Risk factors and public health interventions associated with adolescent pregnancy prevention among females aged 10–19 years in Kenya: a scoping review protocol by Abdu Mohiddin, Kimbley Asaso Omwodo, Danielle Denwood, Augustine Gitonga

“…Despite ongoing interventions, in developing countries such as Kenya, adolescent pregnancy rates continue to be high. There is a need for more synthesised evidence on regional-specific risk factors to support tailored prevention strategies.Objective This scoping review aims to explore what is known about the risk factors and intervention strategies focused on adolescent pregnancy prevention in Kenya.Methods and analysis Using the Arksey and O’Malley framework combined with a three-step search strategy as recommended by the Joanna Briggs Institute, relevant articles will be identified from the PubMed, Scopus, Web of Science, CINAHL and PsycINFO databases. …”
Get full text

Association between physicians' interaction with pharmaceutical companies and their clinical practices: A systematic review and meta-analysis. by Hneine Brax, Racha Fadlallah, Lina Al-Khaled, Lara A Kahale, Hala Nas, Fadi El-Jardali, Elie A Akl

“…Out of the 19 studies, 15 found a consistent association between interactions promoting a medication, and inappropriately increased prescribing rates, lower prescribing quality, and/or increased prescribing costs. …”
Get full text

Efficacy of switching from originator adalimumab to biosimilar adalimumab-AACF in patients with axial spondyloarthritis: a 12-month observational study by Fanny Alcira Reyes Neira, Barbara Bayeh, Karina Rossi Bonfiglioli, Nadia Emi Aikawa, Ana Paula Luppino Assad, Renata Miossi, Fernando Henrique Carlos de Souza, Carlos Emilio Insfrán, Henrique Ayres Mayrink Giardini, Emily Figueiredo Vieira Neves Yuki, Eloisa Bonfa, Carla Gonçalves Schahin Saad, Ana Cristina de Medeiros-Ribeiro, Julio Cesar Bertacini de Moraes, Andrea Yukie Shimabuco

“…Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP remained stable when comparing T0 to T6 [1.56 (± 0.88) vs. 1.50 (± 0.82), P = 0.73] and T12 [1.56 (± 0.88) vs. 1.26 (± 0.86), P = 0.13]. A similar pattern was observed for ASDAS-erythrocyte sedimentation rate (ESR; P > 0.05) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI; P > 0.05). …”
Get full text

Clinicopathological Evaluation of Rhabdomyosarcoma with Emphasis on Myogenin Expression and FOXO1 Gene Fusion in Various Morphological Subtypes: A Cohort Study by Sindhu Ramamurthy, Ahwini Nargund, Geeta V Patil Okaly, Usha Amirtham, Arun Kumar, Ahok Kumar

“…Among the four histomorphological subtypes of RMS, distinguishing the dense pattern of Embryonal RMS (ERMS) from the solid pattern of Alveolar RMS (ARMS) solely based on morphology is challenging and necessitates ancillary techniques. …”
Get full text

Increasing population growth by asymmetric segregation of a limiting resource during cell division by Nurit Avraham, Ilya Soifer, Miri Carmi, Naama Barkai

“…Abstract We report that when budding yeast are transferred to low‐metal environment, they adopt a proliferation pattern in which division is restricted to the subpopulation of mother cells which were born in rich conditions, before the shift. …”
Get full text

Metal–organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy by Tao Jiang, Zixiang Tang, Shumiao Tian, Haitian Tang, Zhekun Jia, Fangjian Li, Chenyue Qiu, Lin Deng, Lang Ke, Pan He, Gang Liu, Chengchao Chu, Yongfu Xiong

“…Remarkably, ultrasound irradiation induced substantial oxidative stress and immunogenic cell death, promoting the release of damage-associated molecular patterns (DAMPs), which elevated the maturation rate of tumor-infiltrating dendritic cells (DCs) and significantly increased the proportion of CD8⁺ T cells. …”
Get full text

The role of hypoxia-senescence co-related molecular subtypes and prognostic characteristics in hepatocellular carcinoma by Fuqing Chen, Yifan Cai, Xiangmei Chen, Changzhou Chen, Qinliang Fang, Jianming Liu, Yibin Zhang, Jianyin Zhou

