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    Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats by Ammanuel Y. Wabreha, Nasser Adjei, Bruce Ladenheim, Jean Lud Cadet, Atul P. Daiwile

    Published 2025-08-01
    “…Herein, we sought to identify the alteration in the expression of voltage gated and calcium activated potassium channels after extended access to oxycodone self-administration.MethodsWe used male Sprague-Dawley rats that self-administered oxycodone for 20 days according to short-access (ShA, 3 h per day) and long-access (LgA, 9 h per day) paradigms.ResultsLgA rats escalated their oxycodone intake and developed into two phenotypes, named long-access high (LgA-H, escalated intake) and long-access low (LgA-L, non-escalated intake) rats, based on the quantities of oxycodone intake during the self-administration experiment. …”
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