Editorial: The pharmacological effects and mechanisms of drugs against human diseases by modulating redox homeostasis - volume II by Xiaofang Zhang, Xiaofang Zhang, Ming Xu, Zhihao Liu, Luchen Shan

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Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes’ expression and upregulating Nrf2/Heme oxygenase-1 by Yasmin Mahran, Amira M. Badr, Sheka Aloyouni, Manal Mubarak Alkahtani, Wedad S. Sarawi, Rehab Ali, Deema Alsultan, Sarah Almufadhili, Dalia H. Almasud, Iman H. Hasan

“…Cisplatin-induced testicular damage is primarily driven by oxidative stress and inflammation. Ferroptosis has recently been identified to contribute to cisplatin-testicular toxicity. …”
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Gut microbiota contributes to polystyrene nanoplastics-induced fetal growth restriction by disturbing placental nicotinamide metabolism by Yijing He, Qiao Li, Qinfeng Sun, Heran Li, Tianhang Yu, Miaoyu Chen, Genkui Zhang, Biao Zhang, Weihan Wang, Shiqiang Ju

“…Specifically, PS-NPs exposure observably reduced the levels of nicotinamide (NAM) and nicotinamide adenine dinucleotide (NAD+) in the placenta, resulting in decreased ATP production, increased oxidative stress and ferroptosis. Meanwhile, PS-NPs disrupted the maternal gut microbiome, specifically manifested as a reduction in Lactobacillus levels and abundances of norank_f_Muribaculaceae, Turicibacter, Alloprevotella, Parabacteroides and Ruminococcus. …”
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Genotoxic effects of green-synthesized silver nanoparticles on human lymphocytes by Juana Sánchez-Alarcón, Mirta Milić, Stefano Bonassi, María Isabel Álvarez Núñez, Guillermo Alejandro Higareda Campos, Eder José Ordoñez-Frías, Rafael Valencia-Quintana

“…The green-synthesized AgNPs were produced through a green reduction method using silver nitrate (AgNO₃, Reasol®, 99.98% purity) and green tea infusions (Lagg’s®), with synthesis monitored by colorimetry. …”
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Antioxidant supplementation boosts the advantages of CrossFit workouts on oxidative and muscle damage markers in obese males by Morteza Nemati, Neda Bozorgtabar, Maha Hoteit, Zahra Sadek, Abdullah Almaqhawi, Ali Rashidy-Pour, Nematollah Nemati, Mohammad Rashidi, Niloofar Karimi, Mitra Khademosharie, Reza Bagheri, Ayoub Saeidi, Maisa Hamed Al Kiyumi, Katie M. Heinrich, Hassane Zouhal

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Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgeni... by Nan Zhang, Zongyuan Zhao, Xiaoxiao Chen, Hanbing Yao, Min Zhu, Shuqing Ma, Hui Wang, Xianghong Yin, Ying Zhou, Chenfei Zheng, Jianmin Li, Jingye Pan, Kaicheng Wang, Bin Yang, Yunting Wang, Junming Fan, Yongsheng Gong, Rong Liu, Jing Zeng, Xiaofang Fan, Yangping Shentu

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Integrated analysis of transcriptome and proteome provides novel insights into the response mechanisms of maca (Lepidium meyenii Walp.) to UV-B radiation by Zaihang Yu, Xueting Zhong, Li Xiao, Yuxi Cai, Ke Shen, Yu Luo, Xinxin Li, Hong Xu, Zihan Chen, Xiaomei Wang, Yi Wu, Yajun Wang, Wei Fan, Zhanqi Wang

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Survey of workplace stressors among Hungarian elite athletes by Viktória Resperger, Anikó Kapros, Tamás Berki, Tamás Berki

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Mental stress due to poor organizational climate and high work commitment as predictor of 10-year registered sickness absence: a cohort study based on The Population Study of Women... by Marit Knapstad, Lauren Lissner, Cecilia Björkelund, Kristina Holmgren

“…The aim of this study was to examine whether perceived work-related stress, measured by The Work Stress Questionnaire (WSQ), predicted registered sickness absence up to 10 years later in a general working population of women.Design A survey-linkage study based on the 2004–2005 wave of the Swedish ‘Population Study of Women in Gothenburg (PSWG)’ and 10-year follow-up in the official MiDAS sickness absence register.Subjects A population-based cohort of women aged 38 and 50 in 2004/2005 were invited (participation rate 59%). …”
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Study on the pharmacological effects and active compounds of Apocynum venetum L. by Xiu Yi, Wang SiYi, Yu Jiaqi, Jing Lijia, Guo Na, Jiao Yuzhi, Zhai Weiwei, Li Xiaomao

