Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Creep constitutive model of strain energy density considering the whole process of creep deformation. by Yuemei Li

“…The continuous medium strain energy theory is used to analyze the sudden change process of creep macroscopic mechanical behavior, and the critical strain energy density value is defined as the control parameter to predict the occurrence time of accelerated creep. …”
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Genome-wide study and expression analysis of soybean ERF transcription factors and overexpression of GmERF205 enhances drought resistance in soybean by Nan Wu, Yongqi Feng, Tao Jiang, Zhaobo Li, Yulan Liu, Minghao Yuan

“…Furthermore, we predicted that this transcription factor would be localized in the nucleus, a hypothesis that was confirmed by subcellular localization experiments. …”
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Machine Learning for the Photonic Evaluation of Cranial and Extracranial Sites in Healthy Individuals and in Patients with Multiple Sclerosis by Antonio Currà, Riccardo Gasbarrone, Davide Gattabria, Nicola Luigi Bragazzi, Giuseppe Bonifazi, Silvia Serranti, Paolo Missori, Francesco Fattapposta, Carlotta Manfredi, Andrea Maffucci, Luca Puce, Lucio Marinelli, Carlo Trompetto

“…Classification models achieved perfect performance (accuracy = 1.00), and cortical site regression models showed strong predictive power (EDSS: R²_CV = 0.980; FSS: R²_CV = 0.939). …”
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Is L‐Arginine an Appropriate Alternative for Conventional Anti‐Atherosclerotic Therapy?: A Comprehensive Review by Ali Mortezaei, Mohammad Ghorbani, Bardia Hajikarimloo, Omar Sameer, Toba Kazemi, Ebrahim Salavati, Mohsen Hamidpour, Mohammad Esmail Gheydari

“…Results L‐Arg supplementation has shown promising effects on NO production, improving endothelial function and reducing oxidative stress in preclinical models. Clinical studies have indicated moderate improvements in vascular health markers, including reductions in inflammation and oxidative stress, although results have varied across studies. …”
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PO32 | Effect of the sodium-glucose co-transporter-2 (SGLT2) inhibitors on platelet activation and lipid peroxidation: results of a pilot study

“…Results: In patients treated with gliflozins, we observed significant reductions markers of platelet activation and oxidative stress: 11-dehydro-TXB2 (p=0.032) (Figure 1, panel A), 8-iso-prostaglandin (PG)F2α (p=0.026) (Figure 1, panel B). …”
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Nature-based virtual reality relaxation to improve mental health and sleep in undergraduate students: A randomized controlled trial by Junggeun Ahn, Jiu Kim, Youngeun Park, Riah Kim, Heeseung Choi

“…The VR intervention group showed significant reductions in perceived stress levels ( p  = .001) and improvements in subjective sleep patterns ( p  = .046), with these effects sustained at follow-up. …”
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Exploring ribosome biogenesis in lung adenocarcinoma to advance prognostic methods and immunotherapy strategies by Zipei Song, Yuheng Wang, Miaolin Zhu, Pengpeng Zhang, Zhihua Li, Xin Geng, Xincen Cao, Jianan Zheng, Jianwei Tang, Liang Chen

“…Compared to other prognostic models, RBS demonstrated superior performance in prognosis prediction. The low-RBS group exhibited a tumor microenvironment (TME) more favorable for efficient immune monitoring and reaction, higher responsiveness to immunotherapy, and a better prognosis. …”
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“I became alright after birth”: Mechanisms driving improvements in mental health symptoms in the postpartum transition among persons at risk for HIV in South Africa by Katherine E. Kabel, Jane H. Lee, Jennifer N. Githaiga, Linda Gwangqa, Madison R. Fertig, Lauren R. Gulbicki, Maria J. Bustamante, Lucia Knight, Conall O’Cleirigh, Christina Psaros, Amelia M. Stanton

“…Background: Pregnant and postpartum persons (PPPs) are at increased risk for HIV acquisition, and depression and posttraumatic stress disorder (PTSD) negatively impact engagement in HIV prevention behaviors like pre-exposure prophylaxis (PrEP) use, thereby increasing risk. …”
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Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer by Florian Uhlitz, Philip Bischoff, Stefan Peidli, Anja Sieber, Alexandra Trinks, Mareen Lüthen, Benedikt Obermayer, Eric Blanc, Yana Ruchiy, Thomas Sell, Soulafa Mamlouk, Roberto Arsie, Tzu‐Ting Wei, Kathleen Klotz‐Noack, Roland F Schwarz, Birgit Sawitzki, Carsten Kamphues, Dieter Beule, Markus Landthaler, Christine Sers, David Horst, Nils Blüthgen, Markus Morkel

“…Experimental targeting of EGFR‐BRAF‐MEK in cancer organoids affected signaling and gene expression contingent on predictive KRAS/BRAF mutations and induced cell plasticity overriding default developmental trajectories. …”
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The impact of ride hailing on parking (and vice versa) by Alejandro Henao, Wesley E. Marshall

“…This includes building a classification tree-based model to predict the replaced driving trips as a function of car ownership, destination land type, parking stress, and demographics. …”
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Analysis and Case Study of Internal Forces in Nut Column Transmission System of Shiplifts by WANG Di, LIAO Le-kang, JIN Liao

