Physiological insights into the responses of tea plants to aluminum through an integrated transcriptomic and metabolomic analysis by Xinwan Zhang, Shijie Luo, Xiali Ye, Lin Liu, Xinxin Jia, Deyuan Jiang, Weiwei Wen

“…Compared to 0 mM Al treatment, low Al concentrations (0.4 mM) enhanced root vitality by 8.91%, while higher Al concentrations (10 and 100 mM) reduced root vigor by 19.31% and 76.81%, respectively. In a similar pattern, the electron transfer rate in leaves remained stable under low Al levels but significantly decreased under high Al conditions. …”
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Impact of Malaria Diagnostic Technologies on the Disease Burden in the Sub-Saharan Africa by Josephine Wambani, Patrick Okoth

“…However, in certain areas, the rate of decline has slowed or even reversed the gains made so far. …”
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Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis by Xu Yingkai, Jiang Jianfeng, Hu Zhiyong, Zhou Zhifeng, Wang Lei

“…Abstract Background Osteosarcoma (OS) is the most common primary malignant bone tumor characterized by a high rate of metastasis. The clinical efficacy of current targeted drugs for OS is limited, highlighting the urgent need to identify novel therapeutic targets. …”
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Dr Papineau Meets Dr Masquelet—Management of Open Calcaneal Fractures, Combining Two Techniques: A Case Report by Shuvendu P Roy, Yogendra Gupta, Gurinder Bedi, Vishwadeep Sharma

“…Aim and background: Open fractures of the calcaneum are often the source of significant morbidity due to the high rate of wound infection and significant morbidity, ranging from malunion to amputation. …”
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Fluid–solid coupling productivity analysis of multi-stage fractured horizontal wells in shale reservoirs by Qian QI, Ming YUE, Weiyao ZHU, Wenjiang MA

“…The simulation results of the model align with actual field data, showing that gas production follows an “L-shaped” decline pattern with a coincidence rate exceeding 70%, verifying the model’s accuracy.…”
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Safety and efficacy of prone position ventilation in patients with severe pneumonia in neurosurgical intensive care units by CHENG Longyang，LI Jun，LI Shaoya，LI Chuanqing，XU Manman，WANG Rong，ZHAO Penglai

“…Changes in blood gas analysis［pH，arterial partial pressure of oxygen（PaO2），arterial partial pressure of carbon dioxide（PaCO2），oxygenation index］and hemodynamics［heart rate（HR），mean arterial pressure（MAP）］were compared before prone positioning，and at 1 day，3 days，5 days，and 7 days after resuming supine position following prone position treatment. …”
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Clinical characteristics and outcomes of non-tuberculous mycobacterial pulmonary infections after hematopoietic stem cell transplantation: A retrospective cohort study by Zahia Esber, Hamza Salam, Shefali Godara, Ayman Soubani

“…Conclusion: Outcomes vary significantly among non-tuberculous mycobacterial pulmonary infections based on mycobacterial species, rate of colonization and degree of immunosuppression. …”
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Isokinetic knee strength as a predictor of cardiorespiratory responses during loaded aerobic capacity test in elite athletes by Bekir Çar, Ahmet Kurtoğlu, Özdemir Atar, Musa Türkmen, Özgür Eken, Mehmet Soyler, Monira I. Aldhahi

“…Cardiorespiratory parameters—average breath volume (ABV), average breath frequency (ABF), auxiliary oxygen density (AOD), and heart rate (HR)—were recorded during the Bruce Protocol conducted under two conditions: unloaded and with a 10 kg loaded vest. …”
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Neuroendocrine tumors of the digestive system: pathologic and molecular characteristics by V. V. Delektorskaya

“…The grade (G) is based on the proliferative activity of the tumor assessed by the mitotic rate or by Ki-67 immunohistochemistry. Several markers are useful in the identification of a primary organ of NETs in metastatic lesions are also discussed. …”
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Network meta-analysis of erlotinib, gefitinib, afatinib and icotinib in patients with advanced non-small-cell lung cancer harboring EGFR mutations. by Wenhua Liang, Xuan Wu, Wenfeng Fang, Yuanyuan Zhao, Yunpeng Yang, Zhihuang Hu, Cong Xue, Jing Zhang, Jianwei Zhang, Yuxiang Ma, Ting Zhou, Yue Yan, Xue Hou, Tao Qin, Xiaoxiao Dinglin, Ying Tian, Peiyu Huang, Yan Huang, Hongyun Zhao, Li Zhang

