GPCR kinases phosphorylate GPCR C-terminal peptides in a hierarchical manner by Arnelle Löbbert, Nils Lorz, Edda S. F. Matthees, Philip Rößler, Carsten Hoffmann, Alvar D. Gossert

“…Our data reveal that the kinases are promiscuous with respect to the substrate peptide, but produce clearly defined phosphorylation patterns on each substrate. We found pronounced differences in the rates at which certain residues are phosphorylated, in particular in the PXPP motifs in rhodopsin and β1AR. …”
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Breastfeeding Supports and Services in Rural Hawaii: Perspectives of Community Healthcare Workers by Jeanie L. Flood

“…In the state of Hawaii, breastfeeding initiation rates are higher than the national average but fall below target rates for duration. …”
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Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT by CJ Hawkey, Anthony J Avery, Carol AC Coupland, Colin J Crooks, Jennifer S Dumbleton, FD Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson

“…Limitations and future work Studying subjects already established on aspirin probably contributed to the low event rate. A future study should investigate subjects starting on aspirin when the event rate is higher. …”
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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…By testing simulated SECM samples, the method demonstrated a substantial reduction in the false-negative rate even with up to 75% cumulus cell contamination. …”
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Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy by Wei Wu, Qihan Fu, Lulu Liu, Yi Zheng, Hangyu Zhang, Peng Zhao, Weijia Fang, Xuanwen Bao, Shaobing Cheng, Xiaomeng Dai, Xudong Zhu, Zhou Tong, Fanglong Liu

“…A receiver operating characteristic curve was used to evaluate the accuracy rate of neural network, reaching 100%.Conclusion Our analysis unraveled the difference in the molecular nature and genomic variance in MSI and MSS colon cancer. …”
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Functional Connectivity Biomarker Extraction for Schizophrenia Based on Energy Landscape Machine Learning Techniques by Janerra D. Allen, Sravani Varanasi, Fei Han, L. Elliot Hong, Fow-Sen Choa

“…Schizophrenia is associated with impaired functional connectivity but characterizing the complex abnormality patterns has been challenging. In this work, we used resting-state functional magnetic resonance imaging (fMRI) data to measure functional connectivity between 55 schizophrenia patients and 63 healthy controls across 246 regions of interest (ROIs) and extracted the disease-related connectivity patterns using energy landscape (EL) analysis. …”
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Overweight and Helicobacter pylori infection: a correlation in metabolic dysfunction-associated fatty liver disease by Xu Chen, Jiayue Fu, Jiayue Fu, Kejia Jin, Kejia Jin, Zixuan Yang, Zixuan Yang, Yidan Qian, Yidan Qian, Kehan Mei, Yihan Wang, Jialei Min, Yilin Du, Zaisheng Zhu, Zaisheng Zhu, Shengcun Li, Shengcun Li

“…Therefore, eradication of H. pylori infection may have positive implications for reducing the incidence rate of overweight MAFLD.…”
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Epidemiology and genetic characterization of porcine reproductive and respiratory syndrome virus in Fujian Province, China, from 2023 to 2024 by Long-Bin Kang, Long-Bin Kang, Qiu-Yong Chen, Qiu-Yong Chen, Bing He, Bing He, Ren-Jie Wu, Ren-Jie Wu, Jing-Li Qiu, Jing-Li Qiu, Ru-Jing Chen, Ru-Jing Chen, Xue-Min Wu, Xue-Min Wu, Long-Bai Wang, Long-Bai Wang, Lun-Jiang Zhou, Lun-Jiang Zhou

“…The results revealed that the overall prevalence rate of PRRSV was 16.79% (44/262), PRRSV-1 and PRRSV-2 genotypes were co-prevalent in Fujian. …”
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CONCOMITANT CARDIOVASCULAR DISEASES AND ANTIHYPERTENSIVE TREATMENT IN OUTPATIENT PRACTICE (BY THE RECVASA REGISTRY DATA) by M. M. Loukianov, S. A. Boytsov, S. S. Yakushin, S. Yu. Martsevich, A. N. Vorobyev, A. V. Zagrebelnyy, N. N. Nikulina, K. G. Pereverzeva, E. A. Pravkina, A. D. Deev, E. V. Kudryashov, E. N. Belova

