Effects of intravenous immunoglobulin on the negatively transformed subpopulations of neutrophilic granulocytes in newborns with congenital pneumonia and neonatal sepsis by I. V. Nesterova, S. V. Kovaleva, G. A. Chudilova, L. V. Lomtatidze, T. V. Smerchinskaya, V. N. Chapurina

“…Limitation of the negative NG transformation in their functionally significant subpopulations in newborns with CAP and NS was accompanied by positive clinical effects, i.e., optimization of antibiotic therapy, reduced duration of treatment, and improved mortality rates.…”
Get full text

Genotypic profile of Staphylococcus spp., Enterococcus spp., and E. coli colonizing dogs, surgeons, and environment during the intraoperative period: a cross-sectional study in a v... by Mareliza Possa de Menezes, Marita Vedovelli Cardozo, Natália Pereira, Mariana Bugov, Newton Valerio Verbisck, Vanessa Castro, Alessandra Figueiredo de Castro Nassar, Paola Castro Moraes

“…Conclusion Our study revealed high rates of methicillin-resistant Staphylococcus spp. and tetracycline-resistant Enterococcus spp. colonizing the environment in a veterinary teaching hospital in Brazil. …”
Get full text

Prevalence and determinants of hypertension in rwanda: a secondary data analysis using the WHO STEPS survey 2022 by Jean Damascene Hagenimana, Kagisha Divine Pascaline, Felix K. Rubuga, Kelly Mwiza, Sabine Musange F., Nathalie Umutoni, Caroline Mudereri, Jocelyne Uwitonze, Emmanuel Christian Nyabyenda, Piero I. Mazimpaka, Olivier N. Wane, Eric remera, Uwimana Aline, Marie Rosette NAHIMANA, Jeanine Condo, Gashaija Absolomon

“…The overall prevalence of hypertension was 16.8%, with higher rates observed among older individuals and those with obesity. …”
Get full text

Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia by Lin Zhang, Li Guo, Xiaohui Liu, Jing Han, Yuanqiang Zhu, Chaozong Ma, Ye Li, Weiliang Ye

“…The inclusion of HCs provides evidence that rTMS-induced changes align with normative network patterns, and the responder analysis suggests that connectivity modulation is linked to clinical improvement. …”
Get full text

Genomic epidemiology and phylodynamics of Acinetobacter baumannii bloodstream isolates in China by Qixia Luo, Mengru Chang, Ping Lu, Qian Guo, Xiaoqing Jiang, Tingting Xiao, Haoyu Zhang, Yingying Ma, Yan Zhang, Wei Yu, Erjia Zhang, Yunbo Chen, Ping Shen, Jinru Ji, Chaoqun Ying, Zhiying Liu, the BRICS Working Group, Huaiqiu Zhu, Yonghong Xiao

“…Abstract In recent decades, Acinetobacter baumannii has become a major global nosocomial pathogen, with bloodstream infections (BSIs) exhibiting mortality rates exceeding 60% and imposing substantial economic burdens. …”
Get full text

Characteristics and risk factors for outcomes in patients with Mycoplasma pneumoniae mono- and coinfections: A multicenter surveillance study in Wuhan, China, 2023 by Banghua Chen, Jie Pan, Ying Peng, Yuanyuan Zhang, Yunan Wan, Hongjie Wei, Kangguo Li, Wentao Song, Yunkang Zhao, Kang Fang, Huiming Ye, Jiali Cao, Jia Rui, Zeyu Zhao, Tianmu Chen

“…Children aged 1–10 years had the highest incidence, whereas those over 60 years had elevated hospitalization, severe infection, and fatality rates. Coinfection patterns differed by age, with bacterial-viral-Chlamydia pneumoniae (C. pneumoniae) / other pathogens prevalent in infants, bacterial-viral pathogens prevalent in preschoolers, and viral-viral pathogens prevalent in school-aged children. …”
Get full text

Human growth and development across time and space by Michael Hermanussen, Christiane Scheffler, Jana Fritsch, Piotr Fedurek, Joanna Nieczuja-Dwojacka, Maria Kaczmarek, Sylvia Kirchengast, Dominik Hagmann, Birgit Bühler, Katarzyna Górka, Sylwia Bartkowiak, Başak Koca Özer, Esin Köksal Babacan, Kübra Baran, Martin Musalek, Takashi Satake, Roshan Peiris, Toshie Hirohara, Komei Hattori, Natalia Nowak-Szczepanska, Anna Apanasewicz-Grzegorczyk, Aleksandra Gomula, Slawomir Koziel