“…Moreover, except for axial force, all other internal forces in the adjustment beam exceeded those in the nut column, providing critical insights for structural optimization. (4) Stress comparison: Calculated stress values, though slightly exceeding experimental results, remained within allowable stress limits, demonstrating the rationality of the current design. …”
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Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures by Nicholas A Graham, Aspram Minasyan, Anastasia Lomova, Ashley Cass, Nikolas G Balanis, Michael Friedman, Shawna Chan, Sophie Zhao, Adrian Delgado, James Go, Lillie Beck, Christian Hurtz, Carina Ng, Rong Qiao, Johanna ten Hoeve, Nicolaos Palaskas, Hong Wu, Markus Müschen, Asha S Multani, Elisa Port, Steven M Larson, Nikolaus Schultz, Daniel Braas, Heather R Christofk, Ingo K Mellinghoff, Thomas G Graeber

“…Using a pan‐cancer analysis of CNA data from patient tumors and experimental systems, here we show that principal component analysis‐defined CNA signatures are predictive of glycolytic phenotypes, including 18F‐fluorodeoxy‐glucose (FDG) avidity of patient tumors, and increased proliferation. …”
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Effect of legacy and emerging pollutants on genome-wide methylation patterns in black hake (Merluccius polli) natural populations by Carmen Blanco-Fernandez, María Bobes-Villa, Ainhoa López, Daniel Menéndez, Kathryn R. Elmer, Eva Garcia-Vazquez, Gonzalo Machado-Schiaffino

“…Elevated Pb was significantly associated with a reduction in hake condition factor. Differentially methylated loci were associated with diverse pathways associated to responses for all pollutants (e.g. immune response, gene expression regulation), pointing to signs of stress within the population. …”
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Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma by Qi Wang, Juan Liu, Ming Yang, Jun Zhou, Yaxuan Li, Jingjing Zheng, Hao Jia, Shuhua Yue, Yinpeng Le, Yuxin Su, Wenrui Ma, Ni An, Yunfang Wang, Jiahong Dong

“…The secretory nature of AKR1B1 not only underscores its predictive value but also facilitates the intercellular transmission of drug resistance. …”
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Effects of supercritical CO2, water, and supercritical CO2-based water on the mechanical properties and fracturability of shale by Qiao Lyu, Jinghong Deng, Yijun Shen, Yonggang Ding, Yushuai Shi, Gan Feng, Jingqiang Tan

“…The key findings are as follows: (1) Uniaxial compressive strength (UCS) of shale decreased by 10.72%, 11.95%, and 23.67% at 15 MPa, and by 42.40%, 46.84%, and 51.65% at 45 MPa after immersion in ScCO2, DW, and ScCO2+DW, respectively, with the most pronounced effect observed in ScCO2+DW; (2) Microstructural analysis revealed that while ScCO2 and DW do not significantly alter the microstructure, immersion in ScCO2+DW results in a more complex surface morphology; (3) Acoustic emission (AE) analysis indicates a reduction in stress for crack damage, with a decreased fractal dimension of AE signals in different fluids. …”
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Relationship between Professional Self-Concept with Intention to Leave, and Professional Quality of Life among Psychiatric Nurses by Sajjad Javanbakht, Mohammad Pourebrahimi, Mohammad Saatchi, Zahra Tamizi, Reza Ahmadi Jirandeh, Mobina Sanaeipour, Mohammadjavad Hosseinabadi-Farahani

“…Professional self-concept was the only predictor of compassion satisfaction and secondary trauma stress. Burnout was predicted by both professional self-concept and satisfaction with salary. …”
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Transformation of Ukrainian students’ attitudes toward wheelchair users amid the Russian-Ukrainian war by Andriej Szpakow, Krystyna Kowalczuk, Yuliia Antonova-Rafi, Igor Khudetskyy, Oryna Detsyk, Olga Fedortsiv, Oksana Hdyrya, Andriy Bazylevych, Liudmila Vilchynskaya

“…The increase in positive emotions, reduction in tension, stress, helplessness, and shame indicate an improvement in mental well-being. …”
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Reprotoxicity of zinc oxide nanoparticles synthesized with Crataegus monogyna leaves extract: testis and sperm function by F. REMITA, A. TALBI, C. ABDENNOUR, K. KHELILI, Y. BEDOUH, F. HAMOUD, F. DUMAN, Z. BOUSLAMA, R. ROUABHI, M. R. DJEBAR

“…Compared to the control, ZNP1 has a significant reduction of testicular and epididymis weights, sperm concentration, live sperm, motility, VCL, VSL, VAP, LIN, and BCF, with a significant increase of MDA and a significant decrease of GSH levels. …”
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Impact of terminal ileal microbiota dysbiosis and tryptophan metabolism alterations on mental disorders in patients with Crohn’s disease by Yin Lin, Fang-Tao Wang, Kai Xia, Ren-Yuan Gao, Yi-Ran Jiao, Min Fang, Chun-Qiu Chen

“…Results CD patients with MD showed a significant reduction in microbial diversity within the ileal mucosa. …”
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