan province by Mahdiye Amani, Maryam Omidi Najafabadi, Seyed Mehdi Mirdamadi, Ali Mohammadi Torkashvand

“…Conversely, tomatoes demonstrate the highest economic water productivity at 0.0408 USD/m³, reflecting their high market value and economic importance. Scenario analyses predict an 80 % decline in water security and a 32 % increase in energy demand under projected population growth. …”
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Association between circulating Klotho levels and hypertension: insights from NHANES, Mendelian randomization, and an Asian cohort by Yu Fu, Mengling Peng, He Cai, Yaoting Zhang, Bing Li, Yang Zheng

“…The MR analysis yielded no evidence of a causal association between genetically predicted Klotho levels and hypertension risk (IVW OR = 1.005 [95% CI: 0.999–1.011], p = 0.09). …”
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Determinants of Behavioral Intention and Compliance Behavior Among Transportation Network Vehicle Service Drivers During the COVID-19 Pandemic by Ma. Janice J. Gumasing

“…In turn, behavioral intention strongly predicts compliance behavior (β = 0.643, <i>p</i> < 0.001), confirming its mediating role in linking influencing factors to actual adherence. …”
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Systematic regulation of immune checkpoint molecules by redox regulators CNC-bZIP transcription factors by Haoming Ning, Qiufang Yang, Yonggang Ren, Lu Qiu

“…Abstract Background Although oxidative stress is strongly connected to the initiation and progression of cancer, the underlying molecular pathways remain unknown. …”
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Social Media Suicide Watch by Katherine Prothro

“…Ethical Analysis The strongest argument in favor of apps like Samaritan’s Radar is their potential to predict individuals at risk for suicide and self-harm accurately. …”
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Examining Trauma Cognitions as a Mechanism of the BRITE Intervention for Female-Identifying Individuals with PTSD Symptoms and Alcohol Misuse by Elizabeth A. Lehinger, Molly Joseph, Antoine Lebeaut, Scott Graupensperger, Debra Kaysen, Michele A. Bedard-Gilligan

“…Trauma cognitions have been widely supported as a mechanism of change in post-traumatic stress disorder (PTSD) treatment. Less is known about the mediating role of trauma cognitions in early interventions addressing PTSD symptoms and co-occurring conditions such as alcohol misuse. …”
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Channelization and flow depletion shift benthic macroinvertebrate and fish communities in urban rivers. by Shufeng Chen, Changcheng Guo, Xu Wang, Yalin Wu, Yidong Wang, Yinhua Wang, Hongyu Guo

“…Aquatic ecosystems worldwide are increasingly affected by human activities, with urbanization representing a major source of environmental stress. Channelization and flow depletion are key stressors in urban aquatic ecosystems. …”
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Germinación y Desarrollo de Plántulas de Tres Híbridos de Maíz bajo Soluciones Osmóticas. IV. Manitol by Jesús Rafael Méndez Natera, Faida Taimi Ybarra Pérez, José Fernando Merazo Pinto

“…The -6 bars OP created with mannitol is suggested to screen corn cultivars for tolerance to water stress. …”
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From prevention to management: Exploring the impact of diet on multiple sclerosis by Koukach Dalya, Aljumaily Maryam, Al-Attiyah Noora, Al-Amer Rawdhah, Attia Yasmine, Tayyem Reema

“…Among these, Mediterranean and plant-based diets have shown the most consistent benefits, including reductions in fatigue, improved quality of life, and modulation of inflammatory markers. …”
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Multi-objective optimization of an origami inspired super-expandable scaffold for distraction osteogenesis by MA Bagheri, CE Aubin, ML Nault, I Villemure

“…A Bayesian machine learning platform was used to predict key structural and mechanical properties influencing bone regeneration, followed by multi-objective optimization. …”
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Identification of bioaccessible and neuroprotective peptides from fermented casein hydrolysate by Ruirui Li, Shufang Shan, Yujie Xu, Jingyuan Xiong, Guo Cheng

“…We performed molecular docking against Kelch-like ECH-associated protein 1 (Keap1) to predict potential bioactive peptides and validated the predicted effects in BV2 microglial cells induced by LPS. …”
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Estimation of Longitudinal and Transverse Elastic Moduli of Native Brazilian Woods by Static Bending Tests by Fabricio da Silva Aguiar, Guilherme dos Santos Silva, Herisson Ferreira dos Santos, Elvys Dias Reis, Francisco Antonio Rocco Lahr, André Luis Christoforo

“…The results showed that, for L/h ratios below 18, the apparent modulus of elasticity was significantly affected by shear effects, exhibiting reductions of up to 18.47%. The E/G ratio ranged from 14.84 to 21.15, corresponding to a reduction of up to 7% and an increase of up to 32%, respectively, about the value proposed by ABNT NBR 7190-1 (2022). …”
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