The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…Here, we investigated the effects of the human RNASET2 alarmin in two different human PCa cell lines focusing on cell proliferation, colony formation, adhesion, migration rates, and release of soluble immune-modulatory factors. …”
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Differences in Kinematic and Muscle Activity Between ACL Injury Risk and Healthy Players in Female Football: Influence of Change of Direction Amplitude in a Cross-Sectional Case–Co... by Loreto Ferrández-Laliena, Lucía Vicente-Pina, Rocío Sánchez-Rodríguez, Graham J Chapman, Jose Heredia-Jimenez, César Hidalgo-García, José Miguel Tricás-Moreno, María Orosia Lucha-López

“…<i>Background and Objectives</i>: Anterior cruciate ligament (ACL) injury rates remain high and have a significant impact on female football players. …”
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Applying energy efficiency strategies to university buildings using Design Builder program "Case study of the Faculty of Commerce building at Sohag University as a case study" تطبي... by Heba Talah Anwar khelef, Ahmed A Farghaly, Mohamed H ElHafnawy

“…University buildings consume a large percentage of energy rates in buildings in general due to their occupants, their activities and their occupancy pattern, as the higher education sector constitutes a small but important part of the existing global buildings sector, which is 20% of the non-residential horizontal area. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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RNAi-mediated suppression of toll-like receptor NlToll1 enhances Nilaparvata lugens susceptibility to entomopathogenic fungal infection by Zhu-Long Shao, Chen-Ping Lan, Xiao-Ping Yu, Zheng-Liang Wang

“…Toll-like receptors (TLRs) are a family of crucial pattern recognition proteins that are responsible for the immunologic recognition of invading pathogen in insects. …”
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Analysis of the Contextual Factors Influencing the Expansion of Construction Violations with an Emphasis on the Role and Position of Key Urban Stakeholders (Case Study: Isfahan Met... by Ahmad Shahivandi, Afsaneh Talebi Varnosfaderani

“…Additionally, natural population growth—encompassing births, improvements in healthcare, and reduced mortality rates—had a factor loading of 0.74, further impacting the urbanization process. …”
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Influences of coal-rock interface morphology’s spatiotemporal evolutionary characteristics on top coal caving law by Yupeng Shen, Tuo Yang, Jianzhuang Liu, Yang Li, Jianqiao Luo, Xiaonan Zhang

“…The sinusoidal periodic change pattern in top coal caving volume became more evident, which decreased the top coal recovery rate. …”
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A Robust Behavioral Biometrics Framework for Smartphone Authentication via Hybrid Machine Learning and TOPSIS by Moceheb Lazam Shuwandy, Qutaiba Alasad, Maytham M. Hammood, Ayad A. Yass, Salwa Khalid Abdulateef, Rawan A. Alsharida, Sahar Lazim Qaddoori, Saadi Hamad Thalij, Maath Frman, Abdulsalam Hamid Kutaibani, Noor S. Abd

“…Also, the proposal has been shown to be resilient against both environmental variation-based attacks by achieving accuracy above 93% and spoofing attacks by obtaining a detection rate of 96%. This emphasizes that the proposed technique provides a promising solution to many authentication issues and offers a user-friendly and scalable method to improve the security of the smartphone against cybersecurity attacks.…”
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Response of the Invasive Cyanobacterium <i>Raphidiopsis raciborskii</i> to Iron and Phosphorus Concentrations in the Habitat: Effects on Growth and Cellular Phosphorus Distribution by Wenting Shen, Han Yang, Gaibian Ding, Bo Li, Xin Gan, Zijie Yuan, Liqing Wang, Wei Zhang

“…The results revealed that under conditions of sufficient inorganic phosphorus, there was a logarithmic relationship between ferric ammonium citrate (Fe³⁺) and the specific growth rate of <i>R. raciborskii</i>. Fe³⁺ > 2 mg/L enhanced IPS enrichment and biomass accumulation. …”
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Extreme Oncoplastic Surgery for Multifocal/Multicentric and Locally Advanced Breast Cancer by Chaitanyanand B. Koppiker, Aijaz Ul Noor, Santosh Dixit, Laleh Busheri, Gautam Sharan, Upendra Dhar, Hari Kiran Allampati, Smeeta Nare

“…EO followed by RT results in acceptable local-regional control, low rate of complications, and high patient satisfaction. …”
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Predictive value of D-Dimer and thromboplastin time as coagulation indicators for COVID-19 patients by Marwan Alshipli, Thamer A Altaim, Ammar A Oglat, Samira Ahmed Alsenany, Osama Khodrog, Hanan Hasan, Sally Mohammed Farghaly Abdelaliem, A Matrieh, Bassam Z Shakhreet, Riziq Allah Gaowgzeh

