MCM3 promotes hepatocellular carcinoma progression via Epithelial-mesenchymal Transition through AKT/Twist signaling pathway by Wei-Guo Tang, Jin-Feng Feng, Xian Li, Qi-Man Sun, Jin-Wu Hu, Xiao-Lu Ma, Yan-Yan Nie, Yang Xu, Jian Sun, Qi-Meng Chang

“…Introduction and Objectives: Hepatocellular carcinoma (HCC), a leading cause of cancer fatalities, challenges clinicians with high recurrence and metastasis rates, urging the need for novel prognostic markers and therapeutic avenues. …”
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Isokinetic Evaluation of Quadriceps and Hamstring Muscle Performance in the Rehabilitation Phase after ACL Reconstruction by Nicolae Stanciu, Razvan Marian Melinte, Mark Slevin, Octav Marius Russu, Cristian Trâmbițaș, Cezara Ilinca Stanciu, Elena Georgiana Bălănescu, Dan Avrămiuc, Gabriel Koszoruș, Klara Brînzaniuc

“…While male and athletic participants exhibited higher absolute and relative strength values (p < 0.05), recovery rates were consistent across subgroups. Adductor and abductor strength also showed post-rehabilitation symmetry and robustness, supporting their relevance in functional assessment.…”
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The Influence of Biochar on Growth of Lettuce and Potato by Kalika P Upadhyay, Doug George, Roger S Swift, Victor Galea

“…The pH and electrical conductivity increased as the biochar rates increased in all experiments. These results provide an avenue for soil management system by using biochar as an amendment in horticultural crops. …”
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TS-InSAR assessment of groundwater overexploitation-land subsidence linkage: Hengshui case study by Yan An, Qiang Shen, C.K. Shum, Fan Gao, Xu Zhang, Liming Jiang, Hansheng Wang

“…New hydrological insights for the region: Results show subsidence dominates in Hengshui City, with rates up to 141 mm/year (2017–2024), mainly due to falling confined aquifer heads and delayed aquitard drainage. …”
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Effect of nonpharmaceutical interventions on the epidemic trends of scarlet fever in China: a population-based surveillance and modelling study by Xiaojuan Zhang, Yuanhai You, Jie Liu, Lu Sun, Haijian Zhou, Xingxing Zhang, Bike Zhang

“…Findings: During 2005-2024, 876,680 cases were reported (crude annual incidence: 3.22/100 000). The annual morbidity rates for three periods were 3.56, 1.58, and 3.25/100 000. …”
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Revealing the effect of layer-varying deposition strategy on laser-directed energy deposition bionic gradient NiTi alloy by Zhongxiong Kang, Chaorui Jiang, Mengqi Liu, Zhihui Zhang, Jie Zhao

“…The strategy includes different process parameters (the laser power and scanning speed), the scanning paths (alternative optimised spiral pattern, x-axis rotation pattern, and arc alternative pattern) and interlayer interval time. …”
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Design of a Low Threshold Single-Mode In-P Laser Using Regrowth-Free Fabrication by A. Sharma, P. Landais, M. Srivastava, M. Wallace, F. Smyth, A. Kaszubowska-Anandarajah, P. Anandarajah

“…Subsequently, the extracted parameters are used in a rate equation model to predict the performance of the laser in terms of its L <inline-formula><tex-math notation="LaTeX">$ - $</tex-math></inline-formula> I characteristics and the sidemode suppression ratio (SMSR). …”
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Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy by Alexander Pil Henriksen, Cristina Leal Rodríguez, Hannah Currant, Ioannis Louloudis, Jorge Hernansanz Biel, Maria Herrero-Zazo, Ewan Birney, Thomas Folkmann Hansen, Gianluca Mazzoni, Amalie Dahl Haue, Henning Bundgaard, Christian Erikstrup, Khoa Manh Dinh, Liam Quinn, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sørensen, Christina Mikkelsen, Michael Schwinn, Ole Birger Vestager Pedersen, Henrik Ullum, Sisse Rye Ostrowski, Karina Banasik, Søren Brunak

“…As populations get older and medicine consumption rises, the rate of concurrent drug use and polypharmacy among patients is increasing. …”
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Early-stage resectable non-small cell lung cancer in Hungary by Gabriella Gálffy, Réka Hécz, Réka Bujdosó, Eszter Gáspár, Réka Korompay, Judit Hoffer, Szilvia Szécsényi, Celia Blasszauer, Dániel Reibl, Erika Tóth, Krisztina Bogos, László Agócs, László Agócs, Ferenc Rényi-Vámos, Ferenc Rényi-Vámos, Éva Mórocz

“…This study provides a comprehensive analysis of early-stage resectable non-small cell lung cancer (NSCLC) in Hungary, investigating incidence rates, demographic trends, treatment patterns and survival outcomes. …”
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GNSS-Based Models of Displacement, Stress, and Strain in the SHETPENANT Region: Impact of Geodynamic Activity from the ORCA Submarine Volcano by Belén Rosado, Vanessa Jiménez, Alejandro Pérez-Peña, Rosa Martín, Amós de Gil, Enrique Carmona, Jorge Gárate, Manuel Berrocoso

