IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. by Helen M Lazear, Alissa Lancaster, Courtney Wilkins, Mehul S Suthar, Albert Huang, Sarah C Vick, Lisa Clepper, Larissa Thackray, Margaret M Brassil, Herbert W Virgin, Janko Nikolich-Zugich, Ashlee V Moses, Michael Gale, Klaus Früh, Michael S Diamond

“…Whereas the gene induction pattern in DKO mDC was similar to WT cells, remarkably, almost no ISG induction was detected in TKO or Mavs(-/-) mDC. …”
Get full text

Dual orexin receptor antagonists for the treatment of insomnia: systematic review and network meta-analysis by Rebeka Bustamante Rocha, Fernanda Ferreira Bomtempo, Gabriela Borges Nager, Giulia Isadora Cenci, João Paulo Mota Telles

“…Concerning TST, an apparent dose-dependent pattern was noticed, with higher doses relating to a longer TST. …”
Get full text

In Silico Designed Multi-Epitope Vaccine Based on the Conserved Fragments in Viral Proteins for Broad-Spectrum Protection Against Porcine Reproductive and Respiratory Syndrome Viru... by Shaukat Ullah, Hikmat Ullah, Kainat Fatima, Tan Lei

“…This virus includes two major genotypes, PRRSV1 and PRRSV2, both characterized by high mutation rates and genetic variability, complicating the development of a universally effective vaccine and disease control. …”
Get full text

Cumulative risk of revision after primary total hip arthroplasty in registries internationally: systematic review and meta-analysis of selected hip stems and cups by Christophe Combescure, James A Smith, Christophe Barea, Lotje A Hoogervorst, Rob Nelissen, Perla J Marang-van de Mheen, Anne Lübbeke, the Arthroplasty registry group

“…Purpose: The objective was to investigate the consistency in cumulative revision rates (CRRs) for a selection of total hip arthroplasty cups and stems across national/regional hip arthroplasty registries worldwide. …”
Get full text

Erosion of estimated genomic breeding values with generations is due to long distance associations between markers and QTL by Didier Boichard, Sébastien Fritz, Pascal Croiseau, Vincent Ducrocq, Thierry Tribout, Beatriz C. D. Cuyabano

“…In Method 2 all the QTL contributions to SNP effects are regressed based on SNP-QTL recombination rates and summed to predict the GEBV at the next generation. …”
Get full text

Fabrication and Characterization of Si Substrate-Free InGaN Light-Emitting Diodes and Their Application in Visible Light Communications by Chia-Lung Tsai, Ying-Chang Li, Yi-Chen Lu, Sheng-Hsiung Chang

“…A direct line-of-sight optical link using the proposed thin-film LEDs achieved data transmission rates of up to 100 Mb/s over a distance of 100 cm, indicating that the proposed LEDs have potential for use as optical transmitters in indoor visible light communications.…”
Get full text

Succession of Lichens in Front of Retreating Glaciers in Sweden and Norway by Josef P. Halda, Jan Košnar, Alena Lukešová

“…Lichen succession follows the expected pattern, primarily shaped by terrain microtopography, climate, and substrate type. …”
Get full text

Numerical modelling of rope elasticity for heave compensation lifting in offshore crane operations by Bassey Asanga, Akanimo Ekpenyong, Aniekan Ikpe

“…The heave, roll and pitch motions were observed to be a regular wave pattern. The comparison of the variations of heave, roll and pitch (including their rates and accelerations) within resonating time (50 seconds) during WOC with WC revealed that the heave compensation system could reduce heave, roll and pitch motion.…”
Get full text

Barriers and facilitators for the practice of occupational therapy in mental health: findings from a global practitioner survey of the World Federation of Occupational Therapists by Tiago S. Jesus, Pedro C. Monteiro, Ritchard Ledgerd, Claudia von Zweck, World Federation of Occupational Therapists

“…Of the nine surveyed factors, six (66%) were rated more often as barriers for practice, including “waiting times”, “services funding”, “intervention costs”, and “therapists availability”. …”
Get full text

Consumer health knowledge: cultural norms and marketing of healthcare products by Ogbonnaya Ukeh Oteh, Ambrose Ogbonna Oloveze, Raymond Ozoemena Obasi, Opara Obinna Justin

“…The research follows a survey pattern as data was collected for 4 – 5 months in year 2020 using a structured questionnaire while mean rating analysis and Pearson Coefficient correlation were used to analyze the result. …”
Get full text

Evaluation of newly transplanted blackberry tolerance to a selection of preemergence herbicides by Kayla Knepp, Matthew B. Bertucci, Aaron J. Cato, Amanda L. McWhirt, Nilda R. Burgos