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Nickel hydroxide nanosheet interacts with nitric oxide to stimulate glycolytic pathway, nutrient assimilation and defense system against arsenic toxicity in wheat by Sarika Kumari, Pravneet Kaur, Iram Wahid, Rafiq Ahmad, Byeong-Il Lee, Moksh Mahajan, M. Iqbal R. Khan

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Can quinoa (Chenopodium quinoa) replace traditional cereals under current climate scenarios? by Hongju Sun, Hongju Sun, Waqas ud Din Khan, Waqas ud Din Khan, Waqas ud Din Khan, Mohsin Tanveer, Usman Ijaz, Zhanyuan Lu, Zhanyuan Lu, Zhanyuan Lu, Sergey Shabala, Sergey Shabala

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GmBSK1-GmGSK1-GmBES1.5 regulatory module controls heat tolerance in soybean by Ze-Hao Hou, Yuan Gao, Jia-Cheng Zheng, Meng-Jie Zhao, Ying Liu, Xiao-Yu Cui, Zhi-Yong Li, Ji-Tong Wei, Tai-Fei Yu, Lei Zheng, Yuan-Chen Jiao, Shu-Hui Yang, Jia-Min Hao, Jun Chen, Yong-Bin Zhou, Ming Chen, Lijuan Qiu, You-Zhi Ma, Zhao-Shi Xu

“…Methods: Transgenic technology and CRISPR/Cas9 technology were used to generated GmBSK1-OE, GmBES1.5-OE and gmbsk1 transgenic soybean plants, and transcriptome analysis, LUC activity assay and EMSA assay were carried out to elucidate the potential molecular mechanism underlying GmBSK1-GmBES1.5-mediated heat stress tolerance in soybean. Results: CRISPR/Cas9-generated gmbsk1 knockout mutants exhibited increased sensitivity to heat stress due to a reduction in their ability to scavenge reactive oxygen species (ROS). …”
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Restoration of tendon repair microenvironment by grapefruit exosome-loaded microneedle system for tendinopathy therapy by Yuan Zhang, Yuan Zhang, Ruiyang Zhang, Ti Zhang, Yuhao Mu, Talante Juma, Xu Li, Hao Li, Quanyi Guo, Yongping Cao

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Mini-αA Upregulates the miR-155-5p Target Gene CDK2 and Plays an Antiapoptotic Role in Retinal Pigment Epithelial Cells during Oxidative Stress by Qianyin Chen, Huimin Lin, Shengnan Li, Xuan Deng, Jinglin Zhang

“…The reactive oxygen species level was detected by flow cytometry. miR-155-5p target genes were predicted via bioinformatics. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed for miR-155-5p target genes. …”
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Metformin mitigates potassium bromate-induced liver grievance in rat through attenuating NF-kB and PI3K/Akt pathway by Bo Ma, Sheng Zheng, Ning Xie, Juan Yang, Xueli Zeng, Pei Liu, Shunling Zhang, Ji Li

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Mental health disorders, childhood adversities, and recent stressors as risk factors for non-suicidal self-injury, and suicidality among LGBTQA + higher education students by Emma Rebecca Wallace, Margaret McLafferty, Rachel McHugh, Caoimhe Ward, Louise McBride, John Brady, Susan Lagdon, Anthony J. Bjourson, Colum P. Walsh, Siobhan O’Neill, Elaine K. Murray

“…In addressing these risk factors, educational settings may offer unique opportunities for the practice of inclusion, preventative care, and harm reduction for LGBTQA + students.…”
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Burnout and its predictor’s variables in Mobarakeh Steel Company by A Salahian, MR Matinisadr, MR Nouri, N Malekpor

“…Results: Findings indicated that in proposed model, predictor variables predict burnout by mediating job stress, and burnout has a significant relationship with outcome variables. …”
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Airway remodeling in chronic obstructive pulmonary disease: characteristics and opportunities by Minjie Pan, Xiaojing Zhou

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Investigation of a phytaspase activity from Nicotiana benthamiana: purification, identification, and characterization by Anastasia Barsukova, Lei Zhao, Svetlana Trusova

“…Phytaspases are specific plant proteases related to stress development and plant defense responses to adverse factors, such as insect or agrobacterial attacks. …”
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