“…These patterns align with the known structural framework of the region. …”
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Epidemiologic, microbiologic and imaging characteristics of urinary tract infections in hospitalized children < 2 years of age diagnosed with anatomic abnormalities of the urinary... by Zohar Landau, Evgenia Cherniavsky, Salman Abofreha, Ilan Linder, Ron Leibovitz, Diana Roif-Kaminsky, Michael Friger, Natalya Bilenko, Eugene Leibovitz

“…In the study group, Ec nonsusceptibility rates to ampicillin, amoxicillin/clavulanic acid, cefazolin, cefuroxime, TMP/SMX and ceftriaxone were 58%, 40%, 14%, 14%, 12% and 10%, respectively, with no differences vs. controls. …”
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Optimizing Effects of Organic Farming and Moderately Low Nitrogen Levels on Soil Carbon and Nitrogen Pools by Guanghua Wang, Yu Yang, Yuqi Chen, Shilong Yu, Xiaomin Huang, Min Jiang, Zujian Zhang, Lifen Huang

“…Therefore, a field trial was conducted to elucidate the impacts of different cultivation patterns and nitrogen application rates on soil carbon and nitrogen pools, especially on how these factors affect the components of soil organic carbon. …”
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Role of TRP channels and HSPs in thermal stress response in the aphid parasitoid Aphelinus asychis (Hymenoptera: Aphelinidae) by Xiang LIU, Zhi-wei KANG, Xing-lin YU, Fan LI, Tong-xian LIU, Qiang LI

“…The results showed that the maximum temperature that allowed A. asychis survival was approximately 41°C; females had higher survival rates than that of the males at 40 and 41°C. Short-term heat-shock resulted in increased expression of Aasyshsp in males, and Aasyhsp40, Aasyhsp68, Aasyhsp70-4, Aasyhsp70-5 and Aasyhsp90 were upregulated and then downregulated, whereas Aasyhsp70-3 was upregulated at 41°C. …”
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Optimization of ivacaftor-loaded solid lipid nanoparticles for solubility enhancement by Akshay Parihar, Akshay Parihar, Bhupendra G. Prajapati, Bhupendra G. Prajapati, Bhupendra G. Prajapati, Himanshu Paliwal

“…The in vitro dissolution study showed improved release pattern from the optimized formulation and release profile followed first-order model indicating a sustained release pattern from lipid matrix.ConclusionThis delivery system presented development of stable nanoparticle formulation exhibiting sustained release pattern, which may contribute to therapeutic outcomes in comparison with drug alone. …”
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Development adjustment technology of extending life cycle for nearly-abandoned reservoirs by ZHANG Lianfeng,ZHANG Yilin,GUO Huanhuan,LI Hongsheng,LI Junjie,LIANG Limei,LI Wenjing,HU Shukui

“…Based on the characteristics of remaining oil distribution, a technical concept of heterogeneous composite driving and streamline well pattern densification adjustment was proposed. By adjusting the well pattern to alter streamlines, creating a staggered row and column well pattern with a change in streamline direction of over 30° and a streamline deflection rate of 80%, the effective mobilization of remaining oil is promoted. …”
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Evaluation of planting arrangment and methods on quantitative and qualitative characteristics of tomato (Lycopersicon esculentum) seeds by H. Khazaei

“…The highest and lowest fruit and seed yield were obtained in Rokh (two row per ridge and 120×30 cm planting pattern) and Toroq (one row per ridge and 140×50 cm planting pattern) regions, respectively with 2.7 and 3.1 times difference. …”
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Epidemiological characterization of chronic myeloid leukaemia patients at an oncologic centre: A retrospective observational study by Ana Maria Meireles, Rita Calisto, Maria José Bento, Pedro Martinho Gouveia, Susana Bizarro, Manuel Teixeira, Cláudia Moreira, Ana Espírito Santo, Mário Mariz

“…At three months, the early molecular response rate was 77 %. At 12 months of treatment, of the 67 patients with response evaluation, 93 % achieved complete cytogenetic response and 49 % major molecular response. …”
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BERT-based network for intrusion detection system by Yong Yang, Xing Peng

“…After feature extraction is completed, we further perform classification using a classifier based on a bidirectional gated recurrent unit (GRU) network, which is able to efficiently process sequence data and reduce computational complexity while capturing temporal dependencies in the sequences. …”
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Immune Escape and Drug Resistance Mutations in Patients with Hepatitis B Virus Infection: Clinical and Epidemiological Implications by Maria Antonia De Francesco, Franco Gargiulo, Francesca Dello Iaco, Laert Zeneli, Serena Zaltron, Giorgio Tiecco, Simone Pellizzeri, Emanuele Focà, Arnaldo Caruso, Eugenia Quiros-Roldan

“…Hepatitis B virus (HBV) genetic variability, shaped by high mutation rates and selective pressures, complicates its management and increases the emergence of drug-resistant and immune-escape variants. …”
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A Permutation Entropy Method for Sleep Disorder Screening by Cristina D. Duarte, Marcos M. Meo, Francisco R. Iaconis, Alejandro Wainselboim, Gustavo Gasaneo, Claudio Delrieux

“…<b>Conclusions:</b> The advantages of this approach, including compatibility with single-channel EEG (enabling potential wearable applications), independence from sleep-stage annotations, and generalizability across recording montages and sampling rates, stablish a framework for non-specific sleep pathology detection. …”
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