“…Pooled data on objective response rate (ORR), progression free survival (PFS), overall survival (OS) were calculated. …”
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Demographic and clinical characteristics of patients with benign bone tumors: Evidence of bimodal age distribution in a Hispanic population by Blake C. Martin, Mohammad Khalil, Juan Lopez-Alvarenga, Michael Sander

“…This indicates an incidence rate of 0.00018 per person-year. The average age was 38.8 years (SD 24.0), with females representing 58 % of the sample. …”
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Reduced Inter-Element Interference mmWave MIMO Antenna and Its Application in WBAN by Jawad Ahmad, Mohammad Hashmi

“…A specific absorption rate (SAR) analysis confirmed that the design complies with safety standards for both 1g and 10g tissue models. …”
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Factors associated with interstitial lung disease in patients with rheumatoid arthritis by Benyapa Suppa-Udom, Supparerk Disayabutr, Suwimon Wonglaksanapimon, Krittachat Butnian, Wanruchada Katchamart

“…Patients exhibited low disease activity [mean Disease Activity Score 28-erythrocyte sedimentation rate score (SD) 2.69 (0.90)] and mild functional impairment [median Health Assessment Questionnaire score (range) 0.25 (0–0.63)]. …”
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Comparative analysis of START and CAVI arterial stiffness scores in hypertensive patients by A. N. Sumin, A. V. Shcheglova, I. B. Bakholdin

“…Parameters were associated with age (r=0,412 for CAVI and r=0,355 for START; p<0,001), smoking duration (r=0,390 and r=0,361; p<0,001), glomerular filtration rate (r=-0,317 and r= -0,318; p<0,001), body mass index (r=-0,176 and r=-0,185; p=0,001). …”
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Genetic and clinical characteristics of catecholaminergic polymorphic ventricular tachycardia in a Taiwanese nationwide cohort by Grace Chia-Yen Hsu, Mei-Hwan Wu, Jing-Yuan Chuang, Shuenn-Nan Chiu, Ming-Tai Lin, Ling-Ping Lai, Shih-Fan Sherri Yeh, Sheng-Fu Liu, Ting-Tse Lin, Fu-Tien Chiang, Jyh-Ming Jimmy Juang

“…Among the 29 Taiwanese patients with CPVT-related gene mutations, 55% had RYR2 mutations, a rate similar to other ethnicities. Three out of 12 RYR2 variants were unreported. …”
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Three-dimensional cell sheet model improves in vitro prediction accuracy of osteogenic potential for biodegradable magnesium-based metals by Liangwei Chen, Guanxi Wu, Siyu Liu, Ziyu Yan, Honglei Yue, Jianhua Zhu, Na Ge, Yifei Wang, Qingxiang Li, Guanqi Liu, Tingting Zhang, Haowen Zheng, Shaozhe Xin, Guangyunhao Sun, Chuanbin Guo, Jianmin Han

“…Flow cytometry showed higher Ki67 expression and lower ROS levels and apoptosis rate in cell sheets. ShRNA-mediated silencing of N-Cadherin in cell sheets significantly compromised their cytoprotective capacity against Mg metal-induced toxicity. …”
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Distribution and extended triage of high-risk human papillomavirus genotyping based on vaginal self-sampling by Ling Li, Yun Zhao, Rong Liu, Chen Yao, Zhijun Zhang, Yingying Hu, Ruifang Wu, Ruifang An, Hui Du, Xinfeng Qu, Lihui Wei, Bei Lin, Mingzhu Li, Chao Zhao, Jingran Li, Zhixin Lin, Jihong Deng, Songling Zhang

“…Different HPV subtypes have different detection rates for CIN2+, and combining HPV16/18/33 significantly improved the sensitivity for detecting CIN2+.…”
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The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…Here, we investigated the effects of the human RNASET2 alarmin in two different human PCa cell lines focusing on cell proliferation, colony formation, adhesion, migration rates, and release of soluble immune-modulatory factors. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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RNAi-mediated suppression of toll-like receptor NlToll1 enhances Nilaparvata lugens susceptibility to entomopathogenic fungal infection by Zhu-Long Shao, Chen-Ping Lan, Xiao-Ping Yu, Zheng-Liang Wang

“…Toll-like receptors (TLRs) are a family of crucial pattern recognition proteins that are responsible for the immunologic recognition of invading pathogen in insects. …”
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