Long-term real-world outcomes of first-line immunotherapy in non-small cell lung cancer – a population-based cohort study in Sweden by Gunnar Wagenius, Anders Vikström, Anders Berglund, Stina Salomonsson, Goran Bencina, Xiaohan Hu, Diana Chirovsky, Hans Brunnström

“…Background: In a previous study, we explored real-world programmed death-ligand 1 (PD-L1) testing and treatment patterns for patients with advanced non-small cell lung cancer (NSCLC) in the era of immune-oncology. …”
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Opportunities for immunocorrection aiming for reduction of morbidity in the areas with adverse occupational and environmental conditions by S. V. Petlenko, E. G. Golovacheva, O. I. Afanasieva

“…Origin and severity of immune system disorders depends on the spectrum and duration of exposure to adverse factors and patterns of professional activity at the chemically hazardous facilities. …”
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Determinants of chronic disease patients' intention to use Internet diagnosis and treatment services: based on the UTAUT2 model by Jing Zhao, Bei Li, Jianwei Sun, Xu Zeng, Jing Zheng

“…Employing a five-point Likert scale, the survey investigated the usage patterns of Internet diagnosis and treatment services among chronic disease patients in Shenzhen, China, as well as the factors influencing their behavioral intention. …”
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Organisation of physical education in universities for students with disabilities: Modular approach by L. V. Zakharova, O. N. Moskovchenko, U. Solimene, N. V. Tretyakova, N. V. Bannikova, N. V. Lyulina, O. A. Kattsin

“…The evaluation of the validity of differences in the average values of the studied indicators was performed according to Student’s t-test at a significance level of 5%. The growth rates of indicators were calculated according to Brody’s formula.Results and scientific novelty. …”
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Fungi present distinguishable isotopic signals in their lipids when grown on glycolytic versus tricarboxylic acid cycle intermediates by S. Jabinski, S. Jabinski, V. Kučera, V. Kučera, M. Kopáček, M. Kopáček, J. Jansa, T. B. Meador, T. B. Meador, T. B. Meador

“…<p>Microbial activity in soils controls both the size and turnover rates of large carbon (<span class="inline-formula">C</span>) inventories stored in the subsurface, having important consequences for partitioning of <span class="inline-formula">C</span> between terrestrial and atmospheric reservoirs as well as recycling of mineral nutrients such as nitrogen or phosphorus (often bound to the <span class="inline-formula">C</span>) that support plant growth. …”
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Predicting Financial Distress through Ranking Working Capital Management Components Using Random Forest Algorithm by Pouya Sadeghi, Daryush Farid, Hamid Reza Mirzaei, Abolfazl Dehghani

“…These scores, being close to 1, suggested that the model's estimations were performed with a high degree of accuracy.The analysis of the relative importance of each working capital management component in achieving this 85% accuracy rate revealed some key insights. The Average Collection Period (ACP) was identified as the most important factor in predicting financial distress. …”
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Prevalence and sequence of chronic conditions in older people with dementia: a multi-province, population-based cohort study by Susan E. Bronskill, Azmina Artani, Laura C. Maclagan, Xuesong Wang, Hannah Chung, J. Michael Paterson, Andrea Gruneir, Karen A. Phillips, Rasaq Ojasanya, Xibiao Ye, Kayla McLean, Fernanda Ewerling, Claire Godard-Sebillotte, Victoria Massamba, Louis Rochette, Isabelle Vedel, Larry Shaver, Catherine Pelletier, Colleen J. Maxwell

“…While there is evidence demonstrating a strong association between coping and PMH, less is known about how coping patterns differ across age groups. Given that age can impact coping ability, addressing this knowledge gap is warranted. …”
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Clinical, epidemiological, and virological features of Mpox in Beijing, China – May 31–June 21, 2023 by Xiangfeng Dou, Fu Li, Zhenyong Ren, Daitao Zhang, Jia Li, Dan Li, Yulan Sun, Haoyuan Jin, Renqing Li, Weihong Li, Xin Zhang, Yang Yang, Lei Jia, Yu Han, Wai Li, Yang Pan, Wenjie Tan, Peng Yang, Quanyi Wang

“…There were high oropharyngeal swab (75.8%) and blood (84.6%) positivity rates. All MPXV strains belonged to the B.1.3 branch of the West African lineage. …”
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A low-cost mitigation system for ammonia removal from broiler house exhaust air by Jingjing Luo, Jinsheng Rong, Shizhen Zhou, Haoliang Wang, Miao Li, Xiliang Yan, Yingbao Wu, Yan Wang