“…Abstract Hepatocellular carcinoma (HCC) is known for its high invasiveness, high fatality rate. Both hypoxia and senescence play crucial roles in the initiation and progression of cancer, yet their prognostic implications in HCC are yet to be fully understood. …”
Get full text

An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits by Ellen M. Howerton, Valerie Morrill, Rose Schrott, Jason Daniels, Ashley Y. Song, Kelly Benke, Heather Volk, Homayoon Farzadegan, Aimee Anido Alexander, Amanda L. Tapia, Gabriel S. Dichter, Lisa A. Croen, Lisa Wiggins, Genevieve Wojcik, M. Daniele Fallin, Christine Ladd-Acosta

“…Results We identified a region about 3.5 kb upstream of ZFP57 on chromosome 6 as differentially methylated (family-wise error rate [fwer] < 0.1) by continuous SRS T-score in the full sample (N = 857; fwer = 0.074) and among ASD cases only (N = 390; fwer = 0.021). …”
Get full text

Intra-familial transmission of Hepatitis B virus in a peri-urban community from the Democratic Republic of the Congo by Florence Cindibu Kalonji, Yu Nakagama, Evariste Tshibangu-Kabamba, Nadine Kayiba Kalenda, Shun Nakagama, Sachie Nakagama, Pathy Kamanga Nkolongo, Nestor Kalala-Tshituka, Alphonse Lufuluabu Mpemba, Faustin Ndjibu Mpoji, André Kabongu Kalala, Benjamin Muamba Mpoyi, Dieudonné Mumba Ngoyi, Natsuko Kaku, Yusuke Shimakawa, Ghislain Tumba Disashi, Yasutoshi Kido

“…The overall HBsAg prevalence was 3.8% [95% CI 2.6–5.7], with the highest rate (10.1% [95% CI 4.9–18.2]) found in children aged 5 years and younger. …”
Get full text

A mobile app to improve adherence to colorectal cancer screening and post polypectomy surveillance guidelines by María A. Casas, Francisco Schlottmann, Leandro Steinberg, Xavier Bessa, Anna Serradesanferm, Angels Pozo, Sonia Torres, Antoni Castells, Francesc Balaguer, Jaume Grau, Lisandro Pereyra, María Pellisé

“…The app was increasingly and repeatedly used by professionals during the study period (72% retention rate). Among screening consultations, 2,082 (68.2%) patients were classified as average risk, suggesting the use of fecal occult blood test (FOBT) instead of colonoscopy. …”
Get full text

Antimicrobial susceptibility profiles of thermophilic Campylobacter species from human, pig, and chicken feces in Rwanda by Noel Gahamanyi, Noel Gahamanyi, Arsene Musana Habimana, Jean Paul Harerimana, Josiane Mukayisenga, Salomon Ntwali, Anathali Umuhoza, Emmanuel Nsengiyumva, Emmanuel Irimaso, Jean Bosco Shimirwa, Cheol-Ho Pan, Erick Vitus Komba, Claude Mambo Muvunyi, Nadine Rujeni, Raghavendra G. Amachawadi

“…Multi-drug resistance (MDR) was observed among the isolates, with the highest rates observed in chicken isolates (88.0%). Proportions of MDR among pig (40.9%) and human (40.7%) isolates were more or less similar. …”
Get full text

The diagnostic utility of lung ultrasound in the assessment of interstitial lung disease associated with rheumatoid arthritis by Shaoyu Zheng, Zexuan Zhou, Guangzhou Du, Qingzi Chen, Shaoqi Chen, Jianqun Lin, Shijian Hu, Weijin Zhang, Kedi Zheng, Jinghua Zhuang, Meigan Huang, Barbara Ruaro, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Marco Matucci-Cerinic, Daniel E. Furst, Yukai Wang

“…Sonographic ILD was detected in 76 patients who underwent LUS examination. The concordance rate between two modalities was 83.33% (Kappa value = 0.64, 95% CI 0.50–0.78). …”
Get full text

Analysis of HBV infection characteristics and OBI prevalence in pregnant women: a focus on HBcAb + alone or in combination with HBeAb + subgroups in Northwest China by Yun Xie, Ru Kang, Xiaoyue Cheng, Dan Li, Qi Wang, Jiao Li, Xuan Guo, Wenhui Gao, Xin He, Liutong Jiang, Gaili Meng

