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5001
Distribution and extended triage of high-risk human papillomavirus genotyping based on vaginal self-sampling
Published 2025-08-01“…Different HPV subtypes have different detection rates for CIN2+, and combining HPV16/18/33 significantly improved the sensitivity for detecting CIN2+.…”
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5002
The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners
Published 2025-05-01“…Here, we investigated the effects of the human RNASET2 alarmin in two different human PCa cell lines focusing on cell proliferation, colony formation, adhesion, migration rates, and release of soluble immune-modulatory factors. …”
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5003
Epstein Barr virus antibody and cancer risk in two prospective cohorts in Southern China
Published 2025-07-01“…The associations showed an increased dose-response pattern, and keep persistent even up to ten years prior to diagnosis. …”
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5004
Differences in Kinematic and Muscle Activity Between ACL Injury Risk and Healthy Players in Female Football: Influence of Change of Direction Amplitude in a Cross-Sectional Case–Co...
Published 2025-07-01“…<i>Background and Objectives</i>: Anterior cruciate ligament (ACL) injury rates remain high and have a significant impact on female football players. …”
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5005
Applying energy efficiency strategies to university buildings using Design Builder program "Case study of the Faculty of Commerce building at Sohag University as a case study" تطبي...
Published 2025-03-01“…University buildings consume a large percentage of energy rates in buildings in general due to their occupants, their activities and their occupancy pattern, as the higher education sector constitutes a small but important part of the existing global buildings sector, which is 20% of the non-residential horizontal area. …”
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5006
Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients
Published 2024-12-01“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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5007
Modulatory role of radioprotective 105 in mitigating oxidative stress and ferroptosis via the HO-1/SLC7A11/GPX4 axis in sepsis-mediated renal injury
Published 2025-07-01“…Abstract Sepsis-associated acute kidney injury (SA-AKI) is a critical condition characterized by high morbidity and mortality rates, particularly in intensive care settings. This study focuses on RP105, a pattern recognition receptor, exploring its role in moderating the mechanisms of oxidative stress and ferroptosis during SA-AKI, offering insights into its potential as a therapeutic target. …”
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5008
Evaluating the effectiveness of the Drink Less smartphone app for reducing alcohol consumption compared with usual digital care: a comprehensive synopsis from a 6-month follow-up R...
Published 2025-06-01“…Results The retention rate at 6-month follow-up was 80%. The data were not missing completely at random with differences detected in educational qualifications, occupation and income, indicating that multiple imputation was the most appropriate analytic approach. …”
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5009
Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month f...
Published 2021-11-01“…The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. …”
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5010
Somatization symptoms and burnout: a correlational study among emergency nurses
Published 2025-08-01“…Data collection occurred between December 26, 2023, and January 18, 2024, using the Chinese versions of the Maslach burnout inventory–general survey (MBI-GS) and the somatic symptom disorder self-rating scale (SSD-CN). Statistical analyses were performed using SPSS version 25.0.ResultsThe mean SSD score was 39.58 ± 13.61, with 53.4% of participants exhibiting moderate to severe somatization symptoms. …”
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5011
BASSET: Bandpass-adaptive Single-pulse Search Toolkit—Optimized Subband Pulse Search Strategies for Faint Narrowband Fast Radio Bursts
Published 2025-01-01“…In conjunction with the pulse calibration and the Markov Chain Monte Carlo simulated injection experiments, this work updates the quantified parameter space of the detection rate. Moreover, a parallel-accelerated version of the BASSET code was provided and evaluated through simulation. …”
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5012
Analysis of the Contextual Factors Influencing the Expansion of Construction Violations with an Emphasis on the Role and Position of Key Urban Stakeholders (Case Study: Isfahan Met...
Published 2025-06-01“…Additionally, natural population growth—encompassing births, improvements in healthcare, and reduced mortality rates—had a factor loading of 0.74, further impacting the urbanization process. …”
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5013
Evaluating the Effects of Mitigating Urban Heat Islands of Green Infrastructure on Increasing the Productivity of Light and Heavy Work (Case Study: Tabriz Metropolitan)
Published 2025-06-01“…The primary inputs for the model included a land use/land cover raster map, a reference evapotranspiration (ET0) raster map, a biophysical table containing details about each land use/land cover class, a vector map of city buildings, and an energy consumption rate table categorized by building type and air temperature. …”
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5014
A 60-year atmospheric nitrate isotope record from a southeastern Greenland ice core with minimal postdepositional alteration
Published 2025-06-01“…The ice core from the southeastern Dome (SE-Dome) in Greenland is a potential record of variations in atmospheric chemistry that has experienced a lower postdepositional effect owing to a high accumulation rate (<span class="inline-formula">∼1</span> m water equivalent per year). …”
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5015
Differences in the inflammatory response and outcome among hospitalized patients during different waves of the COVID-19 pandemic
Published 2025-03-01“…Systemic inflammatory indexes like neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-platelet ratio (NPR), Systemic Immune-Inflammation Index (SII), and systemic inflammation response index (SIRI) were calculated.ResultsThe Delta wave, characterized by the longest hospitalizations and the highest rates of severe cases and mortality, showed significant elevations in inflammatory biomarkers. …”
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5016
Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort
Published 2025-05-01“…Furthermore, the prevalence of PRISm varied from 2.0% to 12.5% depending on the definitions and predicted equations, with the Chinese equation, LLN definition in Chinese equation and fixed definition in GLI equation yielding higher prevalence rates.Conclusion: Our findings highlight concerns about the comparability of studies and the interchangeability of various definitions and reference equations for PRISm.Keywords: PRISm, definitions, clinical features, prevalence, reference equations…”
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5017
Tratamento de sequelas de queimadura de face com laser de CO2 fracionado em pacientes com fototipos III a VI Treatment of facial burn sequelae using fractional CO2 lasers in patien...
Published 2012-03-01“…CONCLUSIONS: The treatment with CO2F laser with mild parameters was well tolerated and resulted in high satisfaction rates for patients with facial burn sequelae as well as improved skin texture, distensibility, and surface irregularities. …”
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5018
Investigation of Population Changes and Determination of the Bean Pod Borer Helicoverpa armigera (Lepidoptera:Noctuidae) Peak in Bean Phaseolus vulgaris Linnaeus Fields by Pheromon...
Published 2024-11-01“…The investigation of the distribution and damage level of bean pod borer in important bean-growing areas of Markazi province over two years in five bean-growing regions (Arak, Khomain, Shazand, Milajerd, and Khondab) showed that Khomain and Khondab had the highest and lowest infestation rates, respectively. Red pods showed more sensitivity to this pest compared to green and white pods. …”
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5019
Effect of Different Treatments on the Structure Sequence and Digestive Characteristics of Oyster Hypoglycemic Peptides
Published 2025-07-01“…Moreover, the retention rates of OHPs' inhibitory activity against α-amylase and α-glucosidase were enhanced by alcohol precipitation and activated carbon adsorption treatments. …”
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5020
Silent Revolution in Research for Sustainability
Published 2016-06-01“…A variety of new arrangements have come into existence that promote international collaboration, including Horizon 2020 with its emphasis on societal challenges, the Bill & Melinda Gates Foundation which has inspired a family of grand challenges funds on health and development, and the Future Earth joint program of research for global sustainability. …”
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