“…The mean number of prescribed AHDs was 1.73. The mean incidence rate of target blood pressure achievement was 26.1%. …”
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Selenium + Vitamin E Supplementation in Anestrus Goats: A Strategy to Enhance Reproductive Outcomes Under a Semi-Arid Production System by Raquel Santos-Silva, Cesar A. Meza-Herrera, Brenda Castro-Roque, Guadalupe Calderón-Leyva, Cayetano Navarrete-Molina, Oscar Angel-García, Jessica M. Flores-Salas, Angeles De Santiago-Miramontes, Fernando Arellano-Rodriguez, Cesar A. Rosales-Nieto

“…The response variables included estrus induction (EI), ovulatory rate (OR), corpus luteum diameter (CLD), left and right ovary diameters (LOD and ROD), embryo implantation (EMBRYO), and pregnancy rates (PREG). …”
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Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... by Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

“…The same applied for PBMC mitochondrial functionality and metabolic activity as assessed by ex vivo approaches, whereas non-mitochondrial respiration rate was significantly affected by L-carnitine supplementation over time. …”
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hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNA by Xin-bo Huang, Yue Zhang, Jing-wen Fan, Xin-yu Yu, Yun-lan Fang, Jin-xin Ren, Bin-yan Liu

“…However, it remains largely unclear whether A2B1 could function as a nucleic acid pattern-recognition receptor during cytoplasmic RNA virus infection. …”
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Characterizing timber harvest occurrence and intensity to inform forest carbon management across the eastern United States by Matthew B. Russell, Catherine J. Chamberlain, Lynn Riley, Natalia A. Mushegian, John S. Gunn, Ethan P. Belair, Sebastian U. Busby

“…Timber harvesting plays an important role in determining how forest management practices influence carbon storage and sequestration patterns. We analyzed recent harvesting patterns across the eastern United States to quantify harvest area, intensity, and type of silviculture across timberlands. …”
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The role of city parks in creating ‘wellbeing societies’: A case study of Piłsudski Park in Łódź, Poland by Melanie Kay Smith, Joanna Kowalczyk-Anioł, Jakub Janiszewski, Karolina Grabarczyk

“…Although social interactions are rated lower overall, they are particularly significant for younger and older users, as well as marginalized groups such as unemployed individuals. …”
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Comparative analysis of data transformation methods for detecting non-technical losses in electricity grids by Maria Gabriel Chuwa, Daniel Ngondya, Rukia Mwifunyi

“…The high accuracy and low false positive rates enable utilities to recover unbilled revenue and reduce inspection costs, amplifying savings compared to raw data or traditional approaches. …”
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Importance of hospital-specific antibiotic policy for ensuring maternal quality of care in India: A narrative review by Arijit Banerjee, Jhuma Biswas

“…Recommendations were adapted to local resistance patterns, resource availability, and patient demographics. …”
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Proactive Data Placement in Heterogeneous Storage Systems via Predictive Multi-Objective Reinforcement Learning by Suchuan Xing, Yihan Wang

“…The system incorporates a sophisticated reward mechanism that balances performance gains against migration overhead, while employing prioritized experience replay and adaptive learning rates to handle non-stationary workload characteristics. …”
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Residential solar adoption—main determinants and the future of small-scale photovoltaics by Severin Reissl, Luis Sarmiento, Johannes Emmerling

“…We present a data-driven microsimulation model analyzing residential photovoltaic adoption in Germany to address uncertainties in future adoption rates. We develop and calibrate a technology adoption model incorporating economic, financial, and behavioral factors to replicate historical adoption patterns from 2007 to 2020 and project future scenarios. …”
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Evaluating anti-MRSA antibiotic stewardship with a focus on trends in consumption and resistance in a tertiary hospital in Alexandria, Egypt from 2019 to 2023 by Ehab Elmongui, Adel Zaki, Amel Elsheredy, Asmaa Abd Elhameed

“…The study compared these consumption patterns with resistance rates in Staphylococcus spp., including MRSS, from January 2020 to December 2023. …”
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Spatiotemporal Analysis of Disease Spread Using a Soliton-Based SIR Framework for Nomadic Populations by Qura Tul Ain, Xiaoli Qiang, Noor Ul Ain, Zheng Kou

“…Numerical simulations demonstrate the effects of varying key parameters such as transmission rates, recovery rates, and advection–diffusion coefficients on the epidemic’s progression. …”
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