“…In this study, we utilized computational fluid dynamics (CFD) simulations to model a broiler house and analyzed airflow patterns at varying screen distances to assess their effect on indoor ventilation. …”
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Infrared Compositional Measurements in Comet C/2017 K2 (Pan-STARRS) at Heliocentric Distances Beyond 2.3 au by Chemeda Ejeta, Erika Gibb, Michael A. DiSanti, Hideyo Kawakita, Boncho P. Bonev, Neil Dello Russo, Nathan X. Roth, Younas Khan, Adam J. McKay, Michael R. Combi, Lori Feaga, Mohammad Saki, Ronald J. Vervack Jr, Yinsi Shou

“…Comet C/2017 K2 (Pan-STARRS) provided a rare opportunity to investigate the evolution of coma composition and outgassing patterns over a transitional heliocentric distance ( R _h ) range where activity drivers in comets are thought to change from “hypervolatile” (CO, CH _4 , C _2 H _6 , and/or CO _2 )-dominated to H _2 O-dominated. …”
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Gut Microbiota and Lipid Metabolism in Bullfrog Tadpoles: A Comparative Study Across Nutritional Stages by Zhilong Wang, Pengxiang Liu, Jun Xie, Huirong Yang, Guangjun Wang, Kai Zhang, Rui Shu, Zhifei Li, Jingjing Tian, Hongyan Li, Wenping Xie, Wangbao Gong, Yun Xia

“…These insights provide a theoretical foundation for nutritional interventions aimed at enhancing tadpole growth and survival rates.…”
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Bridging micro and macroevolution: insights from chromosomal dynamics in plants by Carmen Benítez-Benítez, Ashwini V. Mohan, Rogelio Sánchez-Villegas, Inés Gómez-Ramos, Ana Valdés-Florido, Kay Lucek, Marek Slovák, Marek Slovák, Filip Kolář, Filip Kolář, Ilia J. Leitch, Modesto Luceño, Isabel Larridon, Angelino Carta, Angelino Carta, Joan Cuscó-Borràs, Enrique Maguilla, Alegría Montero-Ramírez, Patrick G. Meirmans, Alison Dawn Scott, Santiago Martín-Bravo, Marcial Escudero

“…At the macroevolutionary level, we investigated the association between karyotype diversity and diversification rates using evidence from comparative genomics, chromosomal evolution modelling across phylogenies, and the association with several traits across different angiosperm lineages. …”
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Progressive subcortical involvement as spinocerebellar ataxia type 3 advances by Pubing Yuan, Yonghua Huang, Minghui Dai, Xin Jin, Dingxin Zheng, Die Xiao, Lihua Deng, Peiling Ou, Linfeng Shi, Yifan Chen, Jian Wang, Wei Chen, Yuanchao Zhang, Chen Liu

“…Abstract Background and objectives Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disease characterized by heterogeneous motor and nonmotor manifestations. The progressive pattern of subcortical shape abnormalities and their associations with the clinical phenotypes in SCA3 remain unknown. …”
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Characteristics of Anemia in Children Aged 6 Months to 5 Years Attending External Consultations at a Pediatric Hospital in Lisbon, Portugal by Réka Maulide Cane, Sérgio Chicumbe, Youssouf Keita, Anaxore Casimiro, Bárbara Martins Saraiva, Joana Vasconcelos, Beatriz Luzio Vaz, Afonso Sousa, Mafalda Cabral, Francisco Branco Caetano, Luís Varandas, Isabel Craveiro

“…Five children (6.8%) had normal hemoglobin but abnormal red-cell indices, with microcytic (60.0%; 3/5) or normocytic (40.0%; 2/5) patterns. Anemia rates were higher in males (55.1%), children aged 24–59 months, those residing in the Metropolitan Lisbon Area (82.6%), children whose caregivers had only basic or secondary education (58.0%), and those whose mothers were born in foreign countries (48.4%). …”
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WGCNA-ML-MR integration: uncovering immune-related genes in prostate cancer by Jing Lv, Jing Lv, Yuhua Zhou, Yuhua Zhou, Shengkai Jin, Shengkai Jin, Chaowei Fu, Chaowei Fu, Yang Shen, Yang Shen, Bo Liu, Bo Liu, Menglu Li, Yuwei Zhang, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…BackgroundProstate cancer is one of the most common tumors in men, with its incidence and mortality rates continuing to rise year by year. Prostate-specific antigen (PSA) is the most commonly used screening indicator, but its lack of specificity leads to overdiagnosis and overtreatment. …”
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Effect of transport stress on apoptosis and autophagy in goat lung cells by Yu Zhuo, Yunhai Hu, Yangshan Jin, Tian Ye, Yanzhen Yang, Ben Liu, Ben Liu, Ben Liu, Wenya Zheng, Wenya Zheng, Songlin Ding, Xue Yang, Xue Yang, Lucheng Zheng, Lucheng Zheng, Wei Hu, Wei Hu, Manxin Fang, Manxin Fang, Wanting Yi, Wenjing Xing