“…Taking a decolonial view on the historical well-being of the Xavante, the overall health status of this Brazilian population has significantly worsened despite changes in the administrative frameworks, including reductions in mortality rates and increased hospital service usage. In addition to height, the alterations in body weight, the effects of fat mass on physical fitness, lifestyle, sports, and general health in Polish, Czech, and Turkish populations were discussed. …”
Get full text

Somatization symptoms and burnout: a correlational study among emergency nurses by Ningxiang Li, Ningxiang Li, Ningxiang Li, Nan Xie, Nan Xie, Nan Xie, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Hao Zhang, Hao Zhang, Hao Zhang, Luying Zhong, Luying Zhong, Luying Zhong, Dongmei Diao, Dongmei Diao, Dongmei Diao, Ling Zhu, Ling Zhu, Ling Zhu, Yue Zhou, Yue Zhou, Yue Zhou

“…To address this issue, healthcare management should consider implementing alternative shift patterns, optimizing workforce allocation, and revising compensation systems to ensure equitable labor distribution. …”
Get full text

Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries by Junqing Xie, Mike Du, Yuchen Guo, Cesar Barboza, James T. Brash, Antonella Delmestri, Talita Duarte-Salles, Talita Duarte-Salles, Jasmine Gratton, Romain Griffier, Raivo Kolde, Wai Yi Man, Núria Mercadé-Besora, Marek Oja, Sarah Seager, Katia Verhamme, Dina Vojinovic, Edward Burn, Daniel Prieto-Alhambra, Daniel Prieto-Alhambra, Martí Català, Annika M. Jödicke

“…Annual period prevalence and incidence rates of opioid prescriptions were estimated, and long-term trends were quantified as the percent change from 2012 to 2019. …”
Get full text

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (<i>RdRp</i>) Region and <i>VP1</i> Gene in Sapovirus GI.1 and GI.2 by Fuminori Mizukoshi, Ryusuke Kimura, Tatsuya Shirai, Asumi Hirata-Saito, Eri Hiraishi, Kosuke Murakami, Yen Hai Doan, Hiroyuki Tsukagoshi, Nobuhiro Saruki, Takeshi Tsugawa, Kana Kidera, Yoshiyuki Suzuki, Naomi Sakon, Kazuhiko Katayama, Tsutomu Kageyama, Akihide Ryo, Hirokazu Kimura

“…Further, the MRCAs of the <i>RdRp</i> region and <i>VP1</i> gene in HuSaV GI.2 diverged in 1960 and 1943, respectively. The evolutionary rates were higher for <i>VP1</i> gene in HuSaV GI.1 than that in HuSaV GI.2, furthermore, were higher in GI.1 Cluster B than GI.1 Cluster A. …”
Get full text

Barriers and facilitators to implementing a task-sharing mental health intervention for Sickle Cell Disease populations in low- and middle-income countries: a qualitative analysis... by John Patena, Leah Elster, Tania Hameed, Sumedha Kulkarni, Alden Yuanhong Lai, Annika C. Sweetland, Joyce Gyamfi, Temitope Ojo, Angela Odoms-Young, Charmaine Royal, Emmanuel Peprah

“…BackgroundPeople living with Sickle Cell Disease (SCD) experience higher rates of common mental disorders (CMD). There is an alarming treatment gap in the provision of adequate mental health services for CMDs in low- and middle-income countries (LMIC). …”
Get full text

Triatoma dimidiata, domestic animals and acute Chagas disease: a 10-year follow-up after an eco-bio-social intervention by Jose G. Juarez, Andrea M. Moller-Vasquez, María Granados-Presa, Pamela Pennington, Norma Padilla, Sujata Balasubramanian, Lisa D. Auckland, Elsa Berganza, Estuardo Alvarado Liberato, Henry Esquivel, Ranferi Trampe, Louisa A. Messenger, Celia Cordón-Rosales, Gabriel L. Hamer, Sarah A. Hamer

“…Results Persistent household infestation by T. dimidiata was observed across all four communities, with infestation rates ranging from 17% to 38% and colonization levels ranging from 9% to 29%. …”
Get full text

Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…However, relatively little attention has been given to urbanized areas characterized by high rates of population growth and land development. …”
Get full text