“…Results from these trials verify that flumioxazin, napropamide, oryzalin, and pendimethalin at the tested rates would be appropriate options for weed control in newly planted blackberries. …”
Get full text

Dietary inflammatory index and mortality in middle-aged and elderly patients with metabolic syndrome by Xiangmei Li, Lei Liu, Xing Li, Long Yang, Li Men

“…Promoting an anti-inflammatory dietary pattern may be a cost-effective, non-pharmacologic approach to reducing the risk of cardiometabolic mortality in an aging population with a high cardiometabolic burden.…”
Get full text

A Comprehensive Analysis of the Radiographic Characteristics and Bilateral Symmetry of the Mental Foramen by Radhwan Algabri, Faisal Abulohoom, Abdelrahman Fadag, Hesham Al‐Sharani, Sami Al‐Aqab, Nassr Al‐Hutbany, Emad Alryashi, Ahmed Keshk, Ahmed Yaseen Alqutaibi

“…Gender differences were significant for the shape of the MF and the pattern of the canal on the right side. The symmetry rates for various features included horizontal positions (87.4%), vertical positions (82.6%), and shapes (80.4%). …”
Get full text

Modulatory role of radioprotective 105 in mitigating oxidative stress and ferroptosis via the HO-1/SLC7A11/GPX4 axis in sepsis-mediated renal injury by Hong Duo, Yanwei Yang, Jun Luo, Yumeng Cao, Qian Liu, Jiarui Zhang, Siqi Du, Jian You, Guqing Zhang, Qifa Ye, Huaqin Pan

“…Abstract Sepsis-associated acute kidney injury (SA-AKI) is a critical condition characterized by high morbidity and mortality rates, particularly in intensive care settings. This study focuses on RP105, a pattern recognition receptor, exploring its role in moderating the mechanisms of oxidative stress and ferroptosis during SA-AKI, offering insights into its potential as a therapeutic target. …”
Get full text

Functional Identification Reveals That TaTGA16-2D Promotes Drought and Heat Tolerance by Jingna Ru, Jiamin Hao, Xiaoqian Ji, Bingqing Hao, Jiale Yang, Hongtao Wang, Baoquan Quan, Pengyan Guo, Jiping Zhao, Chao Wang, Huawei Shi, Zhaoshi Xu

“…Under heat stress, the survival rates of transgenic lines exceeded 34%, compared to less than 18% in wild-type plants. …”
Get full text

Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstiti... by Tomoyuki Araya, Toshiyuki Kita, Tsukasa Ueda, Nanao Terada, Tamami Sakai, Kenta Yamamura, Koji Kurokawa, Yuka Uchida, Takashi Sone, Hideharu Kimura, Kazuo Kasahara

“…The overall response and disease control rates were 77.8% (95% CI, 40.0–97.2) and 88.9% (95% CI, 51.8–97.2), respectively. …”
Get full text

Negative Regulation of <i>GmNAC35</i> by miR164 Enhances Drought Tolerance in Soybean by Wentao Hu, Man Zhang, Jie Lu, Miaomiao Zhang, Reqing He, Youlin Zhu, Dong Wang, Liyun Jiang

“…Conversely, <i>GmNAC35</i> showed an inverse pattern, indicating negative regulation by miR164. …”
Get full text

Monolayer graphene/platinum-modified 3D origami microfluidic paper-based biosensor for smartphone-assisted biomarkers detection by Arda Fridua Putra, Annisa Septyana Ningrum, Suyanto Suyanto, Vania Mitha Pratiwi, Muhammad Yusuf Hakim Widianto, Irkham Irkham, Wulan Tri Wahyuni, Isnaini Rahmawati, Fu-Ming Wang, Chi-Hsien Huang, Ruri Agung Wahyuono

“…Key results: The optimized 10 mM G/Pt catalyst significantly improved reaction rates (18× faster), leading to a rapid detection time constant of 6.69 and 4.59 s for dopamine and NADH, respectively. …”
Get full text

An integrated high-resolution bathymetric model for the Danube Delta system by L. Alaerts, L. Alaerts, J. Lambrechts, N. R. Randresihaja, N. R. Randresihaja, L. Vandenbulcke, O. Gourgue, E. Hanert, E. Hanert, M. Grégoire

“…These error rates are comparable to those observed in bathymetry interpolation in rivers with similar source datasets. …”
Get full text

Combined alverine citrate and simeticonein preparation in the treatment of irritable bowel syndrome by Ye. A. Poluektova, S. Yu. Kuchumova, V. T. Ivashkin

“…Thirteen patients had clinical pattern of diarrhea predominance (IBS-D), 17 – predominance of constipation (IBS-С). …”
Get full text