“…Despite a decline in HBsAg positivity, HBV remains moderately prevalent, the persistently high HBV susceptibility rate (31.07%) underscores an urgent need for targeted vaccination efforts among women of childbearing age in Northwest China.…”
Get full text

Strata pressure behavior law and regional-level intelligent early warning for high-intensity mining in extended working faces of medium-thick coal seams in Yuheng mining area by Feng CUI, Cheng ZONG, Xingping LAI, Tao XIE, Yunhu BAI, Yi ZHANG, Chong JIA, Hao WANG, Zhong LUO, Hao LIU

“…High-intensity mining and extended working faces have significantly modified strata pressure manifestation patterns and triggered spatiotemporal evolution of mining-induced pressure. …”
Get full text

Prevalence, microbiology, and antimicrobial susceptibility profile of bacterial skin and soft tissue infections in pediatric patients with malignancies at a referral teaching hospi... by Seyed Reza Abdipour Mehrian, Fatemeh Noushadi, Yaser Pourasghar, Armina Farkarian, Elahe Meftah, Fatemeh Homayounifar, Ali Amanati

“…However, it is important to acknowledge that this study was conducted at a single center and the high rate of culture-negative results suggests that non-bacterial etiologies or prior antibiotic use may play a significant role. …”
Get full text

Amivantamab versus standard therapies among patients with advanced non-small cell lung cancer and epidermal growth factor receptor exon 20 insertion mutations after platinum-based... by Lan Shen, Guangyuan Hu, Yan Wang, Jing Zhao, Xin Li, Jianmin Zhuo, Grace Kah Mun Low, Shun Lu

“…Effectiveness comparison, including real-world progression-free survival (rwPFS), real-world time to next therapy (rwTTNT) and real-world objective response rate (rwORR) was conducted between CHRYSALIS patients and the EC. …”
Get full text

The effect of photodynamic therapy on the wound process dynamics in patients with purulent hand diseases by J. L. Chepurnaya, G. G. Melkonyan, N. T. Gul’muradova, A. A. Sorokin

“…Photodynamic therapy was performed on the second postsurgical day by a laser apparatus “Atkus-2” (wave length 661 nm) with a gel form of the chlorinseries photosensitizer photoditazin in the form of an application at the rate of 1 g ml per 3–5 cm2 of the wound surface. …”
Get full text

Probabilistic seasonal dengue forecasting in Vietnam: A modelling study using superensembles. by Felipe J Colón-González, Leonardo Soares Bastos, Barbara Hofmann, Alison Hopkin, Quillon Harpham, Tom Crocker, Rosanna Amato, Iacopo Ferrario, Francesca Moschini, Samuel James, Sajni Malde, Eleanor Ainscoe, Vu Sinh Nam, Dang Quang Tan, Nguyen Duc Khoa, Mark Harrison, Gina Tsarouchi, Darren Lumbroso, Oliver J Brady, Rachel Lowe

“…As a climate-sensitive disease, environmental conditions and past patterns of dengue can be used to make predictions about future outbreak risk. …”
Get full text

Deep learning and genomic best linear unbiased prediction integration: An approach to identify potential nonlinear genetic relationships between traits by F. Shokor, P. Croiseau, H. Gangloff, R. Saintilan, T. Tribout, T. Mary-Huard, B.C.D. Cuyabano

“…When applied to a real dataset from the French Holstein dairy cattle population, DLGBLUP detected nonlinear genetic relationships between pairs of traits, such as conception rate and protein content, and SCC and fat yield, although, no significant increase in prediction accuracy was observed. …”
Get full text

Longitudinal Digital Phenotyping of Multiple Sclerosis Severity Using Passively Sensed Behaviors and Ecological Momentary Assessments: Real-World Evaluation by Zongqi Xia, Prerna Chikersal, Shruthi Venkatesh, Elizabeth Walker, Anind K Dey, Mayank Goel

“…Smartphone sensors recorded call activity, location, and screen use, while fitness trackers captured heart rate, sleep patterns, and step count. We extracted patient-level behavioral features and categorized them into 2 feature sets: one from the prediction period (called action) and one from the preceding period (called context). …”
Get full text