A longitudinal qualitative study of clinical nurses caring for hospitalized adults during the first fifteen months of COVID-19: lessons in professional survival and leadership by Elizabeth M. Norman, Mildred Ortu Kowalski, Roxanne Sabatini, Carol S. Jones, Wendy Silverstein

“…At the time of this April surge, nurses were exposed to a virus with no standard treatments and high mortality rates. Using a longitudinal qualitative design, the team hoped to answer questions about what compelled these nurses to continue to come to work? …”
Get full text

Antidepressant Switching as a Proxy Phenotype for Drug Nonresponse: Investigating Clinical, Demographic, and Genetic Characteristics by Chris Wai Hang Lo, Alexandra C. Gillett, Matthew H. Iveson, Michelle Kamp, Chiara Fabbri, Win Lee Edwin Wong, Dale Handley, Oliver Pain, Evangelos Vassos, Naomi R. Wray, Heather C. Whalley, Danyang Li, Allan H. Young, Andrew M. McIntosh, Cathryn M. Lewis

“…Background: Selective serotonin reuptake inhibitors (SSRIs) are a first-line pharmacological therapy in major depressive disorder (MDD), but treatment response rates are low. Clinical trials lack the power to study the genetic contribution to SSRI response. …”
Get full text

Long-term outcomes of dupilumab therapy in severe asthma: A retrospective, multicenter, real-world study by Carlo Mümmler, MD, Alexandra Lenoir, MD, Jeremias Götschke, MD, Michael Gerckens, MD, Merle Kaiser, MD, Moritz Kayser, MD, Nora Drick, MD, Hendrik Suhling, MD, Leonie Biener, MD, Carmen Pizarro, MD, Dirk Skowasch, MD, Nikolaus Kneidinger, MD, PhD, Jürgen Behr, MD, Katrin Milger, MD

“…Real-world data on the continuation and cessation patterns of dupilumab and long-term treatment efficacy are scarce. …”
Get full text

Oncolytic Vaccinia Virus Armed with GM-CSF and IL-7 Enhances Antitumor Immunity in Pancreatic Cancer by Wenyi Yan, Yujing Xuan, Ruimin Wang, Ziyan Huan, Yu Guo, Huilin Dun, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas Robert Lemoine, Yaohe Wang, Pengju Wang

“…The synergistic effects of VVL-GL7 and the PD-1 blockade further improved therapeutic outcomes, resulting in significantly higher tumor remission rates compared to monotherapy and achieving complete tumor regression in pancreatic cancer models. …”
Get full text

Toward improving retention in HIV care after pregnancy: lessons from a post-pandemic cohort in the United States by Alexandra H. Latham, Alexandra H. Latham, Alexandra H. Latham, Andrea Lugo Morales, Andrea Lugo Morales, Andrea Lugo Morales, Elizabeth Barba Gutierrez, Elizabeth Barba Gutierrez, Elizabeth Barba Gutierrez, Michael Jochum, Michael Jochum, Sarah Conrad, Sarah Conrad, Eva H. Clark, Kassandra Goytia, Megan Alam, Jessica Gerard, Jessica Gerard, Jennifer McKinney, Jennifer McKinney, Jennifer McKinney

“…IntroductionPeople living with HIV (PLWH) often experience low rates of retention in HIV care (RIC) and suboptimal viral suppression postpartum. …”
Get full text

Silent Revolution in Research for Sustainability by Bruce Alder

“…A variety of new arrangements have come into existence that promote international collaboration, including Horizon 2020 with its emphasis on societal challenges, the Bill &amp; Melinda Gates Foundation which has inspired a family of grand challenges funds on health and development, and the Future Earth joint program of research for global sustainability. …”
Get full text

Seasonal population dynamics and dietary switching of Vulpes spp. amplify Echinococcus spp. transmission in the Eastern Tibetan plateau: implications for wildlife-mediated zoonotic... by Xu Wang, Chuizhao Xue, Xueying Deng, Qilu Chen, Chunyang Li, Baixue Liu, Ying Wang, Yan Kui, Qingqiu Zuo, Jianhai Yin, Shuai Han, Yujuan Shen, Jianping Cao

“…This dietary diversification correlated with seasonal resource scarcity, driving foxes to exploit alternative prey. The infection rates of Echinococcus in V. ferrilata displayed the U-shaped seasonal patterns. …”
Get full text