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    Rheology as a Tool to Investigate the Degradability of Hyaluronic Acid Dermal Fillers by Grimaldi G, Galasso G, Capillo MC, Alonci G, Bighetti S, Bettolini L, Sommatis S, Mocchi R, Carugno A, Zerbinati N

    Published 2025-05-01
    “…Although HA is widely acknowledged for its safety and efficacy the study of its degradability represents a critical aspect in ensuring safety.Methods: Rotational rheology was chosen to study the HA-based fillers interaction with hyaluronidase enzyme; this allows to establish a correlation between the viscoelastic parameters of the sample and its degradation.Results: The obtained results indicate that the products exhibit sensitivity to the enzyme and that the rheological parameters vary depending on the contact time and dosage of administration.Conclusion: Our findings propose a standardized rheological protocol for assessing the degradability of HA-based dermal fillers, offering an alternative to existing methods.Keywords: hyaluronic acid, adverse drug reaction, aesthetic dermatology, cosmetic dermatology…”
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