“…Within the two groups of patients, the rate of coagulation disorders was as follows: mild = 8.8 % within coagulation disorders, 4.8% within the two Groups; severe = 91.2 % within coagulation disorders, 77.8 % within the two Groups. …”
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Epstein Barr virus antibody and cancer risk in two prospective cohorts in Southern China by Ming-Fang Ji, Yong-Qiao He, Min-Zhong Tang, Wen-Qiong Xue, Xia Yu, Hua Diao, Da-Wei Yang, Zhi-Ming Mai, Io Hong Cheong, Zhi-Yang Zhao, Biao-Hua Wu, Fu-Gui Li, Ji-Yun Zhan, Chang-Ling Huang, Hao-Lin Ma, Jun Li, Yan-Cheng Li, Tong-Min Wang, Ying Liao, Xue-Yin Chen, Zhi-Heng Liang, Shi-Feng Lian, Yun Du, Xue-Jun Liang, Zisis Kozlakidis, Jun Ma, Wei-Hua Jia

“…The associations showed an increased dose-response pattern, and keep persistent even up to ten years prior to diagnosis. …”
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Paradigm shift of respiratory viruses causing lower respiratory tract infection in children during COVID-19 pandemic in India by Mannat Kang, Subhabrata Sarkar, Suresh Kumar Angurana, Pankaj Singh, Meenakshi Rana, Ishani Bora, Rishi Chetanya, Bharatendu Singh, Jayashree Muralidharan, Radha Kanta Ratho

“…No significant difference in positivity rate of Inf A pdmH1N1, Inf A H3N2 and Inf B was seen. …”
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Risk of developing drug abuse in administration of a new hexaazaisowurtzitane derivative-based analgesic (experimental study) by S. G. Krylova, T. N. Pove’teva, K. A. Lopatina, Yu. V. Nesterova, E. P. Zueva, O. G. Afanas’eva, P. V. Kulpin, E. A. Kiseleva, N. I. Suslov, D. A. Kulagina, S. V. Sysolyatin, V. V. Zhdanov

“…Previous in vivo and in silico studies (docking, molecular modeling, molecular dynamics simulation) on the multi-target mechanism of thiowurtzine explain the absence of its morphine-like effect by the fact that the major targets of the analgesic are TRPA1 receptors and voltage-gated Ca 2+ channels. With a high degree of probability, the conclusions made herein predict no drug abuse development when thiowurtzine is used in the clinical setting. …”
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Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies. by Yanina Sguassero, Cristina B Cuesta, Karen N Roberts, Elizabeth Hicks, Daniel Comandé, Agustín Ciapponi, Sergio Sosa-Estani

“…In the long-term, the rate of negativization was between 20% and 45%. The main sources of bias identified across cohort studies were the lack of control for confounding and attrition bias. …”
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Heritability and Genetics of Type 2 Diabetes Mellitus in Sub-Saharan Africa: A Systematic Review and Meta-Analysis by Evans Adu Asamoah, Christian Obirikorang, Emmanuel Acheampong, Max Efui Annani-Akollor, Edwin Ferguson Laing, Eddie-Williams Owiredu, Enoch Odame Anto

“…Sub-Saharan Africa (SSA) is observing an accelerating prevalence rate of type 2 diabetes mellitus (T2DM) influenced by gene-environment interaction of modifiable and nonmodifiable factors. …”
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Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response by Cong Tang, Patrícia Corredeira, Sandra Casimiro, Qi Shi, Qiwei Han, Wesley Sukdao, Ana Cavaco, Cecília Melo-Alvim, Carolina Ochôa Matos, Catarina Abreu, Steven Walsh, Gonçalo Nogueira-Costa, Leonor Ribeiro, Rita Sousa, Ana Lorena Barradas, João Eurico Fonseca, Luís Costa, Emma V. Yates, Gonçalo J. L. Bernardes

“…By measuring the total concentrations of cysteine, free cysteine, lysine, tryptophan, and tyrosine protein-incorporated biomarkers and analyzing the results with supervised machine learning, we identify 78% of cancers with 0% false positive rate (N = 97) with an AUROC of 0.95. The cancer, healthy, and autoimmune/infectious biomarker pattern are statistically significantly different (p < 0.0001). …”
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Fosfomycin susceptibility in multidrug resistant uropathogens: A retrospective study in the era of antimicrobial resistance by Jasleen Kaur, Priya Bhat, Upasana Bhumbla

“…Background: Urinary tract Infection is one of the most prevalent clinical entities affecting people worldwide. The accelerating rate of antimicrobial resistance due to the unimpeded and rampant use of antimicrobials with over the counter availability of drugs has limited the therapeutic options for the treatment of UTI. …”
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Dental caries and actual utilization of dental services among primary school children in Egypt: a cross-sectional study by Mariam Osman Mohamed, Basman Elsayed Hamza, Rabaa Mahmoud Aboubakr, Nasr Mohamed Attia

“…Children whose fathers had a higher educational level demonstrated lower dental caries scores in both dentitions (DMFT: B=-0.300, P = 0.023), (deft: B= -0.429, P = 0.035). A higher utilization rate of dental services was noted among children from families with higher incomes (Odds Ratio (OR) = 2.607, P = 0.006). …”
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Salmonella spp. Inactivation During Hot Air Drying of Apples: Influence of Temperature, Bed Depth, and Air Velocity by Xiyang Liu, Elizabeth M. Grasso-Kelley, Alvin Lee, Lilybell Warda, Nathan M. Anderson

“…Increased air velocity shortened the constant-rate drying period, promoted a faster temperature increase in the apple cubes, and resulted in higher lethality within a shorter drying period. …”
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