“…IntroductionRoad transportation exposes goats to thermal, mechanical, and microbial stressors that can compromise their welfare by triggering pulmonary apoptosis and autophagy processes associated with tissue damage and immunosuppression.MethodsTo explore potential biomarkers for transport-related welfare assessment, this study analyzed lung tissues from nine Ganxi goats (n = 9; 0 h control, 2 h/6 h transport groups) through an integrated experimental approach: TUNEL assays quantified apoptosis rates, immunohistochemistry mapped protein localization, Western blotting analyzed protein expression levels, and qPCR profiled gene expression of apoptotic regulators (Bax, Bcl-2) alongside autophagy-related markers (LC3B, p62, PINK1, Parkin).ResultsResults indicated time-dependent cellular stress patterns, where the 2 h group displayed elevated apoptosis rates, while the 6 h group exhibited upregulated Parkin expression (p &lt; 0.05) and altered regulation of apoptotic [Bcl-2-associated X-protein (Bax)/B-cell lymphoma-2 (Bcl-2)] and autophagy-related genes (Microtubule-associated protein 1 light chain 3B (LC3B), p62, PTEN-induced putative kinase 1 (PINK1)/Parkin). …”
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Changing trends in oral mucosal diseases in China (2016–2024): a cross-sectional study of 316,166 patients with focus on COVID-19 impact and use of chinese patent medicines by Peiru Zhou, Xu Zhang, Yifan Chen, Jiakun Fang, Yanhong Meng, Furong Yang, Pan Wei, Hong Hua

“…Despite variations in prevalence rates of oral mucosal diseases across regions, previous studies often involved small sample sizes with insufficient data analysis. …”
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Comprehensive assessment of adverse event profiles associated with bispecific antibodies in multiple myeloma by Mobina Golmohammadi, Shahzad Raza, Maram Albayyadhi, Hossein Sholehrasa, Jack Khouri, Louis Williams, Doris K. Hansen, Azam Moradi, Xuan Xu, Moath Albliwi, Ali Hajj Ali, Danai Dima, Faiz Anwer, Barry Paul, Majid Jaberi-Douraki

“…GPRC5D/FcRH5 are associated with less grade 3/4 hematologic toxicity whereas BCMA BsAbs were associated with lower grade 3/4 CRS rates, compared to GPRC5D/FcRH5. These insights are crucial for guiding treatment decisions and developing strategies to improve patient outcomes.…”
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Effects of Live and Peptide-Based Antimicrobiota Vaccines on <i>Ixodes ricinus</i> Fitness, Microbiota, and Acquisition of Tick-Borne Pathogens by Apolline Maitre, Lourdes Mateos-Hernandez, Myriam Kratou, Natalia Egri, Jennifer Maye, Manel Juan, Adnan Hodžić, Dasiel Obregón, Lianet Abuin-Denis, Elianne Piloto-Sardinas, Andrea C. Fogaça, Alejandro Cabezas-Cruz

“…The vaccination altered the feeding patterns and fitness of the ticks, with the Live vaccine group showing a higher weight and faster feeding time. …”
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Effects of Regulated Deficit Irrigation on Leaf Nutrients, Enzyme Activities, and Root Zone Soil Nutrients during Fruit Expansion and Coloration-Sugar Accumulation Stages of Citrus... by ZHONG Yun, HUANG Zhikun, ZHU Shijiang, HAO Kun, ZHU Zirong, ZHANG Wei, CHEN Hongde

“…The aim was to explore the response patterns of soil nutrients, citrus leaf nutrients, antioxidant enzyme activities, and root-zone soil nutrients to water stress under drip irrigation across different growth stages. …”
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